Research Article
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Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery

Year 2021, Volume: 4 Issue: 1, 17 - 21, 01.01.2021
https://doi.org/10.19127/bshealthscience.788064

Abstract

This study aimed to evaluate the efficacy of hyaluronic acid/trehalose drop for corneal epithelial and stromal healing after phacoemulsification surgery at Maltepe University, Department of Ophthalmology, Istanbul, Turkey. It is a retrospective randomized comparative study.The patients had phacoemulsification surgery divided into two groups. These patients received either a mixture of sodium hyaluronate and trehalose (HT, Thealoz Duo®, Thea)(Group 1) or sodium hyaluronate 0.15% (Eye Still®; Teka) (Group 2) postoperatively. Effect on corneal epithelial and stromal healing was evaluated using Oxford staining and the vertical scar length measured by optic coherence tomography (OCT) respectively. Preoperative and postoperative findings for Oxford staining, Schirmer’s test, tear film break-uptime (TBUT) and ocular surface disease index(OSDI) scores were also evaluated. The correlation between scar length and tear film parameters was examined. The effect of trehalose on the epithelial healing and stromal scar formation was evaluated. Group 1 and 2 each had 30 eyes. The two groups were similar according to age and sex distribution. In terms of epithelial healing, it was faster in the trehalose group, although there was no statistical difference between the two groups. The length of the stromal scar was not significantly different between groups, though a smaller scar formation was observed in group 1 compared to those in group 2 at both 1 week and 1 month postoperatively. There was also no significant difference between the groups in tear film parameters. The stromal scar length was correlated with the Schirmer test on the 15th day. Although it was not statistically significant, the hyaluronic acid/trehalose may affect epithelial healing and stromal scar formation in a positive way after phacoemulsification surgery. Larger and longer studies are needed.

