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Short-Term Outcomes and Mortality of Late Preterm Infants

Year 2016, Volume: 33 Issue: 2, 198 - 203, 01.03.2016

Abstract

Background: Late preterm infants have increased rates of morbidity and mortality compared to term infants. Determining the risk factors in these infants leads to more comprehensive preventive and treatment strategies. Aims: Our aim was to analyse the morbidity rates such as respiratory system diseases, infections, congenital anomalies, hypoglycemia and hematologic abnormalities and mortality rates in a large group of patients at a referral center.  Study Design: Retrospective cross-sectional study. Methods: Medical records of late preterm and term infants who were managed at the referral center were analysed.  Results: 41752 births were analysed in 3 years. 71.9% of all births were between 37-42 gestational weeks (i.e. term) and 16.1% were between 34-37 weeks (i.e. late preterm). Compared to term infants, late preterm infants had increased rates of short-term problems. The rate of mortality increased with decreased gestational age. The duration of hospitalization was significantly higher in the smallest late preterm infants. Conclusion: This study demonstrated the need that late preterm infants who have higher risk for morbidity and mortality, compared to term infants require close monitoring. The rate of mortality and hospitalization increased with decreased gestational age.

References

  • 1. Kramer MS, Demissie K, Yang HM, Platt RW, Sauve R, Liston R et al. The contribution of mild and moderate preterm birth to infant mortality. JAMA 2000;284:843-9. [CrossRef]
  • 2. Raju TNK, Higgins RD, Stark AR, Leveno KJ. Optimizing care and outcome for late preterem (near-term) infants: a summary of the workshop sponsored by the NICHD. Pediatrics 2006;118:1207-14. [CrossRef]
  • 3. Wang ML, Dorer DJ, Fleming MP, Catlin EA. Clinical outcomes of near-term infants. Pediatrics 2004;114:372-6. [CrossRef]
  • 4. Whitsett JA, Rice WR, Warner BB, Wert SE Pryhuber GS. Acute respiratory disorders. In: MacDonald MG, Mullet MD, Seshia MMK (eds). Avery’s Neonatology, 6th ed. Philadelphia, USA, Lippincott Williams and Wilkins; 2005:pp. 569-76.
  • 5. Edwards MS. Postnatal bacterial infections. In: Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin’s Neonatal Perinatal Medicine. Diseases of the Fetus and Infant. 9th ed. St. Louis, USA, Elsevier; 2011;pp. 793-830.
  • 6. Kaplan M, Wong RJ, Sibley E, Stevenson DK. Neonatal jaundice and liver disease. In: Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin’s Neonatal Perinatal Medicine. Diseases of the Fetus and Infant. 9th ed. St. Louis, USA, Elsevier; 2011;pp. 1443-96. [CrossRef]
  • 7. Luchtman-Jones L, Wilson DB. Hematologic problems in the fetus and neonate. In: Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin’s Neonatal Perinatal Medicine. Diseases of the Fetus and Infant. 9th ed. St. Louis, USA, Elsevier; 2011;pp. 1303-60.
  • 8. Martin JA, Hamilton BE, Sutton PD. Births: Final data for 2006. In: National vital statistics reports; Hyattsville (MD): National Center for Health Statistics; 2009;57:p. 1-102.
  • 9. Centers of Disease Control and Prevention National Center for Health Statistics VitalStatt. Available at: http://www.cdc.gov/ nchs/vitalstats.htm.
  • 10. Binarbaşı P, Akın Y, Narter F, Telatar B, Polatoğlu E, Ağzıkuru T. Mortality and morbidity in late preterm newborns. Turk Arch Ped 2013;48:17-22.
  • 11. Çelik İH, Demirel G, Canpolat FE, Dilmen U. A common problem for neonatal intensive care units: late preterm infants, a prospective study with term controls in a large perinatal center. J Matern Fetal Neonatal Med 2013;26:459-62. [CrossRef]
  • 12. Turkish Population and Health Research 2008 data. (Turkish) Available at: http://www.hips.hacettepe.edu.tr/tnsa2008/
