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Nutritional Aspects for Modulation of Poultry Immune Stimulation

Year 2024, , 464 - 476, 15.08.2024
https://doi.org/10.47115/bsagriculture.1518799

Abstract

The immune system's defense mechanism has been affected by the management and nutrition conditions in poultry production. In biological aspects, Bursa Fabricius and Thymus are primary lymphoid organs that defend the body against diseases. The spleen, cecal tonsils, immunoglobulins, and various forms of mucosal immunity, BALT (bronchus-associated lymphoid tissue), MALT (mucosa-associated lymphoid tissue), CALT (conjunctiva-associated lymphoid tissue), and GALT (gut-associated lymphoid tissue), are also vital to their overall health. The management program (environmental conditions, heating, lighting practices) and feed (feed ingredients, composition, and feed additives) significantly affect birds' immunity and performance. Dietary supplementation enhances immune system activation by improving the lymphoid tissues and beneficial immune modulators and responses. During the past fifteen years, alternative feed additives (amino acids, minerals, vitamins, probiotics, prebiotics, synbiotics, and organic acids) have impacted animal production performance and immunity. Besides, feed additives, such as probiotics, prebiotics, vitamins, minerals, and organic acids, are essential for sustaining hormonal, physiological, and immunological processes. These additives, probiotics, vitamins (A, C, D, E), mineral (selenium) supplementations, and organic acids boost the immune system's activity against microbial pathogens and physiological stress mechanisms. Finally, this paper aims to review the current improvement in the relationship between nutrition and immunity in poultry.

