Research Article
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Year 2025, Volume: 15 Issue: 3, 597 - 601, 30.09.2025
https://doi.org/10.33808/clinexphealthsci.1635799

Abstract

References

  • Carroll LJ, Hogg-Johnson S, van der Velde G, Haldeman S, Holm LW, Carragee EJ, Hurwitz EL, Côté P, Nordin M, Peloso PM, Guzman J, Cassidy JD. Course and prognostic factors for neck pain in the general population: results of the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders. J Manipulative Physiol Ther. 2009;32(2 Suppl):S87-96. https://doi.org/10.1016/j.jmpt.2008.11.013.
  • Carroll LJ, Hurwitz EL, Côté P, Hogg‑Johnson S, Carragee EJ, Nordin M, Holm LW, van der Velde G, Cassidy JD, Guzman J, Peloso PM, Haldeman S. Research priorities and methodological implications: the Bone and Joint Decade 2000–2010 Task Force on neck pain and its associated disorders. Spine (Phila Pa 1976). 2008;33(4):214–220. https://doi.org/10.1097/BRS.0b013e318164462c
  • Yang L, Yang C, Pang X, Li D, Yang H, Zhang X, Yi Y, Peng B. Mechanoreceptors in diseased cervical intervertebral disc and vertigo. Spine. 2017;42(8):540–546. https://doi.org/10.1097/BRS.0000000000001801
  • Evans G. Identifying and treating the causes of neck pain. Med Clin North Am. 2014;98(3):645–661. https://doi.org/10.1016/j.mcna.2014.01.015
  • Navone SE, Marfia G, Giannoni A, Beretta M, Guarnaccia L, Gualtierotti R, Nicoli D, Rampini P, Campanella R. Inflammatory mediators and signalling pathways controlling intervertebral disc degeneration. Histol Histopathol. 2017;32(6):523–542. https://doi.org/10.14670/HH‑11‑846
  • Wu SK, Chen HY, You JY, Bau JG, Lin YC, Kuo LC. Outcomes of active cervical therapeutic exercise on dynamic intervertebral foramen changes in neck pain patients with disc herniation. BMC Musculoskelet Disord. 2022;23(1):728. https://doi.org/10.1186/s12891‑022‑05670-6
  • Korniluk A, Koper‑Lenkiewicz OM, Kamińska J, Kemona H, Dymicka‑Piekarska V. Mean platelet volume (MPV): new perspectives for an old marker in the course and prognosis of inflammatory conditions. Mediators Inflamm. 2019:9213074. https://doi.org/10.1155/2019/9213074
  • Yi P, Jiang J, Wang Z, Wang X, Zhao M, Wu H, Ding Y. Comparison of mean platelet volume (MPV) and red blood cell distribution width (RDW) between psoriasis patients and controls: a systematic review and meta-analysis. PLoS One. 2022;17(2):e0264504. https://doi.org/10.1371/journal.pone.0264504
  • Taso M, Sommernes JH, Kolstad F, Sundseth J, Bjorland S, Pripp AH, Zwart JA, Brox JI. A randomised controlled trial comparing the effectiveness of surgical and nonsurgical treatment for cervical radiculopathy. BMC Musculoskelet Disord. 2020;21(1):171. https://doi.org/10.1186/s12891-020-3188-6
  • Bozan N, Alpaycı M, Aslan M, Cankaya H, Kıroğlu AF, Turan M, Ayral A, Senkoy E, Ilter S. Mean platelet volume, red cell distribution width, platelet‑to‑lymphocyte and neutrophil‑to‑lymphocyte ratios in patients with ankylosing spondylitis and their relationships with high‑frequency hearing thresholds. Eur Arch Otorhinolaryngol. 2016;273(11):3663–3672. https://doi.org/10.1007/s00405‑016‑3980‑y
  • Djuric N, Lafeber GCM, Vleggeert‑Lankamp CLA. The contradictory effect of macrophage-related cytokine expression in lumbar disc herniations: a systematic review. Eur Spine J. 2020;29(7):1649–1659. https://doi.org/10.1007/s00586-019-06220-w
  • Sadowska A, Touli E, Hitzl W, Greutert H, Ferguson SJ, Wuertz‑Kozak K, Hausmann ON. Inflammaging in cervical and lumbar degenerated intervertebral discs: analysis of proinflammatory cytokine and TRP channel expression. Eur Spine J. 2018;27(3):564–577. https://doi.org/10.1007/s00586‑017‑5360‑8
  • Zahorec R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102(1):5-14. PMID: 11723675
  • Kilinc E, Dagistan Y , Dagistan E, Cosgun Z. Is There a Link between Lumbar Disc Herniation and Hemogram Parameters? Anatol Clin 2016;69(11-12):411-414. https://doi.org/10.21673/anadoluklin.357593
  • Yang X, Arts MP, Bartels RHMA, Vleggeert‑Lankamp CLA. The type of cervical disc herniation on MRI does not correlate to clinical outcomes. Bone Joint J. 2022;104‑B(11):1242–1248. https://doi.org/10.1302/0301‑620X.104B11.BJJ‑2022‑0657.R2
  • Rzepakowska A, Pietruszewska W, Żurek M, Molga‑Magusiak M, Leszczyński M, Niemczyk K. Preoperative lymphocyte count, neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions—retrospective study. PeerJ. 2023;11:e15642. https://doi.org/10.7717/peerj.15642
  • Xiang Z, Liu W, Fu S, Hu J, Yang Y. Clinical value of lymphocyte count in autoimmune diabetic nephropathy. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023;48(11):1639–1649. https://doi.org/10.11817/j.issn.1672-7347.2023.230110

