Case Report
BibTex RIS Cite

Year 2021, Volume: 3 Issue: 2, 24 - 27, 30.08.2021

Ali Kal

Abstract

References

  • 1. Egbert PR, Pollard RB, Gallagher JG, Merigan TC. Cytomegalovirus retinitis in immunosuppressed hosts. Ocular manifestations. Ann Intern Med 1980;93:664–70.
  • 2. Shahnaz S, Choksi MT, Tan IJ. Bilateral cytomegalovirus retinitis in a patient with systemic lupus erythematosus and endstage renal disease. Mayo Clin Proc 2003;78:1412–5.
  • 3. Evans BG. Management of blinding disease: loss of immunity and superinfection. Eye 2005;19:1035–6
  • 4. Schlingemann RO, Wertheim-van Dillen P, Kijlstra A, Bos PJ, Meenken C, Feron EJ. Bilateral cytomegalovirus retinitis in a patient with systemic lupus erythematosus. Br J Ophthalmol 1996;80:1109–10.
  • 5. Scott WJ, Giangiacomo J, Hodges KE. Accelerated cytomegalovirus retinitis secondary to immunosuppressive therapy. Arch Ophthalmol 1986;104:1117–8, 1124
  • 6. Eid AJ, Bakri SJ, Kijpittayarit S, Razonable RR: Clinical features and outcomes of cytomegalovirus retinitis after transplantation. Transpl Infect Dis 2008, 10:13–18.
  • 7. Schachat AP: Non-Hodgkin’s lymphoma. In Gold DH, Weingest TA(eds): ‘‘The Eye in Systemic Disease.’’ Lippincott, 1990.
  • 8. Martin DF, Sierra-Madero J, Walmsley S. Valganciclovir Study Group. A controlled trial of valganciclovir as induction therapy for cytomegalovirus retinitis. N Engl J Med 2002; 346:1119–26.
  • 9. Voigt V, Andoniou CE, Schuster IS. Cytomegalovirus establishes a latent reservoir and triggers long-lasting inflammation in the eye. PLoS Pathog 2018;14:e1007040.
  • 10- Port AD, Orlin A, Kiss S, Patel S, D'Amico DJ, Gupta MP. Cytomegalovirus Retinitis: A Review. J Ocul Pharmacol Ther. 2017 May;33(4):224-234.
  • 11.Sener AG, Payzın B, Afsar İ, Saklamaz A, Türker M. Cytomegalovırus (CMV) Retinitis in a Patient with Non-Hodgkin Lymphoma. Turkiye Klinikleri J Ophthalmol 2007, 16:275-278
  • 12. Hodge WG, Boivin JF, Shapiro SH, Shah KC, Dionne MA. Iatrogenic risk factors for cytomegalovirus retinitis. Can J Ophtalmol 2005;40:701-10.
  • 13. Pathanapitoon K, Tesavibul N, Choopong P, et al. Clinical manifestations of cytomegalovirus-associated posterior uveitis and panuveitis in patients without human immunodeficiency virus infection. JAMA Ophthalmol 2013;131:638–45.
  • 14-Svozílková P, Heissigerová J, Brichová M. A possible coincidence of cytomegalovirus retinitis and intraocular lymphoma in a patient with systemic non-Hodgkin’s lymphoma. Virol J 2013;10:18.
  • 15-DerzkoDzulynsky LA, Berger AR, Berinstein NL. Cytomegalovirus retinitis and low grade nonHodgkin’s lymphoma: case report and review of the literature. Am J Hematol 1998;57:228–32.
  • 16-Chawla R, Venkatesh P, Garg P. Cytomegalovirus retinitis in a patient with nonHodgkin’s lymphoma: a diagnostic dilemma. Eur J Ophthalmol 2005;15:153–7.
  • 17-Tyagi M, Ambiya V, Mathai A, Narayanan R. Atypical cytomegalovirus retinitis in non-Hodgkin’s lymphoma BMJ Case Rep 2015. doi:10.1136/bcr-2015-210812
  • 18- Fan J, Gong D, Truong C, Miko B, Horowitz J, Chen RWS. Cytomegalovirus Retinitis with Belatacept Immunsupresion. Retina Cases Brief Rep. 2019;00:1-5

