Usability of Hemp Plant in Poultry Nutrition

Year 2024, , 442 - 448, 15.08.2024

Hasan Alp Sahin , Rabia Vildan Şahin

https://doi.org/10.47115/bsagriculture.1457465

Abstract

Hemp (Cannabis sativa L.) is an annual plant with 2n=20 chromosomes, one-year, C3 group, cultivated for its long and strong fibers and seeds. It is a plant that should be cultivated in a controlled manner due to the presence of THC (tetrahydrocannabinol) in its natural structure. Producers who avoid control and monitoring have turned to alternative products instead of hemp farming. Countries that cultivate cannabis in large areas; France, China, and Canada. Some countries are updating their cannabis-related laws and making efforts to increase hemp acreage. It is known that hemp farming has been practiced in Anatolia since 1500 BC. Various products such as hemp seeds, hemp pulp, hemp oil have been used in various studies in poultry feeding studies, while no negative results have been encountered, but various positive results have been suggested and their use is recommended. It is of great importance to investigate the effects of cannabidiols, which have strong antimicrobial, antioxidant and immunostimulant effects, as they are expected to support the immune system in poultry, especially broilers. Some of the studies in which hemp products are used in poultry nutrition are as follows; Addition of hemp meal to laying hen diets has been reported to make no significant difference in egg production, feed consumption, feed utilization, body weight gain or egg quality, but results in lower palmitic acid concentrations and higher Linoleic acid (LA) and alpha-linolenic acid (ALA) concentrations, which are healthier for human consumption. Hemp seeds and hemp oil used in chicken rations caused an increase in the omega-3 polyunsaturated fatty acid content and color intensity of egg yolks, but no adverse effects were observed on the sensory profiles of cooked eggs. Addition of cannabis meal to fast growing broiler diets did not affect performance or mortality, and no effect on the number of Clostridium perfringens in the cecum was reported. Hemp seeds have a remarkable effect on the growth of broiler chicks and can help reduce feed expenditures for broiler rearing. In this paper, the use and usability of the hemp plant, whose production areas are expanding rapidly, in poultry will be examined.

