Losartan Mı Nebivolol Mu ? Hangisi Erektil Disfonksiyonda Daha Etkin ?

Year 2023, Volume: 1 Issue: 2, 119 - 127, 25.09.2023

Ali Haydar Yılmaz , Mustafa Kaplangoray , Edhem Deveci

Abstract

Hipertansif hastaları ED (erektil disfonksiyon) karşı korumak ve cinsel sağlık açısından daha iyi klinik düzelme sağlamak ve bu ilaçların ED üzerine olumlu etkilerini değerlendirmek için bu hastalara önerilebilecek daha önce bilinen nebivolol ve çok bilinmeyen losartan içerikli ilaçları karşılaştırmak amaçlanmıştır. 18 yaş üstü diyabetik cinsel aktif erkek hastalara iki ayrı form doldurulacak. Hastalar losartan kullananlar, nebivolol kullananlar ve bu ilaçları kullanmayan kontrol grubu olmak üzere 3 grup olacaktır. Toplam 85 hasta çalışmaya alınmıştır. Erkek cinsel sağlık değerlendirme formuna göre losartan ve nebivolol grubu kontrol grubuna göre anlamlıdır (p<0,0001). Uluslararası erektil işlev formuna göre de losartan ve nebivolol grubu da kontrol grubuna göre istatistiksel olarak anlamlı bulunmuştur (p<0,0001). Nebivolol ED üzerindeki olumlu etkisini damar endotelinden NO salınımını sağlayarak vazodilatasyon yaparak gösterir. Ancak losartan ile kıyaslandığında yapılan çalışmalarda görüldüğü gibi losartan klinik düzelme daha üstün görülmektedir.

Keywords

Losartan, Nebivolol, Hipertansiyon, Erektil Disfonksiyon.

Losartan or Nebivolol ? Which One Is More Effective in Erectile Dysfunction ?

Abstract

To protect hypertensive patients against ED (erectile dysfunction) and to provide better clinical improvement in terms of sexual health and to evaluate the positive effects of these drugs on ED, it is aimed to compare the drugs containing previously known nebivolol and unknown losartan that can be recommended to these patients. Two separate forms will be filled out for diabetic sexually active male patients over the age of 18. Patients will be in 3 groups: those who use losartan, those who use nebivolol, and the control group who do not use these drugs. A total of 85 patients were enrolled in the study. According to the male sexual health assessment form, the losartan and nebivolol group are statistically significant compared to the control group (p<0.0001). According to the international erectile function form, losartan and nebivolol group were also found to be statistically significant compared to the control group (p<0.0001). Nebivolol shows its positive effect on ED by vasodilation by ensuring the release of NO from the vascular endothelium. However, as can be seen from the studies conducted in comparison with losartan, the clinical improvement of losartan is seen to be superior.

Keywords

Losartan, Nebivolol, Hypertension, Erectile Dysfunction

Supporting Institution

None

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