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The role of endothelin-1 in the pathogenesis of diabetes

Year 2014, Volume: 4 Issue: 3, 158 - 167, 15.12.2014

Abstract

Diabetes mellitus is not only an endocrine system disease, it is also a vascular disease which has microvascular and macrovascular complications. Endothelial dysfunction occurs due to an imbalance between endothelium-derived dilator and constrictor factors which has a role in the pathogenesis or progression of diabetes microvascular and macrovascular complications. These complications are named as “diabetic vasculopathy”. Endothelin-1 (ET-1) is a potent vasoconstrictor autacoid and also has proinflammatory, profibrotic, and proliferative properties which may contribute to diabetic vasculopathy. Endothelial and vascular smooth muscle cell mechanism are intended for therapeutic targets of diabetic vasculopathy. Clinical trials and experimental studies with ET-1 antagonists give a hope for diabetic vasculopaty treatments. This review focuses on the role of ET-1 in the pathogenesis of diabetes and insulin resistance and discusses the potential therapeutic benefit of targeting ET-1 receptor antagonists particularly in the prevention of diabetic complications.

References

  • Takahashi, K, Brooks RA, Kanse SM, Ghatei MA, Kohner EM, Bloom SR. Production of endothelin 1 by cultured bovine retinal endothelial cells and presence of endothelin receptors on associated pericytes. Diabetes 1989;38:1200-1202.
  • Nyborg NC, Pieto D, Benedito S, Nielsen PJ. Role of the endothelium in acetylcholine-induced relaxation and spontaneous tone of bovine isolated retinal small arteries. Invest Ophthalmol Vis Sci. 1991;32:27- 31.
  • Fagan KA, McMurtry IF, Rodman DM. Role of endothelin-1 in lung disease. Respir Res. 2001;2:90-101.
  • Kayaalp O, Endotelin, Akılcı Tedavi Yönünden Tıbbi Farmakoloji. 13. Baskı, İstanbul: Güneş Tıp Kitabevi; 2012. s. 130-135.
  • Bouallegue A, Daou GB, Srivastava AK. Endothelin-1-induced signaling pathways in vascular smooth muscle cells. Curr Vasc Pharmacol. 2007;5:45-52.
  • Donald EK. Role of collecting duct endothelin in control of renal function and blood pressure. Am J Physiol. 2013;305:659-668.
  • Barton M, Yanagisawa M. Endothelin: 20 years from discovery to therapy. Can J Physiol Pharmacol. 2008;86:485-498.
  • Arai H, Hori S, Aramori I, Ohkubo H, Nakanishi S. Cloning and expression of a cDNA encoding an endothelin receptor. Nature. 1990;348:730-732.
  • Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, Masaki T. Cloning of a cDNA encoding a non-isopeptideselective subtype of the endothelin receptor. Nature. 1990;348:732-735.
  • Pierce KL, Premont RT, Lefkowitz RJ. Seven-transmembrane receptors. Nat Rev Mol Cell Biol. 2002;3:639-650.
  • Endoh M, Fujita S, Yang HT, Talukder MA, Maruya J, Norota I. Endothelin: receptor subtypes, signal transduction, regulation of Ca2+ transients and contractility in rabbit ventricular myocardium. Life Sci. 1998;62:1485-1489.
  • Galie N, Manes A, Branzi A. The endothelin system in pulmonary arterial hypertension. Cardiovasc Res. 2004;61:227-237.
  • Foschi M1, Chari S, Dunn MJ, Sorokin A. Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase. EMBO J. 1997; 3;16(21):6439-6451.
  • Bertram GK, Endothelins, Basic & Clinical Pharmacology.Twelfth Edition, USA: Mc Graw Hill Medical, 2012. p. 304-306.
  • Wasa S, Fan J, Miyauchi T, Watanabe T. Blockade of endothelin receptors reduces diet-induced hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice. Pathobiology. 2001;69:1-10.
  • Jansson PA. Endothelial dysfunction in insulin resistance and type 2 diabetes. J Intern Med. 2007;262:173-183.
  • Ergul A. Endothelin-1 and diabetic complications: focus on the vasculature. Pharmacol Res. 2011;63:477-482.
  • Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54:1615-1625.
  • Pernow J, Shemyakin A, Bohm F. New perspectives on endothelin-1 in atherosclerosis and diabetes mellitus. Life Sci. 2012;91:507-516.
