Naringenin-Based Oximes and Hydrazones: Synthesis, Molecular Docking with Bovine Serum Albumin and Drug-Likeness, Admet Profiling Studies

Year 2025, Volume: 21 Issue: 1, 66 - 74, 26.03.2025

Ferhat Melihcan Abay , Hafize Özcan , Ayşen Şuekinci Yılmaz , Ömer Zaim

https://doi.org/10.18466/cbayarfbe.1552978

Abstract

Scientists are now increasingly interested in the flavonoid molecule naringenin due to the broad spectrum of biological roles it conducts. Oximes and hydrazones were created employing derivatives of the naringenin-active substances 7-piperidinethoxy and 7-morpholinethoxy to contribute to this research. The ability of the produced compounds to bind to BSA was determined by molecular docking and their potential as medications was assessed using various methods. Based on Lipinski's rule of five, none of the substances were hazardous or carcinogenic, and their blood-brain barrier crossing values were all within permissible limits.

Keywords

BSA, Flavonoid, Hydrazones, Lipinski, Oximes

Ethical Statement

There are no ethical issues after the publication of this manuscript.

Supporting Institution

Trakya University

Project Number

TÜBAP 2018/232

Thanks

We gratefully acknowledge the financial support of the scientific research project commission of Trakya University (TÜBAP 2018/232).

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