References

  • Abd El-Hack ME, El-Saadony MT, Salem HM, El-Tahan AM, Soliman MM, Youssef GBA, Taha AE, Soliman SM, Ahmed AE, El-kott AF, Al Syaad KM, Swelum AA. 2022. Alternatives to antibiotics for organic poultry production: types, modes of action and impacts on bird's health and production. Poult Sci, 101(4): 101696.
  • Abd El-Hack ME, El-Saadony MT, Shafi ME, Qattan SYA, Batiha Ge, Khafaga AF, Abdel-Moneim AE, Alagawany M. 2020. Probiotics in poultry feed: A comprehensive review. J Anim Physiol Anim Nutr, 104(6): 1835-1850.
  • Abd El-Hady AM. 2020. Effect of incorporating natural zeolite with or without phytase enzyme into broilers diets on blood constituents and carcass traits. Egypt Poult Sci J, 40: 225-242.
  • Abdelrahman MM, Al-Baadani HH, Qaid MM, Al-Garadi MA, Suliman GM, Alobre MM, Al-Mufarrej SI. 2023. Using natural zeolite as a feed additive in broilers’ diets for enhancing growth performance, carcass characteristics, and meat quality traits. Life, 13: 1548.
  • Abidin Z, Khatoon A. 2013. Heat stress in poultry and the beneficial effects of ascorbic acid (vitamin C) supplementation during periods of heat stress. World’s Poult Sci J, 69: 135-152.
  • Abo-Al-Ela HG, El-Kassas S, El-Naggar K, E. Abdo S, Jahejo AR, Wakeel RA. 2021. Stress and immunity in poultry: light management and nanotechnology as effective immune enhancers to fight stress. Cell Stress and Chaperones, 26: 457-472.
  • Adabi SG, Ceylan N, Çiftci İ, Ceylan, A. 2019. Response of growing chicks to supplementation of low protein diets with leucine, valine and glycine-glutamic acid. S Afr J Anim, 49: 1047-1062.
  • Adabi SHG, Cooper RG, Ceylan N, Corduk M. 2011. L-carnitine and its functional effects in poultry nutrition. J World’s Poult Sci, 67(2): 277-296.
  • Adhikari P, Yadav S, Cosby DE, Cox NA, Jendza JA, Kimy WK. 2020. Research Note: Effect of organic acid mixture on growth performance and Salmonella Typhimurium colonization in broiler chickens. Poult Sci, 99(5): 2145862.
  • Aizenshtein R, Yosipovicha M, Kvint R, Shadmon S, Krispel E, Shuster E, Eliyahu D, Finger A, Banet-Noach C, Shahar E, Pitcovski J. 2016. Practical aspects in the use of passive immunization as an alternative to attenuated viral vaccines. Vaccine, 34(22): 2513-2518.
  • Alagawany M, Abd El-Hack ME, Farag MR, Sachan S, Karthik K, Dhama K. 2018. The use of probiotics as eco-friendly alternatives for antibiotics in poultry nutrition. Environ Sci Pollut Res Int, 25(11): 10611-10618.
  • Alagawany M, Elnesr SS, Farag MR, Tiwari R, Yatoo MI, Karthik K, Michalak I, Dhama K. 2021. Nutritional significance of amino acids, vitamins and minerals as nutraceuticals in poultry production and health - a comprehensive review. Vet Quart, 41(1): 1-29.
  • Alkie TN, Yitbarek A, Hodgins DC, Kulkarni RR, Taha-Abdelaziz K, Sharif S. 2019. Development of innate immunity in chicken embryos and newly hatched chicks: a disease control perspective. Avian Pathol, 48(4): 288-310.
  • Allmang C, Wurth L, Krol A. 2009. The selenium to selenoprotein pathway in eukaryotes: More molecular partners than anticipated. Biochim Biophys Acta, 1790(11): 1415-1423.
  • Ashayerizadeh A, Dabiri N, Ashayerizadeh O, Mirzadeh KH, Roshanfekr H, Mamooee M. 2009. Effect of dietary antibiotic, probiotic and prebiotic as growth promoters, on growth performance, carcass characteristics and hematological indices of broiler chickens. Pak J Biol Sci, 12: 52-57.
  • Aviagen. 2009. Immunosuppression in broilers. Aviagen publishers, New York, USA, 0809-AVN-021, pp:254.
  • Awad WA, Chareeb K, Abdel-Raheem S, Bohm J. 2009. Effects of dietary inclusion of probiotic and symbiotic on broiler chickens' growth performance, organ weight, and intestinal histomorphology. Poult Sci, 88: 49-56.
  • Azzam MMM, Dong XY, Xie P, Wang C, Zou XT. 2011. The effect of supplemental l-threonine on laying performance, serum free amino acids, and immune function of laying hens under high-temperature and high-humidity environmental climates. J Appl Poult Res, 20: 361-370.
  • Bai SP, Wu AM, Ding XM, Lei Y, Bai J, Zhang KY, Chio JS. 2013. Effects of probiotic-supplemented diets on growth performance and intestinal immune characteristics of broiler chickens. Poult Sci, 92: 663-670.
  • Baker DH. 2009. Advances in protein-amino acid nutrition of poultry. Amino Acids, 37: 29-41.
  • Bakyaraj S, Bhanja SK, Majumdar S, Dash B. 2012. Modulation of post-hatch growth and immunity through in ovo supplementated nutrients in broiler chickens. J Sci Food Agric, 92: 313-20.
  • Bhanja SK, Mandal AB. 2005. Effect of in ovo injection of critical amino acids on pre- and post-hatch growth, immunocompetence, and development of digestive organs in broiler chickens. Asian Australas J Anim Sci, 18: 524-31.
  • Borum PR. 1983. Carnitine. Annu Rev Nutr, 3: 233-259.
  • Bouyeh, M. 2012. Effect of excess lysine and methionine on immune system and performance of broilers. Ann Biol Res, 3: 3218-3224.
  • Buchmann K. 2014. Evolution of innate immunity: clues from invertebrates via fish to mammals. Front Immunol, 5: 459.
  • Butcher GD, Miles D. 2002. Interrelationship between nutrition and immunity. UF/IFAS Extension. University of Florida.
  • Buyse J, Swennen Q, Niewold TA, Klasing KC, Janssens GPJ, Baumgartner M, Goddeeris BM. 2007. Dietary L-carnitine supplementation enhances the lipopolysaccharide-induced acute phase protein response in broiler chickens. Vet Immunol Immunopathol, 118(1-2): 154-119.
  • Calder PC. 2013. Feeding the immune system. Proc Nutr Soc, 72: 299-309.
  • Chalamaiah M, Yu W, Wu J. 2018. Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: A review. Food Chem, 245: 205-222.
  • Chandra RK, Kumari S. 1994. Nutrition and immunity: An overview J Nutr, 124: 1433-1435.
  • Chen C, Sander J, Dale NM. 2003. The effect of dietary lysine deficiency on the immune response to Newcastle disease vaccination in chickens. Avian Diseases, 47(4): 1346-1351.
  • Clarke G, Stilling RM, Kennedy PJ, Stanton C, Cryan JF, Dinan TG. 2014. Minireview: gut microbiota: the neglected endocrine organ. Mol Endocrinol, 28: 1221-1238.
  • Csernus B, Biró S, Babinszky L, Komlósi I, Jávor A, Stündl L, Remenyik J, Bai P, Oláh J, Pesti-Asbóth G, Czeglédi L. 2020. Effect of carotenoids, oligosaccharides and anthocyanins on growth performance, immunological parameters and intestinal morphology in broiler chickens challenged with escherichia coli lipopolysaccharide. Animals (Basel), 10(2): 347.
  • Dashtestani F, Ma’mani L, Jokar F, Maleki M, Fard EM, Salekdeh HG. 2021. Zeolite-based nanocomposite as a smart pH-sensitive nanovehicle for release of xylanase as poultry feed supplement. Sci Rep, 11: 21386.
  • Dashtestani SA, Kang DR, Park JR, Siddiqui SH, Ravichandiran P, Yoo DJ, Na CS, Shim KS. 2019. Effect of in ovo injection of l-arginine in different chicken embryonic development stages on post-hatchability, immune response, and myo-d and myogenin proteins. Animals, 9: 357.
  • Davison F. 2022. The importance of the avian immune system and its unique features. Elsevier, London, UK, pp: 1-9.
  • Dekruyff R, Kim YT, Siskind GW, Weksler ME. 1980. Age related changes in the in vitro immune response: increased suppressor cell activity in immature and aged mice. J Immunol, 125: 142.
  • Dong ZL, Wang YW, Song D, Hou YJ, Wang WW, Qi WT, Yun TT, Li AK. 2016. The effects of dietary supplementation of microencapsulated enterococcus fecalis and the extract of camellia oleifera seed on growth performance, intestinal morphology, and intestinal mucosal immune functions in broiler chickens. Anim Feed Sci Technol, 212: 42-51.
  • Elgeddawy SA, Shaheen HM, El-Sayed YS, Abd Elaziz M, Darwish A, Samak D, Alagawany M. 2020. Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken. J Anim Physiol Anim Nutr, 104: 549-557.
  • El-Shenway MA, Soltan AM. 2015. Effect of dietary probiotic and/or prebiotic supplementation on growth performance, carcass traits and some serum biochemical alterations in broiler chicken. J Anim Sci Adv, 5: 1480-1492.
  • Elsherbeni A, Youssef I, Kamal M, Youssif MAM. 2024. Impact of adding zeolite to broilers' diet and litter on growth, blood parameters, immunity, and ammonia emission. Poult Sci, 103(7): 103981.
  • Emadi M, Jahanshiri F, Azizi JF, Kaveh K, Bejo MH, Ideris A, Assumaidaee AA, Alimon RA. 2010. Immunostimulatory effects of arginine in broiler chickens challenged with vaccine strain of infectious Bursal Disease virus. J Anim Vet Adv, 9: 594-600.
  • Fakhoury HMA, Kvietys PR, AlKattan W, Anouti FA, Elahi MA, Karras SN, Grant WB. 2020. Vitamin D and intestinal homeostasis: Barrier, microbiota, and immune modulation. J Steroid Biochem Mol Biol, 200: 105663.
  • Fernandes JI, Murakami AE, Martins EN, Sakamoto MI, Garcia ER. 2009. Effect of arginine on the development of the pectoralis muscle and the diameter and the protein: deoxyribonucleic acid rate of its skeletal myofibers in broilers. Poultr Sci, 88: 1399-406.
  • Feye KM, Dittoe DK, Jendza JA, Caldas-Cueva yJP, Mallmann zBA, Booher zB, Tellez-Isaias G, Owens zCM, Kidd, zMT, Rickex SC. 2021. A comparison of formic acid or monoglycerides to formaldehyde on production efficiency, nutrient absorption, and meat yield and quality of Cobb 700 broilers. Poult Sci, 100: 101476.
  • Fonseca BB, Beletti ME, Da Silva MS, Da Silva PL, Duarte IN, Rossi DA. 2010. Microbiota of the cecum, ileum morphology, pH of the crop and performance of broiler chickens supplemented with probiotics. Rev Bras Zootec, 39: 1756-1760.
  • Förstermann U, Pollock JS, Schmidt HH, Heller M, Murad F. 1991. Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proc Natl Acad Sci, 88: 1788-1792.
  • Fussell LW. 1998. Poultry industry strategies for control of immunosuppressive diseases. Poult Sci, 77: 1193-1196.
  • Ganan M, Silván JM, Carrascosa AV, Martínez-Rodríguez AJ. 2012. Alternative strategies to use antibiotics or chemical products for controlling Campylobacter in the food chain. Food Contr, 24: 6-14.
  • Ganguly S. 2013. Supplementation of prebiotics, probiotics and acids on immunity in poultry feed: a brief review. World’s Poult Sci J, 69(3): 639-648.
  • Gao YY, Zhang X, Xu L, Peng H, Wang C, Bi Y. 2019. Encapsulated blends of essential oils and organic acids improved performance, intestinal morphology, cecal microflora, and jejunal enzyme activity of broilers. Czech J Anim Sci, 64(5): 189-198.
  • Garcia P, Wang Y, Viallet J, Jilkova ZM. 2021. The chicken embryo model: a novel and relevant model for immune-based studies. Front Immunol, 12: 791081.
  • Ghazala AA, Atta AM, Elkloub K, Mustafa MEL, Shata RFH. 2011. Effect of dietary supplementation of organic acids on performance, nutrients digestibility and health of broiler chicks. Int J Poultry Sci, 10(3): 176-184.
  • Golzar SHA, Rahimi SH, Kamali MA, Torshizi KMA. 2007. The effects of two dietary levels of L-carnitine and vegetable fat powder on quality of cockerels sperm, and fertility and hatchability in broiler breeders. J Vet Res, 62: 107-114.
