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Disruption of bacterial cell-to-cell communication (Quorum Sensing): a promising novel way to combat bacteria-mediated diseases

Year 2013, Volume: 3 Issue: 3, 159 - 163, 30.01.2014

Abstract

Antibiotics are commonly used for the treatment of bacterial infections. The inappropriate and indiscriminate application of antibiotics in pharmacotherapy has led to the development of widespread resistance to these agents. With the emergence and spread of multi antibiotic-resistant bacteria, it is becoming increasingly more difficult to treat bacterial infections with currently available antibiotics. Thus, we are facing a post-antibiotic era with a reduced capability to fight bacteria, and, hence, there is an increasing need for new strategies to cope with infectious diseases. The discovery that many pathogenic bacteria employ quorum sensing (QS) to regulate their pathogenicity and virulence factor production makes the QS system an attractive target for antimicrobial therapy. Targeting the pathogenesis instead of killing the organism may provide less selective pressure for the development of resistance. Therefore, it has been suggested that inactivating the QS system in bacteria by the use of QS inhibitors holds great promise for the treatment of infectious diseases.


Key words: Cell-to-cell communication, antibiotic resistance, quorum sensing inhibitors

References

  • Livermore DM. The need for new antibiotics. Clin Microbiol Infect. 2004; 10(Suppl 4):1-9.
  • Hentzer M, Givskov M. Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. J Clin Invest. 2003;112: 1300-1307.
  • Rasmussen TB, Givskov M. Quorum-sensing inhibitors as antipathogenic drugs. Int J Med Microbiol. 2006; 296:149-161.
  • Fuqua WC, Winans SC, Greenberg EP. Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J Bacteriol. 1994;176:269-275.
  • Nealson KH, Platt T and Hastings JW. Cellular control of the synthesis and activity of the bacterial luminescent system. J Bacteriol. 1970; 104:313-322.
  • Rasmussen TB, Manefield M, Andersen JB, Eberl L, Anthoni U, Christophersen C, Steinberg P, Kjelleberg S, Givskov M. How Delisea pulchura furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1. Microbiol. 2000;146: 3237-3244.
  • Antunes LCM, Ferreira RBR. Intercellular communication in bacteria. Crit Rev Microbiol. 2009; 35:69-80.
  • Bosgelmez-Tinaz G. Quorum Sensing in Gram-Negative Bacteria. Turk J Biol. 2003; 27: 85-93.
  • Smith RS, Iglewski BH. Pseudomonas aeruginosa quorum sensing systems and virulence. Curr Opin Microbiol. 2003; 6:56-60.
  • Atkinson S, Throup JP, Stewart GSAB, Williams PA. Hierarchical quorum-sensing system in Yersinia pseudotuberculosis is involved in the regulation of motility and clumping. Mol Microbiol. 1999; 33:1267-1277.
  • Lutter E, Lewenza S, Dennis JJ, Visser MB, Sokol PA. Distribution of quorum-sensing genes in the Burkholderia cepacia complex. Infect Immun. 2001; 69(7): 4661-4666.
  • Surette MG, Bassler BL. Quorum sensing in Escherichia coli and Salmonella typhimurium. P Natl Acad Sci USA. 1998; 95: 7046-7050.
  • Davies DG, Parsek MR, Pearson JP, Iglewski BH, Costerton JW, Greenberg EP. The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science 1998;280:295-298.
  • Bjarnsholt T, Jensen OP, Burmolle M, Hentzer M, Haagensen JAJ, Hougen HP, Calum H, Madsen KG, Moser C, Molin S, Hoiby N, Givskov M. Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent. Microbiol. 2005;151:373-383.
