EN
Droplet-based Microfluidic Device for the Synthesis of Silica Nanoparticles
Abstract
Microfluidic reactors are advantageous for nanomaterial synthesis due to their capability to provide controlled reaction environment. In this work, a droplet based microfluidic reactor is designed for the synthesis of silica nanoparticles. The synthesis is carried out in a very controlled environment and a uniform size and shape distribution is achieved. The classical synthesis protocol for silica nanoparticles is modified to use nonpolar solvents in the reaction so that this platform can later be used for coating hydrophobic nanomaterials. Therefore, this study not only presents a new device but also a new synthesis method. The results are compared with conventional batch wise synthesis methods and the obtained nanoparticles showed better size distribution.
Keywords
Supporting Institution
TÜBİTAK
Project Number
114C092
Thanks
E. Y. Erdem would like to acknowledge the Tübitak 2232 grant that founded this research. She also thanks Mr. Alican Özkan and Mr. Arsalan Nikdoost for their help in laboratory studies.
References
- 1. He, Q, Shi, J. 2010. Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility. Journal of Materials Chemistry; 21: 5845-5855.
- 2. Zhao, CX, He, L, Qiao, SZ, Middelberg, APJ. 2011. Nanoparticle synthesis in microreactors. Chemical Engineering Science; 66(7): 1463-1479.
- 3. Wu, KCW, Yamauchi, Y. 2012. Controlling physical features of mesoporoussilica nanoparticles (MSNs) for emergingapplications. Journal of Materials Chemistry; 22:1251-1256.
- 4. Mebert, AM, Baglole, CJ, Desimone, MF, Maysinger, Dusica. 2017. Nanoengineered silica: properties, applications and toxicity. Food and Chemical Toxicology; 109(1): 753-770.
- 5. Erdem, EY, Cheng, JC, Doyle, FM, Pisano, AP. 2014. Multitemperature zone, droplet-based microreactor for increased temperature control in nanoparticle synthesis. Small; 10(6): 1076-1080.
- 6. Phillips, TW, Lignos, IG, Maceiczyk, RM, DeMello, AJ, DeMello, A. 2014. Nanocrystal synthesis in microfluidic reactors: where next?. Lab Chip.; 14(17): 3172-3180,
- 7. Chang, CH, Paul, BK, Remcho, VT, Atre, S, Hutchison, JE. 2008. Synthesis and post-processing of nanomaterials using microreaction technology. Journal of Nanoparticle Research; 10: 965-980.
- 8. Nightingale, AM, deMello, JC. 2012. Segmented flow reactors for nanocrystal synthesis. Advanced Materials; 25(13): 1813-1821.
Details
Primary Language
English
Subjects
Engineering
Journal Section
Research Article
Authors
Publication Date
September 29, 2020
Submission Date
April 29, 2020
Acceptance Date
September 7, 2020
Published in Issue
Year 2020 Volume: 16 Number: 3
APA
Erdem, E. Y. (2020). Droplet-based Microfluidic Device for the Synthesis of Silica Nanoparticles. Celal Bayar University Journal of Science, 16(3), 245-249. https://doi.org/10.18466/cbayarfbe.729586
AMA
1.Erdem EY. Droplet-based Microfluidic Device for the Synthesis of Silica Nanoparticles. CBUJOS. 2020;16(3):245-249. doi:10.18466/cbayarfbe.729586
Chicago
Erdem, Emine Yegan. 2020. “Droplet-Based Microfluidic Device for the Synthesis of Silica Nanoparticles”. Celal Bayar University Journal of Science 16 (3): 245-49. https://doi.org/10.18466/cbayarfbe.729586.
EndNote
Erdem EY (September 1, 2020) Droplet-based Microfluidic Device for the Synthesis of Silica Nanoparticles. Celal Bayar University Journal of Science 16 3 245–249.
IEEE
[1]E. Y. Erdem, “Droplet-based Microfluidic Device for the Synthesis of Silica Nanoparticles”, CBUJOS, vol. 16, no. 3, pp. 245–249, Sept. 2020, doi: 10.18466/cbayarfbe.729586.
ISNAD
Erdem, Emine Yegan. “Droplet-Based Microfluidic Device for the Synthesis of Silica Nanoparticles”. Celal Bayar University Journal of Science 16/3 (September 1, 2020): 245-249. https://doi.org/10.18466/cbayarfbe.729586.
JAMA
1.Erdem EY. Droplet-based Microfluidic Device for the Synthesis of Silica Nanoparticles. CBUJOS. 2020;16:245–249.
MLA
Erdem, Emine Yegan. “Droplet-Based Microfluidic Device for the Synthesis of Silica Nanoparticles”. Celal Bayar University Journal of Science, vol. 16, no. 3, Sept. 2020, pp. 245-9, doi:10.18466/cbayarfbe.729586.
Vancouver
1.Emine Yegan Erdem. Droplet-based Microfluidic Device for the Synthesis of Silica Nanoparticles. CBUJOS. 2020 Sep. 1;16(3):245-9. doi:10.18466/cbayarfbe.729586