  • Gordon J, Manley NR. 2011. Mechanisms of thymus organogenesis and morphogenesis. Development, 138: 3865-78.
  • Gottardo ET, Junior AMB, Lemke BV, Silva AM, Pasa CLB, Fernandes JIM. 2017. Immune response in Eimeria sp. and E. coli challenged broilers supplemented with amino acids. Austral J Vet Sci, 49: 175-184.
  • Gurjar RS. 2013. Cell-mediated immunity after ocular Arktype infectious bronchitis virus vaccination. MSC thesis, Auburn University.
  • Gül M, Tunç MA, Cengiz S, Yildiz A. 2014. Effect of organic acids in diet on laying hens’ performance, egg quality indices, intestinal microflora, and small intestinal villi height. Europ Poult Sci, 78: 1612-9199.
  • Hajati H. 2018. Application of organic acids in poultry nutrition. Int J Avian & Wildlife Biol, 3(4): 324-329.
  • Hamal KR, Burgess SC, Pevzner IY, Erf GF. 2006. Maternal antibody transfer from dams to their egg yolks, egg whites, and chicks in meat lines of chickens. Poult Sci, 85(8): 1364-72.
  • Haq Z, Jain RK, Khan N, Dar MY, Ali S, Gupta M, Varun TK. 2016. Recent advances in role of chromium and its antioxidant combinations in poultry nutrition: a review. Vet World, 9(12): 1392-1399.
  • Heak C, Sukon P, Sornplang P. 2018. Effect of direct-fed microbials on culturable gut microbiotas in broiler chickens: A meta-analysis of controlled trials. Asian Australas J Anim Sci, 31: 1781-1794.
  • Hibbs JR, Taintor RR, Vavrin Z, Rachlin EM. 1988. Nitric oxide: A cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun, 157: 87-94.
  • Hieu TV, Guntoro B, Qui NH, Quyen NTK, Hafiz FAA. 2022. The application of ascorbic acid as a therapeutic feed additive to boost immunity and antioxidant activity of poultry in heat stress environment. Vet World, 15(3): 685-693.
  • Jain AK, Mishra A, Singh AP, Patel P, Sheikh AA, Chandraker TR, Vandre R. 2021. Effects of different concentration of organic and inorganic trace minerals (zinc, selenium, and chromium) supplementation on expression of chTLR4 gene and humoral immune response in broilers. Vet World, 14(5): 1093-1101.
  • Johnson CS, Corte C, Swan PD. 2006. Marginal vitamin C status is associated with reduced fat oxidation during submaximal exercise in young adults. Nutr Metab, 3: 35.
  • Junior AF, dos Santos JP, Sousa IdO, Martin I, Alves EGL, Rosado IR. 2018. Gallus gallus domesticus: immune system and its potential for generation of immunobiologics. Ciênc Rural, 48(08): e20180250.
  • Kabir SML. 2009. The role of probiotics in the poultry industry. Int J Mol Sci, 10: 3531-3546.
  • Karachaliou CE, Vassilakopoulou V, Livaniou E. 2021. IgY technology: Methods for developing and evaluating avian immunoglobulins for the in vitro detection of biomolecules. World J Methodol, 11(5): 243-262.
  • Khaksefidi A, Rahimi SH. 2005. Effect of probiotic inclusion in the diet of broiler chickens on performance, feed efficiency and carcass quality. Asian-Aust J Anim Sci, 18: 1153-1156.
  • Khan RU, Khan A, Naz S, Ullah Q, Puvaˇca N, Laudadio V, Mazzei D, Seidavi A, Ayasan T, Tufarelli V. 2023. Pros and cons of dietary Vitamin A and its precursors in poultry health and production: A comprehensive review antioxidants. Antioxidants, 12: 1131.
  • Khan RU, Naz S, Raziq F, Qudratullah Q, Khan NA, Laudadio V, Tufarelli V, Ragni M. 2022. Prospects of organic acids as safe alternative to antibiotics in broiler chickens diet. Environ Sci Pollut R, 29: 32594-32604.
  • Kidd MT. 2004. Nutritional modulation of immune function in broilers. Poult Sci, 83: 650-657.
  • Kim WK, Singh AK, Wang J, Applegate T. 2022. Functional role of branched chain aminoacids in poultry: a review. Poult Sci, 101: 101715.
  • Korver DR. 2023. Review: Current challenges in poultry nutrition, health, and welfare. Anim, 17: 100755.
  • Kubena LF, Kwon YM, Byrd JA, Woodward CL, Moore RW, Ziprin RL, Anderson RC, Nisbet DJ, Ricke SC. 2001. Drinking water treatment and dietary treatment effects on Salmonella enteritidis in leghorn hens during forced molt. Poult Sci, 80: 88.
  • Kubinska M, Tykałowski B, Jankowski J, Koncicki A. 2014. Immunological and biochemical indicators in turkeys fed diets with a different Methionine content. Pol J Vet Sci, 17: 687-695.
  • Lee SI, Kim HS, Kim I. 2015. Microencapsulated organic acid blend with MCFAs can be used as an alternative to antibiotics for laying hens. Turk J of Vet Anim Sci, 39: 520-527.
  • Leibetseder J. 1995. Studies on the effects of L-carnitine in poultry. Arch Anim Nutr, 48: 97-108.
  • Lewis ED, Meydani SN, Wu D. 2019. Regulatory role of vitamin E in the immune system and inflammation. HHS Public Access, 71(4): 487-494.
  • Li L, Liu Z, Fang B, Xu J, Dong X, Yang L, Zhang Z, Guo S, Ding B. 2022. Effects of Vitamin A and K3 on immune function and intestinal antioxidant capacity of aged laying hens. Braz J Poult Sci, 24(4): 1-10.
  • Liao X, Shao Y, Sun G, Yang Y, Zhang L, Guo Y, Luo X, Lu L. 2020. The relationship among gut microbiota, short-chain fatty acids, and intestinal morphology of growing and healthy broilers. Poult Sci, 99(11): 5883-5895.
  • Líndez AMI, Reith W. 2021. Arginine-dependent immune responses. Cell Mol Life Sci, 78(13): 5303-5324.
  • Liu G, Ajao AM, Shanmugasundaram R, Taylor J, Ball E, Applegate TJ, Selvaraj R, Kyriazakis I, Olukosi OA, Kim WK. 2023. The effects of arginine and branched-chain amino acid supplementation to reduced-protein diet on intestinal health, cecal short-chain fatty acid profiles, and immune response in broiler chickens challenged with Eimeria spp: Poult Sci, 102(7): 102773.
  • Liu Y, Yang X, Xin H, Chen S, Yang C, Duan Y, Yang X. 2017. Effects of a protected inclusion of organic acids and essential oils as antibiotic growth promoter alternative on growth performance, intestinal morphology and gut microflora in broilers. Anim Sci J, 88: 1414-1424.
  • Loddi MM, Sato RN, Ariki J, Pedroso AA, Moraes VM, Kishibe R. 2004. Ação isolada ou combinada de antibiótico ou probiótico como promotores de crescimento em rações iniciais de frangos de corte. In: Reunião Anual da Sociedade Brasileira de Zootecnia, pp: 254.
  • Manangi MK, Vazques-A˜non M, Richards JD, Carter S, Knight CD. 2015. The impact of feeding supplemental chelated trace minerals on shell quality, tibia breaking strength, and immune response in laying hens. J Appl Poult Res, 24: 316-326.
  • Mast J., Buyse J, Goddeeris B.M. 2000. Dietary L-carnitine supplementation increases antigen specific Ig G production in broiler chickens. B J Nutr, 83: 161-166.
  • Mirzaaghatabar F, Saki AA, Zamani P, Aliarabi H, Matin HRH. 2011. Effect of different levels of diet methionine and metabolisable energy on broiler performance and immune system. Food Agric Immunol, 22: 93-103.
  • Mohammadi FF, Seidavi A, Bouyeh M. 2023. The effect of the chelated form of trace elements in diet on weight gain, production traits, egg specific gravity, immune system, blood parameters, liver enzymes, and progesterone hormone in Ross 308 broiler breeder chickens. Ital J Anim Sci, 22(1): 524-536.
  • Mohammed AA, Jacobs JA, Murugesan GR, Cheng HW. 2018. Effect of dietary synbiotic supplement on behavioral patterns and growth performance of broiler chickens reared under heat stress. Poult Sci, 97: 1101-1108.
  • Mohammed AA, Jiang S, Jacobs JA, Cheng HW. 2019. Effect of a synbiotic supplement on cecal microbial ecology, antioxidant status, and immune response of broiler chickens reared under heat stress. Poult Sci, 98: 4408-4415.
  • Mohammed AA, Mahmoud MA, Zaki RS, Cheng HW. 2024. Effect of a probiotic supplement (Bacillus subtilis) on struggling behavior, immune response, and meat quality of shackled broiler chickens exposed to pre-slaughter stress. Poult Sci, 2024: 104051.
  • Montout L, Poullet N, Bambou J. 2021. Systematic review of the interaction between nutrition and immunity in livestock: effect of dietary supplementation with synthetic amino acids. Animals, 11: 2813.
  • Moreno FMR, Sarantinopoulos P, Tsakalidou R, Vuyst LD. 2006. The role and application of enterococci in food and health. Int J Food Microbiol, 106: 1-24.
  • Morgan PM. 2021. Immune response in mammals and chickens. IgY-technology: production and application of egg yolk antibodies. Springer, Heidelberg, Germany, pp: 31-47.
  • Naukkarinen A, Hippelãinen M. 1989. Development of the peripheral immune function in the chicken: A study on the bursa of Fabricius isolated from the rest of the gut-associated lymphoid tissue (GALT). Apmis Acta Pathol Microbiol Immunol Scand, 97: 787-92.
  • Neveling DP, Dicks LMT. 2021. Probiotics: An Antibiotic replacement strategy for healthy broilers and productive rearing. Probiotics Antimicrob Proteins, 13: 1-11.
  • Nguyen DH, Lee KY, Mohammadigheisar M, Kim IH. 2018. Evaluation of the blend of organic acids and medium-chain fatty acids in matrix coating as antibiotic growth promoter alternative on growth performance, nutrient digestibility, blood profiles, excreta microflora, and carcass quality in broilers. Poult Sci, 97(12): 4351-4358.
  • O’Neal DM, Ketterson ED. 2012. Life-history evolution, hormones, and avian immune function. In: Demas GE, Nelson RJ (eds) Ecoimmunology. Oxford University Press, Inc., New York, NY, USA, pp: 142.
  • Ohta Y, Tsushima N, Koide K, Kidd MT, Ishibashi T. 1999. Effect of amino acid injection in broiler breeder eggs on embryonic growth and hatchability of chicks. Poult Sci, 78: 1493-1498.
  • Onbaşılar EE, Erol H. 2007. Effects of different forced molting methods on postmolt production, corticosterone level, and immune response to sheep red blood cells in laying hens. J Appl Poult Res, 16(4): 529-536.
  • Packer L, Suzuki Y. 1993. Vitamin E and alpha-lipoate: Role in antioxidant recycling and activation of the NK-B transcription factor. Mol Asp Med, 14: 229-239.
  • Pal M. 2017. The role of minerals and vitamins in poultry production. Agri World, 2017: 68-71.
  • Panda AK, Bhanja SK, Sunder GS. 2015. Early post-hatch nutrition on immune system development and function in broiler chickens. World’s Poult Sci J, 71(2): 285-296.
  • Park SY, Birkhold SG, Kubena LF, Nisbet DJ, Ricke SC. 2004. Review on the role of dietary zinc in poultry nutrition, immunity, and reproduction. Biol Trace Elem Res, 101: 147-163.
  • Pereira EPV, Tilburg MFV, Florean EOPT, Guedes MIF. 2019. Egg yolk antibodies (IgY) and their applications in human and veterinary health: A review. Int Immunopharmacol, 73: 293-303.
  • Pompeua MA, Cavalcantib LFL, Torala FLB. 2018. Effect of vitamin E supplementation on growth performance, meat quality, and immune response of male broiler chickens: A meta-analysis. Livest Sci, 208: 5-13.
  • Pope JT, Walker GK, Rubio AA, Brake J, Jendza, yJA, Fahrenholzy AC. 2022. Effects of corn particle size distributions and formic acid on productive and processing performance of broilers. J Appl Poult Res, 31: 100288.
