1. Ranta JK, Raatikainen K, Romppanen J, Pulkki K, Heinonen S. Decreased
PAPP-A is associated with preeclampsia, premature delivery and small
for gestational age infants but not with placental abruption. Eur J Obstet
Gynecol Reprod Biol 2011;157:48-52.
2. Jelliffe-Pawlowski LL, Baer RJ, Currier RJ, Lyell DJ, Blumenfeld YJ,
El-Sayed YY, et al. Early-onset severe preeclampsia by first trimester
pregnancy-associated plasma protein A and total humanchorionic
gonadotropin. Am J Perinatol 2015;32:703-12.
3. Conner SN, Longman RE, Cahill AG. The role of ultrasound in the
diagnosis of fetal genetic syndromes. Best Pract Res Clin Obstet Gynaecol
2014;28:417-28.
4. Pitkanen S, Laitinen P, Yla-Outinen A, Heikkila M, Honkasalo T, Ryynanen
M, et al. Extremely large nuchal translucency measurement predicts
adverse pregnancy outcome. J Obstet Gynaecol 2015;35:22-4.
5. Westin M, Saltvedt S, Almström H, Grunewald C, Valentin L. By how
much does increased nuchal translucency increase the risk of adverse
pregnancy outcome in chromosomally normal fetuses? A study of 16,260
fetuses derived from an unselected pregnant population. Ultrasound Obstet
Gynecol 2007;29:150-8.
6. Abele H, Wagner P, Sonek J, Hoopmann M, Brucker S, Artunc-Ulkumen
B, et al. First trimester ultrasound screening for Down syndrome based on
maternal age, fetal nuchal translucency and different combinations of the
additional markers nasal bone, tricuspid and ductus venosus flow. Prenat
Diagn 2015;35:1182-6.
7. Kelekci S, Yazicioğlu HF, Oguz S, Inan I, Yilmaz B, Sönmez S. Nasal bone
measurement during the 1st trimester: is it useful? Gynecol Obstet Invest
2004;58:91-5.
8. Sahota DS, Leung TY, Chan LW, Law LW, Fung TY, Chan OK, et al.
First-trimester fetal nasal bone length in an ethnic Chinese population.
Ultrasound Obstet Gynecol 2009;34:33-7.
9. Cicero S, Dezerega V, Andrade E, Scheier M, Nicolaides KH. Learning
curve for sonographic examination of the fetal nasal bone at 11-14 weeks.
Ultrasound Obstet Gynecol 2003;22:135-7.
10. Kesim M, Karlik I, Ustaoglu M, Erdogan H. The diagnosis of low birth
weight in our clinic. T Klin J Gynecol Obst 1997;7:143-8.
11. Maiz N, Valencia C, Emmanuel EE, Staboulidou I, Nicolaides KH.
Screening for adverse pregnancy outcome by ductus venosus Doppler at
11-13+6 weeks of gestation. Obstet Gynecol 2008;112:598-605.
12. Mazzoni GT Jr, Cabral AC, de Lima Faria MM, Castro MJ, de Carvalho
Pires M, et al. Ultrasound evaluation of the fetal nasal bone: what is the
most appropriate first-trimester cut-off point for aneuploidy screening?
Arch Gynecol Obstet 2012;285:1263-70.
13. Cicero S, Curcio P, Papageorghiou A, Sonek J, Nicolaides K. Absence
of nasal bone in fetuses with trisomy 21 at 11-14 weeks of gestation: an
observational study. Lancet 2001;358:1665-7.
14. Sonek JD, McKenna D, Webb D, Croom C, Nicolaides K. Nasal bone
length throughout gestation: normal ranges based on 3537 fetal ultrasound
measurements. Ultrasound Obstet Gynecol 2003;21:152-5.
15. Ozer A, Ozaksit G, Kanat-Pektas M, Ozer S. First trimester examination of fetal
nasal bone in the Turkish population. J Obstet Gynaecol Res 2010;36:739-44.
16. Cansu A, Ozgur H, Guven S, Dinc G, Dinc H. Fetal nasal bone length at
11(+0) - 13(+6) weeks of gestation: an evaluation of 554 consecutive cases.
Clin Exp Obstet Gynecol 2014;41:556-60.