Keywords

Poultry nutrition, Hemp, Antioxidant, Immune system, Feeding performance

References

• Al Ubeed HMS, Bhuyan DJ, Alsherbiny MA, Basu A, Vuong QV. 2022. A comprehensive review on the techniques for extraction of bioactive compounds from medicinal cannabis. Molecules, 27: 604. https://doi.org/10.3390/molecules27030604.
• Andre CM, Hausman JF, Guerriero G. 2016. Cannabis sativa: the plant of the thousand and one molecules. Front Plant Sci, 7: 19. https://doi.org/10.3389/fpls.2016. 00019.
• Aydoğan M, Terzı̇ YE, Gizlenci Ş, Acar M, Esen A, Meral H. 2020. Türkiye’de kenevir yetiştiriciliğinin ekonomik olarak yapılabilirliği: Samsun ili Vezirköprü ilçesi örneği, Anadolu J Agri Sci, 35: 35-50.
• Bakyaraj S, Bhanja SK, Majumdar S, Dash B. 2012. Modulation of post-hatch growth and immunity through in ovo supplemented nutrients in broiler chickens. J Sci Food Agri, 92(2): 313-320.
• Balpınar Ö, Aytaç S. 2021. Tibbi kenevir ve sağlik: Farmakolojik bir derleme. Ankara Ecz Fak Derg, 45(3): 631-651. https://doi.org/10.33483/jfpau.859372.
• Beşir A, Yazıcı Bektaş N, Mortaş M, Yazıcı F. 2022. Kenevirde THC ve CBD faktörlerinin değerlendirilmesi. Osmaniye Korkut Ata Üniv Fen Bil Enst Derg, 5(2): 1092-1104.
• Bhanja SK, Mandal AB. 2005. Effect of in ovo injection of critical amino acids on pre- and post-hatch growth, immunocompetence and development of digestive organs in broiler chickens. Asian-Aust J Anim Sci, 18(4): 524-531.
• Callaway JC. 2004. Hempseed as a nutritional resource: an overview. Euphytica, 140: 65-72. https://doi.org/10.1007/s10681-004-4811-6.
• Castillo A, Tolón MR, Fernández-Ruiz J, Romero J, MartinezOrgado J. 2010. The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB2 and adenosine receptors. Neurobiol Dis, 37(2): 434-440. https://doi.org/10.1016/j.nbd.2009.10.023.
• Crippa JA, Zuardi A W, Martín-Santos R, Bhattacharyya S, Atakan Z, McGuire P, Fusar-Poli P. 2009. Cannabis and anxiety: a critical review of the evidence. Hum Psychopharmacol, 24(7): 515-523.
• Da Silva VK, De Freitas BS, Da Silva Dornelles A, Nery LR, Falavigna L, Ferreira RDP. 2014. Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: implications for neuroprotection. Mol Neurobiol, 49(1): 222-233. https://doi.org/10.1007/s12035-013-8514-7
• ElSohly MA, Radwan MM, Gul W, Chandra S, Galal A. 2017. Phytochemistry of Cannabis sativa L. Prog Chem Org Nat Prod, 103: 1-36.
• Eriksson M, Wall H. 2012. Hemp seed cake in organic broiler diets. Anim Feed Sci Technol, 171: 205-213.
• Ferket PR. 2006. Incubation and in ovo Nutrition affects Neonatal Development, 33rd Annual Carolina Poultry Nutrition Conference. September 26, RTP, NC, US, pp: 18-28.
• Gakhar N, Goldberg E, Jing M, Gibson R, House JD. 2012. Effect of feeding hemp seed and hemp seed oil on laying hen performance and egg yolk fatty acid content: evidence of their safety and efficacy for laying hen diets. Poult Sci, 91(3): 701-711.
• Goldberg EM, Gakhar N, Ryland D, Aliani M, Gibson RA, House JD. 2012. Fatty acid profile and sensory characteristics of table eggs from laying hens fed hempseed and hempseed oil. J Food Sci, 74: 153-160.
• Göre M, Kurt O. 2021. Bitkisel üretimde yeni bir trend: Kenevir. Int J Life Sci Biotechnol, 4(1): 138-157. https://doi.org/10.38001/ijlsb.789970.
• Gustafsson SB, Jacobsson SOP. 2019. Effects of cannabinoids on the development of chick embryos in ovo. Sci Rep, 9: 13486. https://doi.org/10.1038/s41598-019-50004-7.
• Hazekamp A, Fischedick JT, Llano MD, Lubbe A, Ruhaak RL. 2010. Chemistry of cannabis. In: Liu HW (Ben), Mander L, editors. Comprehensive Natural Products II: Chemistry and Biology. Elsevier, London, UK, pp: 1033-1084.
• House JD, Neufeld J, Leson G. 2010. Evaluating the quality of protein from hemp seed (Cannabis sativa L.) products through the use of the protein digestibility-corrected amino acid score method. J Agri Food Chem, 58(22): 11801-11807. https://doi.org/10.1021/jf102636b.
• Kalmendal R. 2008. Hemp seed cake fed to broilers. Dissertation, Swedish University of Agricultural Sciences, Department of Animal Nutrition and Management, Uppsala, Sweden, pp: 43.
• Khaksar S, Bigdeli MR. 2017. Intra-cerebral cannabidiol infusion-induced neuroprotection is partly associated with the TNF-α/TNFR1/NF-кB pathway in transient focal cerebral ischaemia. Brain Inj. 31(13-14): 1932-1943. https://doi.org/10.1080/02699052.2017.1358397.
• Khan RU, Durrani FR, Chand N, Anwar H, Naz S, Farooqi FA, Manzoor MN. 2009. Effect of Cannabis sativa fortified feed on muscle growth and visceral organs in broiler chicks. Int J Biol Biotech, 6(3): 179-186.
• Khan RU, Durrani FR, Chand N, Anwar H. 2010. Influence of feed supplementation with Cannabis sativa on quality of broilers carcass. Pakistan Vet J, 30: 34-38.
