Evaluation of Factors Affecting Obesity and Eating Disorders in Patients with Schizophrenia

Year 2023, Volume: 6 Issue: 4, 543 - 550, 15.10.2023

Murat Urhan , Özge Küçükerdönmez

https://doi.org/10.19127/bshealthscience.1299069

Abstract

The aim of this study was to evaluate some risk factors affecting the development of obesity and eating disorders in schizophrenia patients. The study included 160 schizophrenia patients (76 females, 84 males) aged between 18-60 years who were receiving outpatient treatment in Manisa Mental Health and Diseases Hospital and 206 healthy individuals (103 females, 103 males) as the control group. A questionnaire was applied to the participants by face-to-face interview method, socio-demographic characteristics were determined and anthropometric measurements were taken. Eating Attitude Test-26 was used to assess the risk of eating disorder. Obesity and eating disorder risk in individuals were evaluated using binary logistic regression models. It was determined that the body mass index (BMI) was 28.3±5.97 kg/m2 in female cases and 27.8±5.18 kg/m2 in male cases, and these values were 25.1±4.61 kg/m2 in females and 25.7±3.71 kg/m2 in males in the control group. It was found that 30.9% of the female cases were overweight and 21.9% were obese. 51.2% of the male cases were overweight and 23.8% were obese. It was found that the probability of being overweight or obese was 3.48 times [OR=3.48 (2.23-5.43)] and the probability of being overweight or obese was 3.8 times [OR=3.80 (2.34-6.19)] higher in antipsychotic users compared to healthy individuals. While 18.8% of the cases had an eating disorder risk, this rate was 7.8% in the control group (P=0.001). In both groups, the rate of individuals with eating disorder risk was higher in females. It was found that the probability of having an eating disorder risk was 2.64 times [OR=2.64 (1.31-5.28)] higher in cases than in healthy individuals, 2.30 times [OR=2.30 (1.17-4.52)] higher in female than in male and 2.74 times [OR=2.74 (1.44-5.23)] higher in antipsychotic users. It is known that schizophrenia patients have a high risk of developing obesity and eating disorders. These unfavorable factors lead to an increase in the prevalence of metabolic syndrome and mortality due to cardiovascular disease. Longitudinal studies should be conducted to understand the psychological, psychopathological, genetic and neurophysiological mechanisms underlying the relationship between obesity and eating disorders in these patients.

Keywords

Schizophrenia, Obesity, Eating disorders, Body mass index, Antipsychotics

Şizofreni Hastalarında Obezite ve Yeme Bozukluğunu Etkileyen Etmenlerin Değerlendirilmesi

Abstract

Bu çalışmada şizofreni hastalarında obezite ve yeme bozukluğu gelişimini etkileyen bazı risk faktörlerinin değerlendirilmesi amaçlanmıştır. Çalışmaya Manisa Ruh Sağlığı ve Hastalıkları Hastanesinde ayaktan tedavi gören, 18-60 yaş arası 160 şizofreni hastası (76 kadın, 84 erkek) ve kontrol grubu olarak 206 sağlıklı birey (103 kadın, 103 erkek) dahil edilmiştir. Katılımcılara yüz yüze görüşme yöntemi ile anket uygulanmış, sosyo-demografik özellikleri belirlenmiş ve antropometrik ölçümleri alınmıştır. Yeme bozukluğu riskinin değerlendirilmesinde Yeme Tutum Testi-26 kullanılmıştır. Bireylerde obezite ve yeme bozukluğu riski ikili (binary) lojistik regresyon modelleri kullanılarak değerlendirilmiştir. Kadın olgularda beden kütle indeksinin (BKİ) 28,3±5,97 kg/m2, erkekler olgularda 27,8±5,18 kg/m2 olduğu, kontrol grubunda ise bu değerlerin kadınlarda 25,1±4,61 kg/m2, erkeklerde 25,7±3,71 kg olduğu belirlenmiştir. Kadın olguların %30,9’unun fazla kilolu, %21,9’unun obez, erkek olguların %51,2’sinin fazla kilolu, %23,8’inin obez olduğu saptanmıştır. Olguların sağlıklı bireylere göre fazla kilolu veya obez olma olasılığının 3,48 kat [OR=3,48 (2,23-5,43)], antipsikotik kullananların ise 3,8 kat [OR=3,80 (2,34-6,19)] daha fazla olduğu bulunmuştur. Olguların %18,8’inde yeme bozukluğu riski görülürken kontrol grubundaki bireylerde bu oran %7,8 olarak belirlenmiştir (P=0,001). Her iki grupta da kadınlarda yeme bozukluğu riskine sahip bireylerin oranı daha fazladır. Olgularda yeme bozukluğu riski görülme olasılığının sağlıklı bireylere göre 2,64 kat [OR=2,64 (1,31-5,28], kadınlarda görülme olasılığının erkeklere göre 2,30 kat [OR=2,30 (1,17-4,52] ve antipsikotik kullananlarda 2,74 kat [OR=2,74 (1,44-5,23] daha fazla olduğu saptanmıştır. Şizofreni hastalarında obezite ve yeme bozukluğu gelişme riskinin yüksek olduğu bilinmektedir. Bu olumsuz etkenler hastalarda metabolik sendrom prevalansının ve kardiyovasküler hastalık nedenli mortalitenin artmasına neden olmaktadır. Bu hastalarda obezite ve yeme bozukluğu arasındaki ilişkilerin altında yatan psikolojik, psikopatolojik, genetik ve nörofizyolojik mekanizmaların anlaşılmasına yönelik uzunlamasına araştırmalar yapılmalıdır.

Keywords

Şizofreni, Obezite, Yeme bozukluğu, Beden kütle indeksi, Antipsikotik

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