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Screening for Inverdale (FecXI) Mutation in BMP15 Gene in Prolific Turkish Awassi Sheep

Year 2021, , 130 - 132, 01.10.2021
https://doi.org/10.47115/bsagriculture.988347

Abstract

In the early 1980s, by the determination of the Boorola gene (FecB) in Booroola sheep with high ovulation rate, there has been a great interest for identification of genes that are responsible for prolificacy and their use in breeding programs. The mutation occurred in Bone morphogenetic protein 15 (BMP15), Bone morphogenetic protein-1B (BMPR-1B) and Growth differentiation factor 9 (GDF9) genes have been found to increase the ovulation rate. Additionally some others gene are known to exist based on expressed inheritance patterns although the location of mutations has yet to be found. In the BMP15 gene, with almost the same phenotypic expression eight distinct mutations have been recognized, among them Hanna (FecXH) and Inverdale (FecXI) were identified first in Romney sheep in New Zealand. X-linked dominant genes with sterility in homozygous females are the modes of inheritance of the BMP15 gene. A total of 88 prolific Awassi sheep were screened for the presence of the FecXI mutation in the BMP15 gene and FecXI mutation was not found in any of the sheep tested.

References

  • Abulyazid, I., Sharada, H. M., Abdalla, M. S., Saleh, H. M., & Hassanin, W. F. 2011. FecX1 gene as a monitor for the production of twins in the Egyptian sheep. Roavs, 1 (4): 217-219.
  • Davis, G. H., McEwan, J. C., Fennessy, P. F., Dodds, K. G., & Farquhar, P. A. 1991. Evidence for the presence of a major gene influencing ovulation rate on the X chromosome of sheep. Biol Reprod, 44 (4): 620–624.
  • Davis, G. H., McEwan, J. C., Fennessy, P. F., Dodds, K. G., McNatty, K. P., & Wai-Sum, O. 1992. Infertility due to bilateral ovarian hypoplasia in sheep homozygous (FecX1 FecX1) for the Inverdale prolificacy gene located on the X chromosome. Biol Reprod, 46 (4): 636-640.
  • Davis, G. H., Galloway, S. M., Ross, I. K., Gregan, S. M., Ward, J., Nimbkar, B. V., Ghalsasi, P. M., Nimbkar, C., Gray, G. D., & Inounu, I. 2002. DNA tests in prolific sheep from eight countries provide new evidence on origin of the Booroola (FecB) mutation. Biol Reprod, 66 (6): 1869-1874.
  • Davis, G. H. 2005. Major genes affecting ovulation rate in sheep. Genet Sel Evol, 37: 11-23.
