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Year 2017, Volume: 34 Issue: 3, 226 - 231, 01.05.2017

Abstract

References

  • 1. Global initiative for chronic Obstructive Lung Disease. 2015 Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease. Available at website: www.goldcopd.org/ guidelines-global-strategy-for-diagnosis-management
  • 2. Vestbo J, Hurd SS, Agustí AG, Jones PW, Vogelmeier C, Anzueto A, et al. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease, GOLD executive summary. Am J Respir Crit Care Med 2013;187:347-65.
  • 3. Anzueto A. Impact of exacerbations on COPD. Eur Resp Rew 2010;115:113-8.
  • 4. Halpern MT, Stanford RH, Borker R. The burden of COPD in the U.S.A: results from the confronting COPD survey. Respir Med 2003;97(Suppl C)81-9.
  • 5. Thomsen M, Ingebrigtsen TS, Marott JL, Dahl M, Lange P, Vestbo J. et al. Inflamatory biomarkers and exacerbations in chronic obstructive pulmonary disease. JAMA 2013;309:2353-61.
  • 6. Thomsen M, Dahl M, Lange P, Vestbo J, Nordestgaard BG. Inflamatory biomarkers and comorbidites in copd. Am J Respir Crit Care 2012;186:982-8.
  • 7. Anzueto A, Leimer I, Kesten S. Impact of frequency of COPD exacerbations on pulmonary function, health status and clinical outcomes. Int J Chron Obstruct Pulmon Dis 2009;4:245-51.
  • 8. Bafadhel M, McKenna S, Terry S, Mistry V, Reid C, Haldar P, et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med 2011;184:662-71.
  • 9. Stockley RA, O'Brien C, Pye A, Hill SL. Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD. Chest 2000;117:1638-45.
  • 10. Mannino DM, Thorn D, Swensen A, Holguin F. Prevalence and outcomes of diabetes, hypertension, and cardiovascular disease in COPD. Eur Respir J 2008;32:962-9.
  • 11. Connors AF Jr, Dawson NV, Thomas C, Harrell FE Jr, Desbiens N, Fulkerson WJ, et al. Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments). Am J Respir Crit Care Med 1996;154:959-67.
  • 12. Soler-Cataluña JJ, Martínez-García MA, Román Sánchez P, Salcedo E, Navarro M, Ochando R. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax 2005;60:925- 31.
  • 13. Chang CL, Robinson SC, Mills GD, Sullivan GD, Karalus NC, McLachlan JD, et al. Biochemical markers of cardiac dysfunction predict mortality in acute exacerbations of COPD. Thorax 2011;66:764-8.
  • 14. Boudestein CM, Rutten FH, Cramer MJ, Lammers JW, Hoes AW. The impact of concurrent heart failure on prognosis in patients with chronic obstructive pulmonary disease. Eur J Heart Fail 2009;11:1182- 8.
  • 15. Jyothula S, Safdar Z. Update on pulmonary hypertension complicating chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2009;4:351-63.
  • 16. De Gennaro L, Brunetti ND, Cuculo A, Pellegrino PL, Di Biase M. Systemic inflamation in nonischemic dilated cardiomyopathy. Heart Vessels 2008;23:445-50.
  • 17. Villacorta H, Masetto AC, Mesquita E. C-reactive protein: an inflammatory marker with prognostic value in patients with decompensated heart failure. Arq Bras Cardiol 2007;88:585-9.

Association Between the Inflammatory Biomarkers and Left Ventricular Systolic Dysfunction in Patients with Exacerbations of Chronic Obstructive Pulmonary Disease

