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Year 2020, Volume: 16 Issue: 2, 119 - 127, 24.06.2020

Abstract

References

  • 1. Panyam J, Labhasetwar V. 2012. Biodegradable Nanoparticle from Drug and Gene Delivery to Cells and Tissue. Advanced Drug Delivery Reviews; 64:61–71. 2. Gilding D, Reed A. 1979. Biodegradable polymers for use in surgery—polyglycolic/poly(actic acid) homo- and copolymers: 1. Polymer; 20 (12):1459–1464. 3. Dangi RS, Shakya S. 2013. Preparation , optimization and characterization of PLGA nanoparticle. International Journal of Pharmacy & Life Sciences; 4 (7):2810–2818. 4. Jameela SR, Misra A, Jayakrishnan A. 1995. Cross-linked chitosan microspheres as carriers for prolonged delivery of macromolecular drugs. Journal of Biomaterials Science, Polymer Edition; 6 (7):621–632. 5. Calvo P, Lopez CR, Vila-Jato JL, Alonso MJ. 1997. Novel Hydrophilic Chitosan – Polyethylene Oxide Nanoparticles as Protein Carriers. Journal of Applied Polymer Science; 63:125–132. 6. Naskar S, Sharma S, Kuotsu K. 2019. Chitosan-based nanoparticles: An overview of biomedical applications and its preparation. Journal of Drug Delivery Science and Technology; 49:66–81. 7. Schroeder A, Kost J, Barenholz Y. 2009. Ultrasound, Liposomes, and Drug Delivery: Principles for using Ultrasound to Control the release of Drugs from Liposomes. Chemistry and Physics of Lipids; 162:1–16. 8. Tsai M, Bai S, Chen R. 2008. Cavitation effects versus stretch effects resulted in different size and polydispersity of ionotropic gelation chitosan–sodium tripolyphosphate nanoparticle. Carbohydrate Polymers; 71:448–457. 9. Grieser F, Ashokkumar M, Sostaric J. Sonochemistry and sonoluminescence in colloidal systems. In: Crum L (ed) Sonochemistry and Sonoluminescence, NATO ASI Series, ,1999, pp 345–362. 10. Tang ESKSK, Huang M, Lim LYY. 2003. Ultrasonication of chitosan and chitosan nanoparticles. International Journal of Pharmaceutics; 265 (1–2):103–114. 11. Al-Nemrawi NK, Alsharif SSM, Dave RH. 2018. Preparation of chitosan-tpp nanoparticles: The influence of chitosan polymeric properties and formulation variables. International Journal of Applied Pharmaceutics; 10 (5):60–65. 12. Fan W, Yan W, Xu Z, Ni H. 2012. Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique. Colloids and Surfaces B: Biointerfaces; 90:21–27. 13. Gan Q, Wang T, Cochrane C, McCarron P. 2005. Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery. Colloids and Surfaces B: Biointerfaces; 44 (2–3):65–73. 14. Phu D Van, Duy NN, Quoc LA, Hien NQ. 2009. The effect of ph and molecular weight of chitosan on silver nanoparticles synthesized by irradiation. Research And Development Center For Radiation Technology; 47:166–171. 15. Floris A, Meloni MC, Lai F, Marongiu F, Maccioni AM, Sinico C. 2013. Cavitation effect on chitosan nanoparticle size: A possible approach to protect drugs from ultrasonic stress. Carbohydrate Polymers; 94 (1):619–625. 16. Antoniou J, Liu F, Majeed H, Yokoyama W, Zhong F. 2015. Physicochemical and morphological properties of size-controlled chitosan-tripolyphosphate nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects; 465:137–146. 17. Silva VJDD. 2013. Preparation and characterization of chitosan nanoparticles for gene delivery, Master degree thesis. 18. Czechowska-Biskup R, Rokita B, Ulanski P, Rosiak JM. 2015. Preparation of gold nanoparticles stabilized by chitosan using irradiation and sonication methods. Progress on Chemistry and Application of Chitin and its Derivatives; 20:18–33. 19. Li J, Huang Q. 2012. Rheological properties of chitosan–tripolyphosphate complexes: From suspensions to microgels. Carbohydrate Polymers; 87 (2):1670–1677. 20. Kim S, Fernandes MM, Matamá T, Loureiro A, Gomes AC, Cavaco-Paulo A. 2013. Chitosan–lignosulfonates sono-chemically prepared nanoparticles: Characterisation and potential applications. Colloids and Surfaces B: Biointerfaces; 103:1–8. 