  • Matsumoto T, Kobayashi T, Kamata K. Relationships among ET-1, PPARgamma, oxidative stress and endothelial dysfunction in diabetic animals. J Smooth Muscle Res. 2008;44:41-55.
  • Mather KJ. The vascular endothelium in diabetes-a therapeutic target? Rev Endocr Metab Disord. 2013;14:87-99.
  • Hocher B, Schwarz A, Reinbacher D, Jacobi J, Lun A, Priem F, Bauer C, Neumayer HH, Raschack M. Effects of endothelin receptor antagonists on the progression of diabetic nephropathy. Nephron. 2001;87:161-169.
  • Takayuki M, Rheure AML, Kumiko T, Tsuneo K, Rita C. Linking the beneficial effects of current therapeutic approaches in diabetes to the vascular endothelin system. Life Sci. 2014; Jan 11.
  • Ito H, Hirata Y, Adachi S, Tanaka M, Tsujino M, Koike A, Nogami A, Murumo F, Hiroe M. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest. 1993; 92: 398-403.
  • Sessa WC, Kaw S, Hecker M, Vane JR. The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes. Biochem Biophys Res Commun. 1991;174:613-618.
  • John P, Alexey S, Felix B. New perspectives on endothelin-1 in atherosclerosis and diabetes mellitus. Life Sci. 2012;91:507-516.
  • Yoshio T, Masuyama J, Mimori A, Takeda A, Minota S, Kano S. Endothelin-1 release from cultured endothelial cells induced by sera from patients with systemic lupus erythematosus. Ann Rheum Dis. 1995;54:361-365.
  • Hecker M, Vane JR. The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes. Biochem Biophys Res Commun. 1991;174:613-618.
  • Settergren M, Pernow J, Brismar K, Jorneskog G, Kalani M. Endothelin-A receptor blockade increases nutritive skin capillary circulation in patients with type 2 diabetes and microangiopathy. J Vasc Res. 2008;45:295-302.
  • Collier A, Leach JP, McLellan A, Jardine A, Morton JJ, Small M. Plasma endothelin-like immunoreactivity levels in IDDM patients with microalbuminuria. Diabetes Care. 1992;15:1038-1040.
  • Haak T, Jungmann E, Felber A, Hillmann U, Usadel KH. Increased plasma level of endothelin in diabetic patients with hypertension. Am J Hypertens. 1992;5:161-166.
  • Kawamura M, Ohgawara H, Naruse M, Suzudi N, Iwasaki N, Naruse K, Hori S, Demura H, Omori Y. Increased plasma endothelin in NIDDM patients with retinopathy. Diabetes Care. 1992;15:1396-1397.
  • Calles-Escandon J, Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev. 2001;22:36-52.
  • Taskinen M-R. Type 2 diabetes as a lipid disorder. Curr Mol Med. 2005;5:297-308.
  • Lundman P, Eriksson M, Schenck-Gustafsson K, Karpe F, Tornvall P. Transient triglyceridemia decreases vascular reactivity in young, healthy men without risk factors for coronary heart disease. Circulation. 1997;96:3266-3268.
  • Natali A, Toschi E, Baldeweg S, Casolaro A, Baldi S, Sironi AM, Yudkin JS, Ferrannini E. Haematocrit, type 2 diabetes, and endothelium- dependent vasodilatation of resistance vessels. Eur Heart J. 2000;21:515-520.
  • Goldfine A, Beckman J, Betensky R, Devlin H, Hurley S, Varo N, Schonbeck U, Patti ME, Creager MA. Family history of diabetes is a major determinant of endothelial function. J Am Coll Cardiol. 2006;47:2456-2461.
  • Nyström T, Gutniak M, Zhang Q, Holst JJ, Ahrén B, Sjöholm A. Effects of glucagons-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. Am J Physiol. 2004;287:E1209-E1215.
  • Caballero AE. Endothelial dysfunction in obesity and insülin resistance: a road to diabetes and heart disease. Obes Res. 2003;11:1278-1289.
  • Jeong-a K, Monica M, Kwang Kon K, Michael J.Q. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation. 2006;113:1888-1904.
  • Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001;414:799-806.
  • Nystrom FH, Quon MJ. Insulin signalling: metabolic pathways and mechanisms for specificity. Cell Signal. 1999;11:563-574.
  • Sedaghat AR, Sherman A, Quon MJ. A mathematical model of metabolic insulin signaling pathways. Am J Physiol. 2002;283:E1084-E1101.
  • Lam HC. Role of endothelin in diabetic vascular complications. Endocrine. 2001;14:277-284.
