Naringenin Baskılanmış Kriyojel Membranların Hazırlanması ve Adsorpsiyon Davranışlarının İncelenmesi

Year 2023, , 149 - 154, 01.07.2023

Emel Demirtaş , Mehmet Odabaşı

https://doi.org/10.34248/bsengineering.1269745

Abstract

Naringenin önemli terapötik (tedavi edici) etkileri olan flavonoid sınıfından bir flavanondur. Yurt dışında fazlaca çalışılmış bir bileşik olan naringenin ülkemizde çok fazla dikkat çekmemiş olduğu düşünülmektedir. Yaygın şekilde bitkilerde bulunan bu naringenin molekülüne dikkat çekmek için yeni bir yöntem olan moleküler baskılama yöntemi kullanılarak naringenin baskılanmış kriyojeller sentezlenmiştir. Elementel analiz, termogravimetrik analiz ve şişme testleri gibi karakterizasyon çalışmaları ile birlikte adsorpsiyon ve seçicilik testleri de gerçekleştirilmiştir. Elde edilen bulgulardan bazıları aşağıda özetlenmiştir: Naringenin baskılanmış polimerlerde bozunma sıcaklığı 1,7 °C kadar yükselmiştir. Naringenin baskılanmış polimerdeki naringenin miktarı baskılanmamışa oranla %16,36’lık oranda yüksek bulunmuştur. MIP ve NIP için şişme değerleri sırasıyla %850 %967 olarak hesaplanmıştır.

Keywords

Naringenin, Moleküler baskılanmış polimer, Naringenin saflaştırılması

Supporting Institution

Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK

Project Number

121Z173

Thanks

Bu çalışma Türkiye Bilimsel ve Teknolojik Araştırma Kurumu tarafından desteklenmiştir (Hibe Numarası: 121Z173). Bu destek için TÜBİTAK'a çok teşekkür ederiz.

Preparation of Naringenin Imprinted Cryogel Membranes and Investigation of Adsorption Behaviors

Abstract

Naringenin is a flavanone of the flavonoid class with significant therapeutic effects. It is thought that naringenin, a compound that has been studied extensively abroad, has not received much attention in our country. Naringenin imprinted cryogels were synthesized using a new method, molecular imprinting, to draw attention to this molecule of naringenin, which is commonly found in plants. Along with characterization studies such as elemental analysis, thermogravimetric analysis and swelling tests, adsorption and selectivity tests were also carried out. Some of the findings are summarized below: The degradation temperature of naringenin in imprinted polymers increased by 1.7 °C. The amount of naringenin in MIP was found to be 16.36% higher than in the NIP. Swelling values for MIP and NIP were calculated as 850% 967%, respectively.

Keywords

Naringenin, Molecularly imprinted polymer, Naringe purification

Project Number

121Z173

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