21. Hu B, Pan C, Sun Y, Hou Z, Ye H, Hu B, Zeng X. 2008. Optimization of fabrication parameters to produce chitosan–tripolyphosphate nanoparticles for delivery of tea catechins. Journal of Agricultural and Food Chemistry; 56:7451–7458. 22. Krishna Sailaja A, Amareshwar P. 2011. Preparation of bovine serum albumin loaded chitosan nanoparticle using reverse micelle method. Research Journal of Pharmaceutical, Biological and Chemical Sciences; 2 (3):837–846. 23. D’Souza M. 2015. Types of Design of Experiments. Nanoparticulate Vaccine Delivery Systems;, pp 61–70. 24. Gan Q, Wang T. 2007. Chitosan nanoparticle as protein delivery carrier-Systematic examination of fabrication conditions for efficient loading and release. Colloids and Surfaces B: Biointerfaces; 59 (1):24–34. 25. Sahu SK, Prusty AK. 2010. Design and evaluation of a nanoparticulate system prepared by biodegradable polymers for oral administration of protein drugs. Pharmazie; 65:824–829. 26. Queiroz MF, Melo KRT, Sabry DA, Rocha HAO. 2014. Does the Use of Chitosan Contribute to Oxalate Kidney Stone Formation? Marine Drugs; 13 (1):141–158. 27. Huang P, Li Z, Hu H, Cui D. 2010. Synthesis and Characterization of Bovine Serum Albumin-Conjugated Copper Sulfide Nanocomposites. Journal of Nanomaterials; 2010:6. 28. Qi L, Xu Z. 2004. Lead sorption from aqueous solutions on chitosan nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects; 251 (1):183–190. 29. Xu Y, Du Y. 2003. Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles. International Journal of Pharmaceutics; 250 (1):215–226.
  • [1]. Panyam J, Labhasetwar V. 2012. Biodegradable Nanoparticle from Drug and Gene Delivery to Cells and Tissue. Advanced Drug Delivery Reviews.; 64:61–71.
  • [2]. Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. 2001. Biodegradable polymeric nanoparticles as drug delivery devices. Journal of Controlled Release.; 70 (1–2):1–20.
  • [3]. Jameela SR, Misra A, Jayakrishnan A. 1995. Cross-linked chitosan microspheres as carriers for prolonged delivery of macromolecular drugs. Journal of Biomaterials Science, Polymer Edition.; 6 (7):621–632.
  • [4]. Calvo P, Lopez CR, Vila-Jato JL, Alonso MJ. 1997. Novel Hydrophilic Chitosan – Polyethylene Oxide Nanoparticles as Protein Carriers. Journal of Applied Polymer Science.; 63:125–132.
  • [5]. Naskar S, Sharma S, Kuotsu K. 2019. Chitosan-based nanoparticles: An overview of biomedical applications and its preparation. Journal of Drug Delivery Science and Technology.; 49:66–81.
  • [6]. Schroeder A, Kost J, Barenholz Y. 2009. Ultrasound, Liposomes, and Drug Delivery: Principles for using Ultrasound to Control the release of Drugs from Liposomes. Chemistry and Physics of Lipids.; 162:1–16.
  • [7]. Tsai M, Bai S, Chen R. 2008. Cavitation effects versus stretch effects resulted in different size and polydispersity of ionotropic gelation chitosan–sodium tripolyphosphate nanoparticle. Carbohydrate Polymers.; 71:448–457.
  • [8]. Grieser F, Ashokkumar M, Sostaric J. 1999. Sonochemistry and sonoluminescence in colloidal systems. Sonochemistry and Sonoluminescence NATO ASI Series.;, pp 345–362.
  • [9]. Tang ESKSK, Huang M, Lim LYY. 2003. Ultrasonication of chitosan and chitosan nanoparticles. International Journal of Pharmaceutics.; 265 (1–2):103–114.
  • [10]. Al-Nemrawi NK, Alsharif SSM, Dave RH. 2018. Preparation of chitosan-tpp nanoparticles: The influence of chitosan polymeric properties and formulation variables. International Journal of Applied Pharmaceutics.; 10 (5):60–65.
  • [11]. Fan W, Yan W, Xu Z, Ni H. 2012. Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique. Colloids and Surfaces B: Biointerfaces.; 90:21–27.
