Year 2020, Volume 16 , Issue 2, Pages 119 - 127 2020-06-24

Studies have been carried out to determine the optimum conditions for chitosan nanoparticles. Various formulations have been made which can affect the size and polydispersity index of the nanoparticles and the process variables have been investigated. These formulation and process variables are defined and optimized to obtain the smallest particle size. The concentration of chitosan polymer and crosslinker concentration were studied as formulation variables. Mixing speed, mixing time, pH, sunlight effect, sonication time and sonication power parameters were selected as process variables. In the experiments performed for one parameter all other parameters are kept constant. The optimum conditions were determined by the effect of formulation and process variables on particle size and polydispersity index. For characterization of chitosan nanoparticles; Zeta-Sizer, UV-Vis, FTIR and SEM analytical techniques were used. Optimum conditions found at 50 W, 5 min, 30-10 pulse adjustment with sonicator device, chitosan:TPP mass ratio 5:1, pH value of 5 and with sunlight. After the optimum conditions obtained BSA loading is performed and characterization studies carried out. It is believed that chitosan nanoparticles produced by optimum conditions determined as a result of the study can be used in many areas include as a drug delivery system in future studies.
chitosan nanoparticle, ionic gelation, optimization, tripolyphosphate, ultrasonication
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Primary Language en
Subjects Engineering
Journal Section Articles
Authors

Orcid: 0000-0002-6920-7064
Author: Nisa İrem BÜYÜK (Primary Author)
Institution: YEDITEPE UNIVERSITY
Country: Turkey


Orcid: 0000-0002-7176-4484
Author: Pelin PELİT ARAYICI
Institution: Yildiz Technical University
Country: Turkey


Author: Serap DERMAN
Institution: Yildiz Technical University
Country: Turkey


Author: Zeynep MUSTAFAEVA
Institution: Yildiz Technical University
Country: Turkey


Orcid: 0000-0002-9495-9321
Author: Sevil YÜCEL
Institution: Yildiz Technical University
Country: Turkey


Dates

Publication Date : June 24, 2020

Bibtex @research article { cbayarfbe658921, journal = {Celal Bayar University Journal of Science}, issn = {1305-130X}, eissn = {1305-1385}, address = {}, publisher = {Celal Bayar University}, year = {2020}, volume = {16}, pages = {119 - 127}, doi = {}, title = {An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization}, key = {cite}, author = {Büyük, Nisa İrem and Peli̇t, Pelin and Derman, Serap and Mustafaeva, Zeynep and Yücel, Sevil} }
APA Büyük, N , Peli̇t, P , Derman, S , Mustafaeva, Z , Yücel, S . (2020). An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization. Celal Bayar University Journal of Science , 16 (2) , 119-127 . Retrieved from https://dergipark.org.tr/en/pub/cbayarfbe/issue/55133/658921
MLA Büyük, N , Peli̇t, P , Derman, S , Mustafaeva, Z , Yücel, S . "An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization". Celal Bayar University Journal of Science 16 (2020 ): 119-127 <https://dergipark.org.tr/en/pub/cbayarfbe/issue/55133/658921>
Chicago Büyük, N , Peli̇t, P , Derman, S , Mustafaeva, Z , Yücel, S . "An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization". Celal Bayar University Journal of Science 16 (2020 ): 119-127
RIS TY - JOUR T1 - An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization AU - Nisa İrem Büyük , Pelin Peli̇t , Serap Derman , Zeynep Mustafaeva , Sevil Yücel Y1 - 2020 PY - 2020 N1 - DO - T2 - Celal Bayar University Journal of Science JF - Journal JO - JOR SP - 119 EP - 127 VL - 16 IS - 2 SN - 1305-130X-1305-1385 M3 - UR - Y2 - 2020 ER -
EndNote %0 Celal Bayar Üniversitesi Fen Bilimleri Dergisi An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization %A Nisa İrem Büyük , Pelin Peli̇t , Serap Derman , Zeynep Mustafaeva , Sevil Yücel %T An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization %D 2020 %J Celal Bayar University Journal of Science %P 1305-130X-1305-1385 %V 16 %N 2 %R %U
ISNAD Büyük, Nisa İrem , Peli̇t, Pelin , Derman, Serap , Mustafaeva, Zeynep , Yücel, Sevil . "An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization". Celal Bayar University Journal of Science 16 / 2 (June 2020): 119-127 .
AMA Büyük N , Peli̇t P , Derman S , Mustafaeva Z , Yücel S . An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization. Celal Bayar Univ J Sci. 2020; 16(2): 119-127.
Vancouver Büyük N , Peli̇t P , Derman S , Mustafaeva Z , Yücel S . An Optimization Study for Chitosan Nanoparticles: Synthesis and Characterization. Celal Bayar University Journal of Science. 2020; 16(2): 127-119.