Can Systemic Inflammation Be Predicted in Cervical Discopathy Patients Using Hemogram Data?

Year 2025, Volume: 15 Issue: 3, 597 - 601, 30.09.2025
https://doi.org/10.33808/clinexphealthsci.1635799

Abstract

Objective: To compare hemogram data of patients with single-level discopathy, multi-level discopathy and no discopathy on cervical MRI
Methods: The patients' clinical history, MRI images and hemogram data were retrospectively accessed from our hospital data system. The subjects’ values of hemogram parameters including neutrophil count, lymphocyte count, white blood cell (WBC) count, platelet (PLT) count, neutrophil /lymphocyte ratio (NLR), PLT/lymphocyte ratio, MPV and RDW were recorded. In addition, cervical MRI images and radiological reports were accessed from the hospital data system.
Results: In the study, data from a total of 416 patients were evaluated in 3 groups. The first was the single-level cervical discopathy (CDH) group (n=79), the second was multilevel CDH (n=186), the third was the control group (n=151). Statistically, there was no difference between MPV, RDW, WBC, neutrophil and PLT counts in the three groups. While there was no difference between patients without discopathy detected on cervical MRI and patients with single-level discopathy, there was a statistical difference in the PLT/lymphocyte ratio and lymphocyte count compared to the multi-level CDH group. While the lymphocyte count was lower in the patient group without discopathy (p=0.012), the Plt/lymphocyte ratio was higher (p=0.02).
Conclusion: This study, which we conducted using the hemogram data of patients with and without cervical discopathy detected on cervical MRI, shows that we cannot predict systemic inflammation using only the hemogram data.

