Evaluation of the Effects of Mycotoxin Binders in Animal Nutrition

Year 2019, Volume: 2 Issue: 4, 218 - 223, 01.10.2019

Hasan Hüseyin İpçak Ahmet Alçiçek Sema Özüretmen

Abstract

Mycotoxins are small and quite stable molecules which are extremely difficult to remove or eradicate, and which are
considered to be a great threat both for human and animal health in global terms. Especially in farm animals,
mycotoxins can cause decreased performance, reducing in feed consumption, weakening of immunity system,
reproductive disorders, diminished body weight gain and residues on food products of animal origin. The mycotoxins
of major concern as feed contaminants that are potentially removable from feed are mainly aflatoxins, ochratoxin A,
zearalenone, deoxynivalenol, T-2 and fumonisins. One of the methods for reducing the exposure to mycotoxins is to
reduce their absorption and bioavailability by using various mycotoxin binders. The most widely known of these are
aluminosilicates like clay, bentonite, montmorillonite, zeolite, aqueus sodium calcium aluminosilicate (HSCAS) and
active carbons. Another method is the degradation of mycotoxins into non-toxic metabolites by using indigestable
complex carbonhydrates (bacterium and yeast cell walls), enzyme, vitamin, amino-acid and synthetic polymers like
cholestralamine, polivinil-polipirrolidon polymers (PVPP). The purpose of this review is to identify the benefits and
risky aspects of using toxin binders in animal nutrition and to give some idea about the future of this practice.

