A Solitary Fibrous Tumor of the Subglottic Larynx: Case Report and Literature Review

Year 2016, Volume: 33 Issue: 6, 698 - 700, 01.11.2016

Sung-joon Park Young Hen Lee Ki Yeol Lee Kyoung Ho Oh Younghye Kim

Abstract

Background: Solitary fibrous tumors (SFT) arising from the larynx are extremely rare; most occur in the supraglottic larynx. Case Report: Herein, we detail a new case of a subglottic SFT presenting as a well-encapsulated soft-tissue tumor with hoarseness. It showed isoattenuation, similar to the adjacent muscle on pre-contrast computed tomography (CT) images, and strong, heterogeneous enhancement following contrast material administration, which may reflect hypervascularity. On pathological examination, it consisted of spindle cells, squeezed between abundant collagen, and focally prominent vascularity in a staghorn feature. The tumor cells were immunoreactive for CD34, BCL2 and CD99. Based on the combination of architectural and immunohistochemical criteria, we ultimately diagnosed this case as an SFT. Conclusion: Until now, only 14 cases of laryngeal SFT have been described in the literature: 13 located in the supraglottic areas and only one located in the subglottic/tracheal area. Therefore the present case is the second case of a subglottic SFT reported. Although rare, SFT should be included in the differential diagnosis of a well-marginated laryngeal mass with highly intense contrast enhancement, which suggests rich tumor vascularity.

Keywords

Larynx, benign neoplasm, solitary fibrous tumor

References

• 1. Liu Y, Li K, Shi H, Tao X. Solitary fibrous tumours in the extracranial head and neck region: correlation of CT and MR features with pathologic findings. Radiol Med 2014;119:910-9. [CrossRef]
• 2. Kim HJ, Kim HJ, Kim YD, Yim YJ, Kim ST, Jeon P, et al. Solitary fibrous tumor of the orbit: CT and MR imaging findings. AJNR Am J Neuroradiol 2008;29:857-62. [CrossRef]
• 3. Ganly I, Patel SG, Stambuk HE, Coleman M, Ghossein R, Carlson D, et al. Solitary fibrous tumors of the head and neck: a clinicopathologic and radiologic review. Arch Otolaryngol Head Neck Surg 2006;132:517-25. [CrossRef]
• 4. Morvan JB, Veyrieres JB, Mimouni O, N’Guyen AT, Fouet B, Cathelinaud O, et al. Solitary fibrous tumour of the larynx: a case report. Eur Ann Otorhinolaryngol Head Neck Dis 2011;128:262-5. [CrossRef]
• 5. Chang SK, Yoon DY, Choi CS, Yun EJ, Seo YL, Nam ES. CT, MR, and angiography findings of a solitary fibrous tumor of the larynx: a case report. Korean J Radiol 2008;9:568-71. [CrossRef]
• 6. Fábio Muradás Girardi1 MBB, Adriana Muradás Girardi. Solitary fibrous tumor of the larynx: report of two new cases. J Bras Patol Med Lab 2014;50:229-33.
• 7. Thompson LD, Karamurzin Y, Wu ML, Kim JH. Solitary fibrous tumor of the larynx. Head Neck Pathol 2008;2:67-74. [CrossRef]
• 8. Razek AA, Huang BY. Soft tissue tumors of the head and neck: imaging-based review of the WHO classification. Radiographics 2011;31:1923-54. [CrossRef]
• 9. Schulz B, Altendorf-Hofmann A, Kirchner T, Katenkamp D, Petersen I, Knösel T. Loss of cd34 and high igf2 are associated with malignant transformation in solitary fibrous tumors. Pathol Res Pract 2014;210:92-7. [CrossRef