Year 2017, Volume: 34 Issue: 3, 226 - 231, 01.05.2017

Abstract

Nearly a quarter of patients with the exacerbation of chronic obstructive pulmonary disease present with left ventricular systolic dysfunction which may be associated with mortality. Background: Cardiovascular diseases are an important cause of morbidity and mortality in chronic obstructive pulmonary disease patients. The increased inflammatory biomarker levels predict exacerbations and are associated with cardiovascular diseases in stable chronic obstructive pulmonary disease patients but their role in the settings of acute chronic obstructive pulmonary disease exacerbations has not been determined. Aims: To analyse the association between inflammatory biomarkers and heart failure and also to determine the predictors of mortality in patients with exacerbations of chronic obstructive pulmonary disease. Study Design: Prospective observational study. Methods: We analysed 194 patients admitted for acute exacerbation of chronic obstructive pulmonary disease at The Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia. In all patients, C-reactive protein, fibrinogen, N-terminal of the pro-hormone brain natriuretic peptide and white blood count were measured and transthoracic echocardiography was performed. Results: There were 119 men (61.3%) and the median age was 69 years (interquartile range 62-74). Left ventricular systolic dysfunction (ejection fraction <50%) was present in 47 (24.2%) subjects. Patients with left ventricular systolic dysfunction had higher C-reactive protein levels (median 100 vs. 31 mg/L, p=0.001) and fibrinogen (median 5 vs. 4 g/L, p=<0.001) compared to those with preserved ejection fraction. The overall hospital mortality was 8.2% (16/178). The levels of C-reactive protein, fibrinogen, N-terminal pro-brain natriuretic peptide and ejection fraction predicted hospital mortality in univariate analysis. After adjusting for age, hypoxemia and C-reactive protein, ejection fraction remained significant predictors of hospital mortality (OR 3.89, 95% CI 1.05-15.8). Conclusion: Nearly a quarter of patients with the exacerbation of chronic obstructive pulmonary disease present with left ventricular systolic dysfunction which may be associated with mortality.

References

  • 1. Global initiative for chronic Obstructive Lung Disease. 2015 Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease. Available at website: www.goldcopd.org/ guidelines-global-strategy-for-diagnosis-management
  • 2. Vestbo J, Hurd SS, Agustí AG, Jones PW, Vogelmeier C, Anzueto A, et al. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease, GOLD executive summary. Am J Respir Crit Care Med 2013;187:347-65.
  • 3. Anzueto A. Impact of exacerbations on COPD. Eur Resp Rew 2010;115:113-8.
  • 4. Halpern MT, Stanford RH, Borker R. The burden of COPD in the U.S.A: results from the confronting COPD survey. Respir Med 2003;97(Suppl C)81-9.
  • 5. Thomsen M, Ingebrigtsen TS, Marott JL, Dahl M, Lange P, Vestbo J. et al. Inflamatory biomarkers and exacerbations in chronic obstructive pulmonary disease. JAMA 2013;309:2353-61.
  • 6. Thomsen M, Dahl M, Lange P, Vestbo J, Nordestgaard BG. Inflamatory biomarkers and comorbidites in copd. Am J Respir Crit Care 2012;186:982-8.
  • 7. Anzueto A, Leimer I, Kesten S. Impact of frequency of COPD exacerbations on pulmonary function, health status and clinical outcomes. Int J Chron Obstruct Pulmon Dis 2009;4:245-51.
  • 8. Bafadhel M, McKenna S, Terry S, Mistry V, Reid C, Haldar P, et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med 2011;184:662-71.
  • 9. Stockley RA, O'Brien C, Pye A, Hill SL. Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD. Chest 2000;117:1638-45.
  • 10. Mannino DM, Thorn D, Swensen A, Holguin F. Prevalence and outcomes of diabetes, hypertension, and cardiovascular disease in COPD. Eur Respir J 2008;32:962-9.
  • 11. Connors AF Jr, Dawson NV, Thomas C, Harrell FE Jr, Desbiens N, Fulkerson WJ, et al. Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments). Am J Respir Crit Care Med 1996;154:959-67.
  • 12. Soler-Cataluña JJ, Martínez-García MA, Román Sánchez P, Salcedo E, Navarro M, Ochando R. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax 2005;60:925- 31.
  • 13. Chang CL, Robinson SC, Mills GD, Sullivan GD, Karalus NC, McLachlan JD, et al. Biochemical markers of cardiac dysfunction predict mortality in acute exacerbations of COPD. Thorax 2011;66:764-8.
  • 14. Boudestein CM, Rutten FH, Cramer MJ, Lammers JW, Hoes AW. The impact of concurrent heart failure on prognosis in patients with chronic obstructive pulmonary disease. Eur J Heart Fail 2009;11:1182- 8.
  • 15. Jyothula S, Safdar Z. Update on pulmonary hypertension complicating chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2009;4:351-63.
  • 16. De Gennaro L, Brunetti ND, Cuculo A, Pellegrino PL, Di Biase M. Systemic inflamation in nonischemic dilated cardiomyopathy. Heart Vessels 2008;23:445-50.
  • 17. Villacorta H, Masetto AC, Mesquita E. C-reactive protein: an inflammatory marker with prognostic value in patients with decompensated heart failure. Arq Bras Cardiol 2007;88:585-9.
There are 17 citations in total.

