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Year 2016, Volume: 33 Issue: 5, 578 - 580, 01.09.2016

Abstract

References

  • 1. American Academy of Pediatrics: Leptospirosis. In: Pickering LK, Baker CJ, Kimberlin DW, Long SS, editors. Red Book:2012 Report of the Committee on Infectious Diseases. Elk Grove Village, IL: American Academy of Pediatrics; 2012:469-71.
  • 2. Abdulkader RC, Silva MV. The kidney in leptospirosis. Pediatr Nephrol 2008;23:2111-20. [CrossRef]
  • 3. Anisimova IuI, Matiash VI. The pathomorphology and pathogenetic problems of liver involvement in icterohemorrhagic leptospirosis. Lik Sprava 1999;4:111-16.
  • 4. Edwards CN, Nicholson GD, Hassell TA, Everard CO, Callender J. Leptospirosis in Barbados. A clinical study. West Indian Med J 1990;39:27-34.
  • 5. Krishnamurthy S, Mahadevan S, Mandal J, Basu D. Leptospirosis in association with hemophagocytic syndrome: a rare presentation. Indian J Pediatr 2013;80:524-5. [CrossRef]
  • 6. Yang CW, Pan MJ, Wu MS, Chen YM, Tsen YT, Lin CL, et al. Leptospirosis: an ignored cause of acute renal failure in Taiwan. Am J Kidney Dis 1997;30:840-5. [CrossRef]
  • 7. Sripanidkulchai R, Lumbiganon P. Etiology of obscure fever in children at a university hospital in northeast Thailand. Southeast Asian J Trop Med Public Health 2005;36:1243-6.
  • 8. Daher EF, Silva GB, Silveira CO, Falcao FS, Alves MP, Mota JA, et al. Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease). Clinics (Sao Paulo) 2014;69:106-10. [CrossRef]
  • 9. Nguyen TC, Carcillo JA. Bench-to-bedside review: thrombocytopenia-associated multiple organ failure - a newly appreciated syndrome in the critically ill. Crit Care 2006;10:235. [CrossRef]
  • 10. Sevketoglu E, Yildizdas D, Horoz OO, Kihtir HS, Kendirli T, Bayraktar S, et al. Use of therapeutic plasma exchange in children with thrombocytopenia-associated multiple organ failure in the Turkish thrombocytopenia-associated multiple organ failure network. Pediatr Crit Care Med 2014;15:354-9. [CrossRef]

Pediatric Fulminant Leptospirosis Complicated by Pericardial Tamponade, Macrophage Activation Syndrome and Sclerosing Cholangitis

Year 2016, Volume: 33 Issue: 5, 578 - 580, 01.09.2016

Abstract

Background: Leptospirosis is a zoonotic infectious
disease caused by pathogenic spirochetes of the genus
Leptospira. Although it is usually asymptomatic and
self-limited, severe potentially fatal illness accompanied
by multi-organ failure may occur.
Case Report: Here we report an unusual case of severe
leptospirosis successfully treated with continuous
venovenous hemofiltration (CVVHF) and therapeutic
plasma exchange (TPE). The patient presented with
pericardial tamponade, renal failure and macrophage
activation syndrome, and later suffered prolonged jaundice
and sclerosing cholangitis during hospitalization in
the pediatric intensive care unit (PICU). To the best of
our knowledge, sclerosing cholangitis due to leptospirosis
has not been reported in the literature.
Conclusion: Leptospirosis should be kept in mind in
the differential diagnosis of sepsis and septic shock
with fever, thrombocytopenia, jaundice and renal failure.
TPE and CVVHF should start early after the diagnosis
of leptospirosis with multiorgan failure