  • Propulla SG. 2008. Prebiotic: an emerging functional food. pp: 47-53. In: harnessing microbial diversity for use in animal nutrition. Natl Inst Anim Nutr Physiol, Adugodi, Bangalore, India, pp: 412.
  • Ratcliffe MJH, Jacobsen KA. 1994. Rearrangement of immunoglobulin genes in chicken B cell development. Semin Immunol, 6: 175-84.
  • Ratcliffe MJH. 2006. Antibodies, immunoglobulin genes and the bursa of Fabricius in chicken B cell development. Dev Comp Immunol, 30(1-2): 101-118.
  • Ravindran V. 2010. Poultry feed availability and nutrition in developing countries. Poultry Development Review. Food and Agriculture Organization of the United Nations.
  • Rebouche CJ. 1992. Carnitine function and requirements during the life cycle. Faseb J, 6: 3379-3386.
  • Rehman A, Arif M, Sajjad N, Al-Ghadi MQ, Alagawany M, Abd El-Hack ME, Alhimaidi AR, Elnesr SS, Almutairi BO, Amran RA, Hussein EOS, Swelum AA. 2020. Dietary effect of probiotics and prebiotics on broiler performance, carcass, and immunity. Poult Sci, 99: 6946-6953.
  • Rehman ZU, Meng C, Umar S, Munir M, Ding C. 2016. Interaction of infectious bursal disease virus with the immune system of poultry. World Poult Sci J, 72: 805-820.
  • Ren H, Vahjen W, Dadi T, Saliu EM, Zentek J. 2019. Synergistic effects of probiotics and phytobiotics on the intestinal microbiota in young broiler chicken. Microorganisms, 7: 684.
  • Rochell SA, Parsons HC, Dilger R. 2016. Influence of dietary amino acids reductions and Eimeria acervulina infection on growth performance and intestinal cytokine response of broilers fed low crude protein diets. Poult Sci, 95: 2602-2614.
  • Rodriguez PC, Ochoa AC, Al-Khami AA. 2017. Arginine metabolism in myeloid cells shapes innate and adaptive immunity. Front Immunol, 8: 93.
  • Romo MR, Perez-Martinez D, Ferrer CC. 2016. Innate immunity in vertebrates: an overview. Immunol, 148(2): 125-39.
  • Sadiq RK, Abrahimkhil MA, Rahimi N, Banuree SZ, Banuree SAH. 2023. Effects of dietary supplementation of Vitamin E on growth performance and immune system of broiler chickens. J World Poult Res, 13(1): 120-126.
  • Sahin K, Sahin N, Kucuk O. 2003. Effects of chromium and ascorbic acid supplementation on growth, carcass traits, serum metabolites, and antioxidant status of broiler chickens reared at a high ambient temperature (32°C). Nutr Res, 23(2): 225-238.
  • Santos DTT, Corzo A, Kidd MT, McDaniel CD, Torres FRA, Araujo LF. 2010. Influence of in ovo inoculation with various nutrients and egg size on broiler performance. J Appl Poult Res, 19: 1-12.
  • Sarıca Ş, Karataş Ü, Gözalan R. 2009. Kanatlılarda bağışıklık sistemi ve bağışıklık sistemini etkileyen besinsel faktörler. GOÜ Ziraat Fakültesi Dergisi, 26(2): 81-86.
  • Saripinar-Aksu D, Aksu T, Onel SE. 2012. Does inclusion at low levels of organically complexed minerals versus inorganic forms create a weakness in performance or antioxidant defense system in broiler diets? Int J Poult Sci, 11(10): 666-672.
  • Sayed Y, Hassan M, Salem HB, Al‑Amry K, E. Eid G. 2023. Prophylactic influences of prebiotics on gut microbiome and immune response of heat‑stressed broiler chickens. Nature Scientific Reports, 13: 13991.
  • Schneider AF, Zimmermann OF, Gewehr CE. 2017. Zeolites in poultry and swine production. Ciencia Rural, 47: 1-8.
  • Seifert C, Fritz C, Carlini N, Barth SW, Franz CMAP, Watzl B. 2011. Modulation of innate and adaptive immunity by the probiotic Bifidobacterium longum PCB133 in turkeys. Poult Sci, 90: 2275-2280.
  • Selaledi LA, Hassan ZM, Manyelo TG, Mabelebele M. 2020. The current status of the alternative use to antibiotics in poultry production: an african perspective. Antibiotics, 9: 594.
  • Selim S, Abdel-Megeid NS, Abou-Elnaga MK, Mahmoud SF. 2021. Early nutrition with different diets composition versus fasting on immunity-related gene expression and histomorphology of digestive and lymphoid organs of layer-type chicks. Animals, 11: 1568.
  • Shaji S, Selvaraj RK, Shanmugasundaram R. 2023. Salmonella infection in poultry: a review on the pathogen and control strategies. Microorganisms, 11: 2814.
  • Shanmugasundaram, R., Morris, A., Selvaraj, R., 2019. Effect of 25-hydroxycholecalciferol supplementation on turkey performance and immune cell parameters in a coccidial infection model. Poult Sci, 98: 1127-1133.
  • Sharma MK, Lee J, Shi H, Ko H, Goo D, Paneru D, Holladay SD, Gogal RM, Kim WK. 2024. Effect of dietary inclusion of 25-hydroxyvitamin D and vitamin E on performance, gut health, oxidative status, and immune response in laying hens infected with coccidiosis. Poult Sci, 103: 104033.
  • Shehata AA, Yalçın S, Latorre JD, Basiouni S, Attia YA, El-Wahab AA, Visscher C, El-Seedi HR, Huber C, Hafez HM, Eisenreich W, Tellez-Isaias G. 2022. Probiotics, prebiotics, and phytogenic substances for optimizing gut health in poultry. Microorganisms, 10: 395.
  • Shimizu M, Nagashima H, Sano K, Hashimoto K, Ozeki M, Tsuda K, Hatta H. 1992. Molecular stability of chicken and rabbit immunoglobulin G. Biosci Biotech Biochem, 56(2): 270-274.
  • Shojadoost B, Yitbarek A, Alizadeh M, Kulkarni RR, Astill J, Boodhoo N, Sharif S. 2021. Centennial review: effects of vitamins A, D, E, and C on the chicken immune system. Poult Sci, 100(4): 100930.
  • Silverman MN, Pearce BD, Biron CA, Miller AH. 2005. Immune modulation of the hypothalamic-pituitary-adrenal (hpa) axis during viral infection. Viral Immunol, 18(1): 41-78.
  • Sittiya J, Nii T. 2024. Effects of oligosaccharides on performance, intestinal morphology, microbiota and immune reactions in laying hens challenged with dextran sodium sulfate. Poult Sci, 2024: 104062.
  • Śliżewska K, Markowiak-Kopeć P, Żbikowski A, Szeleszczuk P. 2020. The effect of synbiotic preparations on the intestinal microbiota and her metabolism in broiler chickens. Sci Rep, 10: 4281.
  • Song B, Tang D, Yan S, Fan H, Li G, Shahid MS, Mahmood T and Guo Y. 2021. Effects of age on immune function in broiler chickens. J Anim Sci Biotechnol, 12: 42.
  • Spring P, Wenk C, Dawson KA, Newman KE. 2000. The effects of dietary mannan-oligosaccharides on cecal parameters and the concentrations of enteric bacteria in the ceca of Salmonella challenged broiler chicks. Poult Sci, 79: 205-211.
  • Subramaniyan SA, Kang DA, Park JR, Siddiqui SH, Ravichandiran P, Jing D, Sam Na C, Shim KS. 2019. Effect of in ovo injection of l-arginine in different chicken embryonic development stages on post-hatchability, immune response, and myo-d and myogenin proteins. Animals, 9(6): 357.
  • Sun Y, O’Riordan MX. 2013. Regulation of bacterial pathogenesis by intestinal short-chain fatty acids. Adv Appl Microbiol, 85: 93-118.
  • Sunder GS, Panda AK, Gopinath NCS, Rao SVR, Raju MVLN, Reddy MR, Kumar CV. 2008. Effects of higher levels of zinc supplementation on performance, mineral availability, and immune competence in broiler chickens. J Appl Poult Res, 17: 79-86.
  • Swain BK, Johri TS. 2000. Effect of supplemental methionine, choline and their combinations on the performance and immune response of broilers. Br Poult Sci, 41: 83-88.
  • Tawfeeq WS, Al-Mashhdani HE. 2020. Effect of adding propionic acid, formic acid, and antibiotics to broiler diet on the production performance, some histological traits, and microbial characteristics. Plant Arch, 20: 468-472.
  • Tayeb IH, Qader GK. 2012. Effect of feed supplementation of selenium and Vitamin E on production performance and some hematological parameters of broiler. KSU Doğa Bil Derg, 15(3): 46-56.
  • Uni Z, Yadgary L, Yair R. 2012. Nutritional limitations during poultry embryonic development. J Appl Poult Res, 21: 175-184.
  • Vulevic J, Rastall RA, Gibson GR. 2004. Developing a quantitative approach for determining the in vitro prebiotic potential of dietary oligosaccharides. FEMS Microbiol Lett, 236: 153-159.
  • Wei J, Li L, Peng Y, Luo J, Chen T, Xi Q, Zhang Y, Sun J. 2024. The effects of optimal dietary vitamin D3 on growth and carcass performance, tibia traits, meat quality, and ıntestinal morphology of chinese yellow-feathered broiler chickens. Animals. 14: 920.
  • Wickramasuriya SS, Ault J, Ritchie S, Gay CG, Lillehoj HS. 2024. Alternatives to antibiotic growth promoters for poultry: a bibliometric analysis of the research journals. Poult Sci, 103(9): 103987.
  • Wlazlak S, Pietrzak E, Biesek J, Dunislawska A. 2023. Modulation of the immune system of chickens a key factor in maintaining poultry production - a review. Poult Sci. 102: 102785.
  • Wynn JL, Levy O. 2010. Role of Innate Host Defenses in Susceptibility to Early Onset Neonatal Sepsis. Clin Perinatol, 37(2): 307-337.
  • Xu H, Lu Y, Li D, Yan C, Jiang Y, Hu Z, Zhang Z, Du R, Zhao X, Zhang Y, Tian Y, Zhu Q, Liu Y, Wang Y. 2023. Probiotic mediated intestinal microbiota and improved performance, egg quality and ovarian immune function of laying hens at different laying stage. Front Microbiol, 14: 1041072.
  • Xu YQ, Guo YW, Shi BL, Yan SM, Guo XY. 2018. Dietary arginine supplementation enhances the growth performance and immune status of broiler chickens. Livest Sci, 209: 8-13.
  • Yang X, Xin H, Yang C, Yang X. 2018. Impact of essential oils and organic acids on the growth performance, digestive functions and immunity of broiler chickens. Anim Nutr, 4: 388-393.
  • Yasuda M, Kajiwara E, Ekino S, Taura Y, Hirota Y, Horiuchi H, Matsuda H, Furusawa S. 2003. Immunobiology of chicken germinal center: I. Changes in surface Ig class expression in the chicken splenic germinal center after antigenic stimulation. Dev Comp Immunol, 27(2): 159-166.
  • Yeşilyurt N, Yılmaz B, Ağagündüz D, Capasso R. 2021. Involvement of probiotics and postbiotics in the immune system modulation. Biologics, 1: 89-110.
  • Yu J, Dong B, Zhao M, Liu L, Geng T, Gong D, Wang J. 2021. Dietary clostridium butyricum and bacillus subtilis promote goose growth by improving intestinal structure and function, antioxidative capacity and microbial composition. Animals, 11: 3174.
  • Yu Y, Li Q, Zeng X, Xu Y, Jin K, Liu J, Cao G. 2022. Effects of probiotics on the growth performance, antioxidant functions, immune responses, and caecal microbiota of broilers challenged by Lipopolysaccharide. Front Vet Sci, 9: 846649.
  • Zhai W, Gerard PD, Pulikanti R, Peebles ED. 2011. Effects of in ovo injection of carbohydrates on embryonic metabolism, hatchability, and subsequent somatic characteristics of broiler hatchlings. Poult Sci, 90: 2134-43.
  • Zhou P, Tan YQ, Zhang L, Zhou YM, Gao F, Zhou GH. 2014. Effects of dietary supplementation with the combination of zeolite and attapulgite on growth performance, nutrient digestibility, secretion of digestive enzymes and intestinal health in broiler chickens. Asian-Australas J Anim Sci, 27: 1311.
Year 2024, , 464 - 476, 15.08.2024
https://doi.org/10.47115/bsagriculture.1518799