• Konca Y, Yalcin H, Karabacak M, Kaliber M, Durmuscelebi FZ. 2014. Effect of hempseed (Cannabis sativa L.) on performance, egg traits and blood biochemical parameters and antioxidant activity in laying Japanese quail (Coturnix coturnix japonica). British Poult Sci, 55(6): 785-794. http://dx.doi.org/10.1080/00071668.2014.978264.
• Konieczka P, Szkopek D, Kinsner M, Kowalczyk P, Michalczuk M, Bie´n D, Banach J, Matuseviˇcius P, Bogucka J. 2023. Cannabidiol and nano-selenium increase microvascularization and reduce degenerative changes in superficial breast muscle in c. perfringens-infected chickens. Int J Mol Sci, 24: 237. https://doi.org/10.3390/ijms24010237.
• Kopustinskiene DM, Masteikova R, Lazauskas R, Bernatoniene J. 2022. Cannabis sativa L. Bioactive compounds and their protective role in oxidative stress and inflammation. Antioxidants, 11: 660. https://doi.org/10.3390/antiox11040660.
• Kozela E, Juknat A, Vogel Z. 2017. Modulation of astrocyte activity by cannabidiol, a nonpsychoactive cannabinoid. Int J Mol Sci, 18(8): 1669. https://doi.org/10.3390/ijms18081669
• Langer E, Scilcher H. 1999. Propolis-Qualitat und Wirkungen von Proolis bzw. Propolis-zubereitugen. Dtsch Apoth Ztg, 37: 51-63.
• Lee WS, Erdelyi K. 2016. Cannabidiol limits T cell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation. Mol Med, 22(1): 1. https://doi.org/10.2119/molmed.2016.00007.
• Magen I, Avraham Y, Ackerman Z, Vorobiev L, Mechoulam R, Berry EM. 2009. Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation. J Hepatol, 51(3): 528-534. https://doi.org/10.1016/j. jhep.2009.04.021.
• Mahmoudi M, Farhoomand P, Azarfar A. 2012. Effects of graded levels of hemp seed (Cannabis sativa L.) on performance, organ weight and serum cholesterol levels on broilers. J Medic Plants, 2(42): 121-129.
• McPartland JM, Russo EB. 2001. Cannabis and Cannabis extracts: greater than the sum of their parts? J Cannabis Therapeut, 1: 103-132. https://doi.org/10.1300/J175v01n03_08.
• Mechoulam R, Berry EM, Avraham Y, Marzo VD, Fride E. 2006. The endocannabinoid system, mechanism of action and Function. Endocannabinoids, feeding and suckling-from our perspective. Int J Obesity, 30: 24-28.
• O’Sullivan SE, Kendall DA. 2010. Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease. Immunobiology, 215 (8): 611-616.
• Pazos MR, Mohammed N, Lafuente H, Santos M, Martínez-Pinilla E, Moreno E. 2013. Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors. Neuropharmacology, 71: 282-291.
• Pellati F, Borgonetti V, Brighenti V, Biagi M, Benvenuti S, Corsi L. 2018. Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer. BioMed Res Int, 2018: 1691428.
• Pertwee RG. 2008. The diverse CB 1 and CB 2 receptor pharmacology of three plant cannabinoids: D 9-tetrahydrocannabinol, cannabidiol and D 9-tetrahydrocannabivarin. Br J Pharmacol, 153(2): 199-215.
• Rajesh M, Mukhopadhyay P, Btkai S, Patel V, Saito K, Matsumoto S. 2010. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J Am Coll Cardiol, 56(25): 2115-2125.
• Salami SA, Luciano G, O’Grady MN, Biondi L, Newbold CJ, Kerry JP. 2019. Sustainability of feeding plant by-products: a review of the implications for ruminant meat production. Anim Feed Sci Technol, 251: 37-55. https://doi.org/10.1016/j.anifeedsci.
• Santos NAG, Martins NM, Sisti FM, Fernandes LS, Ferreira RS, Queiroz RHC. 2015. The neuroprotection of cannabidiol against MPP+-induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson’s disease. Toxicol Vitr, 30(1): 231-240.
• Schultes RE, Klein WM, Plowman T, Lockwood TE. 1975. Cannabis: An example of taxonomic neglect. Cannabis Cult, 1975: 21-38.
• Siano F, Moccia S, Picariello G, Russo G, Sorrentino G, Di Stasio M, La Cara F, Volpe M. 2019. Comparative study of chemical, biochemical characteristic and ATR-FTIR analysis of seeds, oil and flour of the edible fedora cultivar Hemp (Cannabis sativa L.). Molecules, 24(1): 83.
• Silversides FG, Lefrancois MR. 2005. The effect of feeding hemp seed meal to laying hens. British Poult Sci, 46(2): 231-235.
• Small E, Cronquit A. 1976. A practical and natural taxonomy for cannabis. Taxon, 25: 405-435.
• Smirnov A, Tako E, Ferket PR, Uni Z. 2006. Effects of in ovo feeding of carbohydrates and beta-hydroxy-beta-methylbutyrate on the development of chicken intestine. Poult Sci, 83(12): 2023-2028.
• Smith K. 2000. Hempseed oil: A smart start. The Hemp Rep, 2(14): 1488-3988.
• Wang Y, Mukhopadhyay P, Cao Z, Wang H, Feng D, Haskó G, et al. 2017. Cannabidiol attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury. Sci Rep, 7(1): 1-12.
• Zuardi AW, Morais SL, Guimarães FS, Mechoulam R. 1995. Antipsychotic effect of cannabidiol. J Clin Psychiatry, 56(10): 485-486.