Brenner tumors are rare transitional cell tumors of the ovary. They are usually benign tumors, but there are rarer borderline and malignant types. Most benign Brenner tumors are small and found incidentally. In our case, a 65-year-old female patient who underwent nephroureterctomy by the urology coincidentally had a mass in the left ovary during the operation. The obstetrics and gynecology department was called for consultation, and bilateral salpingotomy was performed as malignancy might occur. In histopathological examination; The mass found in the nephrectomy material was diagnosed as invasive, low-grade papillary urothelial carcinoma, and the mass in the left ovary was diagnosed as benign Brenner tumor. In our article, the histological findings of this rare case are presented and the literature is reviewed.
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Horiuchi, A., Itoh, K., Shimizu, M., Nakai, I., Yamazaki, T., Kimura, K., ... & Konishi, I. (2003). Toward understanding the natural history of ovarian carcinoma development: a clinicopathological approach. Gynecologic oncology, 88(3), 309-317. https://doi.org/ 10.1016/s0090-8258(02)00104-x
Karseladze, A. I. (2001). On the site of origin of epithelial tumors of the ovary. European journal of gynaecological oncology, 22(2), 110-115.
Moon, W. J., Koh, B. H., Kim, S. K., Kim, Y. S., Rhim, H. C., Cho, O. K., ... & Kim, S. H. (2000). Brenner tumor of the ovary: CT and MR findings. Journal of computer assisted tomography, 24(1), 72-76. https://doi.org/10.1097/00004728-200001000-00015
Resta, L., Russo, S., Colucci, G. A., & Prat, J. (1993). Morphologic precursors of ovarian epithelial tumors. Obstetrics & Gynecology, 82(2), 181-186. PMID: 8336861
Sassi, S. H., Dhouib, R., Abbes, I., Mrad, K., Driss, M., Hechich, M., & Romdhane, K. B. (2007). Extraovarien Brenner tumor. Case report and review. American Journal of Case Reports, 8, 40-43.https://doi.org/10.1007/BF02108311
Seidman, J. D., & Khedmati, F. (2008). Exploring the histogenesis of ovarian mucinous and transitional cell (Brenner) neoplasms and their relationship with Walthard cell nests: a study of 120 tumors. Archives of pathology & laboratory medicine, 132(11), 1753-1760.https://doi.org/10.5858/132.11.1753
Tsikouras, P., Galazios, G., Romanidis, K., Pinidis, P., Liberis, A., Giatromanolaki, A., & Sivridis, E. (2016). Brenner tumour of the ovary-an incidental histological finding. European journal of gynaecological oncology, 37(2), 267-269. PMID: 27172761
Zheng, R., & Heller, D. S. (2019). Borderline Brenner tumor: a review of the literature. Archives of pathology & laboratory medicine, 143(10), 1278-1280. https://doi.org/10.5858/arpa.2018-0285-RS
Chapman, W. B. (2001). Developments in the pathology of ovarian tumours. Current Opinion in Obstetrics and Gynecology, 13(1), 53-59. https://doi.org/10.1097/00001703-200102000-00008
Horiuchi, A., Itoh, K., Shimizu, M., Nakai, I., Yamazaki, T., Kimura, K., ... & Konishi, I. (2003). Toward understanding the natural history of ovarian carcinoma development: a clinicopathological approach. Gynecologic oncology, 88(3), 309-317. https://doi.org/ 10.1016/s0090-8258(02)00104-x
Karseladze, A. I. (2001). On the site of origin of epithelial tumors of the ovary. European journal of gynaecological oncology, 22(2), 110-115.
Moon, W. J., Koh, B. H., Kim, S. K., Kim, Y. S., Rhim, H. C., Cho, O. K., ... & Kim, S. H. (2000). Brenner tumor of the ovary: CT and MR findings. Journal of computer assisted tomography, 24(1), 72-76. https://doi.org/10.1097/00004728-200001000-00015
Resta, L., Russo, S., Colucci, G. A., & Prat, J. (1993). Morphologic precursors of ovarian epithelial tumors. Obstetrics & Gynecology, 82(2), 181-186. PMID: 8336861
Sassi, S. H., Dhouib, R., Abbes, I., Mrad, K., Driss, M., Hechich, M., & Romdhane, K. B. (2007). Extraovarien Brenner tumor. Case report and review. American Journal of Case Reports, 8, 40-43.https://doi.org/10.1007/BF02108311
Seidman, J. D., & Khedmati, F. (2008). Exploring the histogenesis of ovarian mucinous and transitional cell (Brenner) neoplasms and their relationship with Walthard cell nests: a study of 120 tumors. Archives of pathology & laboratory medicine, 132(11), 1753-1760.https://doi.org/10.5858/132.11.1753
Tsikouras, P., Galazios, G., Romanidis, K., Pinidis, P., Liberis, A., Giatromanolaki, A., & Sivridis, E. (2016). Brenner tumour of the ovary-an incidental histological finding. European journal of gynaecological oncology, 37(2), 267-269. PMID: 27172761
Zheng, R., & Heller, D. S. (2019). Borderline Brenner tumor: a review of the literature. Archives of pathology & laboratory medicine, 143(10), 1278-1280. https://doi.org/10.5858/arpa.2018-0285-RS
Canday, M., Uslu, M., Ezer, M., Beşeren Havadar, H., et al. (2023). Brenner Tumor Case Report. Caucasian Journal of Science, 10(2), 82-87. https://doi.org/10.48138/cjo.1311549