Phenolic Profile and Cholinesterase, Tyrosinase, Urease and Lipid Peroxidation Inhibition Potentials of Artemisia argyi from Ordu, Turkey

Year 2019, Volume: 15 Issue: 1, 29 - 33, 22.03.2019

Melek Çol Ayvaz

https://doi.org/10.18466/cbayarfbe.430835

Abstract

The present study was designed to reveal a natural resource that could
cure for today’s major diseases such as Alzheimer, Parkinson and bacterial
infection. Furthermore, oxidative stress resulting from lipid peroxidation is a
precursor for many diseases. Therefore, anticholinesterase, antityrosinase,
antiurease activities and the inhibition potential on lipid peroxidation of
methanolic extract of Artemisia argyi
collected from Ordu region were tested. The inhibition ratio
of extract at 0.3 mg/mL concentration for asetylcholinesterase and
butrylcholinesterase were calculated as 8.45 and 10.68%, respectively.            IC₅₀ values for tyrosinase and
urease inhibition properties were also found as 0.505 mg/mL and         0.225 mg/mL. The all obtained values were
compared with known corresponding inhibitors such as galantamine, kojic acid
and thiourea. Besides these, 0.1 mg/mL of the extract prevented lipid
peroxidation in the ratio of 7.19%.  In
the scope of this study, the phenolics of the leaves of A. argyi were also analyzed by using HPLC system and pyrogallol was
identified as the major component with the 30.16 mg/kg concentration. On the
other hand, benzoic acid was not detected in extract. According to obtained
results, A. argyi from Ordu, has the
proposed characteristics that it can be a natural resource that can be used in
the field of medicine for treatment of various diseases especially Alzheimer
and Parkinson, in the cosmetic industry for the elimination of skin problems
and in the agricultural field in order to prevent the loss of nitrogenous
components.

Keywords

Artemisia argyi, Helicobacter pylori, enzyme inhibition, melanogenesis, phenolics

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