The Relationship of Nutrition And Leptin In Cancer

Year 2024, Volume: 3 Issue: 1, 12 - 19, 31.12.2024

Aysel Sarı

Abstract

Leptin hormone has an important role in the consumption of excessive food intake and energy expenditure. While leptin acts as a neuroendocrine hormone, it has an important role in metabolic function. Leptin shows peripheral effects on glucose metabolism and gluconeogenesis, and it is aimed to emphasize its importance in its relationship with nutrition. Malnutrition, which is a serious risk for cancer development and progression, also causes bad negative results in many tumor types. Nutritional balance and energy balance are affected at the level of insulin and leptin hormones, and functionality is important on the relationship between nutrition and leptin and cancer. The negative effects on adipose tissue caused by unbalanced nutrition are effective in cancer formation and insulin, insulin resistance, that is, leptin levels. In addition, many studies have reported that unbalanced nutrition tumor damage.

Keywords

Cancer, Diyet, Nutrition, Leptin, Human

Project Number

yok

References

• Alberts, D. S., Martinez, M. E., & Roe, D. J. (2004). Lack of effect of a high fiber cereal supplement on the recurrence of colorectal cancers: A systemic review and meta-analysis. 92, 181–188.
• Alexandrov, K., Cascorbi, I., & Rojas, M., et al. (2002). CYP1A1 and GSTM1 genotypes affect benzo[A]pyrene DNA adducts in smokers’ lung: Comparison with aromatic/hydrophobic adduct formation. Carcinogenesis, 23, 1967–1969.
• Ahima, R. S., & Flier, J. S. (2000). Adipose tissue as an endocrine organ. Trends in Endocrinology and Metabolism, 11(8), 327–332.
• Aparicio, T., Kotelevets, L., & Tsocas, A., et al. (2005). Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in apc (min/+) mice. Gut, 54, 1136–1145.
• Barber, M. D., McMillan, D. C., Wallace, A. M., Ross, J. A., Preston, T., & Fearon, K. C. (2004). The response of leptin, interleukin-6, and fat oxidation to feeding in weight-losing patients with pancreatic cancer. British Journal of Cancer, 90(6), 1129–1132.
• Benamouzing, R., & Chaussade, S. (1999). Calcium supplementation for preventing colorectal cancer: Where do we stand? The Lancet, 364, 1197–1199.
• Bjorbae, C., & Kahn, B. B. (2004). Leptin signaling in the central nervous system and the periphery. Recent Progress in Hormone Research, 59, 305–331.
• Byers, T., & Perry, G. (1992). Dietary carotenes, vitamin C, and vitamin E as protective antioxidants in human cancers. Annual Review of Nutrition, 12, 139–159.
• Byers, T., Nestle, M., & McTierman, A. (2002). American Cancer Society guidelines on nutrition and physical activity for cancer prevention: Reducing the risk of cancer with healthy food choices and physical activity. CA: A Cancer Journal for Clinicians, 52, 92–119.
• Calle, E. E., Miracle-McMahill, H. L., Thun, M. J., & Heath, C. W. (1995). Estrogen replacement therapy and risk of fatal colon cancer in a prospective cohort of postmenopausal women. Journal of the National Cancer Institute, 87(7), 517–523.
• Carol, J., Fabian, C. J., Kimler, B. F., & Hursting, S. D. (2015). Omega-3 fatty acids for breast cancer prevention and survivorship. Breast Cancer Research, 17(1), 62.
• Clark, L. C., Combs Jr., G. F., Turnbull, B. W., Slate, E. H., & Chalker, D. K., et al. (1996). Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: A randomized controlled trial. JAMA, 276(24), 1957–1963.
