Huzursuz Bacak Sendromu Olan Hastalarda Enflamasyonun Nötrofil Lenfosit Ve Platelet Lenfosit Oranlarının Diğer Parametreler İle Beraber Değerlendirlmesi

Year 2023, Volume: 6 Issue: 2, 270 - 273, 01.04.2023

Hüseyin Duru Gül Duru İhsan Asker

https://doi.org/10.19127/bshealthscience.1223810

Abstract

Huzursuz Bacaklar sendromu (HBS) bacaklarda hareket ettirme isteği ihtiyacı olan uyku bozukluğudur. HBS etyolojisi tam olarak aydınlatılamamış olmakla enflamasyonun da rol oynadığını düşünülmektedir. Nötrofil-lenfosit oranı (NLO), platelet-lenfosit oranı (PLO) sistemik enflamasyonun göstergesi açısından kullanılabilmektedir. Biz bu çalışmada HBS tanılı hastalarda enflamatuvar göstergeler olarak kabul edilen parametreleri ölçerek ve diğer bazı parametreler ile kıyaslayarak enflamasyonun HBS’deki rolünü belirlemeyi amaçladık. HBS tanılı 190 hasta çalışmaya dahil edildi. Tam kan sayımı, C-reaktif protein, ürik asit ölçümleri ve Nötrofil-lenfosit oranı (NLO), platelet-lenfosit oranı (PLO), ferritin, eritrosit sedimantasyon hızı, kalsiyum düzeyleri değerlendirildi ve karşılaştırıldı. White Blood Cell-lenfosit oranı ve Nötrofil-lenfosit oranı (NLO) arasında istatistiksel anlamlı ve orta düzeyli korelasyon bulunmaktadır. Nötrofil-lenfosit oranı (NLO), platelet-lenfosit oranı (PLO) arasında istatistiksel anlamlı ve orta düzeyli korelasyon bulunmaktadır. Demiri düsük olan grupta Nötrofil-lenfosit oranı (NLO), platelet-lenfosit oranı (PLO) arasında istatistiksel anlamlı ve orta düzeyli korelasyon bulunmaktadır. Ca+2 düsük olan grupta Nötrofil-lenfosit oranı (NLO) arasında istatistiksel anlamlı ve orta düzeyli korelasyon bulunmaktadır (r=0,548). Ferritin düsük olan grupta Nötrofil-lenfosit oranı (NLO), platelet-lenfosit oranı (PLO) arasında istatistiksel anlamlı ve orta düzeyli korelasyon bulunmaktadır. Bizim çalışmamızda HBS tanılı hastalarda nötrofil sayısında artma, lenfosit sayısında azalma ve Nötrofil-lenfosit oranında (NLO) artma olduğunu gösterdik. Çalışmamız HBS patofizyolojisinde enflamasyonun rolü olduğunu desteklemektedir.

Keywords

Huzursuz bacaklar sendromu, Ferritin, Kalsiyum, Enflamasyon, Nötrofil, Lenfosit

Supporting Institution

yok

Evaluation of Inflation, Neutrophil Lymphocyte and Platelet Lymphocyte Ratios with Other Parameters in Patients with Remarkable Leg Syndrome

Abstract

Restless Legs Syndrome (RLS) is a sleep disorder with an irresistible need to move the legs. Although the pathogenesis of RLS has not been fully elucidated, it is thought that inflammation also plays a role. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLO) can be used as indicators of systemic inflammation. In this study, we aimed to determine the role of inflammation in RLS by measuring the parameters considered as inflammatory indicators in patients with RLS and comparing them with some other parameters. 190 patients with RLS were included in the study. Complete blood count, C-reactive protein, uric acid measurements and Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLO), ferritin, erythrocyte sedimentation rate, calcium levels were evaluated and compared. There was a statistically significant and moderate correlation between White Blood Cell-lymphocyte ratio and Neutrophil-lymphocyte ratio (NLR). There is a statistically significant and moderate correlation between neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLO). Statistically significant and moderate correlation between Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLO) in the group with low iron There is a statistically significant and moderate correlation between Neutrophil-lymphocyte ratio (NLR) in the group with low Ca+2 (r=0.548). There is a significant and moderate correlation. In our study, we showed an increase in neutrophil count, decrease in lymphocyte count and increase in Neutrophil-lymphocyte ratio (NLR) in patients with RLS. Our study supports the role of inflammation in the pathophysiology of RLS.