  • Rasmussen TB, Bjarnsholt T, Skindorsoe, ME, Hentzer M, Kristoffersen P, Kote M, Nielsen J, Eberl L, Givskov M. Screening for quorumsensing inhibitors (QSI) by use a novel genetic system, the QS selector. J Bacteriol. 2005;187(5):1799-1814.
  • Şentürk S, Ulusoy S, Boşgelmez-Tınaz G, Karahasan A. Quorum sensing and virulence of Pseudomonas aeruginosa during urinary tract infections. J Infect Dis Dev Count. 2012; 6(6):501-507
  • Rumbaugh KP, Griswold JA, Iglewski, BH, Hamood AN. Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections. Infect Immun. 1999; 67: 5854-5862.
  • Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science. 1999;284:1318-1322.
  • Estrela AB, Heck MG, Abraham WR. Novel approaches to control biofilm infections. Curr Med Chem. 2009;16:1512-1530.
  • Kociolek MG. Quorum sensing inhibitors and biofilms. Anti-infect Agents Med Chem. 2009;8:315-326.
  • Hİiby N, Bjarnsholt T, Givskov M, Molin S, Ciofu O. Antibiotic resistance of bacterial biofilms. Int J Antimicrob Ag. 2010;35:322–332.
  • Bosgelmez-Tinaz G, Ulusoy S, Ugur A, Ceylan O. Inhibition of quorum sensing regulated behaviors by Scorzonera sandrasica. Curr Microbiol. 2007; 55: 114-118.
  • Galloway WRJD, Hodgkinson JT, Bowden SD, Welch M, Spring DR. Quorum sensing in gram-negative bacteria: Small molecule modulation of AHL and AI-2 quorum sensing pathways. Chem Rev. 2011;111:28–67.
  • Gram L, de Nys R, Maximillien R, Givskov M, Steinberg P, Kjelleberg S. Inhibitory effects of secondary metabolites from the re dalga Delisea pulchra on swarming motility of Proteus mirabilis. Appl Environ Microbiol. 1996; 62(11): 4284-4287.
  • Hentzer M, Riedel K, Rasmussen TB, Heydorn AJB, Andersen JB, Parsek MR, Rice SA, Eberl S, Molin N, Hoiby N, Kjelleberg S, Givskov M. Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furonone compound. Microbiol. 2002;148: 87Girennavar B, Cepeda ML, Soni KA, Vikram A, Jesudhasan P, Jayaprakasha GK, Pillai SD, Patil B. Grapefruit juice and its furocoumarins inhibits autoinducer signaling and biofilm formation in bacteria. Int J Food Microbiol. 2008; 125: 204-208.
  • Givskov M, de Nys R, Manefield M, Gram L, Maximilien R, Eberl L, Molin S, Steinberg PD, Kjelleberg, S. Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling. J Bacteriol. 1996; 178: 6618-6622.
  • Raffa RB, Iannuzzo JR, Levine DR, Saeid KK, Schwartz RC, Sucic NT, Terleckyj OD, Young JM. Bacterial communication (“quorum sensing”) via ligands and receptors: A novel pharmacologic target for the design of antibiotic drugs. J Pharmacol Exp Ther. 2005;312:417– 4
  • Yang L, Rybtke MT, Jakobsen TH, Hentzer M, Bjarnsholt T, Givskov M, Tolker-Nielsen T. Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors. Antimicrob Agents Chemother. 2009;53:2432–2443.
  • Adonizio AL, Downum K, Bennett BC, Mathee K. Anti-quorum sensing activity of medicinal plants in Southern Florida. J Ethnopharmacol. 2006; 105: 427-435.
  • Skindersoe ME, Alhede M, Phipps R, Yang L, Jensen PO, Rasmussen TB, Bjarnsholt T, Tolker-Nielsen T, Hoeiby N, Givskov M. Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa. Antimicrob Agents and Chemother. 2008;52:3648-3663.
  • Garske LA, Beatson SA, Leech AJ, Walsh SL, Bell SC. Sub-inhibitory concentrations of ceftazidime and tobramycin reduce the quorum sensing signals of Pseudomonas aeruginosa. Pathology. 2004;36:5715

