A therapeutic role of chemical agents in experimental interstitial cystitis models

Year 2011, Volume: 1 Issue: 1, 57 - 64, 31.01.2014

Feriha Ercan Şule Çetinel

Abstract

Experimental interstitial cystitis (IC) models can be set as intravesical installations of chemical substances such as protamin sulfate, systemic application of chemical substances such as lipopolysaccharides, or environmental stress stimulation like cold, acute/chronic stress models. In the studies regarding IC besides denervation of afferent nerve fibers, several antioxidant agents demonstrated a prominent regeneration as inactivation of mast cells, reconstitution of leaky tight junctions in urothelium. Those agents also prevent formation of reactive oxygen radicals, besides inactivation of afferent nerve fibers containing neurotransmitter like substance P. The chemical agents used in those experimental studies are promising for the future treatment models in IC.

Key words: Experimental, interstitial cystitis, mast cell, inflammation, urinary bladder, chemical agents

 

 

Keywords

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Deneysel interstisyel sistit modellerinde kimyasal ajanların tedavi edici rolü

Abstract

Deneysel interstisyel sistit (İS) protamin sülfat (PS) gibi kimyasal maddelerin intravezikal verilmesiyle, lipopolisakkarid gibi kimyasal maddelerin sistemik olarak uygulanmasıyla ya da soğuk, akut ve kronik stres gibi sistemik çevresel uyaranlarla oluşturulabilmektedir. Bu İS modellerinde kullanılan bir çok antioksidan ve antienflamatuvar ajanın yanı sıra afferent sinir lifleri denervasyonunun mast hücresi salgılarını inhibe ettiği, mesane duvarında meydana gelen mast hücre degranülasyonunu ve ürotelyum hücreleri arasındaki bağlantıların açılmasını engellediği, P maddesi gibi nörotransmitterleri taşıyan afferent sinirlerin aktivasyonunu ve reaktif oksijen radikallerinin oluşumunu engellediği gösterilmiştir. Yapılan deneysel çalışmalarda iyileştirici etkisi gösterilen kimyasal ajanların İS tedavilerine ışık tutması açısından önemlidir. 

Anahtar Kelimeler: Deneysel, interstisyel sistit, mast hücresi, enflamasyon, mesane, kimyasal ajanlar

Keywords

Deneysel, interstisyel sistit, mast hücresi, enflamasyon, mesane, kimyasal ajanlar

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