17. Chen M, Lee CP, Tang R, Chan B, Ou CQ, Tang MH. First-trimester
examination of fetal nasal bone in the Chinese population. Prenat Diagn
2006;26:703-6.
Fetal Nasal Bone Length as a Novel Marker for Prediction of Adverse Perinatal Outcomes in the First-Trimester of Pregnancy
Year 2017,
Volume: 34 Issue: 2, 127 - 131, 01.03.2017
Background: Adverse outcomes of pregnancy are a challenging health-care problem. Prediction of adverse pregnancy outcomes is important to prevent the morbidities of the foetus and the mother. Aims: To study the clinical interest of fetal nasal bone length in predicting adverse pregnancy outcomes in the first trimester of pregnancy. Study Design: A population-based retrospective cohort study. Methods: Data from 868 women with first-trimester fetal nasal bone length and birth records available were enrolled. Fetal nasal bone length percentiles were determined and evaluated for their ability to predict adverse pregnancy outcomes such as preterm birth, preterm labour, preterm premature rupture of membranes, early preterm birth, gestational diabetes mellitus, gestational hypertension-preeclampsia, small-for-gestational age foetuses, macrosomia, oligohydramnios, polyhydramnios and fetal distress. Results: Fetal nasal bone length >95th percentile was significantly associated with preterm labor and preterm premature rupture of membranes (p=0.02, accuracy 0.91 and p=0.001, accuracy 0.94, respectively), whereas nasal bone length >99th percentile was significantly associated with preterm labor and oligohydramnios (p=0.006, accuracy 0.95 and p=0.014, accuracy 0.97). Conclusion: Fetal nasal bone length at high percentiles in the first trimester of pregnancy may aid in the prediction of adverse outcomes such as preterm labour, preterm premature rupture of membranes and oligohydramnios.
1. Ranta JK, Raatikainen K, Romppanen J, Pulkki K, Heinonen S. Decreased
PAPP-A is associated with preeclampsia, premature delivery and small
for gestational age infants but not with placental abruption. Eur J Obstet
Gynecol Reprod Biol 2011;157:48-52.
2. Jelliffe-Pawlowski LL, Baer RJ, Currier RJ, Lyell DJ, Blumenfeld YJ,
El-Sayed YY, et al. Early-onset severe preeclampsia by first trimester
pregnancy-associated plasma protein A and total humanchorionic
gonadotropin. Am J Perinatol 2015;32:703-12.
3. Conner SN, Longman RE, Cahill AG. The role of ultrasound in the
diagnosis of fetal genetic syndromes. Best Pract Res Clin Obstet Gynaecol
2014;28:417-28.
4. Pitkanen S, Laitinen P, Yla-Outinen A, Heikkila M, Honkasalo T, Ryynanen
M, et al. Extremely large nuchal translucency measurement predicts
adverse pregnancy outcome. J Obstet Gynaecol 2015;35:22-4.
5. Westin M, Saltvedt S, Almström H, Grunewald C, Valentin L. By how
much does increased nuchal translucency increase the risk of adverse
pregnancy outcome in chromosomally normal fetuses? A study of 16,260
fetuses derived from an unselected pregnant population. Ultrasound Obstet
Gynecol 2007;29:150-8.
6. Abele H, Wagner P, Sonek J, Hoopmann M, Brucker S, Artunc-Ulkumen
B, et al. First trimester ultrasound screening for Down syndrome based on
maternal age, fetal nuchal translucency and different combinations of the
additional markers nasal bone, tricuspid and ductus venosus flow. Prenat
Diagn 2015;35:1182-6.
7. Kelekci S, Yazicioğlu HF, Oguz S, Inan I, Yilmaz B, Sönmez S. Nasal bone
measurement during the 1st trimester: is it useful? Gynecol Obstet Invest
2004;58:91-5.
8. Sahota DS, Leung TY, Chan LW, Law LW, Fung TY, Chan OK, et al.
First-trimester fetal nasal bone length in an ethnic Chinese population.
Ultrasound Obstet Gynecol 2009;34:33-7.
9. Cicero S, Dezerega V, Andrade E, Scheier M, Nicolaides KH. Learning
curve for sonographic examination of the fetal nasal bone at 11-14 weeks.
Ultrasound Obstet Gynecol 2003;22:135-7.
10. Kesim M, Karlik I, Ustaoglu M, Erdogan H. The diagnosis of low birth
weight in our clinic. T Klin J Gynecol Obst 1997;7:143-8.
