Su Bazlı Akıllı Polimerik Malzemeler: Hidrojeller

Year 2024, Volume: 7 Issue: 1, 58 - 70, 31.12.2024

Pelin Saraçoğlu

Abstract

Hidrojeller, yüksek su içeriği ve üç boyutlu polimer ağ yapıları sayesinde biyomedikal alanda çok çeşitli uygulamalara hizmet eden benzersiz özelliklere sahiptir. Doğal veya sentetik polimerlerden üretilebilen bu malzemeler, ilaç ve hücre taşıma, doku yenileme, yara iyileşmesi, tıbbi implantların biyouyumluluğunu artırma gibi birçok işlevi yerine getirirken çevresel mühendislik gibi farklı alanlarda da kullanışlıdır. Kimyasal yapıları, çapraz bağlantıları ve üretim yöntemleriyle özelleştirilebilir, böylece akıllı malzemeler olarak farklı ihtiyaçlara uyarlanabilirler. Polimer zincirlerinin çözünmesini önleyen bu çapraz bağlar hem kimyasal hem de fiziksel yöntemlerle oluşturulabilir ve malzemeye hem elastikiyet hem de stabilite kazandırırlar. Bununla birlikte, hidrojellerin yüksek su içeriği onları canlı dokulara fiziksel olarak benzer kılar ve biyomedikal uygulamalar için ideal bir seçim haline getirir. Gözenekli yapıları, suyun yanı sıra biyomolekülleri ve ilaçları kapsüllemeye olanak tanır. Sulu ortamda oluşan bu malzemeler, organik çözücülere karşı dayanıklıdır ve biyolojik ajanların denatürasyon riskini en aza indirir. Hidrojellerin geri kazanılabilir ve yeniden kullanılabilir olması da onları sürdürülebilir malzeme tasarımı için de cazip hale getirmektedir. Bu derleme makalesi, hidrojellerin yapısal özelliklerini, sentez yöntemlerini ve uygulama alanlarındaki rollerine kısa bir bakış sunmakta, bu malzemelerin gelecekteki gelişimlerine dair önemli bilgiler sunmayı amaçlamaktadır.

Keywords

Polimerik Jeller, Hidrojeller, Çapraz Bağlama

Water-Based Smart Polymeric Materials: Hydrogels

Abstract

Hydrogels, with their high water content and three-dimensional polymer network structures, possess unique properties that serve a wide range of applications in the biomedical field. These materials, which can be produced from natural or synthetic polymers, perform various functions such as drug and cell delivery, tissue regeneration, wound healing, and enhancing the biocompatibility of medical implants, while also being useful in fields like environmental engineering. Their chemical structures, crosslinking, and production methods can be tailored, allowing them to be adapted as smart materials for different needs. The crosslinks, which prevent the dissolution of polymer chains, can be created through both chemical and physical methods, providing the material with elasticity and stability. Moreover, the high water content of hydrogels makes them physically similar to living tissues, rendering them an ideal choice for biomedical applications. Their porous structure enables encapsulation of water, biomolecules, and drugs. Formed in aqueous environments, these materials exhibit resistance to organic solvents and minimize the risk of denaturation of biological agents. Additionally, the recyclability and reusability of hydrogels make them attractive for sustainable material design. This review article provides a concise overview of the structural properties, synthesis methods, and biomedical roles of hydrogels, aiming to offer key insights into their future development.

Keywords

Polymeric Gels, Hydrogels, Crosslinking

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