Microbiological Analysis of Secondary Bacterial Infections in Patients Infected with the SARS-CoV-2 Virus

Year 2021, Volume: 4 Issue: 3, 270 - 273, 01.09.2021

Melek Bilgin Eşe Başbulut Hacer İşler Cemanur Aygün

https://doi.org/10.19127/bshealthscience.867150

Abstract

Accumulating evidence shows that secondary infection increases the risk of disease severity in respiratory diseases. There have been few studies about secondary infections among COVID-19 patients. Therefore we aimed to investigate prevalence, predisposing factors and causative organisms associated with COVID-19 secondary infection. This study was conducted at Training and Research Hospital in Samsun Turkey between March 15, 2020 and June 15, 2020. Hospitalized COVID-19 patients confirmed with Reverse Transcription Polymerase Chain Reaction (RT-PCR) were included in this study. Various clinical specimens (urine, sputum, endotracheal aspirate, blood etc.) of these patients have been sent to the microbiology laboratory were evaluated retrospectively. During the study period, 270 patients have been diagnosed COVID‐19 confirmed with PCR. The bacterial secondary infection rate among COVID-19 patients was 4% (11 of 270). The mortality rate among intensive care unit (ICU) patients with secondary infections was 80%. The most common secondary infection was urinary tract infection followed by bacteremia, and pneumonia. The most common isolated bacteria is Escherichia coli (E. coli) followed by coagulase-negative staphylococci (CoNS). Among COVID-19 patients, secondary infection may significantly inhibit the immune system of host and leads to significant morbidity and mortality. This is problematic and especially impacts patient clinical management, infection control, and antimicrobial stewardship programs. Therefore, further studies are needed to identify the possible pathogens and to evaluate the influence of secondary infections on the severity of SARS-CoV-2 infection.

Keywords

COVID-19, SARS CoV-2, Secondary infection

Project Number

This study was approved by the Ethics Commission of Samsun Training and Research Hospital 05.06.2020 2020/8/8.

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