  • Kohner EM, Patel V, Rassam SM. Role of blood flowand impaired autoregulation in the pathogenesis of diabetic retinopathy. Diabetes. 1995;44:603-607.
  • Pang IH, Yorio T. Ocular actions of endothelins. Proc Soc Exp Biol Med. 1997;215:21-34.
  • Wang Z, Yadav AS, Leskova W, Harris NR. Attenuation of streptozotocininduced microvascular changes in the mouse retina with the endothelin receptor A antagonist atrasentan. Exp Eye Res. 2010;91:670-675.
  • Kalani M. The importance of endothelin-1 for microvascular dysfunction in diabetes. Vasc Health Risk Manag. 2008;4:1061-1068.
  • Fegan PG, Tooke JE, Gooding KM, Tullett JM, MacLeod KM, Shore AC. Capillary pressure in subjects with type 2 diabetes and hypertension and the effect of antihypertensive therapy. Hypertens. 2003;41:1111- 1117.
  • Dumont AS, Dumont RJ, McNeill JH, Kassell NF, Sutherland GR, Verma S. Chronic endothelin antagonism restores cerebrovascular function in diabetes. Neurosurgery. 2003;52:653-660.
  • Zimmermann PA, Knot HJ, Stevenson AS, Nelson MT. Increased myogenic tone and diminished responsiveness to ATP-sensitive K+ channel openers in cerebral arteries from diabetic rats. Circ Res. 1997;81:996-1004.
  • Didion SP, Lynch CM, Baumbach GL, Faraci FM. Impaired endothelium dependent responses and enhanced influence of Rho-kinase in cerebral arterioles in type II diabetes. Stroke. 2005;36:342-347.
  • Lenoir O, Milon M, Virsolvy A, Hénique C, Schmitt A, Massé JM, Kotelevtsev Y, Yanagisawa M, Webb DJ, Richard S, Tharaux PL. Direct action of endothelin-1 on podocytes promotes Diabetic Glomerulosclerosis. J Am Soc Nephrol. 2014;25:1050-1062.
  • Mather KJ. The vascular endothelium in diabetes-a therapeutic target? Rev Endocr Metab Disord. 2013;14:87-99.
  • Emori T, Hirata Y, Ohta K, Kanno K, Eguchi S, Imai T, Shichiri M, Marumo F. Cellular mechanism of endothelin-1 release by angiotensin and vasopressin. Hypertens. 1991;18:165-170.
  • Hong HJ, Chan P, Liu JC, Juan SH, Huang MT, Lin JG, Cheng TH. Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells. Cardiovasc Res. 2004;61:159-168.
  • An SJ, Boyd R, Zhu M, Chapman A, Pimentel DR, Wang HD. NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts. Cardiovasc Res. 2007;75:702-709.
  • Wenzel RR, Ruthemann J, Bruck H, Schafers RF, Michel MC, Philipp T. Endothelin-A receptor antagonist inhibits angiotensin II and noradrenaline in man. Br J Clin Pharmacol. 2001; 52: 151-157.
  • Gagliardini E, Corna D, Zoja C, Sangalli F, Carrara F, Rossi M, Conti S, Rottoli D, Longaretti L, Remuzzi A, Remuzzi G, Benigni A. Unlike each drug alone, lisinopril if combined with avosentan promotes regression of renal lesions in experimental diabetes. Am J Physiol Renal Physiol. 2009;297:F1448-F1456.
  • Goddard J, Eckhart C, Johnston NR, Cumming AD, Rankin AJ, Webb DJ. Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor- mediated and nitric oxide-dependent mechanism. J Am Soc Nephrol. 2004;15:2601-2610.
  • Struthers AD. Aldosterone-induced vasculopathy. Mol Cell Endocrinol. 2004;217:239-241.
  • Schiffrin EL. Effects of aldosterone on the vasculature. Hypertens. 2006;47:312-318.
  • Fredersdorf S1, Endemann DH, Luchner A, Heitzmann D, Ulucan C, Birner C, Schmid P, Stoelcker B, Resch M, Muders F, Riegger GA, Weil J. Increased aldosterone levels in a model of type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 2009;117:15-20.
  • Hollenberg NK, Stevanovic R, Agarwal A, Lansang MC, Price DA, Laffel LM, Williams GH, Fisher ND. Plasma aldosterone concentration in the patient with diabetes mellitus. Kidney Int. 2004;65:1435-1439.
  • Maron BA, Zhang YY, White K, Chan SY, Handy DE, Mahoney CE, Loscalzo J, Leopold JA. Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation. 2012;126:963-974.
  • Pu Q, Neves MF, Virdis A, Touyz RM, Schiffrin EL. Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling. Hypertension. 2003;42:49-55.
  • Barton M. Reversal of proteinuric renal disease and the emerging role of endothelin. Nat Clin Pract Nephrol. 2008;4:490-501.