Abstract

References

  • Abd El-Hack ME, El-Saadony MT, Salem HM, El-Tahan AM, Soliman MM, Youssef GBA, Taha AE, Soliman SM, Ahmed AE, El-kott AF, Al Syaad KM, Swelum AA. 2022. Alternatives to antibiotics for organic poultry production: types, modes of action and impacts on bird's health and production. Poult Sci, 101(4): 101696.
  • Abd El-Hack ME, El-Saadony MT, Shafi ME, Qattan SYA, Batiha Ge, Khafaga AF, Abdel-Moneim AE, Alagawany M. 2020. Probiotics in poultry feed: A comprehensive review. J Anim Physiol Anim Nutr, 104(6): 1835-1850.
  • Abd El-Hady AM. 2020. Effect of incorporating natural zeolite with or without phytase enzyme into broilers diets on blood constituents and carcass traits. Egypt Poult Sci J, 40: 225-242.
  • Abdelrahman MM, Al-Baadani HH, Qaid MM, Al-Garadi MA, Suliman GM, Alobre MM, Al-Mufarrej SI. 2023. Using natural zeolite as a feed additive in broilers’ diets for enhancing growth performance, carcass characteristics, and meat quality traits. Life, 13: 1548.
  • Abidin Z, Khatoon A. 2013. Heat stress in poultry and the beneficial effects of ascorbic acid (vitamin C) supplementation during periods of heat stress. World’s Poult Sci J, 69: 135-152.
  • Abo-Al-Ela HG, El-Kassas S, El-Naggar K, E. Abdo S, Jahejo AR, Wakeel RA. 2021. Stress and immunity in poultry: light management and nanotechnology as effective immune enhancers to fight stress. Cell Stress and Chaperones, 26: 457-472.
  • Adabi SG, Ceylan N, Çiftci İ, Ceylan, A. 2019. Response of growing chicks to supplementation of low protein diets with leucine, valine and glycine-glutamic acid. S Afr J Anim, 49: 1047-1062.
  • Adabi SHG, Cooper RG, Ceylan N, Corduk M. 2011. L-carnitine and its functional effects in poultry nutrition. J World’s Poult Sci, 67(2): 277-296.
  • Adhikari P, Yadav S, Cosby DE, Cox NA, Jendza JA, Kimy WK. 2020. Research Note: Effect of organic acid mixture on growth performance and Salmonella Typhimurium colonization in broiler chickens. Poult Sci, 99(5): 2145862.
  • Aizenshtein R, Yosipovicha M, Kvint R, Shadmon S, Krispel E, Shuster E, Eliyahu D, Finger A, Banet-Noach C, Shahar E, Pitcovski J. 2016. Practical aspects in the use of passive immunization as an alternative to attenuated viral vaccines. Vaccine, 34(22): 2513-2518.
  • Alagawany M, Abd El-Hack ME, Farag MR, Sachan S, Karthik K, Dhama K. 2018. The use of probiotics as eco-friendly alternatives for antibiotics in poultry nutrition. Environ Sci Pollut Res Int, 25(11): 10611-10618.
  • Alagawany M, Elnesr SS, Farag MR, Tiwari R, Yatoo MI, Karthik K, Michalak I, Dhama K. 2021. Nutritional significance of amino acids, vitamins and minerals as nutraceuticals in poultry production and health - a comprehensive review. Vet Quart, 41(1): 1-29.
  • Alkie TN, Yitbarek A, Hodgins DC, Kulkarni RR, Taha-Abdelaziz K, Sharif S. 2019. Development of innate immunity in chicken embryos and newly hatched chicks: a disease control perspective. Avian Pathol, 48(4): 288-310.
  • Allmang C, Wurth L, Krol A. 2009. The selenium to selenoprotein pathway in eukaryotes: More molecular partners than anticipated. Biochim Biophys Acta, 1790(11): 1415-1423.
  • Ashayerizadeh A, Dabiri N, Ashayerizadeh O, Mirzadeh KH, Roshanfekr H, Mamooee M. 2009. Effect of dietary antibiotic, probiotic and prebiotic as growth promoters, on growth performance, carcass characteristics and hematological indices of broiler chickens. Pak J Biol Sci, 12: 52-57.
  • Aviagen. 2009. Immunosuppression in broilers. Aviagen publishers, New York, USA, 0809-AVN-021, pp:254.
  • Awad WA, Chareeb K, Abdel-Raheem S, Bohm J. 2009. Effects of dietary inclusion of probiotic and symbiotic on broiler chickens' growth performance, organ weight, and intestinal histomorphology. Poult Sci, 88: 49-56.
  • Azzam MMM, Dong XY, Xie P, Wang C, Zou XT. 2011. The effect of supplemental l-threonine on laying performance, serum free amino acids, and immune function of laying hens under high-temperature and high-humidity environmental climates. J Appl Poult Res, 20: 361-370.
  • Bai SP, Wu AM, Ding XM, Lei Y, Bai J, Zhang KY, Chio JS. 2013. Effects of probiotic-supplemented diets on growth performance and intestinal immune characteristics of broiler chickens. Poult Sci, 92: 663-670.
  • Baker DH. 2009. Advances in protein-amino acid nutrition of poultry. Amino Acids, 37: 29-41.
  • Bakyaraj S, Bhanja SK, Majumdar S, Dash B. 2012. Modulation of post-hatch growth and immunity through in ovo supplementated nutrients in broiler chickens. J Sci Food Agric, 92: 313-20.
  • Bhanja SK, Mandal AB. 2005. Effect of in ovo injection of critical amino acids on pre- and post-hatch growth, immunocompetence, and development of digestive organs in broiler chickens. Asian Australas J Anim Sci, 18: 524-31.
  • Borum PR. 1983. Carnitine. Annu Rev Nutr, 3: 233-259.
  • Bouyeh, M. 2012. Effect of excess lysine and methionine on immune system and performance of broilers. Ann Biol Res, 3: 3218-3224.
  • Buchmann K. 2014. Evolution of innate immunity: clues from invertebrates via fish to mammals. Front Immunol, 5: 459.
  • Butcher GD, Miles D. 2002. Interrelationship between nutrition and immunity. UF/IFAS Extension. University of Florida.
  • Buyse J, Swennen Q, Niewold TA, Klasing KC, Janssens GPJ, Baumgartner M, Goddeeris BM. 2007. Dietary L-carnitine supplementation enhances the lipopolysaccharide-induced acute phase protein response in broiler chickens. Vet Immunol Immunopathol, 118(1-2): 154-119.
  • Calder PC. 2013. Feeding the immune system. Proc Nutr Soc, 72: 299-309.
  • Chalamaiah M, Yu W, Wu J. 2018. Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: A review. Food Chem, 245: 205-222.
  • Chandra RK, Kumari S. 1994. Nutrition and immunity: An overview J Nutr, 124: 1433-1435.
  • Chen C, Sander J, Dale NM. 2003. The effect of dietary lysine deficiency on the immune response to Newcastle disease vaccination in chickens. Avian Diseases, 47(4): 1346-1351.
  • Clarke G, Stilling RM, Kennedy PJ, Stanton C, Cryan JF, Dinan TG. 2014. Minireview: gut microbiota: the neglected endocrine organ. Mol Endocrinol, 28: 1221-1238.
  • Csernus B, Biró S, Babinszky L, Komlósi I, Jávor A, Stündl L, Remenyik J, Bai P, Oláh J, Pesti-Asbóth G, Czeglédi L. 2020. Effect of carotenoids, oligosaccharides and anthocyanins on growth performance, immunological parameters and intestinal morphology in broiler chickens challenged with escherichia coli lipopolysaccharide. Animals (Basel), 10(2): 347.
  • Dashtestani F, Ma’mani L, Jokar F, Maleki M, Fard EM, Salekdeh HG. 2021. Zeolite-based nanocomposite as a smart pH-sensitive nanovehicle for release of xylanase as poultry feed supplement. Sci Rep, 11: 21386.
  • Dashtestani SA, Kang DR, Park JR, Siddiqui SH, Ravichandiran P, Yoo DJ, Na CS, Shim KS. 2019. Effect of in ovo injection of l-arginine in different chicken embryonic development stages on post-hatchability, immune response, and myo-d and myogenin proteins. Animals, 9: 357.
  • Davison F. 2022. The importance of the avian immune system and its unique features. Elsevier, London, UK, pp: 1-9.
  • Dekruyff R, Kim YT, Siskind GW, Weksler ME. 1980. Age related changes in the in vitro immune response: increased suppressor cell activity in immature and aged mice. J Immunol, 125: 142.
  • Dong ZL, Wang YW, Song D, Hou YJ, Wang WW, Qi WT, Yun TT, Li AK. 2016. The effects of dietary supplementation of microencapsulated enterococcus fecalis and the extract of camellia oleifera seed on growth performance, intestinal morphology, and intestinal mucosal immune functions in broiler chickens. Anim Feed Sci Technol, 212: 42-51.
  • Elgeddawy SA, Shaheen HM, El-Sayed YS, Abd Elaziz M, Darwish A, Samak D, Alagawany M. 2020. Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken. J Anim Physiol Anim Nutr, 104: 549-557.
  • El-Shenway MA, Soltan AM. 2015. Effect of dietary probiotic and/or prebiotic supplementation on growth performance, carcass traits and some serum biochemical alterations in broiler chicken. J Anim Sci Adv, 5: 1480-1492.
  • Elsherbeni A, Youssef I, Kamal M, Youssif MAM. 2024. Impact of adding zeolite to broilers' diet and litter on growth, blood parameters, immunity, and ammonia emission. Poult Sci, 103(7): 103981.