  • [12]. Gan Q, Wang T, Cochrane C, McCarron P. 2005. Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery. Colloids and Surfaces B: Biointerfaces.; 44 (2–3):65–73.
  • [13]. Phu D Van, Duy NN, Quoc LA, Hien NQ. 2009. The effect of ph and molecular weight of chitosan on silver nanoparticles synthesized by irradiation. Research And Development Center For Radiation Technology.; 47:166–171.
  • [14]. Floris A, Meloni MC, Lai F, Marongiu F, Maccioni AM, Sinico C. 2013. Cavitation effect on chitosan nanoparticle size: A possible approach to protect drugs from ultrasonic stress. Carbohydrate Polymers.; 94 (1):619–625.
  • [15]. Antoniou J, Liu F, Majeed H, Yokoyama W, Zhong F. 2015. Physicochemical and morphological properties of sizecontrolled chitosan-tripolyphosphate nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects.; 465:137–146.
  • [16]. Silva VJDD. 2013. Preparation and characterization of chitosan nanoparticles for gene delivery, Master degree.
  • [17]. Czechowska-Biskup R, Rokita BB, Ulanski P, Rosiak JM, Ulaski P, Rosiak JM. 2015. Preparation of gold nanoparticles stabilized by chitosan using irradiation and sonication methods. Progress on Chemistry and Application of Chitin and its Derivatives.; 20:18–33.
  • [18]. Li J, Huang Q. 2012. Rheological properties of chitosan–tripolyphosphate complexes: From suspensions to microgels. Carbohydrate Polymers.; 87 (2):1670–1677.
  • [19]. Kim S, Fernandes MM, Matamá T, Loureiro A, Gomes AC, Cavaco-Paulo A. 2013. Chitosan–lignosulfonates sonochemically prepared nanoparticles: Characterisation and potential applications. Colloids and Surfaces B: Biointerfaces.; 103:1–8.
  • [20]. Hu B, Pan C, Sun Y, Hou Z, Ye H, Hu B, Zeng X. 2008. Optimization of fabrication parameters to produce chitosan–tripolyphosphate nanoparticles for delivery of tea catechins. Journal of Agricultural and Food Chemistry.; 56:7451–7458.
  • [21]. Kolluru LP, Gala RP, Shastri PN, Ubale R. 2015. Design of Experiments: A Valuable Quality by Design Tool in Formulation Development. In D’Souza, MJ, ed.Nanoparticulate Vaccine Delivery Systems.;, p 66.
  • [22]. Gan Q, Wang T. 2007. Chitosan nanoparticle as protein delivery carrier-Systematic examination of fabrication conditions for efficient loading and release. Colloids and Surfaces B: Biointerfaces.; 59 (1):24–34. [23]. Sahu SK, Prusty AK. 2010. Design and evaluation of a nanoparticulate system prepared by biodegradable polymers for oral administration of protein drugs. Pharmazie.; 65:824–829.
  • [24]. Katas H, Hussain Z, Awang SA. 2013. Bovine Serum AlbuminLoaded Chitosan/Dextran Nanoparticles: Preparation and Evaluation of Ex Vivo Colloidal Stability in Serum. Journal of Nanomaterials.; 2013:1–9.
  • [25]. Kiaie N, Aghdam RM, Tafti SHA, Emami SH. 2016. Statistical optimization of chitosan nanoparticles as protein vehicles, using response surface methodology. Journal of Applied Biomaterials & Functional Materials.; 14 (4):413–422.
  • [26]. Chin A, Suarato G, Meng Y. 2014. Evaluation of physicochemical characteristics of hydrophobically modified glycol chitosan nanoparticles and their biocompatibility in murine osteosarcoma and osteoblast-like cells. Journal of Nanotechnology and Smart Materials.; 1:1–7.
  • [27]. Queiroz MF, Melo KRT, Sabry DA, Rocha HAO. 2014. Does the Use of Chitosan Contribute to Oxalate Kidney Stone Formation? Marine Drugs.; 13 (1):141–158.
  • [28]. Huang P, Li Z, Hu H, Cui D. 2010. Synthesis and Characterization of Bovine Serum Albumin-Conjugated Copper Sulfide Nanocomposites. Journal of Nanomaterials.; 2010:6.
  • [29]. Qi L, Xu Z. 2004. Lead sorption from aqueous solutions on chitosan nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects.; 251 (1):183–190.
  • [30]. Xu Y, Du Y. 2003. Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles. International Journal of Pharmaceutics.; 250 (1):215–226.