References

  • Aragona P, Colosi P, Rania LColosi F, Pisani A, Puzzolo D, Micali A. 2014. Protective effects of trehalose on the corneal epithelial cells. Sci World J, 2014: 717835.
  • Bron AJ, Argüeso P, Irkec M, Bright FV. 2015. Clinical staining of the ocular surface: mechanisms and interpretations. Progress in Retinal and Eye Res, 44: 36-61.
  • Bron AJ, Evans VE, Smith JA. 2003. Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea, 22:640-650.
  • Cejka C, Kubinova S, Cejkova J. 2019. Trehalose in ophthalmology. Histol Histopathol, 34: 611-618.
  • Cejkova J, Cejka C, Luyckx J. 2012. Trehalose treatment accelerates the healing of UVB-irradiated corneas. Comparative immunohistochemical studies on corneal cryostat sections and corneal impression cytology. HistolHistopathol, 27: 1029-1040.
  • Chen W, Zhang X, Liu M, Zhang J, Ye Y, Lin Y, Luyckx J, Qu J. 2009. Trehalose protects against ocular surface disorders in experimental murine dry eye through suppression of apoptosis. Exp Eye Res, 89: 311-318.
  • Chiambaretta F, Doan S, Labetoulle M, Rocher N, Fekih LE, Messaoud R, Khairallah M, Baudouin C, HA-trehalose Study Group. 2017. A randomized, controlled study of the efficacy and safety of a new eyedrop formulation for moderate to severe dry eye syndrome. Eur J Ophthal, 27: 1-9.
  • Cho YK, Kim MS. Dry eye after cataract surgery and associated intraoperative risk factors. 2009. Korean J Ophthalmol, 23: 65-73.
  • Francoz M, Karamoko I, Baudouin C, Labbe A. 2011. Ocular surface epithelial thickness evaluation with spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci, 52: 9116-23.
  • Gabison EE, Mourah S, Steinfels E, Yan L, Hoang-Xuan T, Watsky MA, Wever BD, Calvo F, Mauviel A, Menashi S. 2005. Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas; role in epithelio-stromal interactions and matrix metalloproteinase induction. Am J Pathol, 166: 209-219.
  • Garg P, Gupta A, Tandon N, Raj P. 2020. Dry Eye Disease after Cataract Surgery: Study of its Determinants and Risk Factors. Turk J Ophthalmol, 50: 133-142.
  • Hill-Bator A, Misiuk-Hojło M, Marycz K, Grzesiak J. 2014. Trehalose-based eye drops preserve viability and functionality of cultured human corneal epithelial cells during desiccation. Biomed Res Int, 2014: 292139.
  • Hovakimyan M, Ramoth T, Lobler M, Schmitz KP, Witt M, Guthoff R, Stachs O. 2012. Evaluation of protective effects of trehalose on desiccation of epithelial cells in three dimensional reconstructed human corneal epithelium. Curr Eye Res, 37: 982-989.
  • Kasetsuwan N, Satitpitakul V, Changul T, Jariyakosol S. 2013. Incidence and pattern of dry eye after cataract surgery. PLoS One, 8(11): e78657.
  • Mateo Orobia AJ, Casas Pascual P, Cristobal Bescos JA, Perez García D, PeiroEmbid C, Del BueySayas MA, Kulikova VK, Ojeda NL. 2017. Effects of 3% trehalose as an adjuvant treatment after LASIK. Clin Ophthalmol (Auckland, NZ), 11: 347-353.
  • Matsuo T. 2004. Trehalose versus hyaluronan or cellulose in eyedrops for the treatment of dry eye. Jpn J Ophthalmol, 48:3 21-327.
  • McCarty CA, Bansal AK, Livingston PM, Stanislavsky YL, Taylor HR. 1998. The epidemiology of dry eye in Melbourne, Australia. Ophthalmology, 105: 1114-1119.
  • Nakamura T, Sekiyama E, Takaoka M, Bentley AJ, Yokoi N, Fullwood NJ, Kinoshita S. 2008. The use of trehalose-treated freeze-dried amniotic membrane for ocular surface reconstruction. Biomaterials, 29: 3729-3737.
  • Ozek D, Kemer OE. 2018. Effect of the bioprotectant agent trehalose on corneal epithelial healing after corneal cross-linking for keratoconus. Arquivos Brasileiros de Oftalmologia, 81(6): 505-509.
  • Pinto-Bonilla JC, Del Olmo-Jimeno A, Llovet-Osuna F, Hernandez-Galilea E. 2015. A randomized crossover study comparing trehalose/hyaluronate eyedrops and standard treatment: patient satisfaction in the treatment of dry eye syndrome. Ther Clin Risk Manag, 11: 595-603.
  • Rico-Del-Viejo L, Lorente-Velázquez A, Hernández-Verdejo JL, García-Mata R, Benítez-Del-Castillo JM, Madrid-Costa D. 2018. The effect of ageing on the ocular surface parameters. Cont Lens Anterior Eye, 41(1): 5-12.
  • Sambursky, R., Davitt WF 3rd, Latkany R, Tauber S, Starr C, Friedberg M. Dirks MS, McDonald M. 2013. Sensitivity and specificity of a point-of-care matrix metalloproteinase 9 immunoassay for diagnosing inflammation related to dry eye. JAMA Ophthalmol, 131:24-28.
  • Schiffman RM, Christianson MD, Jacobsen G, Hirsch JD, Reis BL. 2000. Reliability and validity of the Ocular Surface Disease Index. Arch Ophthalmol, 118: 615-621.
  • Situ P, Begley CG, Simpson TL. 2019. Effects of Tear Film Instability on Sensory Responses to Corneal Cold, Mechanical, and Chemical Stimuli. Invest Ophthalmol Vis Sci, 60: 2935-2941.
  • Sutu C, Fukuoka H, Afshari NA. 2016. Mechanisms and management of dry eye in cataract surgery patients. Curr Opin Ophthalmol, 27: 24-30.
  • Takeuchi K, Nakazawa M, Ebina Y, Sato K, Metoki T, Miyagawa Y, Ito T. 2010. Inhibitory effects of trehalose on fibroblast proliferation and implications for ocular surgery. Exp Eye Res, 91: 567-577.
  • Takeuchi K, Nakazawa M, Ebina Y. 2011. Effects of trehalose on VEGF-stimulated angiogenesis and myofibroblast proliferation: implications for glaucoma filtration surgery. Invest Ophthalmol Vis Sci, 52: 6987-6993.
  • Trattler WB, Majmudar PA, Donnenfeld ED, McDonald MB, Stonecipher KG, Goldberg DF. 2017. The Prospective Health Assessment of Cataract Patients' Ocular Surface (PHACO) study: the effect of dry eye. Clin Ophthalmol, 11: 1423-1430.
  • Wozniak PA, Schmidl D, Bata AM, Fondi K, Witkowska KJ, Aranha Dos Santos V, Baar C, Room KI, Nepp J, Baumgartner I, Popa-Cherecheanu A, Garhöfer G, Werkmeister RM, Schmetterer L. 2017. Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh-resolution optical coherence tomography. ActaOphthalmol, 95: 307-331.
  • Zaleska-Żmijewska A, Strzemecka E, Wawrzyniak ZM, Szaflik JP. 2019. Extracellular MMP-9-Based Assessment of Ocular Surface Inflammation in Patients with Primary Open-Angle Glaucoma. J Ophthalmol, 240537.
Year 2021, Volume: 4 Issue: 1, 17 - 21, 01.01.2021
https://doi.org/10.19127/bshealthscience.788064