Cytomegalovirus Retinitis in a Patient with Large Cell Diffuse Non-Hodgkin’s Lymphoma

Year 2021, Volume: 3 Issue: 2, 24 - 27, 30.08.2021

Ali Kal

Abstract

Non-Hodgkin lymphoma is a reticuloendothelial malignancy and usually characterized by malignant proliferation of B cell lymphocytes. Immunosuppressive drugs used in reticuloendothelial malignancy treatments may cause opportunistic infections. Cytomegalovirus (CMV) can also cause such an infection.
A patient with nonhodgkin lymphoma who had decreased vision due to CMV retinitis is presented. Cytomegalovirus (CMV) retinitis is rarely seen in lymphoma patients and can be confused clinically with intraocular lymphomas.
A 27-year-old female patient who received chemotherapy for a non-Hodgkin lymphoma (NHL) presented to our clinic with loss of visual field and decreased vision in both eyes. Fundus examination revealed retinal hemorrhages, exudative deposits and perivascular retinitis in both eyes. As it is thought to have CMV retinitis based on the clinical characteristics of the patient, we also examined serum CMV IgG, IgM and CMV DNA levels to support the diagnosis. Immediately, intravenous ganciclovir treatment was started followed by orally vanganciclovir.

Keywords

Non-hodgkin Lymphoma ; cytomegalovirus retinitis ganciclovir valganciclovir

References

  • 1. Egbert PR, Pollard RB, Gallagher JG, Merigan TC. Cytomegalovirus retinitis in immunosuppressed hosts. Ocular manifestations. Ann Intern Med 1980;93:664–70.
  • 2. Shahnaz S, Choksi MT, Tan IJ. Bilateral cytomegalovirus retinitis in a patient with systemic lupus erythematosus and endstage renal disease. Mayo Clin Proc 2003;78:1412–5.
  • 3. Evans BG. Management of blinding disease: loss of immunity and superinfection. Eye 2005;19:1035–6
  • 4. Schlingemann RO, Wertheim-van Dillen P, Kijlstra A, Bos PJ, Meenken C, Feron EJ. Bilateral cytomegalovirus retinitis in a patient with systemic lupus erythematosus. Br J Ophthalmol 1996;80:1109–10.
  • 5. Scott WJ, Giangiacomo J, Hodges KE. Accelerated cytomegalovirus retinitis secondary to immunosuppressive therapy. Arch Ophthalmol 1986;104:1117–8, 1124
  • 6. Eid AJ, Bakri SJ, Kijpittayarit S, Razonable RR: Clinical features and outcomes of cytomegalovirus retinitis after transplantation. Transpl Infect Dis 2008, 10:13–18.
  • 7. Schachat AP: Non-Hodgkin’s lymphoma. In Gold DH, Weingest TA(eds): ‘‘The Eye in Systemic Disease.’’ Lippincott, 1990.
  • 8. Martin DF, Sierra-Madero J, Walmsley S. Valganciclovir Study Group. A controlled trial of valganciclovir as induction therapy for cytomegalovirus retinitis. N Engl J Med 2002; 346:1119–26.
  • 9. Voigt V, Andoniou CE, Schuster IS. Cytomegalovirus establishes a latent reservoir and triggers long-lasting inflammation in the eye. PLoS Pathog 2018;14:e1007040.
  • 10- Port AD, Orlin A, Kiss S, Patel S, D'Amico DJ, Gupta MP. Cytomegalovirus Retinitis: A Review. J Ocul Pharmacol Ther. 2017 May;33(4):224-234.
  • 11.Sener AG, Payzın B, Afsar İ, Saklamaz A, Türker M. Cytomegalovırus (CMV) Retinitis in a Patient with Non-Hodgkin Lymphoma. Turkiye Klinikleri J Ophthalmol 2007, 16:275-278
  • 12. Hodge WG, Boivin JF, Shapiro SH, Shah KC, Dionne MA. Iatrogenic risk factors for cytomegalovirus retinitis. Can J Ophtalmol 2005;40:701-10.
  • 13. Pathanapitoon K, Tesavibul N, Choopong P, et al. Clinical manifestations of cytomegalovirus-associated posterior uveitis and panuveitis in patients without human immunodeficiency virus infection. JAMA Ophthalmol 2013;131:638–45.
  • 14-Svozílková P, Heissigerová J, Brichová M. A possible coincidence of cytomegalovirus retinitis and intraocular lymphoma in a patient with systemic non-Hodgkin’s lymphoma. Virol J 2013;10:18.
  • 15-DerzkoDzulynsky LA, Berger AR, Berinstein NL. Cytomegalovirus retinitis and low grade nonHodgkin’s lymphoma: case report and review of the literature. Am J Hematol 1998;57:228–32.
  • 16-Chawla R, Venkatesh P, Garg P. Cytomegalovirus retinitis in a patient with nonHodgkin’s lymphoma: a diagnostic dilemma. Eur J Ophthalmol 2005;15:153–7.
  • 17-Tyagi M, Ambiya V, Mathai A, Narayanan R. Atypical cytomegalovirus retinitis in non-Hodgkin’s lymphoma BMJ Case Rep 2015. doi:10.1136/bcr-2015-210812
  • 18- Fan J, Gong D, Truong C, Miko B, Horowitz J, Chen RWS. Cytomegalovirus Retinitis with Belatacept Immunsupresion. Retina Cases Brief Rep. 2019;00:1-5
There are 18 citations in total.

