Relationship between Oxidized Low-Density Lipoprotein Treatment and Hepatocellular Carcinoma Associated Transcript 1 Expression

Year 2025, Volume: 8 Issue: 1, 17 - 20

Burcu Bayyurt

Abstract

Long non-coding RNAs (lncRNAs) have multiple biological functions in the vascular system including in endothelial cells (ECs). Hepatocellular carcinoma associated transcript 1 (HULC) is a lncRNA and highly up-regulated in liver cancer. Oxidized low-density lipoprotein (ox-LDL) is a remarkable risk factor for various disease. We investigated and compared HULC expression in human umbilical vein endothelial cells (HUVECs) treated with two different concentration of ox-LDL. We used quantitative polymerase chain reaction (qPCR) method to detect HULC expression level in HUVECs. HULC expression was found to be statistic significantly up-regulated in HUVECs treated with higher concentration of ox-LDL (P<0.001). It may be put forward that high concentration of ox-LDL treatment may be inducer of HULC gene expression in variety of diseases including in cancer and cardiovascular diseases (CVDs).

Keywords

Hepatocellular carcinoma associated transcript 1, Oxidized low-density lipoprotein, Gene expression, Quantitative polymerase chain reaction

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