Abstract

References

  • Aragona P, Colosi P, Rania LColosi F, Pisani A, Puzzolo D, Micali A. 2014. Protective effects of trehalose on the corneal epithelial cells. Sci World J, 2014: 717835.
  • Bron AJ, Argüeso P, Irkec M, Bright FV. 2015. Clinical staining of the ocular surface: mechanisms and interpretations. Progress in Retinal and Eye Res, 44: 36-61.
  • Bron AJ, Evans VE, Smith JA. 2003. Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea, 22:640-650.
  • Cejka C, Kubinova S, Cejkova J. 2019. Trehalose in ophthalmology. Histol Histopathol, 34: 611-618.
  • Cejkova J, Cejka C, Luyckx J. 2012. Trehalose treatment accelerates the healing of UVB-irradiated corneas. Comparative immunohistochemical studies on corneal cryostat sections and corneal impression cytology. HistolHistopathol, 27: 1029-1040.
  • Chen W, Zhang X, Liu M, Zhang J, Ye Y, Lin Y, Luyckx J, Qu J. 2009. Trehalose protects against ocular surface disorders in experimental murine dry eye through suppression of apoptosis. Exp Eye Res, 89: 311-318.
  • Chiambaretta F, Doan S, Labetoulle M, Rocher N, Fekih LE, Messaoud R, Khairallah M, Baudouin C, HA-trehalose Study Group. 2017. A randomized, controlled study of the efficacy and safety of a new eyedrop formulation for moderate to severe dry eye syndrome. Eur J Ophthal, 27: 1-9.
  • Cho YK, Kim MS. Dry eye after cataract surgery and associated intraoperative risk factors. 2009. Korean J Ophthalmol, 23: 65-73.
  • Francoz M, Karamoko I, Baudouin C, Labbe A. 2011. Ocular surface epithelial thickness evaluation with spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci, 52: 9116-23.
  • Gabison EE, Mourah S, Steinfels E, Yan L, Hoang-Xuan T, Watsky MA, Wever BD, Calvo F, Mauviel A, Menashi S. 2005. Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas; role in epithelio-stromal interactions and matrix metalloproteinase induction. Am J Pathol, 166: 209-219.
  • Garg P, Gupta A, Tandon N, Raj P. 2020. Dry Eye Disease after Cataract Surgery: Study of its Determinants and Risk Factors. Turk J Ophthalmol, 50: 133-142.
  • Hill-Bator A, Misiuk-Hojło M, Marycz K, Grzesiak J. 2014. Trehalose-based eye drops preserve viability and functionality of cultured human corneal epithelial cells during desiccation. Biomed Res Int, 2014: 292139.
  • Hovakimyan M, Ramoth T, Lobler M, Schmitz KP, Witt M, Guthoff R, Stachs O. 2012. Evaluation of protective effects of trehalose on desiccation of epithelial cells in three dimensional reconstructed human corneal epithelium. Curr Eye Res, 37: 982-989.
  • Kasetsuwan N, Satitpitakul V, Changul T, Jariyakosol S. 2013. Incidence and pattern of dry eye after cataract surgery. PLoS One, 8(11): e78657.
  • Mateo Orobia AJ, Casas Pascual P, Cristobal Bescos JA, Perez García D, PeiroEmbid C, Del BueySayas MA, Kulikova VK, Ojeda NL. 2017. Effects of 3% trehalose as an adjuvant treatment after LASIK. Clin Ophthalmol (Auckland, NZ), 11: 347-353.
  • Matsuo T. 2004. Trehalose versus hyaluronan or cellulose in eyedrops for the treatment of dry eye. Jpn J Ophthalmol, 48:3 21-327.
  • McCarty CA, Bansal AK, Livingston PM, Stanislavsky YL, Taylor HR. 1998. The epidemiology of dry eye in Melbourne, Australia. Ophthalmology, 105: 1114-1119.
  • Nakamura T, Sekiyama E, Takaoka M, Bentley AJ, Yokoi N, Fullwood NJ, Kinoshita S. 2008. The use of trehalose-treated freeze-dried amniotic membrane for ocular surface reconstruction. Biomaterials, 29: 3729-3737.
  • Ozek D, Kemer OE. 2018. Effect of the bioprotectant agent trehalose on corneal epithelial healing after corneal cross-linking for keratoconus. Arquivos Brasileiros de Oftalmologia, 81(6): 505-509.
  • Pinto-Bonilla JC, Del Olmo-Jimeno A, Llovet-Osuna F, Hernandez-Galilea E. 2015. A randomized crossover study comparing trehalose/hyaluronate eyedrops and standard treatment: patient satisfaction in the treatment of dry eye syndrome. Ther Clin Risk Manag, 11: 595-603.
  • Rico-Del-Viejo L, Lorente-Velázquez A, Hernández-Verdejo JL, García-Mata R, Benítez-Del-Castillo JM, Madrid-Costa D. 2018. The effect of ageing on the ocular surface parameters. Cont Lens Anterior Eye, 41(1): 5-12.
  • Sambursky, R., Davitt WF 3rd, Latkany R, Tauber S, Starr C, Friedberg M. Dirks MS, McDonald M. 2013. Sensitivity and specificity of a point-of-care matrix metalloproteinase 9 immunoassay for diagnosing inflammation related to dry eye. JAMA Ophthalmol, 131:24-28.
  • Schiffman RM, Christianson MD, Jacobsen G, Hirsch JD, Reis BL. 2000. Reliability and validity of the Ocular Surface Disease Index. Arch Ophthalmol, 118: 615-621.
  • Situ P, Begley CG, Simpson TL. 2019. Effects of Tear Film Instability on Sensory Responses to Corneal Cold, Mechanical, and Chemical Stimuli. Invest Ophthalmol Vis Sci, 60: 2935-2941.
  • Sutu C, Fukuoka H, Afshari NA. 2016. Mechanisms and management of dry eye in cataract surgery patients. Curr Opin Ophthalmol, 27: 24-30.
  • Takeuchi K, Nakazawa M, Ebina Y, Sato K, Metoki T, Miyagawa Y, Ito T. 2010. Inhibitory effects of trehalose on fibroblast proliferation and implications for ocular surgery. Exp Eye Res, 91: 567-577.
  • Takeuchi K, Nakazawa M, Ebina Y. 2011. Effects of trehalose on VEGF-stimulated angiogenesis and myofibroblast proliferation: implications for glaucoma filtration surgery. Invest Ophthalmol Vis Sci, 52: 6987-6993.
  • Trattler WB, Majmudar PA, Donnenfeld ED, McDonald MB, Stonecipher KG, Goldberg DF. 2017. The Prospective Health Assessment of Cataract Patients' Ocular Surface (PHACO) study: the effect of dry eye. Clin Ophthalmol, 11: 1423-1430.
  • Wozniak PA, Schmidl D, Bata AM, Fondi K, Witkowska KJ, Aranha Dos Santos V, Baar C, Room KI, Nepp J, Baumgartner I, Popa-Cherecheanu A, Garhöfer G, Werkmeister RM, Schmetterer L. 2017. Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh-resolution optical coherence tomography. ActaOphthalmol, 95: 307-331.
  • Zaleska-Żmijewska A, Strzemecka E, Wawrzyniak ZM, Szaflik JP. 2019. Extracellular MMP-9-Based Assessment of Ocular Surface Inflammation in Patients with Primary Open-Angle Glaucoma. J Ophthalmol, 240537.
There are 30 citations in total.