11. Maiz N, Valencia C, Emmanuel EE, Staboulidou I, Nicolaides KH.
Screening for adverse pregnancy outcome by ductus venosus Doppler at
11-13+6 weeks of gestation. Obstet Gynecol 2008;112:598-605.
12. Mazzoni GT Jr, Cabral AC, de Lima Faria MM, Castro MJ, de Carvalho
Pires M, et al. Ultrasound evaluation of the fetal nasal bone: what is the
most appropriate first-trimester cut-off point for aneuploidy screening?
Arch Gynecol Obstet 2012;285:1263-70.
13. Cicero S, Curcio P, Papageorghiou A, Sonek J, Nicolaides K. Absence
of nasal bone in fetuses with trisomy 21 at 11-14 weeks of gestation: an
observational study. Lancet 2001;358:1665-7.
14. Sonek JD, McKenna D, Webb D, Croom C, Nicolaides K. Nasal bone
length throughout gestation: normal ranges based on 3537 fetal ultrasound
measurements. Ultrasound Obstet Gynecol 2003;21:152-5.
15. Ozer A, Ozaksit G, Kanat-Pektas M, Ozer S. First trimester examination of fetal
nasal bone in the Turkish population. J Obstet Gynaecol Res 2010;36:739-44.
16. Cansu A, Ozgur H, Guven S, Dinc G, Dinc H. Fetal nasal bone length at
11(+0) - 13(+6) weeks of gestation: an evaluation of 554 consecutive cases.
Clin Exp Obstet Gynecol 2014;41:556-60.
17. Chen M, Lee CP, Tang R, Chan B, Ou CQ, Tang MH. First-trimester
examination of fetal nasal bone in the Chinese population. Prenat Diagn
2006;26:703-6.
Canda, M. T., Demir, N., & Sezer, O. (2017). Fetal Nasal Bone Length as a Novel Marker for Prediction of Adverse Perinatal Outcomes in the First-Trimester of Pregnancy. Balkan Medical Journal, 34(2), 127-131.
AMA
Canda MT, Demir N, Sezer O. Fetal Nasal Bone Length as a Novel Marker for Prediction of Adverse Perinatal Outcomes in the First-Trimester of Pregnancy. Balkan Medical Journal. March 2017;34(2):127-131.
Chicago
Canda, Mehmet Tunç, Namık Demir, and Orçun Sezer. “Fetal Nasal Bone Length As a Novel Marker for Prediction of Adverse Perinatal Outcomes in the First-Trimester of Pregnancy”. Balkan Medical Journal 34, no. 2 (March 2017): 127-31.
EndNote
Canda MT, Demir N, Sezer O (March 1, 2017) Fetal Nasal Bone Length as a Novel Marker for Prediction of Adverse Perinatal Outcomes in the First-Trimester of Pregnancy. Balkan Medical Journal 34 2 127–131.
IEEE
M. T. Canda, N. Demir, and O. Sezer, “Fetal Nasal Bone Length as a Novel Marker for Prediction of Adverse Perinatal Outcomes in the First-Trimester of Pregnancy”, Balkan Medical Journal, vol. 34, no. 2, pp. 127–131, 2017.
ISNAD
Canda, Mehmet Tunç et al. “Fetal Nasal Bone Length As a Novel Marker for Prediction of Adverse Perinatal Outcomes in the First-Trimester of Pregnancy”. Balkan Medical Journal 34/2 (March 2017), 127-131.
JAMA
Canda MT, Demir N, Sezer O. Fetal Nasal Bone Length as a Novel Marker for Prediction of Adverse Perinatal Outcomes in the First-Trimester of Pregnancy. Balkan Medical Journal. 2017;34:127–131.
MLA
Canda, Mehmet Tunç et al. “Fetal Nasal Bone Length As a Novel Marker for Prediction of Adverse Perinatal Outcomes in the First-Trimester of Pregnancy”. Balkan Medical Journal, vol. 34, no. 2, 2017, pp. 127-31.
Vancouver
Canda MT, Demir N, Sezer O. Fetal Nasal Bone Length as a Novel Marker for Prediction of Adverse Perinatal Outcomes in the First-Trimester of Pregnancy. Balkan Medical Journal. 2017;34(2):127-31.