Keywords

Restless legs syndrome, Ferritin, Calcium, Inflammation, Neutrophil, Lymphocyte

References

• Acet H, Ertaş F, Akıl MA, Özyurtlu F, Yıldız A, Polat N, Bilik MZ, Aydın M, Oylumlu M, Kaya H, Yüksel M, Akyüz A, Ayçiçek H, Alan S, Toprak N. 2015. Novel predictors of infarct-related artery patency for ST-segment elevation myocardial infarction: platelet-to-lymphocyte ratio, uric acid, and neutrophil-to-lymphocyte ratio. Anatol J Cardiol, 15: 648-656.
• American Academy of Sleep Medicine. 2014. International classification of sleep disorders, 3rd ed. American Academy of Sleep Medicine, Darien, IL, US, pp: 377.
• Bayram SN, Egemen A. 2007. Restless legs syndrome. Türkiye Klin J Pediatr, 16: 245-254.
• Danese E, Montagnana M, Lippi G. 2014. Platelets and migraine. Thromb Res, 134: 17-22.
• de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. 2010. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care, 14: R192. DOI: 10.1186/cc9309.
• Ekbom KA. 1945. Restless legs: a clinical study. Acta Med Scand, 158: 1-123.
• Filiz MB, Çakır T. 2015. Restless legs syndrome with current diagnostic criteria. Turk J Osteoporos, 21: 87-95.
• Higuchi T, Abe M, Mizuno M, Yamazaki T, Suzuki H, Moriuchi M, Oikawa O, Okawa E, Ando H, Okada K. 2015. Association of restless legs syndrome with oxidative stress and inflammation in patients undergoing hemodialysis. Sleep Med, 16: 941-948.
• Jung JY, Lee E, Suh CH, Kim HA. 2019. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are associated with disease activity in polymyalgia rheumatica. J Clin Lab Anal, 33: e23000. DOI: 10.1002/jcla.23000.
• Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. 2009. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med, 133: 628-632.
• Olgun Yazar H, Yazar T, Özdemir S, Kasko Arici Y. 2019. Serum C-reactive protein/albumin ratio and restless legs syndrome. Sleep Med, 58: 61-65.
• Patrick LR. 2007. Restless legs syndrome: pathophysiology and the role of iron and folate. Altern Med Rev, 12: 101-112.
• Patton SM, Ponnuru P, Snyder AM, Podskalny GD, Connor JR. 2011. Hypoxia-inducible factor pathway activation in restless legs syndrome patients. Eur J Neurol, 18: 1329-1335.
• Sonkaya AR, Ceylan M. 2019. Investigation of inflammation with neutrophil/lymphocyte ratio in restless legs syndrome. J Surg Med, 3: 288-291.
• Tak AZA, Şengül Y. 2018. Evaluation of inflammation with neutrophil-tolymphocyte ratio and platelet-to-lymphocyte ratio in restless legs syndrome. Turk J Neurol, 24: 259-263.
• Varım C, Acar BA, Uyanık MS, Acar T, Alagoz N, Nalbant A, Kaya T, Ergenc H. 2016. Association between the neutrophil-to-lymphocyte ratio, a new marker of systemic inflammation, and restless legs syndrome. Singapore Med J, 57: 514-516.
• Weinstock LB, Walters AS, Paueksakon P. 2012. Restless legs syndrome - theoretical roles of inflammatory and immune mechanisms. Sleep Med Rev, 16: 341-354.
• Winkelmann J, Lichtner P, Schormair B, Uhr M, Hauk S, Stiasny-Kolster K, Trenkwalder C, Paulus W, Peglau I, Eisensehr I, Illig T, Wichmann HE, Pfister H, Golic J, Bettecken T, Pütz B, Holsboer F, Meitinger T, Müller-Myhsok B. 2008. Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome. Mov Disord, 23: 350-358.
• Yılmaz M, Kayançiçek H. 2018. A new inflammatory marker: elevated monocyte to hdl cholesterol ratio associated with smoking. J Clin Med, 7: 76.
• Zahorec R. 2001. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy, 102: 5-14.
• Zhai R, Sheu CC, Su L, Gong MN, Tejera P, Chen F, Wang Z, Convery MP, Thompson BT, Christiani DC. 2009. Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis. Thorax, 64: 784-790.