References

  • Carroll LJ, Hogg-Johnson S, van der Velde G, Haldeman S, Holm LW, Carragee EJ, Hurwitz EL, Côté P, Nordin M, Peloso PM, Guzman J, Cassidy JD. Course and prognostic factors for neck pain in the general population: results of the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders. J Manipulative Physiol Ther. 2009;32(2 Suppl):S87-96. https://doi.org/10.1016/j.jmpt.2008.11.013.
  • Carroll LJ, Hurwitz EL, Côté P, Hogg‑Johnson S, Carragee EJ, Nordin M, Holm LW, van der Velde G, Cassidy JD, Guzman J, Peloso PM, Haldeman S. Research priorities and methodological implications: the Bone and Joint Decade 2000–2010 Task Force on neck pain and its associated disorders. Spine (Phila Pa 1976). 2008;33(4):214–220. https://doi.org/10.1097/BRS.0b013e318164462c
  • Yang L, Yang C, Pang X, Li D, Yang H, Zhang X, Yi Y, Peng B. Mechanoreceptors in diseased cervical intervertebral disc and vertigo. Spine. 2017;42(8):540–546. https://doi.org/10.1097/BRS.0000000000001801
  • Evans G. Identifying and treating the causes of neck pain. Med Clin North Am. 2014;98(3):645–661. https://doi.org/10.1016/j.mcna.2014.01.015
  • Navone SE, Marfia G, Giannoni A, Beretta M, Guarnaccia L, Gualtierotti R, Nicoli D, Rampini P, Campanella R. Inflammatory mediators and signalling pathways controlling intervertebral disc degeneration. Histol Histopathol. 2017;32(6):523–542. https://doi.org/10.14670/HH‑11‑846
  • Wu SK, Chen HY, You JY, Bau JG, Lin YC, Kuo LC. Outcomes of active cervical therapeutic exercise on dynamic intervertebral foramen changes in neck pain patients with disc herniation. BMC Musculoskelet Disord. 2022;23(1):728. https://doi.org/10.1186/s12891‑022‑05670-6
  • Korniluk A, Koper‑Lenkiewicz OM, Kamińska J, Kemona H, Dymicka‑Piekarska V. Mean platelet volume (MPV): new perspectives for an old marker in the course and prognosis of inflammatory conditions. Mediators Inflamm. 2019:9213074. https://doi.org/10.1155/2019/9213074
  • Yi P, Jiang J, Wang Z, Wang X, Zhao M, Wu H, Ding Y. Comparison of mean platelet volume (MPV) and red blood cell distribution width (RDW) between psoriasis patients and controls: a systematic review and meta-analysis. PLoS One. 2022;17(2):e0264504. https://doi.org/10.1371/journal.pone.0264504
  • Taso M, Sommernes JH, Kolstad F, Sundseth J, Bjorland S, Pripp AH, Zwart JA, Brox JI. A randomised controlled trial comparing the effectiveness of surgical and nonsurgical treatment for cervical radiculopathy. BMC Musculoskelet Disord. 2020;21(1):171. https://doi.org/10.1186/s12891-020-3188-6
  • Bozan N, Alpaycı M, Aslan M, Cankaya H, Kıroğlu AF, Turan M, Ayral A, Senkoy E, Ilter S. Mean platelet volume, red cell distribution width, platelet‑to‑lymphocyte and neutrophil‑to‑lymphocyte ratios in patients with ankylosing spondylitis and their relationships with high‑frequency hearing thresholds. Eur Arch Otorhinolaryngol. 2016;273(11):3663–3672. https://doi.org/10.1007/s00405‑016‑3980‑y
  • Djuric N, Lafeber GCM, Vleggeert‑Lankamp CLA. The contradictory effect of macrophage-related cytokine expression in lumbar disc herniations: a systematic review. Eur Spine J. 2020;29(7):1649–1659. https://doi.org/10.1007/s00586-019-06220-w
  • Sadowska A, Touli E, Hitzl W, Greutert H, Ferguson SJ, Wuertz‑Kozak K, Hausmann ON. Inflammaging in cervical and lumbar degenerated intervertebral discs: analysis of proinflammatory cytokine and TRP channel expression. Eur Spine J. 2018;27(3):564–577. https://doi.org/10.1007/s00586‑017‑5360‑8
  • Zahorec R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102(1):5-14. PMID: 11723675
  • Kilinc E, Dagistan Y , Dagistan E, Cosgun Z. Is There a Link between Lumbar Disc Herniation and Hemogram Parameters? Anatol Clin 2016;69(11-12):411-414. https://doi.org/10.21673/anadoluklin.357593
  • Yang X, Arts MP, Bartels RHMA, Vleggeert‑Lankamp CLA. The type of cervical disc herniation on MRI does not correlate to clinical outcomes. Bone Joint J. 2022;104‑B(11):1242–1248. https://doi.org/10.1302/0301‑620X.104B11.BJJ‑2022‑0657.R2
  • Rzepakowska A, Pietruszewska W, Żurek M, Molga‑Magusiak M, Leszczyński M, Niemczyk K. Preoperative lymphocyte count, neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions—retrospective study. PeerJ. 2023;11:e15642. https://doi.org/10.7717/peerj.15642
  • Xiang Z, Liu W, Fu S, Hu J, Yang Y. Clinical value of lymphocyte count in autoimmune diabetic nephropathy. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023;48(11):1639–1649. https://doi.org/10.11817/j.issn.1672-7347.2023.230110
There are 17 citations in total.

