Yeni Hormonlar: R-Spondin-1, Nesfatin-1 ve İrisin

Year 2019, Volume: 6 Issue: 1, 37 - 50, 30.06.2019

Canan Gülmez , Onur Atakişi

Abstract

Wnt modülatörlerinden R-spondin ailesi, çeşitli hastalık süreçlerinde görevli olan β-katenin/Wnt sinyal aktivitesini artırma yeteneğinden oldukça dikkat çekmektedir. Metabolik bozukluklar, obezite ve diyabet gibi hastalıklarla ilişkilendirilen irisin ise bu hastalıkların tedavisinde ve izlenmesinde umut vaat edici olarak görülen bir diğer hormondur. Öte yandan anoreksijenik bir hormon olan nesfatin-1’in, obezite ve diyabetin yanı sıra psikiyatrik bozukluklar ve nörojenik hastalıklarda rol oynadığı yapılan çalışmalarla vurgulanmıştır. Son yıllarda giderek artan sayıdaki çalışmaya rağmen bu hormonların etki mekanizmaları iyi anlaşılamamıştır. Bu derlemede R-spondin-1, nesfatin-1 ve irisin hormonlarının yapısı, sentezi ve biyokimyasal etkilerinden bahsedilmiş, çeşitli hastalıklar üzerine etkileriyle ilgili literatür bilgileri özetlenmiştir.

Keywords

Hormon, R-Spondin-1, Nesfatin-1, İrisin

Novel Hormones: R-Spondin-1, Nesfatin-1 and Irisin

Abstract

 

The R-spondin family of Wnt modulators draws considerable attention from the ability to increase the β-catenin / Wnt signal activity in various disease processes. Irisin, which is associated with diseases such as metabolic disorders, obesity and diabetes, is another promising hormone in the treatment and monitoring of these diseases. On the other hand, it has been emphasized that nesfatin-1, an anorexigenic hormone, plays a role in psychiatric disorders and neurogenic diseases in addition to obesity and diabetes. Despite the increasing number of
studies in recent years, the mechanism of action of these hormones is not well understood. In this review, the structure, synthesis and biochemical effects of R-spondin-1, nesfatin-1 and irisin hormones are mentioned.

Keywords

Hormone, R-Spondin-1, Nesfatin-1, Irisin

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