  • Emadi M, Jahanshiri F, Azizi JF, Kaveh K, Bejo MH, Ideris A, Assumaidaee AA, Alimon RA. 2010. Immunostimulatory effects of arginine in broiler chickens challenged with vaccine strain of infectious Bursal Disease virus. J Anim Vet Adv, 9: 594-600.
  • Fakhoury HMA, Kvietys PR, AlKattan W, Anouti FA, Elahi MA, Karras SN, Grant WB. 2020. Vitamin D and intestinal homeostasis: Barrier, microbiota, and immune modulation. J Steroid Biochem Mol Biol, 200: 105663.
  • Fernandes JI, Murakami AE, Martins EN, Sakamoto MI, Garcia ER. 2009. Effect of arginine on the development of the pectoralis muscle and the diameter and the protein: deoxyribonucleic acid rate of its skeletal myofibers in broilers. Poultr Sci, 88: 1399-406.
  • Feye KM, Dittoe DK, Jendza JA, Caldas-Cueva yJP, Mallmann zBA, Booher zB, Tellez-Isaias G, Owens zCM, Kidd, zMT, Rickex SC. 2021. A comparison of formic acid or monoglycerides to formaldehyde on production efficiency, nutrient absorption, and meat yield and quality of Cobb 700 broilers. Poult Sci, 100: 101476.
  • Fonseca BB, Beletti ME, Da Silva MS, Da Silva PL, Duarte IN, Rossi DA. 2010. Microbiota of the cecum, ileum morphology, pH of the crop and performance of broiler chickens supplemented with probiotics. Rev Bras Zootec, 39: 1756-1760.
  • Förstermann U, Pollock JS, Schmidt HH, Heller M, Murad F. 1991. Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proc Natl Acad Sci, 88: 1788-1792.
  • Fussell LW. 1998. Poultry industry strategies for control of immunosuppressive diseases. Poult Sci, 77: 1193-1196.
  • Ganan M, Silván JM, Carrascosa AV, Martínez-Rodríguez AJ. 2012. Alternative strategies to use antibiotics or chemical products for controlling Campylobacter in the food chain. Food Contr, 24: 6-14.
  • Ganguly S. 2013. Supplementation of prebiotics, probiotics and acids on immunity in poultry feed: a brief review. World’s Poult Sci J, 69(3): 639-648.
  • Gao YY, Zhang X, Xu L, Peng H, Wang C, Bi Y. 2019. Encapsulated blends of essential oils and organic acids improved performance, intestinal morphology, cecal microflora, and jejunal enzyme activity of broilers. Czech J Anim Sci, 64(5): 189-198.
  • Garcia P, Wang Y, Viallet J, Jilkova ZM. 2021. The chicken embryo model: a novel and relevant model for immune-based studies. Front Immunol, 12: 791081.
  • Ghazala AA, Atta AM, Elkloub K, Mustafa MEL, Shata RFH. 2011. Effect of dietary supplementation of organic acids on performance, nutrients digestibility and health of broiler chicks. Int J Poultry Sci, 10(3): 176-184.
  • Golzar SHA, Rahimi SH, Kamali MA, Torshizi KMA. 2007. The effects of two dietary levels of L-carnitine and vegetable fat powder on quality of cockerels sperm, and fertility and hatchability in broiler breeders. J Vet Res, 62: 107-114.
  • Gordon J, Manley NR. 2011. Mechanisms of thymus organogenesis and morphogenesis. Development, 138: 3865-78.
  • Gottardo ET, Junior AMB, Lemke BV, Silva AM, Pasa CLB, Fernandes JIM. 2017. Immune response in Eimeria sp. and E. coli challenged broilers supplemented with amino acids. Austral J Vet Sci, 49: 175-184.
  • Gurjar RS. 2013. Cell-mediated immunity after ocular Arktype infectious bronchitis virus vaccination. MSC thesis, Auburn University.
  • Gül M, Tunç MA, Cengiz S, Yildiz A. 2014. Effect of organic acids in diet on laying hens’ performance, egg quality indices, intestinal microflora, and small intestinal villi height. Europ Poult Sci, 78: 1612-9199.
  • Hajati H. 2018. Application of organic acids in poultry nutrition. Int J Avian & Wildlife Biol, 3(4): 324-329.
  • Hamal KR, Burgess SC, Pevzner IY, Erf GF. 2006. Maternal antibody transfer from dams to their egg yolks, egg whites, and chicks in meat lines of chickens. Poult Sci, 85(8): 1364-72.
  • Haq Z, Jain RK, Khan N, Dar MY, Ali S, Gupta M, Varun TK. 2016. Recent advances in role of chromium and its antioxidant combinations in poultry nutrition: a review. Vet World, 9(12): 1392-1399.
  • Heak C, Sukon P, Sornplang P. 2018. Effect of direct-fed microbials on culturable gut microbiotas in broiler chickens: A meta-analysis of controlled trials. Asian Australas J Anim Sci, 31: 1781-1794.
  • Hibbs JR, Taintor RR, Vavrin Z, Rachlin EM. 1988. Nitric oxide: A cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun, 157: 87-94.
  • Hieu TV, Guntoro B, Qui NH, Quyen NTK, Hafiz FAA. 2022. The application of ascorbic acid as a therapeutic feed additive to boost immunity and antioxidant activity of poultry in heat stress environment. Vet World, 15(3): 685-693.
  • Jain AK, Mishra A, Singh AP, Patel P, Sheikh AA, Chandraker TR, Vandre R. 2021. Effects of different concentration of organic and inorganic trace minerals (zinc, selenium, and chromium) supplementation on expression of chTLR4 gene and humoral immune response in broilers. Vet World, 14(5): 1093-1101.
  • Johnson CS, Corte C, Swan PD. 2006. Marginal vitamin C status is associated with reduced fat oxidation during submaximal exercise in young adults. Nutr Metab, 3: 35.
  • Junior AF, dos Santos JP, Sousa IdO, Martin I, Alves EGL, Rosado IR. 2018. Gallus gallus domesticus: immune system and its potential for generation of immunobiologics. Ciênc Rural, 48(08): e20180250.
  • Kabir SML. 2009. The role of probiotics in the poultry industry. Int J Mol Sci, 10: 3531-3546.
  • Karachaliou CE, Vassilakopoulou V, Livaniou E. 2021. IgY technology: Methods for developing and evaluating avian immunoglobulins for the in vitro detection of biomolecules. World J Methodol, 11(5): 243-262.
  • Khaksefidi A, Rahimi SH. 2005. Effect of probiotic inclusion in the diet of broiler chickens on performance, feed efficiency and carcass quality. Asian-Aust J Anim Sci, 18: 1153-1156.
  • Khan RU, Khan A, Naz S, Ullah Q, Puvaˇca N, Laudadio V, Mazzei D, Seidavi A, Ayasan T, Tufarelli V. 2023. Pros and cons of dietary Vitamin A and its precursors in poultry health and production: A comprehensive review antioxidants. Antioxidants, 12: 1131.
  • Khan RU, Naz S, Raziq F, Qudratullah Q, Khan NA, Laudadio V, Tufarelli V, Ragni M. 2022. Prospects of organic acids as safe alternative to antibiotics in broiler chickens diet. Environ Sci Pollut R, 29: 32594-32604.
  • Kidd MT. 2004. Nutritional modulation of immune function in broilers. Poult Sci, 83: 650-657.
  • Kim WK, Singh AK, Wang J, Applegate T. 2022. Functional role of branched chain aminoacids in poultry: a review. Poult Sci, 101: 101715.
  • Korver DR. 2023. Review: Current challenges in poultry nutrition, health, and welfare. Anim, 17: 100755.
  • Kubena LF, Kwon YM, Byrd JA, Woodward CL, Moore RW, Ziprin RL, Anderson RC, Nisbet DJ, Ricke SC. 2001. Drinking water treatment and dietary treatment effects on Salmonella enteritidis in leghorn hens during forced molt. Poult Sci, 80: 88.
  • Kubinska M, Tykałowski B, Jankowski J, Koncicki A. 2014. Immunological and biochemical indicators in turkeys fed diets with a different Methionine content. Pol J Vet Sci, 17: 687-695.
  • Lee SI, Kim HS, Kim I. 2015. Microencapsulated organic acid blend with MCFAs can be used as an alternative to antibiotics for laying hens. Turk J of Vet Anim Sci, 39: 520-527.
  • Leibetseder J. 1995. Studies on the effects of L-carnitine in poultry. Arch Anim Nutr, 48: 97-108.
  • Lewis ED, Meydani SN, Wu D. 2019. Regulatory role of vitamin E in the immune system and inflammation. HHS Public Access, 71(4): 487-494.
  • Li L, Liu Z, Fang B, Xu J, Dong X, Yang L, Zhang Z, Guo S, Ding B. 2022. Effects of Vitamin A and K3 on immune function and intestinal antioxidant capacity of aged laying hens. Braz J Poult Sci, 24(4): 1-10.
  • Liao X, Shao Y, Sun G, Yang Y, Zhang L, Guo Y, Luo X, Lu L. 2020. The relationship among gut microbiota, short-chain fatty acids, and intestinal morphology of growing and healthy broilers. Poult Sci, 99(11): 5883-5895.
  • Líndez AMI, Reith W. 2021. Arginine-dependent immune responses. Cell Mol Life Sci, 78(13): 5303-5324.
  • Liu G, Ajao AM, Shanmugasundaram R, Taylor J, Ball E, Applegate TJ, Selvaraj R, Kyriazakis I, Olukosi OA, Kim WK. 2023. The effects of arginine and branched-chain amino acid supplementation to reduced-protein diet on intestinal health, cecal short-chain fatty acid profiles, and immune response in broiler chickens challenged with Eimeria spp: Poult Sci, 102(7): 102773.