• Cleary, M. P., Phillips, F. C., Getzin, S. C., Jacobson, T. L., & Jacobson, M. K., et al. (2003). Genetically obese MMTV-TGF-alpha/lep(ob)lep(ob) female mice do not develop mammary tumors. Best Cancer Management Team, 77(3), 205–215.
• Cioffi, J. A., Shafer, A. W., Zupancic, T. J., Smith-Gbur, J., Mikhail, A., Platika, D., & Snodgrass, H. R. (1996). Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction. Nature Medicine, 2(5), 585–589.
• Correia, M. L., & Haynes, W. G. (2004). Obesity-related hypertension: Is there a role for selective leptin resistance? Current Hypertension Reports, 6(3), 230–235.
• Cui, Y., Miller, A. B., & Rohan, T. E. (2006). Cigarette smoking and breast cancer risk: Update of a prospective cohort study. Randomized Controlled Trial, 100, 293–299.
• Cooney, K. A., & Gruber, S. B. (2005). Hyperglycemia, obesity, and cancer risks on the horizon. JAMA, 293(2), 235–236.
• Doll, R., & Peto, R. (1981). The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today. Journal of the National Cancer Institute, 66, 1191–1308.
• Eaton, L. (2003). World cancer rates set to double by 2020. BMJ, 326(7392), 728.
• Faust, I. M., Johnson, P. R., & Hirsch, J. J. S. (1977). Adipose tissue regeneration following lipectomy. Science, 197(4301), 391–393.
• Futreal, P. A., Kasprzyk, A., Birney, E., Mullikin, J. C., Wooster, R., & Stratton, M. (2001). Cancer and genomics. Nature, 6822, 850–852.
• Haber, D. (2000). Roads leading to breast cancer. The New England Journal of Medicine, 343(21), 1566–1568.
• Hussain, Z., & Khan, J. A. (2017). Food intake regulation by leptin: Mechanisms mediating gluconeogenesis and energy expenditure. Asian Pacific Journal of Tropical Medicine, 10(10), 940–944.
• Hukshorn, C. J., & Saris, W. H. (2004). Leptin and energy expenditure. Current Opinion in Clinical Nutrition and Metabolic Care, 7(6), 629–633.
• Hadley, C., Miller, E., & Schwartz, S., et al. (2002). Tomatoes, lycopene, and prostate cancer: Progress and promise. Experimental Biology and Medicine, 227, 869–880.
• Hardwick, J. C., Van Den Brink, G. R., Offerhaus, G. J., Van Deventer, S. J., & Peppelenbosch, M. P. (2001). Leptin is a growth factor for colonic epithelial cells. Gastroenterology, 121(1), 79–90.
• Hu, X., Juneja, S. C., Maihle, N. J., & Cleary, M. P. (2002). Leptin—A growth factor in normal and malignant breast cells and for normal mammary gland development. Journal of the National Cancer Institute, 94(22), 1704–1711.
• Hoda, M. R., Keely, S. J., Bertelsen, L. S., Junger, W. G., Dharmasena, D., & Barrett, K. E. (2007). Leptin acts as a mitogenic and anti-apoptotic factor for colonic cancer cells. British Journal of Cancer, 94(3), 346–354.
• Hedayati, M., Yaghmaei, P., Pooyamanesh, Z., Yegane, M. Z., & Rad, L. H. (2011). Leptin: A correlated peptide to papillary thyroid carcinoma? Journal of Thyroid Research, 832163.
• Israel, K., Sanders, B. G., & Kline, K. (1995). RRR-alpha-tocopheryl succinate inhibits the proliferation of human prostatic tumor cells with defective cell cycle/differentiation pathways. Nutrition and Cancer, 24, 161–169.
• Ishikawa, M., Kitayama, J., & Nagawa, H. (2004). Enhanced expression of leptin and leptin receptor (ob-r) in human breast cancer. Clinical Cancer Research, 10(13), 4325–4331.
• Kakehi, E., Kotani, K., Nakamura, T., Takeshima, T., & Kajii, E. (2018). Non-diabetic glucose levels and cancer mortality: A literature review. Current Diabetes Reviews, 14(5), 434–445.