Keywords

Mycotoxins, Toxin binders, Feed, Livestock

References

• Alçiçek A. 2012. Yemlerde aflatoksin oluşumu ve süte geçme durumu. Tarım Gündem, 1(6):82-84.
• Anonymus. 2016. The truth about mycotoxin binders, https://www.biomin.net/en/blog-posts/the-truth-aboutmycotoxin-binders/ (accessed date 29.05.2019).
• Anonymus. 2018. Mycotoxins definition, http://www.mycotoxins.info/en/mycotoxins/mycotoxinsdefinition/ (accessed date 29.05.2019).
• Bursian SJ, Mitchell RR, Yamini B, Fitgerald SD, Murphy PA, Fernadez G, Rottinghaus GE. 2004. Efficacy of a commercial mycotoxin binder in alleviating effects of ochratoxin A fumonisin B1 moniliformin and zearalenone in adult mink Vet Hum Toxicol, 46(3): 122-129.
• Chilaka CA, De Boevre M, Atanda OO, De Saeger S. 2017. The status of fusarium mycotoxins in Sub-Saharan Africa: a review of emerging trends and post-harvest mitigation strategies towards food control. Toxins, 9: 19.
• Denli M, Blandon J,C, Salado S, Perez JF, Calsamiglia S. 2003. Effects of dietary afladetox on aflatoxin m1 residue in milk of dairy cows. Poultry Sci, 88: 1444–1451.
• Devreese M, Antonissen G, De Backer P, Croubels S. 2014. Efficacy of active carbon towards the absorption of deoxynivalenol in pigs Toxins 6: 2998-3004.
• Di Gregorio MC, de Neeff DV, Jager AV, Corassin CH, de Pinho Carăo AC, de Albuquerque R, de Azevedo AC, Oliveira CAF. 2014. Mineral adsorbents for prevention of mycotoxins in animal feeds. Toxin Rev, 33(3): 125-135.
• Döll S, Danicke S, 2004. In vivo detoxification of fusarium toxins, Archiv Anim Nutr, 58: 419-441.
• EFSA 2009. Review of mycotoxin-detoxifyying agents used as feed additives: Mode of action efficacy and feed/food safety,
• AFSSA CODA-CERVA INRA Clermont-Ferrand INRA Toulouse IRTA ISPA.
• Grenier B, Applegate TJ. 2013. Modulation of intestinal functions following mycotoxin ingestion: meta-analysis of published experiments in animals. Toxins, 5: 396-430.
• Huwig A, Freimund S, Kӓppeli O, Dutler H, 2001. Mycotoxin detoxication of animal feed by different adsorbents, Toxicol Letters, 122: 179–188.
• Istiqomah L, Damayanti E, Julendra H, Suryani AE, Sakti AA, Anggraeni AS. 2016. Effect of methionine and lactic acid bacteria as aflatoxin binder on broiler performance. Proceeding of International Biology Conference 2016 AIP Conf Proc, 1854 020017-1–020017-7.
• Jelinek CF, Pohland AE, Wood GE. 1989. Worldwide occurrence of mycotoxins in foods and feeds. J Assoc Off Anal Chem, 72: 223- 230.
• Jin L, Wang W, Degroote J, Van Noten N, Yan H, Majdeddin M, Van Poucke M, Peelman L, Goderis A, Van De Mierop K, Mombaerts R, De Smet S, Michiels J. 2017. Mycotoxin binder improves growth rate in piglets associated with reduction of toll-like receptor-4 and increase of tight junction protein gene expression in gut mucosa. J Anim Sci Biotech, 8: 80.
• Khan FA, Zahoor M. 2014. In vivo detoxification of aflatoxinB1 by magnetic carbon nanostructures prepared from bagasse. BMC Vet Res. 10: 255.
• Laurain J. 2018. Mycotoxin detoxification strategies a review. All About Feed, 26 (4): 13-14.
• Murugesan G,R, Ledoux D,R, Naehrer K, Berthiller F, Applegate T, J, Grenier B, Phillips T, D, Schatzmayr G. 2015. Prevalence and effects of mycotoxins on poultry health and performance and recent development in mycotoxin counteracting strategies. Poultry Sci, 94: 1298–1315.
• Nedeljković-Trailović J, Trailović S, Resanović R, Milićević D, Jovanovic M, Vasiljevic M. 2015. Comparative investigation of the efficacy of three different adsorbents against ota-induced toxicity in broiler chickens. Toxins, 7: 1174-1191.
• Nešić K, Resanović R, Jakić-Dimić D, Nešić V. 2011. Efficiency of various feed additives on the performance of broilers treated with t-2 toxin. Biotech Anim Husbandry, 27 (3): 705-711.
• Peng X, Zhang S, Fang J, Cui H, Zuo Z, Deng J. 2014. Protective roles of sodium selenite against aflatoxin b1-induced apoptosis of jejunum in broilers. Int J Environ Res Public Health, 11: 13130-13143,.
• Queiroz OCM, Han JH, Staples CR, Adesogan AT. 2012. Effect of adding a mycotoxin-sequestering agent on milk aflatoxin M1 concentration and the performance and immune response of dairy cattle fed an aflatoxin B1-contaminated diet. J Dairy Sci, 95: 5901–5908.
• Saminathan M, Selamat J, Pirouz A,A, Abdullah N, Zulkifli I. 2018. Effects of nano-composite adsorbents on the growth performance serum biochemistry and organ weights of broilers fed with aflatoxin-contaminated feed. Toxins, 10: 345.
• Shi D, Zhou J, Zhao L, Rong X, Fan Y, Hamid H, Li W, Ji C, Ma Q, 2018. Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts. J Anim Sci Biotech, 9: 42.
• Śliźewska K, Cukrowska B, Smulikowska S, Cielecka-Kuszyk J. 2019. The effect of probiotic supplementation on performance and the histopathological changes in liver and kidneys in broiler chickens fed diets with aflatoxin B1. Toxins, 11: 112.
• Stanford K, Lou Swift M, Wang Y, McAllister T,A, McKinnon J, Blakley B, Chaves AV. 2018. Effects of feeding a mycotoxin binder on nutrient digestibility alkaloid recovery in feces and performance of lambs fed diets contaminated with cereal ergot. Toxins, 10: 312.
• Wang RJ, Fui SX, Miao CH, Feng DY. 2006. Effects of different mycotoxin adsorbents on performance meat characteristics and blood profiles of avian broilers fed mold contaminated corn. Asian-Aust J Anim Sci, 19 (1): 72-79.
• Whitlow WL. 2006. Evaluation of Mycotoxin Binders, North Carolina State USA http://www,uwex,edu/ces/dairynutrition/documents/MycoMaryland-Binders,pdf p: 132-140.
• Yeanpet C, Thamrongyoswittayakul C, Wachirapakorn C, Songsermsakul P, Somphon N, Wongnen C. 2018. Efficacy of mycotoxin adsorbents on aflatoxin b1 decontamination and in vitro rumen fermentation. Prawarun Agr J, 15(1): 260-268.
• Zouagui Z, Asrar M, Lakhdissi H, Abdennebi EH. 2017. Prevention of mycotoxin effects in dairy cows by adding an anti-mycotoxin product in feed. JMES, 8(10): 3766-3770.