Bibliometric Analysis of Poppy Alkaloids and Morphine Biosynthesis

Year 2025, Volume: 8 Issue: 5, 626 - 635, 15.09.2025

Tahsin Beycioğlu

https://doi.org/10.47115/bsagriculture.1692279

Abstract

This bibliometric analysis examines the scientific literature development in poppy alkaloids and morphine biosynthesis from 1980 to 2024. Using data from 845 Web of Science publications, we conducted comprehensive analyses including annual scientific production, international collaboration networks, keyword analysis, citation patterns, and thematic mapping. Our findings reveal steady growth in scientific output since the 1980s, peaking at 45 publications in 2016. The USA, Canada, UK, Germany, and Australia emerge as the most productive and influential countries in international collaboration networks. Citation analysis identifies Facchini (1996), Morishige (2000), Liscombe (2007), and Hagel (2010) as the field's most influential reference points. Thematic mapping identifies "opium poppy," "molecular-cloning," and "expression" as motor themes driving the field, while "biosynthesis," "alkaloids," and "morphine" constitute core themes. Word cloud analysis shows "Papaver somniferum" as the most frequently used term (frequency: 76), representing 8% of the total research focus according to treemap analysis. This study provides a comprehensive mapping of the scientific structure and developmental dynamics in poppy alkaloids and morphine biosynthesis research, offering valuable insights for identifying research gaps and predicting future directions in this interdisciplinary field.

Keywords

Poppy , Alkaloids , Bibliometric

Ethical Statement

Since no studies involving humans or animals were conducted, ethical committee approval was not required for this study.

References

• Abdi A, Idris N, Alguliyev RM, Aliguliyev RM. 2018. Bibliometric analysis of IPandM Journal (1980-2015). J Scientometr Res, 7(1): 54-62.
• Ameri A, Heydarirad G, Mahdavi Jafari J, Ghobadi A, Rezaeizadeh H, Choopani R. 2015. Medicinal plants contain mucilage used in traditional Persian medicine (TPM). Pharm Biol, 53(4): 615-623.
• Aria M, Cuccurullo C. 2017. bibliometrix: An R-tool for comprehensive science mapping analysis. J Informetr, 11(4): 959-975.
• Baser KHC, Arslan N. 2014. Opium poppy (Papaver somniferum). In: Medicinal and Aromatic Plants of the Middle-East, pp: 305-332.
• Çeliktaş N, Kaya A, Türkmen M. 2022. Application of near infrared spectroscopy combined with multivariate analysis for screening foliar main essential oil components in bay laurel. Eng Agríc, 42(2): e20200040.
• Davis PH, Mill RR, Tan K. 1988. Papaver L. Flora of Turkey and East Aegean Islands. Univ Pres, Edinburgh, UK.
• Derviş H. 2019. Bibliometric analysis using bibliometrix an R package. J Scientometr Res, 8(3): 156-160.
• Diaz-Bárcena A, Giraldo P. 2023. Exploring the research evolution of Papaver somniferum and Cannabis sativa: A bibliometric comparative analysis. Ind Crops Prod, 203: 117143.
• Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM. 2021. How to conduct a bibliometric analysis: An overview and guidelines. J Bus Res, 133: 285-296.
• Freire R, Nicol CJ. 2019. A bibliometric analysis of past and emergent trends in animal welfare science. Anim Welf, 28(4): 465-485.
• Han J, Kang HJ, Kim M, Kwon GH. 2020. Mapping the intellectual structure of research on surgery with mixed reality: Bibliometric network analysis (2000–2019). J Biomed Inform, 109: 103516.
• Kapoor LD. 1997. Oppium Poopy: Botany, Chemistry and Pharmacology. Food Products Press, New York, USA, pp: 450.
• Masihuddin M, Jafri MA, Siddiqui A, Chaudhary S. 2018. Traditional uses, phytochemistry and pharmacological activities of papaver somniferum with special reference of unani medicine an updated review. J Drug Deliv Ther, 8(5-s): 110-114.
• Merigó JM, Yang JB 2017. A bibliometric analysis of operations research and management science. Omega, 73: 37-48
• Özgen Y, Arslan N, Bayraktar N. 2017. Importance and agriculture of poppy, an important plant for Turkey. Agric Eng, 364: 4-8
• Persson O, Danell R, Schneider JW 2009. How to use Bibexcel for various types of bibliometric analysis. Celebr Schol Commun Stud, 5: 9-24
• Portakal P, Tan TG. 2024. Pharmacological and toxicological properties of alkaloids of papaver somniferum (Papper). Bull Vet Pharmacol Toxicol Soc, 15(1): 1-10
• R Core Team. 2020. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria
• Şahin Y. 2023. Determination of chemical content, antioxidant activity and acetylcholinesterase enzyme inhibition properties of poppy (Papaver somniferum L.) plant. Muş Alparslan Üniversitesi, Fen Bilimleri Enstitüsü, Muş, Türkiye pp: 78
• van Eck NJ, Waltman L. 2010. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 84(2): 523-538
• Yavuz E. 2023. Bibliometric analysis for use of time series in animal science. Black Sea J Agric, 6(6): 700-705.