• Kune, G., & Watson, L. (2006). Colorectal cancer protective effects and the dietary micronutrients folate, methionine, vitamins B6, B12, C, E, selenium, and lycopene. Nutrition Cancer, 56(1), 11–21.
• Kim, J., Lim, S. Y., Shin, A., Sung, M. K., Ro, J., Kang, H. S., Lee, K. S., Kim, S. W., & Lee, E. S. (2009). Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: A case-control study. BMC Cancer, 9, 216.
• Kolaczynski, J. W., Considine, R. V., Ohannesian, J., Marco, C., Opentanova, I., Nyce, M. R., Myint, M., & Caro, J. F. (1996). Responses of leptin to short-term fasting and refeeding in humans: A link with ketogenesis but not ketones themselves. Diabetes, 45(11), 1511–1515.
• Liu, Z., Uesaka, T., Watanabe, H., & Kato, N. (2001). High-fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin. International Journal of Oncology, 19(5), 1009–1014.
• Ma, Y., Trump, D. L., & Johnson, C. S. (2010). Vitamin D in combination cancer treatment. Journal of Cancer, 1, 101–107.
• Mark, A. L., Correia, M. L., Rahmouni, K., & Haynes, W. G. (2004). Loss of leptin actions in obesity: Two concepts with cardiovascular implications. Clinical and Experimental Hypertension, 26(7–8), 629–636.
• Meier, U., & Gressner, A. M. (2004). Endocrine regulation of energy metabolism: Review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clinical Chemistry, 50(9), 1511–1525.
• Miyazawa-Hoshimoto, S., Takahashi, K., Bujo, H., Hashimoto, N., Yagui, K., & Saito, Y. (2004). The roles of degree of fat deposition and its localization on VEGF expression in adipocytes. The American Journal of Physiology-Endocrinology and Metabolism, 288, E1128–E1136.
• Mourouti, N., Panagiotakos, D. B., Kotteas, E. A., & Syrigos, K. N. (2017). Optimizing diet and nutrition for cancer survivors: A review. Maturitas, 105, 33–36.
• Moller, H., Mellemgaard, A., Lindvig, K., & Olsen, J. H. (1994). Obesity and cancer risk: A Danish record-linkage study. European Journal of Cancer, 30A(3), 344–350.
• Michaud, D. S., Giovannucci, E., Willett, W. C., Colditz, G. A., Stampfer, M. J., & Fuchs, C. S. (2001). Physical activity, obesity, height, and the risk of pancreatic cancer. Journal of the American Medical Association, 286(8), 921–929.
• Nixon, D. W. (1990). Nutrition and cancer: American Cancer Society guidelines, programs, and initiatives. CA: A Cancer Journal for Clinicians, 40(2), 71–75.
• O'Brien, S. N., Welter, B. H., & Price, T. M. (1999). Presence of leptin in breast cell lines and breast tumors. Biochemical and Biophysical Research Communications, 259(3), 695–698.
• Obeid, R. (2022). High plasma vitamin B12 and cancer in human studies: A scoping review to judge causality and alternative explanations. Nutrients, 14(21), 4476.
• Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2002). Global cancer statistics. CA: A Cancer Journal for Clinicians, 55(2), 74–108.
• Pisani, P., Parkin, D. M., Bray, F., & Ferlay, J. (1999). Estimates of the worldwide mortality from 25 cancers in 1990. The International Journal of Cancer, 83, 18–29.
• Peeters, P. H. M., Bueno-de-Mesquita, H. B., Boshuizen, H. C., Lahmann, P. H., Clavel-Chapelon, F., et al. (2005). Consumption of vegetables and fruits and risk of breast cancer. Journal of the American Medical Association, 293(2), 183–193.
• Popovic, V., Micic, D., Danjanovic, S., Zoric, S., Djurovic, M., Obradovic, S., Petakov, M., Dieguez, C., & Casanueva, F. F. (1998). Serum leptin and insulin concentrations in patients with insulinoma before and after surgery. European Journal of Endocrinology, 138(1), 86–88.