  • 13. Atasay B, Okulu E, Mungan Akın İ, Çandır O, Arsan S, Türmen T. The early clinical outcomes of late preterm newborns. Turkish J Pediatric Dis 2010;4:30-5.
  • 14. Karataş A, Albayrak M, Keskin F, Bıyık I, Okur M, Güneş C, et al. Geç preterm doğum olgularında erken neonatal sonuçlar. Turk J Soc Obstet Gynecol 2013;10:165-72.
  • 15. Lee AC, Mullany LC, Tielsch JM, Katz J, Khartry SK, LeClerq SC, et al. Risk factors for neonatal mortality due to birth asphyxia in southern Nepal. A prospective, community based cohort study. Pediatrics 2008;121:e1381-90. [CrossRef]
  • 16. Lee-Parritz A, Cloherty JP. Diabetes mellitus. In: Cloherty JP, Eichenwald EC, Stark AR (Eds): Manual of Neonatal care 6th ed. Wolters Kluwer, Philadelphia 2008;pp. 9-19.
  • 17. Jackson GL, Rawiki P, Sendelbach D, Manning MD, Engle WD. Hospital course and short term outcomes of term and late preterm neonates following exposure to prolonged rupture of membranes and/or chorioamnionitis. Pediatr Infect Dis J 2012;31:89-90. [CrossRef]
  • 18. Engle WA, Tomashek KM, Wallman C; Committee on Fetus and Newborn, American Academy of Pediatrics. “Late preterm” infants: A population at risk. Pediatrics 2007;123:1390. [CrossRef]
  • 19. Femitha P, Bhat BV. Early neonatal outcome in late preterms. Indian J Pediatr 2012;79:1019-24. [CrossRef]
  • 20. Rubaltelli FF, Bonafe L, Tangucci M, Spagnolo A, Dani C. Epidemiology of neonatal acute respiratory disorders. A multicenter study on incidence and fatality rates of neonatal acute respiratory disorders according to gestational age, maternal age, pregnancy complications and type of delivery. Italian Group of Neonatal Pneumology. Biol Neonate 1998;74:7-15. [CrossRef]
  • 21. Hibbard JU, Wilkins I, Sun L, Gregory K, Haberman S, Hoffman M, et al. Consortium on safe Labor. Respiratory morbidity in late preterm births. JAMA 2010;304;419-25. [CrossRef]
  • 22. Kalyoncu Ö, Aygün C, Çetinoğlu E, Küçüködük Ş. Neonatal mortality and morbidity of late preterm babies. J Matern Fetal Neonatal Med 2010;23:607-12. [CrossRef]
  • 23. Anadkat JS, Kuzniewicz MW, Chaudhari BP, Cole FS, Hamvas A. Increased risk for respiratory distress among white, male, late preterm and term infants. J Perinatol 2012;32:780-878. [CrossRef]
  • 24. Wang ML, Dorer DJ, Fleming MP, Catlin EA. Clinical outcomes of near-term infants. Pediatrics 2004;114:372-6. [CrossRef]
  • 25. Teune MJ, Bakhuizen S, Gyamfi Banneman C, Opmeer BC, van Kaam AH, van Wassenaer AG, et al. A Systematic review of severe morbidity in infants born late preterm. Am J Obstet Gynecol 2011;205:374.e 1-9.
  • 26. Laptook A, Jackson GL. Cold stress and hypoglycemia in the late preterm (near term) infant: impact on nursery admission. Semin Perinatol 2006;30:24-7. [CrossRef]
  • 27. Clapp DW. Developmental regulation of the immune system. Semin Perinatol 2006;30:69-72. [CrossRef]
  • 28. Sinha A, Yokoe D, Platt R. Epidemiology of neonatal infections: experience during and after hospitalization. Pediatr Infect Dis J 2003;22:244-51. [CrossRef]
  • 29. Knashu M, Narayaman M, Bhargava S, Oslovich H. Perinatal outcome associated with preterm birth at 33-36 weeks gestation. A population baset cohort study. Pediatrics 2009;123:109-13. [CrossRef]
  • 30. Tomashek KM, Shapiro-Mendoza CK, Weiss J. Early discharge among late preterm and term newborns and risk of neonatal morbidity. Semin Perinatol 2006;30:61-8. [CrossRef]
  • 31. McIntire DD, Leveno KJ. Neonatal mortality and morbidity rates in late preterm births compared with births at term. Obstet Gynecol 2008;111:35-41. [CrossRef]
  • 32. Haroon A, Ali SR, Ahmed S, Maheen H. Short term neonatal outcome in late preterm vs. term infants. J Coll Physicians Surg Pak 2014;24:34-8.
  • 33. Escobar GJ, Clark RH, Greene JD. Short term outcomes of infants born at 35 and 36 weeks gestation: we need to ask more questions. Semin Perinatol 2006;30:28-33. [CrossRef
Year 2016, Volume: 33 Issue: 2, 198 - 203, 01.03.2016