Bakteriyel iletişimin sisteminin (Quorum Sensing) kesilmesi: Bakteri aracılı hastalıklarla savaşta umut vaat eden yeni bir yol

Year 2013, Volume: 3 Issue: 3, 159 - 163, 30.01.2014

Abstract

Antibiyotikler bakteriyel enfeksiyonların tedavisinde yaygın bir şekilde kullanılmaktadırlar. İlaç tedavisinde antibiyotiklerin gereksiz ve rastgele kullanımları, bu ajanlara karşı yaygın direnç gelişmesine neden olmuştur. Çoklu antibiyotik direncine sahip bakterilerin ortaya çıkması ve hızla yayılması, halihazırda mevcut antibiyotiklerle bakteriyel infeksiyonların tedavisini giderek güçleştirmektedir. Dolayısıyla, bakterilerle savaş yeteneğimizin azaldığı post-antibiyotik bir dönemle karşı karşıyayız ve infeksiyöz hastalıklarla başa çıkmak için yeni stratejilere olan gereksinim gün geçtikçe artmaktadır. Patojenik bakterilerin patojenite ve virülans faktörlerinin üretimini bakteriler arası iletişim sistemini kullanarak düzenlendiklerinin keşfi, bakteriler arası iletişim sistemini antimikrobiyal tedavi için cazip bir hedef haline getirmiştir. Bakterileri öldürmek yerine patogenezi hedef almak, direnç gelişimi için daha az seçici baskı uygulayabilir, bu nedenle bakteriyel iletişim inhibitörleri kullanarak bakteriler arası iletişimin inaktive edilmesi, infeksiyöz hastalıkların tedavisi için büyük umut vaat etmektedir.


Anahtar Kelimeler : Hücreler arası iletişim, antibiyotik direnci, quorum sensing inhibitörleri

