Bu çalışmada,sekiz yeni bazı potansiyel biyolojik aktif 4-(arilidenamino)-2,4-dihidro-1H-1,2,4-triazol-3-on bileşikleri mikrodalga yöntemi kullanılarak sentezlendi. Bu bileşiklerin yapıları farklı spektroskopik yöntemle (IR, 1H NMR, 13C NMR and elemental analiz) kullanılarak karakterize edildi. Bu bileşiklerin asit ayrışma sabitleri teorik olarak 25oC’de yirmi beş farklı çözücü içerisinde SPARC bilgisayar programı vasıtasıyla belirlendi. Çözücülerin asit ayrışma sabitleri üzerindeki etkileri tartışıldı
Microwave-assisted Synthesis of Some New Potential Biological 4-(Arylidenamino)-2, 4-dihydro-3H-1,2,4-Triazol-3-ones and Determination of pKa Values
Abstract
In the present study, eight new 4-(arylideneamino)-2,4-dihydro-1H-1,2,4-triazol-3-ones that may show some potential biological properties were synthesized using microwave method. These compounds were characterized by different spectroscopic techniques (IR, 1H NMR, 13C NMR and elemental analysis). Acid dissociation constants (pKa) were determined theoretically with SPARC computer program in different twenty five solvents at 25oC. The effects of solvents composition on the acid dissociation constants are discussed.
Kahveci, B., Doğan, İ., İslamoğlu, F., & Yılmaz, F. (2016). Microwave-assisted Synthesis of Some New Potential Biological 4-(Arylidenamino)-2, 4-dihydro-3H-1,2,4-Triazol-3-ones and Determination of pKa Values. Celal Bayar University Journal of Science, 12(2), 275-281. https://doi.org/10.18466/cbujos.69902
AMA
1.Kahveci B, Doğan İ, İslamoğlu F, Yılmaz F. Microwave-assisted Synthesis of Some New Potential Biological 4-(Arylidenamino)-2, 4-dihydro-3H-1,2,4-Triazol-3-ones and Determination of pKa Values. CBUJOS. 2016;12(2):275-281. doi:10.18466/cbujos.69902
Chicago
Kahveci, Bahittin, İnci Doğan, Fatih İslamoğlu, and Fatih Yılmaz. 2016. “Microwave-Assisted Synthesis of Some New Potential Biological 4-(Arylidenamino)-2, 4-Dihydro-3H-1,2,4-Triazol-3-Ones and Determination of PKa Values”. Celal Bayar University Journal of Science 12 (2): 275-81. https://doi.org/10.18466/cbujos.69902.
EndNote
Kahveci B, Doğan İ, İslamoğlu F, Yılmaz F (August 1, 2016) Microwave-assisted Synthesis of Some New Potential Biological 4-(Arylidenamino)-2, 4-dihydro-3H-1,2,4-Triazol-3-ones and Determination of pKa Values. Celal Bayar University Journal of Science 12 2 275–281.
IEEE
[1]B. Kahveci, İ. Doğan, F. İslamoğlu, and F. Yılmaz, “Microwave-assisted Synthesis of Some New Potential Biological 4-(Arylidenamino)-2, 4-dihydro-3H-1,2,4-Triazol-3-ones and Determination of pKa Values”, CBUJOS, vol. 12, no. 2, pp. 275–281, Aug. 2016, doi: 10.18466/cbujos.69902.
ISNAD
Kahveci, Bahittin - Doğan, İnci - İslamoğlu, Fatih - Yılmaz, Fatih. “Microwave-Assisted Synthesis of Some New Potential Biological 4-(Arylidenamino)-2, 4-Dihydro-3H-1,2,4-Triazol-3-Ones and Determination of PKa Values”. Celal Bayar University Journal of Science 12/2 (August 1, 2016): 275-281. https://doi.org/10.18466/cbujos.69902.
JAMA
1.Kahveci B, Doğan İ, İslamoğlu F, Yılmaz F. Microwave-assisted Synthesis of Some New Potential Biological 4-(Arylidenamino)-2, 4-dihydro-3H-1,2,4-Triazol-3-ones and Determination of pKa Values. CBUJOS. 2016;12:275–281.
MLA
Kahveci, Bahittin, et al. “Microwave-Assisted Synthesis of Some New Potential Biological 4-(Arylidenamino)-2, 4-Dihydro-3H-1,2,4-Triazol-3-Ones and Determination of PKa Values”. Celal Bayar University Journal of Science, vol. 12, no. 2, Aug. 2016, pp. 275-81, doi:10.18466/cbujos.69902.
Vancouver
1.Bahittin Kahveci, İnci Doğan, Fatih İslamoğlu, Fatih Yılmaz. Microwave-assisted Synthesis of Some New Potential Biological 4-(Arylidenamino)-2, 4-dihydro-3H-1,2,4-Triazol-3-ones and Determination of pKa Values. CBUJOS. 2016 Aug. 1;12(2):275-81. doi:10.18466/cbujos.69902