Abstract

References

  • 1. Kramer MS, Demissie K, Yang HM, Platt RW, Sauve R, Liston R et al. The contribution of mild and moderate preterm birth to infant mortality. JAMA 2000;284:843-9. [CrossRef]
  • 2. Raju TNK, Higgins RD, Stark AR, Leveno KJ. Optimizing care and outcome for late preterem (near-term) infants: a summary of the workshop sponsored by the NICHD. Pediatrics 2006;118:1207-14. [CrossRef]
  • 3. Wang ML, Dorer DJ, Fleming MP, Catlin EA. Clinical outcomes of near-term infants. Pediatrics 2004;114:372-6. [CrossRef]
  • 4. Whitsett JA, Rice WR, Warner BB, Wert SE Pryhuber GS. Acute respiratory disorders. In: MacDonald MG, Mullet MD, Seshia MMK (eds). Avery’s Neonatology, 6th ed. Philadelphia, USA, Lippincott Williams and Wilkins; 2005:pp. 569-76.
  • 5. Edwards MS. Postnatal bacterial infections. In: Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin’s Neonatal Perinatal Medicine. Diseases of the Fetus and Infant. 9th ed. St. Louis, USA, Elsevier; 2011;pp. 793-830.
  • 6. Kaplan M, Wong RJ, Sibley E, Stevenson DK. Neonatal jaundice and liver disease. In: Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin’s Neonatal Perinatal Medicine. Diseases of the Fetus and Infant. 9th ed. St. Louis, USA, Elsevier; 2011;pp. 1443-96. [CrossRef]
  • 7. Luchtman-Jones L, Wilson DB. Hematologic problems in the fetus and neonate. In: Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin’s Neonatal Perinatal Medicine. Diseases of the Fetus and Infant. 9th ed. St. Louis, USA, Elsevier; 2011;pp. 1303-60.
  • 8. Martin JA, Hamilton BE, Sutton PD. Births: Final data for 2006. In: National vital statistics reports; Hyattsville (MD): National Center for Health Statistics; 2009;57:p. 1-102.
  • 9. Centers of Disease Control and Prevention National Center for Health Statistics VitalStatt. Available at: http://www.cdc.gov/ nchs/vitalstats.htm.
  • 10. Binarbaşı P, Akın Y, Narter F, Telatar B, Polatoğlu E, Ağzıkuru T. Mortality and morbidity in late preterm newborns. Turk Arch Ped 2013;48:17-22.
  • 11. Çelik İH, Demirel G, Canpolat FE, Dilmen U. A common problem for neonatal intensive care units: late preterm infants, a prospective study with term controls in a large perinatal center. J Matern Fetal Neonatal Med 2013;26:459-62. [CrossRef]
  • 12. Turkish Population and Health Research 2008 data. (Turkish) Available at: http://www.hips.hacettepe.edu.tr/tnsa2008/
  • 13. Atasay B, Okulu E, Mungan Akın İ, Çandır O, Arsan S, Türmen T. The early clinical outcomes of late preterm newborns. Turkish J Pediatric Dis 2010;4:30-5.
  • 14. Karataş A, Albayrak M, Keskin F, Bıyık I, Okur M, Güneş C, et al. Geç preterm doğum olgularında erken neonatal sonuçlar. Turk J Soc Obstet Gynecol 2013;10:165-72.
  • 15. Lee AC, Mullany LC, Tielsch JM, Katz J, Khartry SK, LeClerq SC, et al. Risk factors for neonatal mortality due to birth asphyxia in southern Nepal. A prospective, community based cohort study. Pediatrics 2008;121:e1381-90. [CrossRef]
  • 16. Lee-Parritz A, Cloherty JP. Diabetes mellitus. In: Cloherty JP, Eichenwald EC, Stark AR (Eds): Manual of Neonatal care 6th ed. Wolters Kluwer, Philadelphia 2008;pp. 9-19.
  • 17. Jackson GL, Rawiki P, Sendelbach D, Manning MD, Engle WD. Hospital course and short term outcomes of term and late preterm neonates following exposure to prolonged rupture of membranes and/or chorioamnionitis. Pediatr Infect Dis J 2012;31:89-90. [CrossRef]
  • 18. Engle WA, Tomashek KM, Wallman C; Committee on Fetus and Newborn, American Academy of Pediatrics. “Late preterm” infants: A population at risk. Pediatrics 2007;123:1390. [CrossRef]
  • 19. Femitha P, Bhat BV. Early neonatal outcome in late preterms. Indian J Pediatr 2012;79:1019-24. [CrossRef]
  • 20. Rubaltelli FF, Bonafe L, Tangucci M, Spagnolo A, Dani C. Epidemiology of neonatal acute respiratory disorders. A multicenter study on incidence and fatality rates of neonatal acute respiratory disorders according to gestational age, maternal age, pregnancy complications and type of delivery. Italian Group of Neonatal Pneumology. Biol Neonate 1998;74:7-15. [CrossRef]
  • 21. Hibbard JU, Wilkins I, Sun L, Gregory K, Haberman S, Hoffman M, et al. Consortium on safe Labor. Respiratory morbidity in late preterm births. JAMA 2010;304;419-25. [CrossRef]
  • 22. Kalyoncu Ö, Aygün C, Çetinoğlu E, Küçüködük Ş. Neonatal mortality and morbidity of late preterm babies. J Matern Fetal Neonatal Med 2010;23:607-12. [CrossRef]
  • 23. Anadkat JS, Kuzniewicz MW, Chaudhari BP, Cole FS, Hamvas A. Increased risk for respiratory distress among white, male, late preterm and term infants. J Perinatol 2012;32:780-878. [CrossRef]
  • 24. Wang ML, Dorer DJ, Fleming MP, Catlin EA. Clinical outcomes of near-term infants. Pediatrics 2004;114:372-6. [CrossRef]
  • 25. Teune MJ, Bakhuizen S, Gyamfi Banneman C, Opmeer BC, van Kaam AH, van Wassenaer AG, et al. A Systematic review of severe morbidity in infants born late preterm. Am J Obstet Gynecol 2011;205:374.e 1-9.
  • 26. Laptook A, Jackson GL. Cold stress and hypoglycemia in the late preterm (near term) infant: impact on nursery admission. Semin Perinatol 2006;30:24-7. [CrossRef]
  • 27. Clapp DW. Developmental regulation of the immune system. Semin Perinatol 2006;30:69-72. [CrossRef]
  • 28. Sinha A, Yokoe D, Platt R. Epidemiology of neonatal infections: experience during and after hospitalization. Pediatr Infect Dis J 2003;22:244-51. [CrossRef]
  • 29. Knashu M, Narayaman M, Bhargava S, Oslovich H. Perinatal outcome associated with preterm birth at 33-36 weeks gestation. A population baset cohort study. Pediatrics 2009;123:109-13. [CrossRef]
  • 30. Tomashek KM, Shapiro-Mendoza CK, Weiss J. Early discharge among late preterm and term newborns and risk of neonatal morbidity. Semin Perinatol 2006;30:61-8. [CrossRef]
  • 31. McIntire DD, Leveno KJ. Neonatal mortality and morbidity rates in late preterm births compared with births at term. Obstet Gynecol 2008;111:35-41. [CrossRef]
  • 32. Haroon A, Ali SR, Ahmed S, Maheen H. Short term neonatal outcome in late preterm vs. term infants. J Coll Physicians Surg Pak 2014;24:34-8.
  • 33. Escobar GJ, Clark RH, Greene JD. Short term outcomes of infants born at 35 and 36 weeks gestation: we need to ask more questions. Semin Perinatol 2006;30:28-33. [CrossRef
There are 33 citations in total.

