Huzursuz Bacak Sendromu Olan Hastalarda Enflamasyonun Nötrofil Lenfosit Ve Platelet Lenfosit Oranlarının Diğer Parametreler İle Beraber Değerlendirlmesi

Year 2023, Volume: 6 Issue: 2, 270 - 273, 01.04.2023

Hüseyin Duru , Gül Duru , İhsan Asker

https://doi.org/10.19127/bshealthscience.1223810

Abstract

Huzursuz Bacaklar sendromu (HBS) bacaklarda hareket ettirme isteği ihtiyacı olan uyku bozukluğudur. HBS etyolojisi tam olarak aydınlatılamamış olmakla enflamasyonun da rol oynadığını düşünülmektedir. Nötrofil-lenfosit oranı (NLO), platelet-lenfosit oranı (PLO) sistemik enflamasyonun göstergesi açısından kullanılabilmektedir. Biz bu çalışmada HBS tanılı hastalarda enflamatuvar göstergeler olarak kabul edilen parametreleri ölçerek ve diğer bazı parametreler ile kıyaslayarak enflamasyonun HBS’deki rolünü belirlemeyi amaçladık. HBS tanılı 190 hasta çalışmaya dahil edildi. Tam kan sayımı, C-reaktif protein, ürik asit ölçümleri ve Nötrofil-lenfosit oranı (NLO), platelet-lenfosit oranı (PLO), ferritin, eritrosit sedimantasyon hızı, kalsiyum düzeyleri değerlendirildi ve karşılaştırıldı. White Blood Cell-lenfosit oranı ve Nötrofil-lenfosit oranı (NLO) arasında istatistiksel anlamlı ve orta düzeyli korelasyon bulunmaktadır. Nötrofil-lenfosit oranı (NLO), platelet-lenfosit oranı (PLO) arasında istatistiksel anlamlı ve orta düzeyli korelasyon bulunmaktadır. Demiri düsük olan grupta Nötrofil-lenfosit oranı (NLO), platelet-lenfosit oranı (PLO) arasında istatistiksel anlamlı ve orta düzeyli korelasyon bulunmaktadır. Ca+2 düsük olan grupta Nötrofil-lenfosit oranı (NLO) arasında istatistiksel anlamlı ve orta düzeyli korelasyon bulunmaktadır (r=0,548). Ferritin düsük olan grupta Nötrofil-lenfosit oranı (NLO), platelet-lenfosit oranı (PLO) arasında istatistiksel anlamlı ve orta düzeyli korelasyon bulunmaktadır. Bizim çalışmamızda HBS tanılı hastalarda nötrofil sayısında artma, lenfosit sayısında azalma ve Nötrofil-lenfosit oranında (NLO) artma olduğunu gösterdik. Çalışmamız HBS patofizyolojisinde enflamasyonun rolü olduğunu desteklemektedir.

Keywords

Huzursuz bacaklar sendromu, Ferritin, Kalsiyum, Enflamasyon, Nötrofil, Lenfosit

Supporting Institution

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Evaluation of Inflation, Neutrophil Lymphocyte and Platelet Lymphocyte Ratios with Other Parameters in Patients with Remarkable Leg Syndrome

Abstract

Restless Legs Syndrome (RLS) is a sleep disorder with an irresistible need to move the legs. Although the pathogenesis of RLS has not been fully elucidated, it is thought that inflammation also plays a role. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLO) can be used as indicators of systemic inflammation. In this study, we aimed to determine the role of inflammation in RLS by measuring the parameters considered as inflammatory indicators in patients with RLS and comparing them with some other parameters. 190 patients with RLS were included in the study. Complete blood count, C-reactive protein, uric acid measurements and Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLO), ferritin, erythrocyte sedimentation rate, calcium levels were evaluated and compared. There was a statistically significant and moderate correlation between White Blood Cell-lymphocyte ratio and Neutrophil-lymphocyte ratio (NLR). There is a statistically significant and moderate correlation between neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLO). Statistically significant and moderate correlation between Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLO) in the group with low iron There is a statistically significant and moderate correlation between Neutrophil-lymphocyte ratio (NLR) in the group with low Ca+2 (r=0.548). There is a significant and moderate correlation. In our study, we showed an increase in neutrophil count, decrease in lymphocyte count and increase in Neutrophil-lymphocyte ratio (NLR) in patients with RLS. Our study supports the role of inflammation in the pathophysiology of RLS.

Keywords

Restless legs syndrome, Ferritin, Calcium, Inflammation, Neutrophil, Lymphocyte

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