  • Davis, G. H., Balakrishnan, L., Ross, I. K., Wilson, T., Galloway, S. M., Lumsden, B. M., Hanrahan, J. P., Mullen, M., Mao, X. Z., & Wang, G. L. 2006. Investigation of the Booroola (FecB) and Inverdale (FecXI) mutations in 21 prolific breeds and strains of sheep sampled in 13 countries. Anim Reprod Sci, 92 (1-2): 87-96.
  • Dinçel, D., Ardıçlı, S., Soyudal, B., Er, M., Alpay, F., Şamlı, H., & Balcı, F. 2015. Analysis of FecB, BMP15 and CAST Gene Mutations in Sakız Sheep. Kafkas Univ Vet Fak Derg, 21 (4): 483-488.
  • Drouilhet, L., Mansanet, C., Sarry, J., Tabet, K., & Bardou, P. 2013. The Highly Prolific Phenotype of Lacaune Sheep Is Associated with an Ectopic Expression of the B4GALNT2 Gene within the Ovary. PLoS Genet, 9 (9): 1-12.
  • Galal, S., Gürsoy, O., & Shaat, I. (2008). Awassi sheep as a genetic resource and efforts for their genetic improvement—A review. Small Rumin Res, 79: 99-108.
  • Galloway, S. M., McNatty, K. P., Cambridge, L. M., Laitinen, M. P., Juengel, J. L., Jokiranta, T. S., McLaren, R. J., Luiro, K., Dodds, K. G., & Montgomery, G. W. 2000. Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner. Nat Genet, 25 (3): 279-283.
  • Gürsel, E., Akış, I., Durak, H., Mengi, A., Öztabak, K. 2011. Determination of BMP-15, BMPR-1B and GDF-9 gene mutations of the indigenous sheep breeds in Turkey. Kafkas Univ Vet Fak Derg, 17 (5): 725-729.
  • Jansson, T. 2014. Genes involved in ovulation rate and litter size in sheep. B.S thesis, Swedish University of Agricultural Sciences Faculty of Veterinary Medicine and Animal Science, Uppsala, pp 19.
  • Karslı, T., Şahin, E., Karslı, B. A., Eren, M. G., & Balcıoğlu, M. S. 2011. Kangal ve Güney Karaman koyunlarinda FecB FecXG, FecXH allellerinin PCR-RFLP Yöntemi Kullanılarak Araştırılması. Lalahan Hay Araşt Enst Der., 51 (2): 71-80
  • Kırıkçı, K., & ÇAM M. A. (2020). Türkiye Yöresel Yeni Koyun Tipi Of Koyunlarında GDF9 (FecG1) Gen Polimorfizmin PCR-RFLP Yöntemi ile Araştırılması. MJAVL, 10 (2): 98-102.
  • Pramod, R. K., Sharma, S. K., Kumar, R., & Rajan, A. 2013. Genetics of ovulation rate in farm animals. Vet. World, 6 (11): 833-838.
  • Roy, J., Polley, S., De, S., Mukherjee, A., Batabyal, S., Pan, S., Brahma, B., Datta, T. K., & Goswami, S. L. 2011. Polymorphism of fecundity genes (FecB, FecX, and FecG) in the Indian Bonpala sheep. Anim Biotechnol, 22 (3): 151–162.
  • Üstün, H., & Oğan, M. M. 2013. Main productive performance of Awassi sheep in the Central Anatolian Region of Turkey. Turkish J Vet Anim Sci, 37 (3): 271-276.
Year 2021, , 130 - 132, 01.10.2021
https://doi.org/10.47115/bsagriculture.988347