Details

Primary Language English
Subjects Surgery
Journal Section Research Article
Authors

Hakika Erdogan 0000-0001-7749-2814

Orkun Muhsinoglu This is me 0000-0002-0348-398X

Publication Date January 1, 2021
Submission Date August 31, 2020
Acceptance Date October 7, 2020
Published in Issue Year 2021 Volume: 4 Issue: 1

Cite

APA Erdogan, H., & Muhsinoglu, O. (2021). Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery. Black Sea Journal of Health Science, 4(1), 17-21. https://doi.org/10.19127/bshealthscience.788064
AMA Erdogan H, Muhsinoglu O. Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery. BSJ Health Sci. January 2021;4(1):17-21. doi:10.19127/bshealthscience.788064
Chicago Erdogan, Hakika, and Orkun Muhsinoglu. “Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery”. Black Sea Journal of Health Science 4, no. 1 (January 2021): 17-21. https://doi.org/10.19127/bshealthscience.788064.
EndNote Erdogan H, Muhsinoglu O (January 1, 2021) Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery. Black Sea Journal of Health Science 4 1 17–21.
IEEE H. Erdogan and O. Muhsinoglu, “Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery”, BSJ Health Sci., vol. 4, no. 1, pp. 17–21, 2021, doi: 10.19127/bshealthscience.788064.
ISNAD Erdogan, Hakika - Muhsinoglu, Orkun. “Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery”. Black Sea Journal of Health Science 4/1 (January 2021), 17-21. https://doi.org/10.19127/bshealthscience.788064.
JAMA Erdogan H, Muhsinoglu O. Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery. BSJ Health Sci. 2021;4:17–21.
MLA Erdogan, Hakika and Orkun Muhsinoglu. “Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery”. Black Sea Journal of Health Science, vol. 4, no. 1, 2021, pp. 17-21, doi:10.19127/bshealthscience.788064.
Vancouver Erdogan H, Muhsinoglu O. Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery. BSJ Health Sci. 2021;4(1):17-21.