  • Liu Y, Yang X, Xin H, Chen S, Yang C, Duan Y, Yang X. 2017. Effects of a protected inclusion of organic acids and essential oils as antibiotic growth promoter alternative on growth performance, intestinal morphology and gut microflora in broilers. Anim Sci J, 88: 1414-1424.
  • Loddi MM, Sato RN, Ariki J, Pedroso AA, Moraes VM, Kishibe R. 2004. Ação isolada ou combinada de antibiótico ou probiótico como promotores de crescimento em rações iniciais de frangos de corte. In: Reunião Anual da Sociedade Brasileira de Zootecnia, pp: 254.
  • Manangi MK, Vazques-A˜non M, Richards JD, Carter S, Knight CD. 2015. The impact of feeding supplemental chelated trace minerals on shell quality, tibia breaking strength, and immune response in laying hens. J Appl Poult Res, 24: 316-326.
  • Mast J., Buyse J, Goddeeris B.M. 2000. Dietary L-carnitine supplementation increases antigen specific Ig G production in broiler chickens. B J Nutr, 83: 161-166.
  • Mirzaaghatabar F, Saki AA, Zamani P, Aliarabi H, Matin HRH. 2011. Effect of different levels of diet methionine and metabolisable energy on broiler performance and immune system. Food Agric Immunol, 22: 93-103.
  • Mohammadi FF, Seidavi A, Bouyeh M. 2023. The effect of the chelated form of trace elements in diet on weight gain, production traits, egg specific gravity, immune system, blood parameters, liver enzymes, and progesterone hormone in Ross 308 broiler breeder chickens. Ital J Anim Sci, 22(1): 524-536.
  • Mohammed AA, Jacobs JA, Murugesan GR, Cheng HW. 2018. Effect of dietary synbiotic supplement on behavioral patterns and growth performance of broiler chickens reared under heat stress. Poult Sci, 97: 1101-1108.
  • Mohammed AA, Jiang S, Jacobs JA, Cheng HW. 2019. Effect of a synbiotic supplement on cecal microbial ecology, antioxidant status, and immune response of broiler chickens reared under heat stress. Poult Sci, 98: 4408-4415.
  • Mohammed AA, Mahmoud MA, Zaki RS, Cheng HW. 2024. Effect of a probiotic supplement (Bacillus subtilis) on struggling behavior, immune response, and meat quality of shackled broiler chickens exposed to pre-slaughter stress. Poult Sci, 2024: 104051.
  • Montout L, Poullet N, Bambou J. 2021. Systematic review of the interaction between nutrition and immunity in livestock: effect of dietary supplementation with synthetic amino acids. Animals, 11: 2813.
  • Moreno FMR, Sarantinopoulos P, Tsakalidou R, Vuyst LD. 2006. The role and application of enterococci in food and health. Int J Food Microbiol, 106: 1-24.
  • Morgan PM. 2021. Immune response in mammals and chickens. IgY-technology: production and application of egg yolk antibodies. Springer, Heidelberg, Germany, pp: 31-47.
  • Naukkarinen A, Hippelãinen M. 1989. Development of the peripheral immune function in the chicken: A study on the bursa of Fabricius isolated from the rest of the gut-associated lymphoid tissue (GALT). Apmis Acta Pathol Microbiol Immunol Scand, 97: 787-92.
  • Neveling DP, Dicks LMT. 2021. Probiotics: An Antibiotic replacement strategy for healthy broilers and productive rearing. Probiotics Antimicrob Proteins, 13: 1-11.
  • Nguyen DH, Lee KY, Mohammadigheisar M, Kim IH. 2018. Evaluation of the blend of organic acids and medium-chain fatty acids in matrix coating as antibiotic growth promoter alternative on growth performance, nutrient digestibility, blood profiles, excreta microflora, and carcass quality in broilers. Poult Sci, 97(12): 4351-4358.
  • O’Neal DM, Ketterson ED. 2012. Life-history evolution, hormones, and avian immune function. In: Demas GE, Nelson RJ (eds) Ecoimmunology. Oxford University Press, Inc., New York, NY, USA, pp: 142.
  • Ohta Y, Tsushima N, Koide K, Kidd MT, Ishibashi T. 1999. Effect of amino acid injection in broiler breeder eggs on embryonic growth and hatchability of chicks. Poult Sci, 78: 1493-1498.
  • Onbaşılar EE, Erol H. 2007. Effects of different forced molting methods on postmolt production, corticosterone level, and immune response to sheep red blood cells in laying hens. J Appl Poult Res, 16(4): 529-536.
  • Packer L, Suzuki Y. 1993. Vitamin E and alpha-lipoate: Role in antioxidant recycling and activation of the NK-B transcription factor. Mol Asp Med, 14: 229-239.
  • Pal M. 2017. The role of minerals and vitamins in poultry production. Agri World, 2017: 68-71.
  • Panda AK, Bhanja SK, Sunder GS. 2015. Early post-hatch nutrition on immune system development and function in broiler chickens. World’s Poult Sci J, 71(2): 285-296.
  • Park SY, Birkhold SG, Kubena LF, Nisbet DJ, Ricke SC. 2004. Review on the role of dietary zinc in poultry nutrition, immunity, and reproduction. Biol Trace Elem Res, 101: 147-163.
  • Pereira EPV, Tilburg MFV, Florean EOPT, Guedes MIF. 2019. Egg yolk antibodies (IgY) and their applications in human and veterinary health: A review. Int Immunopharmacol, 73: 293-303.
  • Pompeua MA, Cavalcantib LFL, Torala FLB. 2018. Effect of vitamin E supplementation on growth performance, meat quality, and immune response of male broiler chickens: A meta-analysis. Livest Sci, 208: 5-13.
  • Pope JT, Walker GK, Rubio AA, Brake J, Jendza, yJA, Fahrenholzy AC. 2022. Effects of corn particle size distributions and formic acid on productive and processing performance of broilers. J Appl Poult Res, 31: 100288.
  • Propulla SG. 2008. Prebiotic: an emerging functional food. pp: 47-53. In: harnessing microbial diversity for use in animal nutrition. Natl Inst Anim Nutr Physiol, Adugodi, Bangalore, India, pp: 412.
  • Ratcliffe MJH, Jacobsen KA. 1994. Rearrangement of immunoglobulin genes in chicken B cell development. Semin Immunol, 6: 175-84.
  • Ratcliffe MJH. 2006. Antibodies, immunoglobulin genes and the bursa of Fabricius in chicken B cell development. Dev Comp Immunol, 30(1-2): 101-118.
  • Ravindran V. 2010. Poultry feed availability and nutrition in developing countries. Poultry Development Review. Food and Agriculture Organization of the United Nations.
  • Rebouche CJ. 1992. Carnitine function and requirements during the life cycle. Faseb J, 6: 3379-3386.
  • Rehman A, Arif M, Sajjad N, Al-Ghadi MQ, Alagawany M, Abd El-Hack ME, Alhimaidi AR, Elnesr SS, Almutairi BO, Amran RA, Hussein EOS, Swelum AA. 2020. Dietary effect of probiotics and prebiotics on broiler performance, carcass, and immunity. Poult Sci, 99: 6946-6953.
  • Rehman ZU, Meng C, Umar S, Munir M, Ding C. 2016. Interaction of infectious bursal disease virus with the immune system of poultry. World Poult Sci J, 72: 805-820.
  • Ren H, Vahjen W, Dadi T, Saliu EM, Zentek J. 2019. Synergistic effects of probiotics and phytobiotics on the intestinal microbiota in young broiler chicken. Microorganisms, 7: 684.
  • Rochell SA, Parsons HC, Dilger R. 2016. Influence of dietary amino acids reductions and Eimeria acervulina infection on growth performance and intestinal cytokine response of broilers fed low crude protein diets. Poult Sci, 95: 2602-2614.
  • Rodriguez PC, Ochoa AC, Al-Khami AA. 2017. Arginine metabolism in myeloid cells shapes innate and adaptive immunity. Front Immunol, 8: 93.
  • Romo MR, Perez-Martinez D, Ferrer CC. 2016. Innate immunity in vertebrates: an overview. Immunol, 148(2): 125-39.
  • Sadiq RK, Abrahimkhil MA, Rahimi N, Banuree SZ, Banuree SAH. 2023. Effects of dietary supplementation of Vitamin E on growth performance and immune system of broiler chickens. J World Poult Res, 13(1): 120-126.
  • Sahin K, Sahin N, Kucuk O. 2003. Effects of chromium and ascorbic acid supplementation on growth, carcass traits, serum metabolites, and antioxidant status of broiler chickens reared at a high ambient temperature (32°C). Nutr Res, 23(2): 225-238.
  • Santos DTT, Corzo A, Kidd MT, McDaniel CD, Torres FRA, Araujo LF. 2010. Influence of in ovo inoculation with various nutrients and egg size on broiler performance. J Appl Poult Res, 19: 1-12.
  • Sarıca Ş, Karataş Ü, Gözalan R. 2009. Kanatlılarda bağışıklık sistemi ve bağışıklık sistemini etkileyen besinsel faktörler. GOÜ Ziraat Fakültesi Dergisi, 26(2): 81-86.
  • Saripinar-Aksu D, Aksu T, Onel SE. 2012. Does inclusion at low levels of organically complexed minerals versus inorganic forms create a weakness in performance or antioxidant defense system in broiler diets? Int J Poult Sci, 11(10): 666-672.