Endotelin-1’in diyabet patojenezindeki rolü

Year 2014, Volume: 4 Issue: 3, 158 - 167, 15.12.2014

Abstract

Diyabet (diabetes mellitus) yalnızca endokrin sistem hastalığı olmayıp, mikrovasküler ve makrovasküler komplikasyonlara neden olabilen bir damar hastalığıdır. Endotelyal işlevde bozukluk, endotel kaynaklı vazokonstriktör ve vazodilatör maddeler arasındaki dengenin bozulması sonucu gelişmekte, bu nedenle diyabet hastalarında görülen mikrovasküler ve makrovasküler komplikasyonların patojenezinde yer almakta veya bu komplikasyonların ilerlemesine neden olmaktadır. Bu komplikasyonlar “diyabetik vaskülopati” olarak adlandırılmaktadır. Endotelin-1 (ET-1) güçlü vazokonstriktör bir otakoit olmasının yanı sıra, proenflamatuvar, proliferatif ve profibrotik özellikleriyle diyabetik vaskülopatiye neden olabilmektedir. Diyabetik vaskülopatinin gelişimini engellemek için kullanılan terapötik hedefler endotel ve damar düz kas hücrelerindeki mekanizmalara yöneliktir. Diyabetik vaskülopati tedavisinde ET-1 reseptör antagonistlerinin kullanılabileceğine ilişkin deneysel ve klinik çalışmaların sonuçları umut vermektedir. Bu derlemede, diyabet patojenezinde ve insülin direncinin gelişmesinde ET-1’in rolüne değinilerek, özellikle diyabetik komplikasyonların önlenmesinde ET-1 reseptör antagonistlerinin olası terapötik yararı üzerinde durulmuştur.