An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization

Year 2020, Volume: 16 Issue: 2, 119 - 127, 24.06.2020

Abstract

Studies have been carried out to determine the optimum conditions for chitosan nanoparticles. Various formulations have been made which can affect the size and polydispersity index of the nanoparticles and the process variables have been investigated. These formulation and process variables are defined and optimized to obtain the smallest particle size. The concentration of chitosan polymer and crosslinker concentration were studied as formulation variables. Mixing speed, mixing time, pH, sunlight effect, sonication time and sonication power parameters were selected as process variables. In the experiments performed for one parameter all other parameters are kept constant. The optimum conditions were determined by the effect of formulation and process variables on particle size and polydispersity index. For characterization of chitosan nanoparticles; Zeta-Sizer, UV-Vis, FTIR and SEM analytical techniques were used. Optimum conditions found at 50 W, 5 min, 30-10 pulse adjustment with sonicator device, chitosan:TPP mass ratio 5:1, pH value of 5 and with sunlight. After the optimum conditions obtained BSA loading is performed and characterization studies carried out. It is believed that chitosan nanoparticles produced by optimum conditions determined as a result of the study can be used in many areas include as a drug delivery system in future studies.

References

  • 1. Panyam J, Labhasetwar V. 2012. Biodegradable Nanoparticle from Drug and Gene Delivery to Cells and Tissue. Advanced Drug Delivery Reviews; 64:61–71. 2. Gilding D, Reed A. 1979. Biodegradable polymers for use in surgery—polyglycolic/poly(actic acid) homo- and copolymers: 1. Polymer; 20 (12):1459–1464. 3. Dangi RS, Shakya S. 2013. Preparation , optimization and characterization of PLGA nanoparticle. International Journal of Pharmacy & Life Sciences; 4 (7):2810–2818. 4. Jameela SR, Misra A, Jayakrishnan A. 1995. Cross-linked chitosan microspheres as carriers for prolonged delivery of macromolecular drugs. Journal of Biomaterials Science, Polymer Edition; 6 (7):621–632. 5. Calvo P, Lopez CR, Vila-Jato JL, Alonso MJ. 1997. Novel Hydrophilic Chitosan – Polyethylene Oxide Nanoparticles as Protein Carriers. Journal of Applied Polymer Science; 63:125–132. 6. Naskar S, Sharma S, Kuotsu K. 2019. Chitosan-based nanoparticles: An overview of biomedical applications and its preparation. Journal of Drug Delivery Science and Technology; 49:66–81. 7. Schroeder A, Kost J, Barenholz Y. 2009. Ultrasound, Liposomes, and Drug Delivery: Principles for using Ultrasound to Control the release of Drugs from Liposomes. Chemistry and Physics of Lipids; 162:1–16. 8. Tsai M, Bai S, Chen R. 2008. Cavitation effects versus stretch effects resulted in different size and polydispersity of ionotropic gelation chitosan–sodium tripolyphosphate nanoparticle. Carbohydrate Polymers; 71:448–457. 9. Grieser F, Ashokkumar M, Sostaric J. Sonochemistry and sonoluminescence in colloidal systems. In: Crum L (ed) Sonochemistry and Sonoluminescence, NATO ASI Series, ,1999, pp 345–362. 10. Tang ESKSK, Huang M, Lim LYY. 2003. Ultrasonication of chitosan and chitosan nanoparticles. International Journal of Pharmaceutics; 265 (1–2):103–114. 11. Al-Nemrawi NK, Alsharif SSM, Dave RH. 2018. Preparation of chitosan-tpp nanoparticles: The influence of chitosan polymeric properties and formulation variables. International Journal of Applied Pharmaceutics; 10 (5):60–65. 12. Fan W, Yan W, Xu Z, Ni H. 2012. Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique. Colloids and Surfaces B: Biointerfaces; 90:21–27. 13. Gan Q, Wang T, Cochrane C, McCarron P. 2005. Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery. Colloids and Surfaces B: Biointerfaces; 44 (2–3):65–73. 14. Phu D Van, Duy NN, Quoc LA, Hien NQ. 2009. The effect of ph and molecular weight of chitosan on silver nanoparticles synthesized by irradiation. Research And Development Center For Radiation Technology; 47:166–171. 15. Floris A, Meloni MC, Lai F, Marongiu F, Maccioni AM, Sinico C. 2013. Cavitation effect on chitosan nanoparticle size: A possible approach to protect drugs from ultrasonic stress. Carbohydrate Polymers; 94 (1):619–625. 