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Year 2015, Volume: 32 Issue: 4, 359 - 363, 01.10.2015

Abstract

References

  • 1. Steegers EAP, von Dadelszen P, Duvekott JJ, Pijnenborg R. Preeclampsia. Lancet 2010;376:631-44. [CrossRef]
  • 2. Sibai BM. Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Obstet Gynecol 2004;103:981-91. [CrossRef]
  • 3. Sibai BM, Taslimi MM, el-Nazer A, Amon E, Mabie BC, Ryan GM. Maternal-perinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsia-eclampsia. Am J Obstet Gynecol 1986;155:501-9. [CrossRef]
  • 4. Sibai BM. The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing? Am J Obstet Gynecol 1990;162:311-6. [CrossRef]
  • 5. Martin JN Jr, Rinehart BK, May WL, Magann EF, Terrone DA, Blake PG. The spectrum of severe preeclampsia: comparative analysis by HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome. Am J Obstet Gynecol 1999;180:1373-84. [CrossRef]
  • 6. Audibert F, Friedman SA, Frangieh AY, Sibai BM. Clinical utility of strict diagnostic criteria for the HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome. Am J Obstet Gynecol 1996;175:460-4. [CrossRef]
  • 7. Abramovici D, Friedman SA, Mercer BM, Audibert F, Kao L, Sibai BM. Neonatal outcome in severe preeclamsia 24 to 36 weeks’ gestation: does the HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome matter? Am J Obstet Gynecol 1999;180:221-5. [CrossRef]
  • 8. Haddad B, Barton JR, Livingston JC, Chahine R, Sibai B. HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome versus severe preeclampsia: Onset at ≤28.0 weeks’gestation. Am J Obstet Gynecol 2000;183:1475-9. [CrossRef

Severe Preeclampsia versus HELLP Syndrome: Maternal and Perinatal Outcomes at

Year 2015, Volume: 32 Issue: 4, 359 - 363, 01.10.2015

Abstract

Background: Preeclampsia and Hemolysis, Elevated Liver enzymes, Low Platelet (HELLP) syndrome are important disorders affecting the health of both the mother and fetus. Prediction of the maternal and perinatal outcomes at early and late gestational age is important for the management of both disorders. Aims: The purpose of the study was to investigate adverse maternal and perinatal outcomes in severe preeclampsia and HELLP syndrome cases according to gestational age. Study Design: Retrospective cross-sectional study. Methods: One hundred and ninety-seven pregnancies with severe preeclampsia and 56 pregnancies with HELLP syndrome were included the study. Clinical characteristics and adverse maternal and perinatal outcomes were noted from medical records. Participants were divided into two groups at <34 and ≥34 weeks’ gestation: the severe preeclampsia group and the HELLP syndrome group. The differences between the outcomes in the groups were investigated. Statistical analysis was performed using the Student t test, Fisher Exact test and Yates’ Chi-square test. Results: Eclampsia was more common in HELLP syndrome cases at <34 weeks’ gestation (p 0.028). However, eclampsia rates were statistically similar between groups at ≥34 weeks’ gestation. The requirement for blood products transfusion was higher in the HELLP group at all gestational weeks. No statistical difference was found in perinatal outcomes between severe preeclampsia and HELLP groups at less than and more than 34 weeks’ gestation. Conclusion: Eclampsia risk increases in HELLP syndrome, especially at gestations less than 34 weeks. Perinatal morbidity at less than 34 weeks’ gestation and mortality were similar in severe preeclampsia and HELLP syndrome cases at the same gestational age.