References

  • Takahashi, K, Brooks RA, Kanse SM, Ghatei MA, Kohner EM, Bloom SR. Production of endothelin 1 by cultured bovine retinal endothelial cells and presence of endothelin receptors on associated pericytes. Diabetes 1989;38:1200-1202.
  • Nyborg NC, Pieto D, Benedito S, Nielsen PJ. Role of the endothelium in acetylcholine-induced relaxation and spontaneous tone of bovine isolated retinal small arteries. Invest Ophthalmol Vis Sci. 1991;32:27- 31.
  • Fagan KA, McMurtry IF, Rodman DM. Role of endothelin-1 in lung disease. Respir Res. 2001;2:90-101.
  • Kayaalp O, Endotelin, Akılcı Tedavi Yönünden Tıbbi Farmakoloji. 13. Baskı, İstanbul: Güneş Tıp Kitabevi; 2012. s. 130-135.
  • Bouallegue A, Daou GB, Srivastava AK. Endothelin-1-induced signaling pathways in vascular smooth muscle cells. Curr Vasc Pharmacol. 2007;5:45-52.
  • Donald EK. Role of collecting duct endothelin in control of renal function and blood pressure. Am J Physiol. 2013;305:659-668.
  • Barton M, Yanagisawa M. Endothelin: 20 years from discovery to therapy. Can J Physiol Pharmacol. 2008;86:485-498.
  • Arai H, Hori S, Aramori I, Ohkubo H, Nakanishi S. Cloning and expression of a cDNA encoding an endothelin receptor. Nature. 1990;348:730-732.
  • Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, Masaki T. Cloning of a cDNA encoding a non-isopeptideselective subtype of the endothelin receptor. Nature. 1990;348:732-735.
  • Pierce KL, Premont RT, Lefkowitz RJ. Seven-transmembrane receptors. Nat Rev Mol Cell Biol. 2002;3:639-650.
  • Endoh M, Fujita S, Yang HT, Talukder MA, Maruya J, Norota I. Endothelin: receptor subtypes, signal transduction, regulation of Ca2+ transients and contractility in rabbit ventricular myocardium. Life Sci. 1998;62:1485-1489.
  • Galie N, Manes A, Branzi A. The endothelin system in pulmonary arterial hypertension. Cardiovasc Res. 2004;61:227-237.
  • Foschi M1, Chari S, Dunn MJ, Sorokin A. Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase. EMBO J. 1997; 3;16(21):6439-6451.
  • Bertram GK, Endothelins, Basic & Clinical Pharmacology.Twelfth Edition, USA: Mc Graw Hill Medical, 2012. p. 304-306.
  • Wasa S, Fan J, Miyauchi T, Watanabe T. Blockade of endothelin receptors reduces diet-induced hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice. Pathobiology. 2001;69:1-10.
  • Jansson PA. Endothelial dysfunction in insulin resistance and type 2 diabetes. J Intern Med. 2007;262:173-183.
  • Ergul A. Endothelin-1 and diabetic complications: focus on the vasculature. Pharmacol Res. 2011;63:477-482.
  • Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54:1615-1625.
  • Pernow J, Shemyakin A, Bohm F. New perspectives on endothelin-1 in atherosclerosis and diabetes mellitus. Life Sci. 2012;91:507-516.
  • Matsumoto T, Kobayashi T, Kamata K. Relationships among ET-1, PPARgamma, oxidative stress and endothelial dysfunction in diabetic animals. J Smooth Muscle Res. 2008;44:41-55.
  • Mather KJ. The vascular endothelium in diabetes-a therapeutic target? Rev Endocr Metab Disord. 2013;14:87-99.
  • Hocher B, Schwarz A, Reinbacher D, Jacobi J, Lun A, Priem F, Bauer C, Neumayer HH, Raschack M. Effects of endothelin receptor antagonists on the progression of diabetic nephropathy. Nephron. 2001;87:161-169.
  • Takayuki M, Rheure AML, Kumiko T, Tsuneo K, Rita C. Linking the beneficial effects of current therapeutic approaches in diabetes to the vascular endothelin system. Life Sci. 2014; Jan 11.
  • Ito H, Hirata Y, Adachi S, Tanaka M, Tsujino M, Koike A, Nogami A, Murumo F, Hiroe M. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest. 1993; 92: 398-403.
  • Sessa WC, Kaw S, Hecker M, Vane JR. The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes. Biochem Biophys Res Commun. 1991;174:613-618.