References

  • 1. American Academy of Pediatrics: Leptospirosis. In: Pickering LK, Baker CJ, Kimberlin DW, Long SS, editors. Red Book:2012 Report of the Committee on Infectious Diseases. Elk Grove Village, IL: American Academy of Pediatrics; 2012:469-71.
  • 2. Abdulkader RC, Silva MV. The kidney in leptospirosis. Pediatr Nephrol 2008;23:2111-20. [CrossRef]
  • 3. Anisimova IuI, Matiash VI. The pathomorphology and pathogenetic problems of liver involvement in icterohemorrhagic leptospirosis. Lik Sprava 1999;4:111-16.
  • 4. Edwards CN, Nicholson GD, Hassell TA, Everard CO, Callender J. Leptospirosis in Barbados. A clinical study. West Indian Med J 1990;39:27-34.
  • 5. Krishnamurthy S, Mahadevan S, Mandal J, Basu D. Leptospirosis in association with hemophagocytic syndrome: a rare presentation. Indian J Pediatr 2013;80:524-5. [CrossRef]
  • 6. Yang CW, Pan MJ, Wu MS, Chen YM, Tsen YT, Lin CL, et al. Leptospirosis: an ignored cause of acute renal failure in Taiwan. Am J Kidney Dis 1997;30:840-5. [CrossRef]
  • 7. Sripanidkulchai R, Lumbiganon P. Etiology of obscure fever in children at a university hospital in northeast Thailand. Southeast Asian J Trop Med Public Health 2005;36:1243-6.
  • 8. Daher EF, Silva GB, Silveira CO, Falcao FS, Alves MP, Mota JA, et al. Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease). Clinics (Sao Paulo) 2014;69:106-10. [CrossRef]
  • 9. Nguyen TC, Carcillo JA. Bench-to-bedside review: thrombocytopenia-associated multiple organ failure - a newly appreciated syndrome in the critically ill. Crit Care 2006;10:235. [CrossRef]
  • 10. Sevketoglu E, Yildizdas D, Horoz OO, Kihtir HS, Kendirli T, Bayraktar S, et al. Use of therapeutic plasma exchange in children with thrombocytopenia-associated multiple organ failure in the Turkish thrombocytopenia-associated multiple organ failure network. Pediatr Crit Care Med 2014;15:354-9. [CrossRef]
There are 10 citations in total.

Details

Other ID JA84ZK66TG
Journal Section Research Article
Authors

Osman Yeşilbaş This is me

Hasan Serdar Kıhtır This is me

Hamdi Murat Yıldırım This is me

Nevin Hatipoğlu This is me

Esra Şevketoğlu This is me

Publication Date September 1, 2016
Published in Issue Year 2016 Volume: 33 Issue: 5

Cite

APA Yeşilbaş, O., Kıhtır, H. S., Yıldırım, H. M., Hatipoğlu, N., et al. (2016). Pediatric Fulminant Leptospirosis Complicated by Pericardial Tamponade, Macrophage Activation Syndrome and Sclerosing Cholangitis. Balkan Medical Journal, 33(5), 578-580.
AMA Yeşilbaş O, Kıhtır HS, Yıldırım HM, Hatipoğlu N, Şevketoğlu E. Pediatric Fulminant Leptospirosis Complicated by Pericardial Tamponade, Macrophage Activation Syndrome and Sclerosing Cholangitis. Balkan Medical Journal. September 2016;33(5):578-580.
Chicago Yeşilbaş, Osman, Hasan Serdar Kıhtır, Hamdi Murat Yıldırım, Nevin Hatipoğlu, and Esra Şevketoğlu. “Pediatric Fulminant Leptospirosis Complicated by Pericardial Tamponade, Macrophage Activation Syndrome and Sclerosing Cholangitis”. Balkan Medical Journal 33, no. 5 (September 2016): 578-80.
EndNote Yeşilbaş O, Kıhtır HS, Yıldırım HM, Hatipoğlu N, Şevketoğlu E (September 1, 2016) Pediatric Fulminant Leptospirosis Complicated by Pericardial Tamponade, Macrophage Activation Syndrome and Sclerosing Cholangitis. Balkan Medical Journal 33 5 578–580.
IEEE O. Yeşilbaş, H. S. Kıhtır, H. M. Yıldırım, N. Hatipoğlu, and E. Şevketoğlu, “Pediatric Fulminant Leptospirosis Complicated by Pericardial Tamponade, Macrophage Activation Syndrome and Sclerosing Cholangitis”, Balkan Medical Journal, vol. 33, no. 5, pp. 578–580, 2016.
ISNAD Yeşilbaş, Osman et al. “Pediatric Fulminant Leptospirosis Complicated by Pericardial Tamponade, Macrophage Activation Syndrome and Sclerosing Cholangitis”. Balkan Medical Journal 33/5 (September 2016), 578-580.
JAMA Yeşilbaş O, Kıhtır HS, Yıldırım HM, Hatipoğlu N, Şevketoğlu E. Pediatric Fulminant Leptospirosis Complicated by Pericardial Tamponade, Macrophage Activation Syndrome and Sclerosing Cholangitis. Balkan Medical Journal. 2016;33:578–580.
MLA Yeşilbaş, Osman et al. “Pediatric Fulminant Leptospirosis Complicated by Pericardial Tamponade, Macrophage Activation Syndrome and Sclerosing Cholangitis”. Balkan Medical Journal, vol. 33, no. 5, 2016, pp. 578-80.
Vancouver Yeşilbaş O, Kıhtır HS, Yıldırım HM, Hatipoğlu N, Şevketoğlu E. Pediatric Fulminant Leptospirosis Complicated by Pericardial Tamponade, Macrophage Activation Syndrome and Sclerosing Cholangitis. Balkan Medical Journal. 2016;33(5):578-80.