References

  • Livermore DM. The need for new antibiotics. Clin Microbiol Infect. 2004; 10(Suppl 4):1-9.
  • Hentzer M, Givskov M. Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. J Clin Invest. 2003;112: 1300-1307.
  • Rasmussen TB, Givskov M. Quorum-sensing inhibitors as antipathogenic drugs. Int J Med Microbiol. 2006; 296:149-161.
  • Fuqua WC, Winans SC, Greenberg EP. Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J Bacteriol. 1994;176:269-275.
  • Nealson KH, Platt T and Hastings JW. Cellular control of the synthesis and activity of the bacterial luminescent system. J Bacteriol. 1970; 104:313-322.
  • Rasmussen TB, Manefield M, Andersen JB, Eberl L, Anthoni U, Christophersen C, Steinberg P, Kjelleberg S, Givskov M. How Delisea pulchura furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1. Microbiol. 2000;146: 3237-3244.
  • Antunes LCM, Ferreira RBR. Intercellular communication in bacteria. Crit Rev Microbiol. 2009; 35:69-80.
  • Bosgelmez-Tinaz G. Quorum Sensing in Gram-Negative Bacteria. Turk J Biol. 2003; 27: 85-93.
  • Smith RS, Iglewski BH. Pseudomonas aeruginosa quorum sensing systems and virulence. Curr Opin Microbiol. 2003; 6:56-60.
  • Atkinson S, Throup JP, Stewart GSAB, Williams PA. Hierarchical quorum-sensing system in Yersinia pseudotuberculosis is involved in the regulation of motility and clumping. Mol Microbiol. 1999; 33:1267-1277.
  • Lutter E, Lewenza S, Dennis JJ, Visser MB, Sokol PA. Distribution of quorum-sensing genes in the Burkholderia cepacia complex. Infect Immun. 2001; 69(7): 4661-4666.
  • Surette MG, Bassler BL. Quorum sensing in Escherichia coli and Salmonella typhimurium. P Natl Acad Sci USA. 1998; 95: 7046-7050.
  • Davies DG, Parsek MR, Pearson JP, Iglewski BH, Costerton JW, Greenberg EP. The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science 1998;280:295-298.
  • Bjarnsholt T, Jensen OP, Burmolle M, Hentzer M, Haagensen JAJ, Hougen HP, Calum H, Madsen KG, Moser C, Molin S, Hoiby N, Givskov M. Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent. Microbiol. 2005;151:373-383.
  • Rasmussen TB, Bjarnsholt T, Skindorsoe, ME, Hentzer M, Kristoffersen P, Kote M, Nielsen J, Eberl L, Givskov M. Screening for quorumsensing inhibitors (QSI) by use a novel genetic system, the QS selector. J Bacteriol. 2005;187(5):1799-1814.
  • Şentürk S, Ulusoy S, Boşgelmez-Tınaz G, Karahasan A. Quorum sensing and virulence of Pseudomonas aeruginosa during urinary tract infections. J Infect Dis Dev Count. 2012; 6(6):501-507
  • Rumbaugh KP, Griswold JA, Iglewski, BH, Hamood AN. Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections. Infect Immun. 1999; 67: 5854-5862.
  • Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science. 1999;284:1318-1322.
  • Estrela AB, Heck MG, Abraham WR. Novel approaches to control biofilm infections. Curr Med Chem. 2009;16:1512-1530.
  • Kociolek MG. Quorum sensing inhibitors and biofilms. Anti-infect Agents Med Chem. 2009;8:315-326.
  • Hİiby N, Bjarnsholt T, Givskov M, Molin S, Ciofu O. Antibiotic resistance of bacterial biofilms. Int J Antimicrob Ag. 2010;35:322–332.
  • Bosgelmez-Tinaz G, Ulusoy S, Ugur A, Ceylan O. Inhibition of quorum sensing regulated behaviors by Scorzonera sandrasica. Curr Microbiol. 2007; 55: 114-118.
  • Galloway WRJD, Hodgkinson JT, Bowden SD, Welch M, Spring DR. Quorum sensing in gram-negative bacteria: Small molecule modulation of AHL and AI-2 quorum sensing pathways. Chem Rev. 2011;111:28–67.
  • Gram L, de Nys R, Maximillien R, Givskov M, Steinberg P, Kjelleberg S. Inhibitory effects of secondary metabolites from the re dalga Delisea pulchra on swarming motility of Proteus mirabilis. Appl Environ Microbiol. 1996; 62(11): 4284-4287.
  • Hentzer M, Riedel K, Rasmussen TB, Heydorn AJB, Andersen JB, Parsek MR, Rice SA, Eberl S, Molin N, Hoiby N, Kjelleberg S, Givskov M. Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furonone compound. Microbiol. 2002;148: 87Girennavar B, Cepeda ML, Soni KA, Vikram A, Jesudhasan P, Jayaprakasha GK, Pillai SD, Patil B. Grapefruit juice and its furocoumarins inhibits autoinducer signaling and biofilm formation in bacteria. Int J Food Microbiol. 2008; 125: 204-208.
  • Givskov M, de Nys R, Manefield M, Gram L, Maximilien R, Eberl L, Molin S, Steinberg PD, Kjelleberg, S. Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling. J Bacteriol. 1996; 178: 6618-6622.
  • Raffa RB, Iannuzzo JR, Levine DR, Saeid KK, Schwartz RC, Sucic NT, Terleckyj OD, Young JM. Bacterial communication (“quorum sensing”) via ligands and receptors: A novel pharmacologic target for the design of antibiotic drugs. J Pharmacol Exp Ther. 2005;312:417– 4
  • Yang L, Rybtke MT, Jakobsen TH, Hentzer M, Bjarnsholt T, Givskov M, Tolker-Nielsen T. Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors. Antimicrob Agents Chemother. 2009;53:2432–2443.
  • Adonizio AL, Downum K, Bennett BC, Mathee K. Anti-quorum sensing activity of medicinal plants in Southern Florida. J Ethnopharmacol. 2006; 105: 427-435.
  • Skindersoe ME, Alhede M, Phipps R, Yang L, Jensen PO, Rasmussen TB, Bjarnsholt T, Tolker-Nielsen T, Hoeiby N, Givskov M. Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa. Antimicrob Agents and Chemother. 2008;52:3648-3663.
  • Garske LA, Beatson SA, Leech AJ, Walsh SL, Bell SC. Sub-inhibitory concentrations of ceftazidime and tobramycin reduce the quorum sensing signals of Pseudomonas aeruginosa. Pathology. 2004;36:5715
There are 31 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Gulgun Bosgelmez-tinaz

