C-GLİKOZİTLERE GENEL BAKIŞ -GENERAL VIEW TO C-GLYCOSIDES
Abstract
C-GLİKOZİTLERE GENEL BAKIŞ
Bu derlemede, doğada bolca bulunan ve önemli farmakolojik özelliklere sahip olan bazı C-glikozit
birimlerinden bahsedilmiş ve pek çok türevi olduğu bilinen C-glikozitlerin son yıllarda üzerinde çok
çalışılmış ve önemli biyolojik aktivite gösteren türevlerinin sınıflandırılması yapılmıştır. Bu çalışmada ayrıca
biyolojik aktivite gösteren bazı sentetik C-glikozit birimlerinden ve bunlarla ilgili literatür bilgilerinden
bahsedilmiştir.
GENERAL VIEW TO C-GLYCOSIDES
In this review, C-glycoside units that are abundantly exist on nature and have important
pharmacological are considered, and they are classified regarding to their important biological activities
reported in the recent studies. Some synthetic C-glycoside units having biological activity are further
described based on the literature information in this study.
Keywords
References
- Levy, D. E., Tang, C., The Chemistry of CGlycoside, Pergamon, USA (1995).
- Du, Y., Linhardt, R. J., Vlahov, I. R., Recent Advances in Stereoselective C-glycoside Synthesis, Tetrahedron, 54 (33): 9913-9959 (1998).
- Tomiyama, H., Kobayashi, Y., Atsushi, N., Tomiyama, A., Tomiyama, N., C-Glycosides and Preparation of Thereof as Antidiabetic Agents, United States Patent No. US 6,627,611 B2 (2003).
- Gervay, J., Flaherty, T. M., Holmes, D., Studies on the Synthesis of C-glycoside Sulfones as Potential Glycosyl Transferase Inhibitors, Tetrahedron, 53 (48): 16355-16364 (1997).
- Wellington, K. W., Benner, S. A., A Review: Synthesis of Aryl C-glycosides Via the Heck Coupling Reaction, Nucleosides, Nucleotides, and Nucleic Acids, 25 (12):1309-1333 (2006).
- Hacksell, U., Daves, G. D. Jr., Edt: Ellis, G.P., West, G. B., The chemistry and biochemistry of C-nucleosides and C-arylglycosides, Progress in Medicinal Chemistry, 22: 1-65 (1985).
- Darnall, K. R., Townsend, L. B., Robins, R. K., The Structure of Showdomycin, a Novel Carbon-Linked Nucleoside Antibiotic Related to Uridine, Proceedings of the National Academy of Sciences of the United States of America, 57: 548553 (1967).
- Salem, P. A., Bodey, G. P., Burgess, M. A., Murphy, W. K., Freireich, E. J., A Phase I Study of Pyrazofurin. Cancer (Phila.), 40: 2806-2809 (1977).
Details
Primary Language
Turkish
Subjects
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Journal Section
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Publication Date
March 1, 2010
Submission Date
December 26, 2014
Acceptance Date
-
Published in Issue
Year 2010 Volume: 6 Number: 1