  • John P, Alexey S, Felix B. New perspectives on endothelin-1 in atherosclerosis and diabetes mellitus. Life Sci. 2012;91:507-516.
  • Yoshio T, Masuyama J, Mimori A, Takeda A, Minota S, Kano S. Endothelin-1 release from cultured endothelial cells induced by sera from patients with systemic lupus erythematosus. Ann Rheum Dis. 1995;54:361-365.
  • Hecker M, Vane JR. The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes. Biochem Biophys Res Commun. 1991;174:613-618.
  • Settergren M, Pernow J, Brismar K, Jorneskog G, Kalani M. Endothelin-A receptor blockade increases nutritive skin capillary circulation in patients with type 2 diabetes and microangiopathy. J Vasc Res. 2008;45:295-302.
  • Collier A, Leach JP, McLellan A, Jardine A, Morton JJ, Small M. Plasma endothelin-like immunoreactivity levels in IDDM patients with microalbuminuria. Diabetes Care. 1992;15:1038-1040.
  • Haak T, Jungmann E, Felber A, Hillmann U, Usadel KH. Increased plasma level of endothelin in diabetic patients with hypertension. Am J Hypertens. 1992;5:161-166.
  • Kawamura M, Ohgawara H, Naruse M, Suzudi N, Iwasaki N, Naruse K, Hori S, Demura H, Omori Y. Increased plasma endothelin in NIDDM patients with retinopathy. Diabetes Care. 1992;15:1396-1397.
  • Calles-Escandon J, Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev. 2001;22:36-52.
  • Taskinen M-R. Type 2 diabetes as a lipid disorder. Curr Mol Med. 2005;5:297-308.
  • Lundman P, Eriksson M, Schenck-Gustafsson K, Karpe F, Tornvall P. Transient triglyceridemia decreases vascular reactivity in young, healthy men without risk factors for coronary heart disease. Circulation. 1997;96:3266-3268.
  • Natali A, Toschi E, Baldeweg S, Casolaro A, Baldi S, Sironi AM, Yudkin JS, Ferrannini E. Haematocrit, type 2 diabetes, and endothelium- dependent vasodilatation of resistance vessels. Eur Heart J. 2000;21:515-520.
  • Goldfine A, Beckman J, Betensky R, Devlin H, Hurley S, Varo N, Schonbeck U, Patti ME, Creager MA. Family history of diabetes is a major determinant of endothelial function. J Am Coll Cardiol. 2006;47:2456-2461.
  • Nyström T, Gutniak M, Zhang Q, Holst JJ, Ahrén B, Sjöholm A. Effects of glucagons-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. Am J Physiol. 2004;287:E1209-E1215.
  • Caballero AE. Endothelial dysfunction in obesity and insülin resistance: a road to diabetes and heart disease. Obes Res. 2003;11:1278-1289.
  • Jeong-a K, Monica M, Kwang Kon K, Michael J.Q. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation. 2006;113:1888-1904.
  • Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001;414:799-806.
  • Nystrom FH, Quon MJ. Insulin signalling: metabolic pathways and mechanisms for specificity. Cell Signal. 1999;11:563-574.
  • Sedaghat AR, Sherman A, Quon MJ. A mathematical model of metabolic insulin signaling pathways. Am J Physiol. 2002;283:E1084-E1101.
  • Lam HC. Role of endothelin in diabetic vascular complications. Endocrine. 2001;14:277-284.
  • Kohner EM, Patel V, Rassam SM. Role of blood flowand impaired autoregulation in the pathogenesis of diabetic retinopathy. Diabetes. 1995;44:603-607.
  • Pang IH, Yorio T. Ocular actions of endothelins. Proc Soc Exp Biol Med. 1997;215:21-34.
  • Wang Z, Yadav AS, Leskova W, Harris NR. Attenuation of streptozotocininduced microvascular changes in the mouse retina with the endothelin receptor A antagonist atrasentan. Exp Eye Res. 2010;91:670-675.
  • Kalani M. The importance of endothelin-1 for microvascular dysfunction in diabetes. Vasc Health Risk Manag. 2008;4:1061-1068.
  • Fegan PG, Tooke JE, Gooding KM, Tullett JM, MacLeod KM, Shore AC. Capillary pressure in subjects with type 2 diabetes and hypertension and the effect of antihypertensive therapy. Hypertens. 2003;41:1111- 1117.