Details

Other ID JA46MU87BT
Journal Section Research Article
Authors

Cahide Bulut This is me

Tuğba Gürsoy This is me

Fahri Ovalı This is me

Publication Date March 1, 2016
Published in Issue Year 2016 Volume: 33 Issue: 2

Cite

APA Bulut, C., Gürsoy, T., & Ovalı, F. (2016). Short-Term Outcomes and Mortality of Late Preterm Infants. Balkan Medical Journal, 33(2), 198-203.
AMA Bulut C, Gürsoy T, Ovalı F. Short-Term Outcomes and Mortality of Late Preterm Infants. Balkan Medical Journal. March 2016;33(2):198-203.
Chicago Bulut, Cahide, Tuğba Gürsoy, and Fahri Ovalı. “Short-Term Outcomes and Mortality of Late Preterm Infants”. Balkan Medical Journal 33, no. 2 (March 2016): 198-203.
EndNote Bulut C, Gürsoy T, Ovalı F (March 1, 2016) Short-Term Outcomes and Mortality of Late Preterm Infants. Balkan Medical Journal 33 2 198–203.
IEEE C. Bulut, T. Gürsoy, and F. Ovalı, “Short-Term Outcomes and Mortality of Late Preterm Infants”, Balkan Medical Journal, vol. 33, no. 2, pp. 198–203, 2016.
ISNAD Bulut, Cahide et al. “Short-Term Outcomes and Mortality of Late Preterm Infants”. Balkan Medical Journal 33/2 (March 2016), 198-203.
JAMA Bulut C, Gürsoy T, Ovalı F. Short-Term Outcomes and Mortality of Late Preterm Infants. Balkan Medical Journal. 2016;33:198–203.
MLA Bulut, Cahide et al. “Short-Term Outcomes and Mortality of Late Preterm Infants”. Balkan Medical Journal, vol. 33, no. 2, 2016, pp. 198-03.
Vancouver Bulut C, Gürsoy T, Ovalı F. Short-Term Outcomes and Mortality of Late Preterm Infants. Balkan Medical Journal. 2016;33(2):198-203.