Details

Primary Language English
Subjects Pain, Orthopaedics
Journal Section Articles
Authors

Deniz Bulut 0000-0001-8156-7639

Hüseyin Aydoğmuş 0000-0001-5231-1941

Early Pub Date September 30, 2025
Publication Date September 30, 2025
Submission Date February 8, 2025
Acceptance Date August 1, 2025
Published in Issue Year 2025 Volume: 15 Issue: 3

Cite

APA Bulut, D., & Aydoğmuş, H. (2025). Can Systemic Inflammation Be Predicted in Cervical Discopathy Patients Using Hemogram Data? Clinical and Experimental Health Sciences, 15(3), 597-601. https://doi.org/10.33808/clinexphealthsci.1635799
AMA Bulut D, Aydoğmuş H. Can Systemic Inflammation Be Predicted in Cervical Discopathy Patients Using Hemogram Data? Clinical and Experimental Health Sciences. September 2025;15(3):597-601. doi:10.33808/clinexphealthsci.1635799
Chicago Bulut, Deniz, and Hüseyin Aydoğmuş. “Can Systemic Inflammation Be Predicted in Cervical Discopathy Patients Using Hemogram Data?”. Clinical and Experimental Health Sciences 15, no. 3 (September 2025): 597-601. https://doi.org/10.33808/clinexphealthsci.1635799.
EndNote Bulut D, Aydoğmuş H (September 1, 2025) Can Systemic Inflammation Be Predicted in Cervical Discopathy Patients Using Hemogram Data? Clinical and Experimental Health Sciences 15 3 597–601.
IEEE D. Bulut and H. Aydoğmuş, “Can Systemic Inflammation Be Predicted in Cervical Discopathy Patients Using Hemogram Data?”, Clinical and Experimental Health Sciences, vol. 15, no. 3, pp. 597–601, 2025, doi: 10.33808/clinexphealthsci.1635799.
ISNAD Bulut, Deniz - Aydoğmuş, Hüseyin. “Can Systemic Inflammation Be Predicted in Cervical Discopathy Patients Using Hemogram Data?”. Clinical and Experimental Health Sciences 15/3 (September2025), 597-601. https://doi.org/10.33808/clinexphealthsci.1635799.
JAMA Bulut D, Aydoğmuş H. Can Systemic Inflammation Be Predicted in Cervical Discopathy Patients Using Hemogram Data? Clinical and Experimental Health Sciences. 2025;15:597–601.
MLA Bulut, Deniz and Hüseyin Aydoğmuş. “Can Systemic Inflammation Be Predicted in Cervical Discopathy Patients Using Hemogram Data?”. Clinical and Experimental Health Sciences, vol. 15, no. 3, 2025, pp. 597-01, doi:10.33808/clinexphealthsci.1635799.
Vancouver Bulut D, Aydoğmuş H. Can Systemic Inflammation Be Predicted in Cervical Discopathy Patients Using Hemogram Data? Clinical and Experimental Health Sciences. 2025;15(3):597-601.

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