• Roslan, A., Sulaiman, N., Ghani, K. A. M., & Nurdin, A. (2022). Cancer-associated membrane protein as targeted therapy for bladder cancer. Pharmaceutics, 14, 2218.
• Redman, C., Scott, J. A., Baines, A. T., Basye, J. L., Clark, L. C., & Calley, C., et al. (1998). Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines. Cancer Targets, 125, 103–110.
• Rouet-Benzine, P., Aparicio, T., Guilmeau, S., Pouzet, C., Descatoire, V., Buyse, M., & Bado, A. (2004). Leptin counteracts sodium butyrate-induced apoptosis in human colon cancer HT-29 cells via NF-kappaB signaling. Journal of Biological Chemistry, 279(16), 16495–16502.
• Stattin, P., Soderberg, S., Hallmans, G., Bylund, A., Kaaks, R., Stenman, U. H., Bergh, A., & Olsson, T. (2001). Leptin is associated with increased prostate cancer risk: A nested case-referent study. The Journal of Clinical Endocrinology & Metabolism, 86(3), 1341–1345.
• Slattery, M. L., Caan, B. J., Potter, J. D., Berry, T. D., Coates, A., Duncan, D., & Edwards, S. L. (1997). Dietary energy sources and colon cancer risk. American Journal of Epidemiology, 145(3), 199–210.
• Sari, A. (2013). The relationship between leptin and fatty acid. Journal of Molecular Biomarkers & Diagnosis, 4(139), 2.
• Sierra-Honigmann, M. R., Nath, A. K., Murakami, C., Garcia-Cardena, G., Papapetropoulos, A., Sessa, W. C., Madge, L. A., Schechner, J. S., Schwabb, M. B., Polverini, P. J., & Flores-Riveros, J. R. (1998). Biological action of leptin as an angiogenic factor. Science, 281(5383), 1683–1686.
• Smith-Warner, S. A., Spiegelman, D., & Yaun, S. S., et al. (1998). Alcohol and breast cancer in women: A pooled analysis of cohort studies. Meta-Analysis, 279, 535–540.
• Smith-Kirwin, S. M., O'Connor, D. M., De Johnston, J., Lancey, E. D., Hassink, S. G., & Funanage, V. L. (1998). Leptin expression in human mammary epithelial cells and breast milk. The Journal of Clinical Endocrinology & Metabolism, 83(5), 1810–1813.
• Somasundar, P., Frankenberry, K. A., Skinner, H., Vedula, G., McFadden, D. W., Riggs, D., Jackson, B., Vangilder, R., Hileman, S. M., & Vona-Davis, L. C. (2004). Prostate cancer cell proliferation is influenced by leptin. Journal of Surgical Research, 118(1), 71–82.
• Thompson, H. J., Wilson, A., Lu, J., Singh, M., Jiang, C., & Upadhyay, P., et al. (1994). Comparison of the effects of an organic and an inorganic form of selenium on a mammary carcinoma cell line. Carcinogenesis, 5, 183–186.
• Terry, P., Rohan, T. E., Wolk, A., & Maehle-Schmidt, M. (2002). Fish consumption and breast cancer risk. Nutrition and Cancer, 44(1), 1–6.
• Venturelli, S., Leischner, C., Helling, T., Burkard, M., & Luigi, M. (2021). Vitamins as possible cancer biomarkers: Significance and limitations. Nutrients, 13(11), 3914.
• Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature, 372(6505), 425–432.
• Warren, B. S., & Devine, C. M. (2016). Meat, poultry, and fish and the risk of breast cancer. Cornell University on Breast Cancer and Environmental Risk Factors. Fact Sheet #39. Erişim adresi: http://envirocancer.cornell.edu. Erişim tarihi: 12.03.2016.
• Williams, G. M. (1992). DNA reactive and epigenetic carcinogens. Experimental and Toxicologic Pathology, 44, 457–464.
• Williams, G. M. (2001). Mechanisms of chemical carcinogenesis and application to human cancer risk assessment. Toxicology, 166(1–2), 3–10.
• World Cancer Research Fund (1997). Food, nutrition and prevention of cancer: A global perspective. Washington DC: World Cancer Research Fund, American Institute for Cancer Research.