The Investigation Of Menthol’s Bioactivity As Theoritical By Using DFT (Density Functional Theory)

Abstract

The Investigation Of  Menthol’s Bioactivity As Theoritical By Using DFT (Density Functional Theory)

Mints are used tradational medicine for hundred years by humankind. The important constitiuent of mint, menthol, is especially in blood is eager to give reaction as an antioksidan. To understand menthol’s bioactivity in body, some thermodynamical values (gibbs free energy, dipol moment HOMO, LUMO and the difference between HOMO, LUMO) of menthol are measured by using DFT. Menthol dissolves in blood easily, reacts as antioksidant  and it is more stable than in gas form. So,It is so stable as  protecting from radicalic attracts. 

Keywords

• Mint, Menthol and DFT

References

1. Chand, S., Patra,N.K., Anwar,M., Patra,D.D. Agronomy And Uses Of Menthol Mint(Mentha Arvensis),Proc.Indian Natl.Sci.Acad., 3, 269-297, 2004.
2. Kähkönen MP, Hopia AI, Vuorela HJ, Rauha JP, Pihlaja K, Kujala TS, Heinonen M. Antioxidant activity of plant extracts containing phenolic compounds. J Agricult Food Chem., 47(10):3954-62, 1999.
3. Zheng W, Wang SY. Antioxidant activity and phenolic compounds in selected herbs. J Agric Food Chem., 49(11):5165-70, 2001.
4. Grzeszczuk,M., Jadczak,D., Estimation of biological value of some species of mint (Mentha L.), Kerva Rolonica,55, 2009.
5. Efferth, T.; Fu, Y.J.; Zu, Y.G.; Schwarz, G.; Konkimall, V.S. Wink, M. Molecular target-guided tumor therapy with natural products derived from traditional Chinese medicine. Curr. Med. Chem., 14, 2024–2032, 2007.
6. Lai, P.K.; Roy, J. Antimicrobial and chemopreventive properties of herbs and spices. Curr. Med.Chem., 11, 1451–1460, 2004.
7. Gende,L.B.;Mendiara,S.,Fernandez,N.J.;Baren,C.V.;Dıleolira,A.;Bandoni,A.;Fritz,R.,Florıs,I.,Eguaras, Essentials oils of some Mentha spp. and their relation with antimicrobial activity against Paenibacillus larvae, the causative agent of American foulbrood in honey bees, by using the bioautography technique, M.,Bulletin of Insectology, 67 (1): 13-20, 2014.
8. Tandan, N.; Prakash,A.; Seema, Y., Antimicrobial Activity and Medicinal Values of Essential Oil of Mentha Piperita L., International Journal of Engineering and Innovative Technology (IJEIT), (2), 8, 2013.

9. Chawla,S.;Thakur,M.,Overview of Mint (Mentha L.) As A promising Health-Prometing Herb, Interrnational Pharmeutical Research And Devolopment(IJPRD), 5(06), 2013.
10. Rozza,A.L., Faria, F.M.; Brito,a.R.S.; Pellizzon,C.H., The Gastroprotective Effect of Menthol: Involvement of Anti-Apoptotic, Antioxidant and Anti-Inflammatory Activities, Plos One, (9),1, 2014.