16. Antoniou J, Liu F, Majeed H, Yokoyama W, Zhong F. 2015. Physicochemical and morphological properties of size-controlled chitosan-tripolyphosphate nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects; 465:137–146. 17. Silva VJDD. 2013. Preparation and characterization of chitosan nanoparticles for gene delivery, Master degree thesis. 18. Czechowska-Biskup R, Rokita B, Ulanski P, Rosiak JM. 2015. Preparation of gold nanoparticles stabilized by chitosan using irradiation and sonication methods. Progress on Chemistry and Application of Chitin and its Derivatives; 20:18–33. 19. Li J, Huang Q. 2012. Rheological properties of chitosan–tripolyphosphate complexes: From suspensions to microgels. Carbohydrate Polymers; 87 (2):1670–1677. 20. Kim S, Fernandes MM, Matamá T, Loureiro A, Gomes AC, Cavaco-Paulo A. 2013. Chitosan–lignosulfonates sono-chemically prepared nanoparticles: Characterisation and potential applications. Colloids and Surfaces B: Biointerfaces; 103:1–8. 21. Hu B, Pan C, Sun Y, Hou Z, Ye H, Hu B, Zeng X. 2008. Optimization of fabrication parameters to produce chitosan–tripolyphosphate nanoparticles for delivery of tea catechins. Journal of Agricultural and Food Chemistry; 56:7451–7458. 22. Krishna Sailaja A, Amareshwar P. 2011. Preparation of bovine serum albumin loaded chitosan nanoparticle using reverse micelle method. Research Journal of Pharmaceutical, Biological and Chemical Sciences; 2 (3):837–846. 23. D’Souza M. 2015. Types of Design of Experiments. Nanoparticulate Vaccine Delivery Systems;, pp 61–70. 24. Gan Q, Wang T. 2007. Chitosan nanoparticle as protein delivery carrier-Systematic examination of fabrication conditions for efficient loading and release. Colloids and Surfaces B: Biointerfaces; 59 (1):24–34. 25. Sahu SK, Prusty AK. 2010. Design and evaluation of a nanoparticulate system prepared by biodegradable polymers for oral administration of protein drugs. Pharmazie; 65:824–829. 26. Queiroz MF, Melo KRT, Sabry DA, Rocha HAO. 2014. Does the Use of Chitosan Contribute to Oxalate Kidney Stone Formation? Marine Drugs; 13 (1):141–158. 27. Huang P, Li Z, Hu H, Cui D. 2010. Synthesis and Characterization of Bovine Serum Albumin-Conjugated Copper Sulfide Nanocomposites. Journal of Nanomaterials; 2010:6. 28. Qi L, Xu Z. 2004. Lead sorption from aqueous solutions on chitosan nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects; 251 (1):183–190. 29. Xu Y, Du Y. 2003. Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles. International Journal of Pharmaceutics; 250 (1):215–226.
  • [1]. Panyam J, Labhasetwar V. 2012. Biodegradable Nanoparticle from Drug and Gene Delivery to Cells and Tissue. Advanced Drug Delivery Reviews.; 64:61–71.
  • [2]. Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. 2001. Biodegradable polymeric nanoparticles as drug delivery devices. Journal of Controlled Release.; 70 (1–2):1–20.
  • [3]. Jameela SR, Misra A, Jayakrishnan A. 1995. Cross-linked chitosan microspheres as carriers for prolonged delivery of macromolecular drugs. Journal of Biomaterials Science, Polymer Edition.; 6 (7):621–632.
  • [4]. Calvo P, Lopez CR, Vila-Jato JL, Alonso MJ. 1997. Novel Hydrophilic Chitosan – Polyethylene Oxide Nanoparticles as Protein Carriers. Journal of Applied Polymer Science.; 63:125–132.
  • [5]. Naskar S, Sharma S, Kuotsu K. 2019. Chitosan-based nanoparticles: An overview of biomedical applications and its preparation. Journal of Drug Delivery Science and Technology.; 49:66–81.
  • [6]. Schroeder A, Kost J, Barenholz Y. 2009. Ultrasound, Liposomes, and Drug Delivery: Principles for using Ultrasound to Control the release of Drugs from Liposomes. Chemistry and Physics of Lipids.; 162:1–16.
  • [7]. Tsai M, Bai S, Chen R. 2008. Cavitation effects versus stretch effects resulted in different size and polydispersity of ionotropic gelation chitosan–sodium tripolyphosphate nanoparticle. Carbohydrate Polymers.; 71:448–457.
  • [8]. Grieser F, Ashokkumar M, Sostaric J. 1999. Sonochemistry and sonoluminescence in colloidal systems. Sonochemistry and Sonoluminescence NATO ASI Series.;, pp 345–362.
  • [9]. Tang ESKSK, Huang M, Lim LYY. 2003. Ultrasonication of chitosan and chitosan nanoparticles. International Journal of Pharmaceutics.; 265 (1–2):103–114.
