Kardiyovasküler Hastalıklar için Yeni Epigenetik Belirteçler: Dairesel RNA'lar

Year 2021, , 189 - 196, 01.05.2021

Nil Özbilüm İzzet Yelkuvan Burcu Bayyurt

https://doi.org/10.19127/bshealthscience.871765

Abstract

Kardiyovasküler hastalık (KVH)’lar, dünyada yüksek morbidite ve mortaliteye neden olurlar. Son araştırmalar, KVH patogenezinde dairesel RNA (circRNA)'ların fonksiyonlarına odaklanmıştır. CircRNA'lar, kovalent olarak kapalı halkasal yapıya sahip, dokuya ve gelişimsel aşamaya özgü farklı ifade/ekspresyon profili olan kodlama yapmayan RNA (ncRNA)'lardır. Serbest uçlarının
olmaması, doğrusal transkriptlerle karşılaştırıldığında daha fazla stabilite sağladığından, circRNA’lar gelecekte ideal terapötik hedef adaylarıdır. Bu çalışmada circRNA'ların biyogenezi, biyolojik özellikleri ve KVH patogenezindeki etki mekanizmaları ile ifade düzeyleri derlenmiştir. Yapılan çalışmalar circRNA'ların KVH'nin ilerlemesinde yakından rol oynadığını ve KVH için umut verici biyobelirteçler olabileceğini doğrulamıştır. Bu bulgular gelecekte KVH'nin önlenmesi, teşhisi ve terapötik müdahalesi için yeni bir yol sağlayabilir.

Keywords

Dairesel RNA, Kardiyovasküler hastalık, Patogenez

New Epigenetic Markers for Cardiovascular Diseases: Circular RNAs

Abstract

Cardiovascular disease causes high morbidity and mortality in the world. Recent researches have focused on the functions of circular RNAs (circRNAs) in KVH pathogenesis. CircRNAs are noncoding RNAs (ncRNAs) that have a covalently closed ring structure, tissue and developmental stage specific different expression profile. Since the absence of free ends provides greater stability compared to linear transcripts, circRNAs are ideal biomarkers and therapeutic target candidates in the future. In this study, the biogenesis and biological properties of circRNAs, their mechanisms of action and expression levels in KVH pathogenesis were reviewed. Studies have confirmed that circRNAs play a role in the progression of CVD and can be promising biomarkers for CVD. These findings may provide a new avenue for CVD prevention, diagnosis, and therapeutic intervention in future.

Keywords

Circular RNA, Cardiovascular disease, Pathogenesis

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