Determination of HNP and pKa Values of Some 3-Alkyl(Aryl)-4-phthalimido-4,5-dihydro-1H-1,2,4-triazol-5-one Compounds by Semi-Neutralization Method

Year 2022, Volume: 9 Issue: 2, 95 - 104, 31.12.2022

Haydar Yüksek , Sevda Manap , Gül Özdemir

https://doi.org/10.48138/cjo.1200631

Abstract

In this study, the effects of solvents and molecular structure upon acidity, five 3-alkyl(aryl)-4-phthalimido-4,5-dihydro-1H-1,2,4-triazol-5-ones (3-7) were potentiometrically titrated with tetrabutylammonium hydroxide (TBAH) in four different anhydrous solvents (isopropyl alcohol, acetonitrile, tert-butyl alcohol and N,N-dimethylformamide) and HNP and corresponding pKa values were determined by half-neutralization method for all cases.

Keywords

124-Triazole, HNP, pKa, titration

Thanks

The authors thank Dr. Zafer Ocak for their contribution.

Bazı 3-Alkil(Aril)-4-ftalimido-4,5-dihidro-1H-1,2,4-triazol-5-on Bileşiklerinin Yarı-Nötralizasyon Metodu İle HNP ve pKa Değerlerinin Tayini

Abstract

Bu çalışmada, asitlik üzerine çözücü ve moleküler yapının etkilerini incelemek için, beş 3-alkil(aril)-4-ftalimido-4,5-dihidro-1H-1,2,4-triazol-5-on (3-7) bileşiğinin dört farklı susuz çözücüde (izopropil alkol, asetonitril, tert-butil alkol ve N,N-dimetilformamid) tetrabutilamonyum hidroksitle (TBAH) potansiyometrik olarak titrasyonları yapılmış ve yarı nötralizasyon yöntemi ile HNP ve karşın olan pKa değerleri her durum için tayin edilmiştir.

Keywords

124-Triazol, HNP, pKa, titrasyon

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