Publication Date January 30, 2014
Submission Date January 30, 2014
Published in Issue Year 2013 Volume: 3 Issue: 3

Cite

APA Bosgelmez-tinaz, G. (2014). Bakteriyel iletişimin sisteminin (Quorum Sensing) kesilmesi: Bakteri aracılı hastalıklarla savaşta umut vaat eden yeni bir yol. Clinical and Experimental Health Sciences, 3(3), 159-163. https://doi.org/10.5455/musbed.20130910085643
AMA Bosgelmez-tinaz G. Bakteriyel iletişimin sisteminin (Quorum Sensing) kesilmesi: Bakteri aracılı hastalıklarla savaşta umut vaat eden yeni bir yol. Clinical and Experimental Health Sciences. February 2014;3(3):159-163. doi:10.5455/musbed.20130910085643
Chicago Bosgelmez-tinaz, Gulgun. “Bakteriyel iletişimin Sisteminin (Quorum Sensing) Kesilmesi: Bakteri aracılı hastalıklarla savaşta Umut Vaat Eden Yeni Bir Yol”. Clinical and Experimental Health Sciences 3, no. 3 (February 2014): 159-63. https://doi.org/10.5455/musbed.20130910085643.
EndNote Bosgelmez-tinaz G (February 1, 2014) Bakteriyel iletişimin sisteminin (Quorum Sensing) kesilmesi: Bakteri aracılı hastalıklarla savaşta umut vaat eden yeni bir yol. Clinical and Experimental Health Sciences 3 3 159–163.
IEEE G. Bosgelmez-tinaz, “Bakteriyel iletişimin sisteminin (Quorum Sensing) kesilmesi: Bakteri aracılı hastalıklarla savaşta umut vaat eden yeni bir yol”, Clinical and Experimental Health Sciences, vol. 3, no. 3, pp. 159–163, 2014, doi: 10.5455/musbed.20130910085643.
ISNAD Bosgelmez-tinaz, Gulgun. “Bakteriyel iletişimin Sisteminin (Quorum Sensing) Kesilmesi: Bakteri aracılı hastalıklarla savaşta Umut Vaat Eden Yeni Bir Yol”. Clinical and Experimental Health Sciences 3/3 (February 2014), 159-163. https://doi.org/10.5455/musbed.20130910085643.
JAMA Bosgelmez-tinaz G. Bakteriyel iletişimin sisteminin (Quorum Sensing) kesilmesi: Bakteri aracılı hastalıklarla savaşta umut vaat eden yeni bir yol. Clinical and Experimental Health Sciences. 2014;3:159–163.
MLA Bosgelmez-tinaz, Gulgun. “Bakteriyel iletişimin Sisteminin (Quorum Sensing) Kesilmesi: Bakteri aracılı hastalıklarla savaşta Umut Vaat Eden Yeni Bir Yol”. Clinical and Experimental Health Sciences, vol. 3, no. 3, 2014, pp. 159-63, doi:10.5455/musbed.20130910085643.
Vancouver Bosgelmez-tinaz G. Bakteriyel iletişimin sisteminin (Quorum Sensing) kesilmesi: Bakteri aracılı hastalıklarla savaşta umut vaat eden yeni bir yol. Clinical and Experimental Health Sciences. 2014;3(3):159-63.

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