Abstract

References

  • Abulyazid, I., Sharada, H. M., Abdalla, M. S., Saleh, H. M., & Hassanin, W. F. 2011. FecX1 gene as a monitor for the production of twins in the Egyptian sheep. Roavs, 1 (4): 217-219.
  • Davis, G. H., McEwan, J. C., Fennessy, P. F., Dodds, K. G., & Farquhar, P. A. 1991. Evidence for the presence of a major gene influencing ovulation rate on the X chromosome of sheep. Biol Reprod, 44 (4): 620–624.
  • Davis, G. H., McEwan, J. C., Fennessy, P. F., Dodds, K. G., McNatty, K. P., & Wai-Sum, O. 1992. Infertility due to bilateral ovarian hypoplasia in sheep homozygous (FecX1 FecX1) for the Inverdale prolificacy gene located on the X chromosome. Biol Reprod, 46 (4): 636-640.
  • Davis, G. H., Galloway, S. M., Ross, I. K., Gregan, S. M., Ward, J., Nimbkar, B. V., Ghalsasi, P. M., Nimbkar, C., Gray, G. D., & Inounu, I. 2002. DNA tests in prolific sheep from eight countries provide new evidence on origin of the Booroola (FecB) mutation. Biol Reprod, 66 (6): 1869-1874.
  • Davis, G. H. 2005. Major genes affecting ovulation rate in sheep. Genet Sel Evol, 37: 11-23.
  • Davis, G. H., Balakrishnan, L., Ross, I. K., Wilson, T., Galloway, S. M., Lumsden, B. M., Hanrahan, J. P., Mullen, M., Mao, X. Z., & Wang, G. L. 2006. Investigation of the Booroola (FecB) and Inverdale (FecXI) mutations in 21 prolific breeds and strains of sheep sampled in 13 countries. Anim Reprod Sci, 92 (1-2): 87-96.
  • Dinçel, D., Ardıçlı, S., Soyudal, B., Er, M., Alpay, F., Şamlı, H., & Balcı, F. 2015. Analysis of FecB, BMP15 and CAST Gene Mutations in Sakız Sheep. Kafkas Univ Vet Fak Derg, 21 (4): 483-488.
  • Drouilhet, L., Mansanet, C., Sarry, J., Tabet, K., & Bardou, P. 2013. The Highly Prolific Phenotype of Lacaune Sheep Is Associated with an Ectopic Expression of the B4GALNT2 Gene within the Ovary. PLoS Genet, 9 (9): 1-12.
  • Galal, S., Gürsoy, O., & Shaat, I. (2008). Awassi sheep as a genetic resource and efforts for their genetic improvement—A review. Small Rumin Res, 79: 99-108.
  • Galloway, S. M., McNatty, K. P., Cambridge, L. M., Laitinen, M. P., Juengel, J. L., Jokiranta, T. S., McLaren, R. J., Luiro, K., Dodds, K. G., & Montgomery, G. W. 2000. Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner. Nat Genet, 25 (3): 279-283.
  • Gürsel, E., Akış, I., Durak, H., Mengi, A., Öztabak, K. 2011. Determination of BMP-15, BMPR-1B and GDF-9 gene mutations of the indigenous sheep breeds in Turkey. Kafkas Univ Vet Fak Derg, 17 (5): 725-729.
  • Jansson, T. 2014. Genes involved in ovulation rate and litter size in sheep. B.S thesis, Swedish University of Agricultural Sciences Faculty of Veterinary Medicine and Animal Science, Uppsala, pp 19.
  • Karslı, T., Şahin, E., Karslı, B. A., Eren, M. G., & Balcıoğlu, M. S. 2011. Kangal ve Güney Karaman koyunlarinda FecB FecXG, FecXH allellerinin PCR-RFLP Yöntemi Kullanılarak Araştırılması. Lalahan Hay Araşt Enst Der., 51 (2): 71-80
  • Kırıkçı, K., & ÇAM M. A. (2020). Türkiye Yöresel Yeni Koyun Tipi Of Koyunlarında GDF9 (FecG1) Gen Polimorfizmin PCR-RFLP Yöntemi ile Araştırılması. MJAVL, 10 (2): 98-102.
  • Pramod, R. K., Sharma, S. K., Kumar, R., & Rajan, A. 2013. Genetics of ovulation rate in farm animals. Vet. World, 6 (11): 833-838.
  • Roy, J., Polley, S., De, S., Mukherjee, A., Batabyal, S., Pan, S., Brahma, B., Datta, T. K., & Goswami, S. L. 2011. Polymorphism of fecundity genes (FecB, FecX, and FecG) in the Indian Bonpala sheep. Anim Biotechnol, 22 (3): 151–162.
  • Üstün, H., & Oğan, M. M. 2013. Main productive performance of Awassi sheep in the Central Anatolian Region of Turkey. Turkish J Vet Anim Sci, 37 (3): 271-276.
There are 17 citations in total.

Details

Primary Language English
Subjects Zootechny (Other)
Journal Section Research Articles
Authors

Yasemin Gedik 0000-0002-3607-1527

Publication Date October 1, 2021
Submission Date August 29, 2021
Acceptance Date September 7, 2021
Published in Issue Year 2021

Cite

APA Gedik, Y. (2021). Screening for Inverdale (FecXI) Mutation in BMP15 Gene in Prolific Turkish Awassi Sheep. Black Sea Journal of Agriculture, 4(4), 130-132. https://doi.org/10.47115/bsagriculture.988347

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