Localizated Hard Palate Adenoid Cystic Carsinoma

Year 2020, Volume: 3 Issue: 1, 18 - 21, 01.01.2020

Dilara Nil Tomrukçu Aysun Atasoy Sındıraç

Abstract

Adenoid cystic carsinoma (ACC) also called cylindroma in the oral cavity is a high grade malignancy tumor due to perineural spread tendency. It is the second most frequent malignant tumor of the salivary glands. It is characterized by slow expansion, local invasion, rare and generally occured in minor salivary glands of the head and neck. Clinically local pain, facial nerve weakness or paralysis and superficial ulseration may occasionally be the initial presenting symptoms, but there are observed especially in late-stage. Bone invasion rarely occurs, at the beginning there are no radiographic changes. This case report aimed to present the oral and radiographic findings of ACC in a female patient. A 81-year-old female patient applied to our clinic complaining with hard swelling that appeared in the middle line of the hard palate 2 months ago and eating difficulty. Intraoral examination showed a fibrotic mass in the midline of the hard palate, extending from the insisive teeth to the molar teeth and the mucosa on the lesion was normal. Panoramic radiograph showed radiolucent lesion with well-defined borders extending from maxillary molar teeth to the nasal cavity and maxillary sinus. In our case, biopsy was performed and lesion diagnosed as ACC histopathological. After maxillary resection, postoperative radiotherapy was performed. Adenoid cystic carcinomas are rarely seen salivary gland tumors in the head and neck region. Dentists can play an important role in the diagnosis of intra-oral tumors.

Keywords

Adenoid cystic carcinoma, Salivary glands, Palatal neoplasms

References

• Barrett AW, Speight PM. 2009. Perineural invasion in adenoid cystic carcinoma of the salivary glands: a valid prognostic indicator? Oral Oncol, 45: 936-40.
• Bradley PJ. 2017. Adenoid cystic carcinoma evaluation and management: progress with optimism! Curr Opin Otolaryngol Head Neck Surg, 25: 147-153.
• Dong J, Tian L, Li S, Mo Y, Liu L, Zhong R. 2015. Differences in extension patterns between adenoid cystic carcinoma of the nasopharynx and nasopharyngeal carcinoma on MRI. Int J Clin Exp Pathol, 8: 15960-15968.
• El-Naggar AK, Huvos AG. 2005. Adenoid cystic carcinoma. In Barnes L, Evenson JW, Reichart P, Sidransky D, (Eds.), World Health Organization classification of tumours. Pathology and genetics of head and neck tumours (pp. 221–222). Lyon: IARC Press.
• Hadfield PJ, Fisher C, Archer DJ. 1996. Adenoid cystic carcinoma of the maxilla–the value of histopathology in diagnosing a second primary. J Laryngol Otol, 110: 503-506.
• Khan AJ, DiGiovanna MP, Ross DA, Sasaki CT, Carter D, Son YH, Haffty BG. 2001. Adenoid cystic carcinoma: a retrospective clinical review. Int J Cancer, 96: 149-158.
• Kowalski PJ, Paulino AF. 2002. Perineural invasion in adenoid cystic carcinoma: Its causation/promotion by brain-derived neurotrophic factor. Hum Pathol, 33: 933-936.
• Mendenhall WM, Morris CG, Amdur RJ, Werning JW, Hinerman RW, Villaret DB. 2004. Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck. Head Neck, 26: 154-162.
• Neville BW, Damm DD, Chi AC, Allen CM. 2015. Oral and maxillofacial pathology 4th edition. St.Louis, MO, Westline Industrial Dr: Elsevier Health Sciences.
• Regezi JA, Sciubba JJ, Jordan RC. 2016. Oral pathology: clinical pathologic correlations 7th edition. St.Louis, MO, Westline Industrial Dr: Elsevier Health Sciences.
• Uraizee I, Cipriani NA, Ginat D. 2018. Adenoid Cystic Carcinoma of the Oral Cavity: Radiology-Pathology Correlation. Head Neck Pathol, 12: 562-566.
• Waldron CA, El-Mofty SK, Gnepp DR. 1988. Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol, 66: 323-33.