  • Sayed Y, Hassan M, Salem HB, Al‑Amry K, E. Eid G. 2023. Prophylactic influences of prebiotics on gut microbiome and immune response of heat‑stressed broiler chickens. Nature Scientific Reports, 13: 13991.
  • Schneider AF, Zimmermann OF, Gewehr CE. 2017. Zeolites in poultry and swine production. Ciencia Rural, 47: 1-8.
  • Seifert C, Fritz C, Carlini N, Barth SW, Franz CMAP, Watzl B. 2011. Modulation of innate and adaptive immunity by the probiotic Bifidobacterium longum PCB133 in turkeys. Poult Sci, 90: 2275-2280.
  • Selaledi LA, Hassan ZM, Manyelo TG, Mabelebele M. 2020. The current status of the alternative use to antibiotics in poultry production: an african perspective. Antibiotics, 9: 594.
  • Selim S, Abdel-Megeid NS, Abou-Elnaga MK, Mahmoud SF. 2021. Early nutrition with different diets composition versus fasting on immunity-related gene expression and histomorphology of digestive and lymphoid organs of layer-type chicks. Animals, 11: 1568.
  • Shaji S, Selvaraj RK, Shanmugasundaram R. 2023. Salmonella infection in poultry: a review on the pathogen and control strategies. Microorganisms, 11: 2814.
  • Shanmugasundaram, R., Morris, A., Selvaraj, R., 2019. Effect of 25-hydroxycholecalciferol supplementation on turkey performance and immune cell parameters in a coccidial infection model. Poult Sci, 98: 1127-1133.
  • Sharma MK, Lee J, Shi H, Ko H, Goo D, Paneru D, Holladay SD, Gogal RM, Kim WK. 2024. Effect of dietary inclusion of 25-hydroxyvitamin D and vitamin E on performance, gut health, oxidative status, and immune response in laying hens infected with coccidiosis. Poult Sci, 103: 104033.
  • Shehata AA, Yalçın S, Latorre JD, Basiouni S, Attia YA, El-Wahab AA, Visscher C, El-Seedi HR, Huber C, Hafez HM, Eisenreich W, Tellez-Isaias G. 2022. Probiotics, prebiotics, and phytogenic substances for optimizing gut health in poultry. Microorganisms, 10: 395.
  • Shimizu M, Nagashima H, Sano K, Hashimoto K, Ozeki M, Tsuda K, Hatta H. 1992. Molecular stability of chicken and rabbit immunoglobulin G. Biosci Biotech Biochem, 56(2): 270-274.
  • Shojadoost B, Yitbarek A, Alizadeh M, Kulkarni RR, Astill J, Boodhoo N, Sharif S. 2021. Centennial review: effects of vitamins A, D, E, and C on the chicken immune system. Poult Sci, 100(4): 100930.
  • Silverman MN, Pearce BD, Biron CA, Miller AH. 2005. Immune modulation of the hypothalamic-pituitary-adrenal (hpa) axis during viral infection. Viral Immunol, 18(1): 41-78.
  • Sittiya J, Nii T. 2024. Effects of oligosaccharides on performance, intestinal morphology, microbiota and immune reactions in laying hens challenged with dextran sodium sulfate. Poult Sci, 2024: 104062.
  • Śliżewska K, Markowiak-Kopeć P, Żbikowski A, Szeleszczuk P. 2020. The effect of synbiotic preparations on the intestinal microbiota and her metabolism in broiler chickens. Sci Rep, 10: 4281.
  • Song B, Tang D, Yan S, Fan H, Li G, Shahid MS, Mahmood T and Guo Y. 2021. Effects of age on immune function in broiler chickens. J Anim Sci Biotechnol, 12: 42.
  • Spring P, Wenk C, Dawson KA, Newman KE. 2000. The effects of dietary mannan-oligosaccharides on cecal parameters and the concentrations of enteric bacteria in the ceca of Salmonella challenged broiler chicks. Poult Sci, 79: 205-211.
  • Subramaniyan SA, Kang DA, Park JR, Siddiqui SH, Ravichandiran P, Jing D, Sam Na C, Shim KS. 2019. Effect of in ovo injection of l-arginine in different chicken embryonic development stages on post-hatchability, immune response, and myo-d and myogenin proteins. Animals, 9(6): 357.
  • Sun Y, O’Riordan MX. 2013. Regulation of bacterial pathogenesis by intestinal short-chain fatty acids. Adv Appl Microbiol, 85: 93-118.
  • Sunder GS, Panda AK, Gopinath NCS, Rao SVR, Raju MVLN, Reddy MR, Kumar CV. 2008. Effects of higher levels of zinc supplementation on performance, mineral availability, and immune competence in broiler chickens. J Appl Poult Res, 17: 79-86.
  • Swain BK, Johri TS. 2000. Effect of supplemental methionine, choline and their combinations on the performance and immune response of broilers. Br Poult Sci, 41: 83-88.
  • Tawfeeq WS, Al-Mashhdani HE. 2020. Effect of adding propionic acid, formic acid, and antibiotics to broiler diet on the production performance, some histological traits, and microbial characteristics. Plant Arch, 20: 468-472.
  • Tayeb IH, Qader GK. 2012. Effect of feed supplementation of selenium and Vitamin E on production performance and some hematological parameters of broiler. KSU Doğa Bil Derg, 15(3): 46-56.
  • Uni Z, Yadgary L, Yair R. 2012. Nutritional limitations during poultry embryonic development. J Appl Poult Res, 21: 175-184.
  • Vulevic J, Rastall RA, Gibson GR. 2004. Developing a quantitative approach for determining the in vitro prebiotic potential of dietary oligosaccharides. FEMS Microbiol Lett, 236: 153-159.
  • Wei J, Li L, Peng Y, Luo J, Chen T, Xi Q, Zhang Y, Sun J. 2024. The effects of optimal dietary vitamin D3 on growth and carcass performance, tibia traits, meat quality, and ıntestinal morphology of chinese yellow-feathered broiler chickens. Animals. 14: 920.
  • Wickramasuriya SS, Ault J, Ritchie S, Gay CG, Lillehoj HS. 2024. Alternatives to antibiotic growth promoters for poultry: a bibliometric analysis of the research journals. Poult Sci, 103(9): 103987.
  • Wlazlak S, Pietrzak E, Biesek J, Dunislawska A. 2023. Modulation of the immune system of chickens a key factor in maintaining poultry production - a review. Poult Sci. 102: 102785.
  • Wynn JL, Levy O. 2010. Role of Innate Host Defenses in Susceptibility to Early Onset Neonatal Sepsis. Clin Perinatol, 37(2): 307-337.
  • Xu H, Lu Y, Li D, Yan C, Jiang Y, Hu Z, Zhang Z, Du R, Zhao X, Zhang Y, Tian Y, Zhu Q, Liu Y, Wang Y. 2023. Probiotic mediated intestinal microbiota and improved performance, egg quality and ovarian immune function of laying hens at different laying stage. Front Microbiol, 14: 1041072.
  • Xu YQ, Guo YW, Shi BL, Yan SM, Guo XY. 2018. Dietary arginine supplementation enhances the growth performance and immune status of broiler chickens. Livest Sci, 209: 8-13.
  • Yang X, Xin H, Yang C, Yang X. 2018. Impact of essential oils and organic acids on the growth performance, digestive functions and immunity of broiler chickens. Anim Nutr, 4: 388-393.
  • Yasuda M, Kajiwara E, Ekino S, Taura Y, Hirota Y, Horiuchi H, Matsuda H, Furusawa S. 2003. Immunobiology of chicken germinal center: I. Changes in surface Ig class expression in the chicken splenic germinal center after antigenic stimulation. Dev Comp Immunol, 27(2): 159-166.
  • Yeşilyurt N, Yılmaz B, Ağagündüz D, Capasso R. 2021. Involvement of probiotics and postbiotics in the immune system modulation. Biologics, 1: 89-110.
  • Yu J, Dong B, Zhao M, Liu L, Geng T, Gong D, Wang J. 2021. Dietary clostridium butyricum and bacillus subtilis promote goose growth by improving intestinal structure and function, antioxidative capacity and microbial composition. Animals, 11: 3174.
  • Yu Y, Li Q, Zeng X, Xu Y, Jin K, Liu J, Cao G. 2022. Effects of probiotics on the growth performance, antioxidant functions, immune responses, and caecal microbiota of broilers challenged by Lipopolysaccharide. Front Vet Sci, 9: 846649.
  • Zhai W, Gerard PD, Pulikanti R, Peebles ED. 2011. Effects of in ovo injection of carbohydrates on embryonic metabolism, hatchability, and subsequent somatic characteristics of broiler hatchlings. Poult Sci, 90: 2134-43.
  • Zhou P, Tan YQ, Zhang L, Zhou YM, Gao F, Zhou GH. 2014. Effects of dietary supplementation with the combination of zeolite and attapulgite on growth performance, nutrient digestibility, secretion of digestive enzymes and intestinal health in broiler chickens. Asian-Australas J Anim Sci, 27: 1311.
There are 162 citations in total.

Details

Primary Language English
Subjects Zootechny (Other)
Journal Section Reviews
Authors

Merve Gündüz 0000-0002-5449-9893

Arda Sözcü 0000-0002-0955-4371

Üzeyir Çağırıcı 0009-0001-2445-0933

Early Pub Date August 4, 2024
Publication Date August 15, 2024
Submission Date July 19, 2024
Acceptance Date August 4, 2024
Published in Issue Year 2024

Cite

APA Gündüz, M., Sözcü, A., & Çağırıcı, Ü. (2024). Nutritional Aspects for Modulation of Poultry Immune Stimulation. Black Sea Journal of Agriculture(7), 464-476. https://doi.org/10.47115/bsagriculture.1518799

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