Antimicrobial Activities of 3-Aryl-4-(benzenesulfonyloxy)-benzylideneamino-4,5-dihyro-1H-1,2,4-triazol-5-one Compounds

Abstract

Çalışmanın sentez bölümünde, ilk olarak 3 adet 3-aril-4-amino-4,5-dihidro-1H-1,2,4-triazol-5-on bileşiğinin bir benzaldehid türevi olan 3-etoksi-4-hidroksibenzaldehidin trietilamin varlığında benzensulfonil klorür ile muamelesinden sentezlenen 3-etoksi-4-(benzensulfoniloksi)-benzaldehid ile ayrı ayrı muamelesinden karşın olan 3 adet 3-aril-4-(benzensulfoniloksi)-benzilidenamino-4,5-dihiro-1H-1,2,4-triazol-5-on bileşiği elde edilmiştir. 3 Adet 1,2,4-triazol türevli Schiff bazı bileşikleri olan 3-aril-4-[3-etoksi-4-(benzensulfoniloksi)-benzilidenamino]-4,5-dihidro-1H-1,2,4-triazol-5-on’ların Klebsiella pneumoniae, Pseudomonas aeruginosa, Echerichia coli, Staphylococcus aureus, Entercoccus faecalis bakterileri üzerindeki antimikrobiyal etkileri disk difüzyon yöntemi ile araştırılmıştır. Yapılan araştırma sonucunda 3-p-klorobenzil-4-[3-etoksi-4-(benzensulfoniloksi)-benzilidenamino]-4,5-dihidro-1H-1,2,4-triazol-5-on’un E. coli ve K. pneumoniae üzerinde antimikrobiyal etki gösterdiği, 3-m-klorobenzil-4-[3-etoksi-4-(benzensulfoniloksi) benzilidenamino]-4,5-dihidro-1H-1,2,4-triazol-5-on’un da yalnızca K. pneumoniae üzerinde etkili olduğu belirlenmiştir.

Keywords

• Schiff bazı
• Antimikrobiyal aktivite
• Disk difüzyon yöntemi

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