Histological Diagnosis Following Radiological Suspicion: A Case of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Masquerading as Duodenal Lesion

Sevinç Hakyemez; Bengisu Ulu Karasu; Hasan Mücahit Özbaş; Esma Çınar

doi:10.70058/cjm.1928049

Histological Diagnosis Following Radiological Suspicion: A Case of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Masquerading as Duodenal Lesion

Abstract

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a common leukemia characterized by monoclonal B-cell proliferation. Extramedullary and extranodal manifestations can occur either in association with systemic CLL or as isolated lesions. Gastrointestinal (GI) tract involvement, however, is uncommon. These patients may be asymptomatic or present with chronic diarrhea, abdominal pain, and gastrointestinal hemorrhage. The prognostic significance of extramedullary CLL remains a matter of debate, although the prognosis in these patients appears to be more favorable in the era of novel targeted drugs. Herein, the case of a patient with a prior diagnosis of CLL undergoing observational follow-up without active therapy, who was found to have duodenal involvement on a biopsy performed following persistent dyspeptic complaints. We highlight the importance of considering GI symptoms when selecting the most appropriate treatment regimen.

Keywords

Ethical Statement

This manuscript does not contain any data that could identify the patient. The figures presented consist solely of anonymized histopathological microscopic images. Therefore, patient privacy is protected, and patient consent is not required for this article.

References

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Details

Primary Language

English

Subjects

Internal Diseases

Journal Section

Case Report

Authors

Sevinç Hakyemez ^*
0009-0002-6557-6871
Türkiye

Bengisu Ulu Karasu
0009-0001-1143-810X
Türkiye

Hasan Mücahit Özbaş
0000-0001-9499-375X
Türkiye

Esma Çınar
0000-0002-7993-1056
Türkiye

Early Pub Date

August 2, 2026

Publication Date

September 30, 2026

Submission Date

April 13, 2026

Acceptance Date

July 29, 2026

Published in Issue

Year 2026 Volume: 3 Number: 3

DOI

https://doi.org/10.70058/cjm.1928049

IZ

https://izlik.org/JA48FG64EN

Cite

RIS / Bibtex

APA

Hakyemez, S., Ulu Karasu, B., Özbaş, H. M., & Çınar, E. (2026). Histological Diagnosis Following Radiological Suspicion: A Case of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Masquerading as Duodenal Lesion. Cerasus Journal of Medicine, 3(3), 245-248. https://doi.org/10.70058/cjm.1928049

AMA

1.Hakyemez S, Ulu Karasu B, Özbaş HM, Çınar E. Histological Diagnosis Following Radiological Suspicion: A Case of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Masquerading as Duodenal Lesion. Cerasus J Med. 2026;3(3):245-248. doi:10.70058/cjm.1928049

Chicago

Hakyemez, Sevinç, Bengisu Ulu Karasu, Hasan Mücahit Özbaş, and Esma Çınar. 2026. “Histological Diagnosis Following Radiological Suspicion: A Case of Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma Masquerading As Duodenal Lesion”. Cerasus Journal of Medicine 3 (3): 245-48. https://doi.org/10.70058/cjm.1928049.

EndNote

Hakyemez S, Ulu Karasu B, Özbaş HM, Çınar E (September 1, 2026) Histological Diagnosis Following Radiological Suspicion: A Case of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Masquerading as Duodenal Lesion. Cerasus Journal of Medicine 3 3 245–248.

IEEE

[1]S. Hakyemez, B. Ulu Karasu, H. M. Özbaş, and E. Çınar, “Histological Diagnosis Following Radiological Suspicion: A Case of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Masquerading as Duodenal Lesion”, Cerasus J Med, vol. 3, no. 3, pp. 245–248, Sept. 2026, doi: 10.70058/cjm.1928049.

ISNAD

Hakyemez, Sevinç - Ulu Karasu, Bengisu - Özbaş, Hasan Mücahit - Çınar, Esma. “Histological Diagnosis Following Radiological Suspicion: A Case of Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma Masquerading As Duodenal Lesion”. Cerasus Journal of Medicine 3/3 (September 1, 2026): 245-248. https://doi.org/10.70058/cjm.1928049.

JAMA

1.Hakyemez S, Ulu Karasu B, Özbaş HM, Çınar E. Histological Diagnosis Following Radiological Suspicion: A Case of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Masquerading as Duodenal Lesion. Cerasus J Med. 2026;3:245–248.

MLA

Hakyemez, Sevinç, et al. “Histological Diagnosis Following Radiological Suspicion: A Case of Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma Masquerading As Duodenal Lesion”. Cerasus Journal of Medicine, vol. 3, no. 3, Sept. 2026, pp. 245-8, doi:10.70058/cjm.1928049.

Vancouver

1.Sevinç Hakyemez, Bengisu Ulu Karasu, Hasan Mücahit Özbaş, Esma Çınar. Histological Diagnosis Following Radiological Suspicion: A Case of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Masquerading as Duodenal Lesion. Cerasus J Med. 2026 Sep. 1;3(3):245-8. doi:10.70058/cjm.1928049