  • [10]. Al-Nemrawi NK, Alsharif SSM, Dave RH. 2018. Preparation of chitosan-tpp nanoparticles: The influence of chitosan polymeric properties and formulation variables. International Journal of Applied Pharmaceutics.; 10 (5):60–65.
  • [11]. Fan W, Yan W, Xu Z, Ni H. 2012. Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique. Colloids and Surfaces B: Biointerfaces.; 90:21–27.
  • [12]. Gan Q, Wang T, Cochrane C, McCarron P. 2005. Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery. Colloids and Surfaces B: Biointerfaces.; 44 (2–3):65–73.
  • [13]. Phu D Van, Duy NN, Quoc LA, Hien NQ. 2009. The effect of ph and molecular weight of chitosan on silver nanoparticles synthesized by irradiation. Research And Development Center For Radiation Technology.; 47:166–171.
  • [14]. Floris A, Meloni MC, Lai F, Marongiu F, Maccioni AM, Sinico C. 2013. Cavitation effect on chitosan nanoparticle size: A possible approach to protect drugs from ultrasonic stress. Carbohydrate Polymers.; 94 (1):619–625.
  • [15]. Antoniou J, Liu F, Majeed H, Yokoyama W, Zhong F. 2015. Physicochemical and morphological properties of sizecontrolled chitosan-tripolyphosphate nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects.; 465:137–146.
  • [16]. Silva VJDD. 2013. Preparation and characterization of chitosan nanoparticles for gene delivery, Master degree.
  • [17]. Czechowska-Biskup R, Rokita BB, Ulanski P, Rosiak JM, Ulaski P, Rosiak JM. 2015. Preparation of gold nanoparticles stabilized by chitosan using irradiation and sonication methods. Progress on Chemistry and Application of Chitin and its Derivatives.; 20:18–33.
  • [18]. Li J, Huang Q. 2012. Rheological properties of chitosan–tripolyphosphate complexes: From suspensions to microgels. Carbohydrate Polymers.; 87 (2):1670–1677.
  • [19]. Kim S, Fernandes MM, Matamá T, Loureiro A, Gomes AC, Cavaco-Paulo A. 2013. Chitosan–lignosulfonates sonochemically prepared nanoparticles: Characterisation and potential applications. Colloids and Surfaces B: Biointerfaces.; 103:1–8.
  • [20]. Hu B, Pan C, Sun Y, Hou Z, Ye H, Hu B, Zeng X. 2008. Optimization of fabrication parameters to produce chitosan–tripolyphosphate nanoparticles for delivery of tea catechins. Journal of Agricultural and Food Chemistry.; 56:7451–7458.
  • [21]. Kolluru LP, Gala RP, Shastri PN, Ubale R. 2015. Design of Experiments: A Valuable Quality by Design Tool in Formulation Development. In D’Souza, MJ, ed.Nanoparticulate Vaccine Delivery Systems.;, p 66.
  • [22]. Gan Q, Wang T. 2007. Chitosan nanoparticle as protein delivery carrier-Systematic examination of fabrication conditions for efficient loading and release. Colloids and Surfaces B: Biointerfaces.; 59 (1):24–34. [23]. Sahu SK, Prusty AK. 2010. Design and evaluation of a nanoparticulate system prepared by biodegradable polymers for oral administration of protein drugs. Pharmazie.; 65:824–829.
  • [24]. Katas H, Hussain Z, Awang SA. 2013. Bovine Serum AlbuminLoaded Chitosan/Dextran Nanoparticles: Preparation and Evaluation of Ex Vivo Colloidal Stability in Serum. Journal of Nanomaterials.; 2013:1–9.
  • [25]. Kiaie N, Aghdam RM, Tafti SHA, Emami SH. 2016. Statistical optimization of chitosan nanoparticles as protein vehicles, using response surface methodology. Journal of Applied Biomaterials & Functional Materials.; 14 (4):413–422.
  • [26]. Chin A, Suarato G, Meng Y. 2014. Evaluation of physicochemical characteristics of hydrophobically modified glycol chitosan nanoparticles and their biocompatibility in murine osteosarcoma and osteoblast-like cells. Journal of Nanotechnology and Smart Materials.; 1:1–7.
  • [27]. Queiroz MF, Melo KRT, Sabry DA, Rocha HAO. 2014. Does the Use of Chitosan Contribute to Oxalate Kidney Stone Formation? Marine Drugs.; 13 (1):141–158.
  • [28]. Huang P, Li Z, Hu H, Cui D. 2010. Synthesis and Characterization of Bovine Serum Albumin-Conjugated Copper Sulfide Nanocomposites. Journal of Nanomaterials.; 2010:6.
  • [29]. Qi L, Xu Z. 2004. Lead sorption from aqueous solutions on chitosan nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects.; 251 (1):183–190.
  • [30]. Xu Y, Du Y. 2003. Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles. International Journal of Pharmaceutics.; 250 (1):215–226.
There are 30 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Articles
Authors