Details

Primary Language English
Subjects Ophthalmology
Journal Section Case Report
Authors

Ali Kal 0000-0001-7544-5790

Publication Date August 30, 2021
Acceptance Date September 29, 2021
Published in Issue Year 2021 Volume: 3 Issue: 2

Cite

APA Kal, A. (2021). Cytomegalovirus Retinitis in a Patient with Large Cell Diffuse Non-Hodgkin’s Lymphoma. Clinical and Experimental Ocular Trauma and Infection, 3(2), 24-27.
AMA Kal A. Cytomegalovirus Retinitis in a Patient with Large Cell Diffuse Non-Hodgkin’s Lymphoma. CEOTI. August 2021;3(2):24-27.
Chicago Kal, Ali. “Cytomegalovirus Retinitis in a Patient With Large Cell Diffuse Non-Hodgkin’s Lymphoma”. Clinical and Experimental Ocular Trauma and Infection 3, no. 2 (August 2021): 24-27.
EndNote Kal A (August 1, 2021) Cytomegalovirus Retinitis in a Patient with Large Cell Diffuse Non-Hodgkin’s Lymphoma. Clinical and Experimental Ocular Trauma and Infection 3 2 24–27.
IEEE A. Kal, “Cytomegalovirus Retinitis in a Patient with Large Cell Diffuse Non-Hodgkin’s Lymphoma”, CEOTI, vol. 3, no. 2, pp. 24–27, 2021.
ISNAD Kal, Ali. “Cytomegalovirus Retinitis in a Patient With Large Cell Diffuse Non-Hodgkin’s Lymphoma”. Clinical and Experimental Ocular Trauma and Infection 3/2 (August 2021), 24-27.
JAMA Kal A. Cytomegalovirus Retinitis in a Patient with Large Cell Diffuse Non-Hodgkin’s Lymphoma. CEOTI. 2021;3:24–27.
MLA Kal, Ali. “Cytomegalovirus Retinitis in a Patient With Large Cell Diffuse Non-Hodgkin’s Lymphoma”. Clinical and Experimental Ocular Trauma and Infection, vol. 3, no. 2, 2021, pp. 24-27.
Vancouver Kal A. Cytomegalovirus Retinitis in a Patient with Large Cell Diffuse Non-Hodgkin’s Lymphoma. CEOTI. 2021;3(2):24-7.
 Download Cover Image

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License(CC BY-NC-SA 4.0)