Synthesis and Biological Evaluation of 3-Alkyl(Aryl)-4-(4-methylthio-benzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-one Derivatives

Year 2024, Volume: 11 Issue: 1, 50 - 57, 02.08.2024

Özlem Gürsoy Kol , Fevzi Aytemiz , Sevda Manap , Haydar Yüksek

https://doi.org/10.48138/cjo.1484675

Abstract

In the present study, 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (3c, f, e) reacted with 4-methylthiobenzaldehyde to afford 3-alkyl(aryl)-4-(4-methylthio-benzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-ones (4c, f, e). The structures of three new compounds were established from the elemental analysis, IR, 1H NMR, and 13C NMR spectral data. The newly synthesized and recently synthesized 3-alkyl(aryl)-4-(4-methylthiobenzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-one derivatives were analyzed using three methods for antioxidant activities. Compound 4a showed the best activity for the metal chelating effect. Furthermore, the compounds' antimicrobial activity was screened.

Keywords

1,2,4-triazole, Synthesis, Antioxidant activity, Antimicrobial activity

Ethical Statement

The approval of an ethical committee is not required.

Supporting Institution

Scientific Research Projects Coordination Unit of Kafkas University

Project Number

2016-FM-61

Thanks

The authors thank Dr. Muzaffer Alkan for their contribution.

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