Details

Other ID JA88AV95ZP
Journal Section Research Article
Authors

Ljiljana Andrijevic This is me

Senka Milutinov This is me

İlija Andrijevic This is me

Daniela Jokic This is me

Marija Vukoja This is me

Publication Date May 1, 2017
Published in Issue Year 2017 Volume: 34 Issue: 3

Cite

APA Andrijevic, L., Milutinov, S., Andrijevic, İ., Jokic, D., et al. (2017). Association Between the Inflammatory Biomarkers and Left Ventricular Systolic Dysfunction in Patients with Exacerbations of Chronic Obstructive Pulmonary Disease. Balkan Medical Journal, 34(3), 226-231.
AMA Andrijevic L, Milutinov S, Andrijevic İ, Jokic D, Vukoja M. Association Between the Inflammatory Biomarkers and Left Ventricular Systolic Dysfunction in Patients with Exacerbations of Chronic Obstructive Pulmonary Disease. Balkan Medical Journal. May 2017;34(3):226-231.
Chicago Andrijevic, Ljiljana, Senka Milutinov, İlija Andrijevic, Daniela Jokic, and Marija Vukoja. “Association Between the Inflammatory Biomarkers and Left Ventricular Systolic Dysfunction in Patients With Exacerbations of Chronic Obstructive Pulmonary Disease”. Balkan Medical Journal 34, no. 3 (May 2017): 226-31.
EndNote Andrijevic L, Milutinov S, Andrijevic İ, Jokic D, Vukoja M (May 1, 2017) Association Between the Inflammatory Biomarkers and Left Ventricular Systolic Dysfunction in Patients with Exacerbations of Chronic Obstructive Pulmonary Disease. Balkan Medical Journal 34 3 226–231.
IEEE L. Andrijevic, S. Milutinov, İ. Andrijevic, D. Jokic, and M. Vukoja, “Association Between the Inflammatory Biomarkers and Left Ventricular Systolic Dysfunction in Patients with Exacerbations of Chronic Obstructive Pulmonary Disease”, Balkan Medical Journal, vol. 34, no. 3, pp. 226–231, 2017.
ISNAD Andrijevic, Ljiljana et al. “Association Between the Inflammatory Biomarkers and Left Ventricular Systolic Dysfunction in Patients With Exacerbations of Chronic Obstructive Pulmonary Disease”. Balkan Medical Journal 34/3 (May 2017), 226-231.
JAMA Andrijevic L, Milutinov S, Andrijevic İ, Jokic D, Vukoja M. Association Between the Inflammatory Biomarkers and Left Ventricular Systolic Dysfunction in Patients with Exacerbations of Chronic Obstructive Pulmonary Disease. Balkan Medical Journal. 2017;34:226–231.
MLA Andrijevic, Ljiljana et al. “Association Between the Inflammatory Biomarkers and Left Ventricular Systolic Dysfunction in Patients With Exacerbations of Chronic Obstructive Pulmonary Disease”. Balkan Medical Journal, vol. 34, no. 3, 2017, pp. 226-31.
Vancouver Andrijevic L, Milutinov S, Andrijevic İ, Jokic D, Vukoja M. Association Between the Inflammatory Biomarkers and Left Ventricular Systolic Dysfunction in Patients with Exacerbations of Chronic Obstructive Pulmonary Disease. Balkan Medical Journal. 2017;34(3):226-31.