References

  • 1. Steegers EAP, von Dadelszen P, Duvekott JJ, Pijnenborg R. Preeclampsia. Lancet 2010;376:631-44. [CrossRef]
  • 2. Sibai BM. Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Obstet Gynecol 2004;103:981-91. [CrossRef]
  • 3. Sibai BM, Taslimi MM, el-Nazer A, Amon E, Mabie BC, Ryan GM. Maternal-perinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsia-eclampsia. Am J Obstet Gynecol 1986;155:501-9. [CrossRef]
  • 4. Sibai BM. The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing? Am J Obstet Gynecol 1990;162:311-6. [CrossRef]
  • 5. Martin JN Jr, Rinehart BK, May WL, Magann EF, Terrone DA, Blake PG. The spectrum of severe preeclampsia: comparative analysis by HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome. Am J Obstet Gynecol 1999;180:1373-84. [CrossRef]
  • 6. Audibert F, Friedman SA, Frangieh AY, Sibai BM. Clinical utility of strict diagnostic criteria for the HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome. Am J Obstet Gynecol 1996;175:460-4. [CrossRef]
  • 7. Abramovici D, Friedman SA, Mercer BM, Audibert F, Kao L, Sibai BM. Neonatal outcome in severe preeclamsia 24 to 36 weeks’ gestation: does the HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome matter? Am J Obstet Gynecol 1999;180:221-5. [CrossRef]
  • 8. Haddad B, Barton JR, Livingston JC, Chahine R, Sibai B. HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome versus severe preeclampsia: Onset at ≤28.0 weeks’gestation. Am J Obstet Gynecol 2000;183:1475-9. [CrossRef
There are 8 citations in total.

Details

Other ID JA79UB98YR
Journal Section Research Article
Authors

Tuğba Kınay This is me

Fulya Kayıkçıoğlu This is me

Canan Küçük This is me

Jale Karakaya This is me

Publication Date October 1, 2015
Published in Issue Year 2015 Volume: 32 Issue: 4

Cite

APA Kınay, T., Kayıkçıoğlu, F., Küçük, C., Karakaya, J. (2015). Severe Preeclampsia versus HELLP Syndrome: Maternal and Perinatal Outcomes at. Balkan Medical Journal, 32(4), 359-363.
AMA Kınay T, Kayıkçıoğlu F, Küçük C, Karakaya J. Severe Preeclampsia versus HELLP Syndrome: Maternal and Perinatal Outcomes at. Balkan Medical Journal. October 2015;32(4):359-363.
Chicago Kınay, Tuğba, Fulya Kayıkçıoğlu, Canan Küçük, and Jale Karakaya. “Severe Preeclampsia Versus HELLP Syndrome: Maternal and Perinatal Outcomes at”. Balkan Medical Journal 32, no. 4 (October 2015): 359-63.
EndNote Kınay T, Kayıkçıoğlu F, Küçük C, Karakaya J (October 1, 2015) Severe Preeclampsia versus HELLP Syndrome: Maternal and Perinatal Outcomes at. Balkan Medical Journal 32 4 359–363.
IEEE T. Kınay, F. Kayıkçıoğlu, C. Küçük, and J. Karakaya, “Severe Preeclampsia versus HELLP Syndrome: Maternal and Perinatal Outcomes at”, Balkan Medical Journal, vol. 32, no. 4, pp. 359–363, 2015.
ISNAD Kınay, Tuğba et al. “Severe Preeclampsia Versus HELLP Syndrome: Maternal and Perinatal Outcomes at”. Balkan Medical Journal 32/4 (October 2015), 359-363.
JAMA Kınay T, Kayıkçıoğlu F, Küçük C, Karakaya J. Severe Preeclampsia versus HELLP Syndrome: Maternal and Perinatal Outcomes at. Balkan Medical Journal. 2015;32:359–363.
MLA Kınay, Tuğba et al. “Severe Preeclampsia Versus HELLP Syndrome: Maternal and Perinatal Outcomes at”. Balkan Medical Journal, vol. 32, no. 4, 2015, pp. 359-63.
Vancouver Kınay T, Kayıkçıoğlu F, Küçük C, Karakaya J. Severe Preeclampsia versus HELLP Syndrome: Maternal and Perinatal Outcomes at. Balkan Medical Journal. 2015;32(4):359-63.