Nisa İrem Büyük 0000-0002-6920-7064

Pelin Pelit 0000-0002-7176-4484

Serap Derman

Zeynep Mustafaeva

Sevil Yücel 0000-0002-9495-9321

Publication Date June 24, 2020
Published in Issue Year 2020 Volume: 16 Issue: 2

Cite

APA Büyük, N. İ., Pelit, P., Derman, S., Mustafaeva, Z., et al. (2020). An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization. Celal Bayar University Journal of Science, 16(2), 119-127.
AMA Büyük Nİ, Pelit P, Derman S, Mustafaeva Z, Yücel S. An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization. CBUJOS. June 2020;16(2):119-127.
Chicago Büyük, Nisa İrem, Pelin Pelit, Serap Derman, Zeynep Mustafaeva, and Sevil Yücel. “An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization”. Celal Bayar University Journal of Science 16, no. 2 (June 2020): 119-27.
EndNote Büyük Nİ, Pelit P, Derman S, Mustafaeva Z, Yücel S (June 1, 2020) An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization. Celal Bayar University Journal of Science 16 2 119–127.
IEEE N. İ. Büyük, P. Pelit, S. Derman, Z. Mustafaeva, and S. Yücel, “An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization”, CBUJOS, vol. 16, no. 2, pp. 119–127, 2020.
ISNAD Büyük, Nisa İrem et al. “An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization”. Celal Bayar University Journal of Science 16/2 (June 2020), 119-127.
JAMA Büyük Nİ, Pelit P, Derman S, Mustafaeva Z, Yücel S. An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization. CBUJOS. 2020;16:119–127.
MLA Büyük, Nisa İrem et al. “An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization”. Celal Bayar University Journal of Science, vol. 16, no. 2, 2020, pp. 119-27.
Vancouver Büyük Nİ, Pelit P, Derman S, Mustafaeva Z, Yücel S. An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization. CBUJOS. 2020;16(2):119-27.