On the Dynamics of Ebola Virus Disease (EVD) with the Impact of Vaccination and Isolation on the Containment of its Spread: A Mathematical Modelling Approach

Year 2023, Volume: 20 Issue: 2, 129 - 145, 01.11.2023

Oludapo Omotola Olubanwo , Deborah Oluwatobi Danıel , Timothy Ayobami Adegboye , Adeniran Nimotali Abosede

Abstract

Ebola is a highly contagious and fatal viral disease that has sparked widespread panic and devastation and thus affected global health, the economy, and social dynamics. Hence, a model is formulated to examine the impact of isolation and vaccination on curbing the transmission dynamics of Ebola Virus Disease (EVD). The model's epidemiological viability in a given region was established. Numerical simulations were conducted using MATLAB to examine the effect of vaccination and isolation on curtailing the spread of the Ebola virus disease. The impact of the parameters used in the model on the basic reproduction number and the estimation of the sensitivity of the parameters were also carried out. It is observed that if the rate of symptomatic infected individuals being isolated and vaccinated is high enough, this would reduce the infection rate. Hence, the isolation of infected individuals and efficacious vaccination with a zerowane-off vaccine will help a great deal in curtailing the spread of the Ebola virus disease.

Keywords

Ebola Virus Disease, Transmission Dynamics, Vaccination, Isolation, Infectious Disease, Mathematical Modelling

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