  • Dumont AS, Dumont RJ, McNeill JH, Kassell NF, Sutherland GR, Verma S. Chronic endothelin antagonism restores cerebrovascular function in diabetes. Neurosurgery. 2003;52:653-660.
  • Zimmermann PA, Knot HJ, Stevenson AS, Nelson MT. Increased myogenic tone and diminished responsiveness to ATP-sensitive K+ channel openers in cerebral arteries from diabetic rats. Circ Res. 1997;81:996-1004.
  • Didion SP, Lynch CM, Baumbach GL, Faraci FM. Impaired endothelium dependent responses and enhanced influence of Rho-kinase in cerebral arterioles in type II diabetes. Stroke. 2005;36:342-347.
  • Lenoir O, Milon M, Virsolvy A, Hénique C, Schmitt A, Massé JM, Kotelevtsev Y, Yanagisawa M, Webb DJ, Richard S, Tharaux PL. Direct action of endothelin-1 on podocytes promotes Diabetic Glomerulosclerosis. J Am Soc Nephrol. 2014;25:1050-1062.
  • Mather KJ. The vascular endothelium in diabetes-a therapeutic target? Rev Endocr Metab Disord. 2013;14:87-99.
  • Emori T, Hirata Y, Ohta K, Kanno K, Eguchi S, Imai T, Shichiri M, Marumo F. Cellular mechanism of endothelin-1 release by angiotensin and vasopressin. Hypertens. 1991;18:165-170.
  • Hong HJ, Chan P, Liu JC, Juan SH, Huang MT, Lin JG, Cheng TH. Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells. Cardiovasc Res. 2004;61:159-168.
  • An SJ, Boyd R, Zhu M, Chapman A, Pimentel DR, Wang HD. NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts. Cardiovasc Res. 2007;75:702-709.
  • Wenzel RR, Ruthemann J, Bruck H, Schafers RF, Michel MC, Philipp T. Endothelin-A receptor antagonist inhibits angiotensin II and noradrenaline in man. Br J Clin Pharmacol. 2001; 52: 151-157.
  • Gagliardini E, Corna D, Zoja C, Sangalli F, Carrara F, Rossi M, Conti S, Rottoli D, Longaretti L, Remuzzi A, Remuzzi G, Benigni A. Unlike each drug alone, lisinopril if combined with avosentan promotes regression of renal lesions in experimental diabetes. Am J Physiol Renal Physiol. 2009;297:F1448-F1456.
  • Goddard J, Eckhart C, Johnston NR, Cumming AD, Rankin AJ, Webb DJ. Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor- mediated and nitric oxide-dependent mechanism. J Am Soc Nephrol. 2004;15:2601-2610.
  • Struthers AD. Aldosterone-induced vasculopathy. Mol Cell Endocrinol. 2004;217:239-241.
  • Schiffrin EL. Effects of aldosterone on the vasculature. Hypertens. 2006;47:312-318.
  • Fredersdorf S1, Endemann DH, Luchner A, Heitzmann D, Ulucan C, Birner C, Schmid P, Stoelcker B, Resch M, Muders F, Riegger GA, Weil J. Increased aldosterone levels in a model of type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 2009;117:15-20.
  • Hollenberg NK, Stevanovic R, Agarwal A, Lansang MC, Price DA, Laffel LM, Williams GH, Fisher ND. Plasma aldosterone concentration in the patient with diabetes mellitus. Kidney Int. 2004;65:1435-1439.
  • Maron BA, Zhang YY, White K, Chan SY, Handy DE, Mahoney CE, Loscalzo J, Leopold JA. Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation. 2012;126:963-974.
  • Pu Q, Neves MF, Virdis A, Touyz RM, Schiffrin EL. Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling. Hypertension. 2003;42:49-55.
  • Barton M. Reversal of proteinuric renal disease and the emerging role of endothelin. Nat Clin Pract Nephrol. 2008;4:490-501.
There are 67 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Demet Sinem Güden This is me

Bahar Tunçtan This is me

Publication Date December 15, 2014
Submission Date December 15, 2014
Published in Issue Year 2014 Volume: 4 Issue: 3

Cite

APA Güden, D. S., & Tunçtan, B. (2014). Endotelin-1’in diyabet patojenezindeki rolü. Clinical and Experimental Health Sciences, 4(3), 158-167. https://doi.org/10.5455/musbed.20140723023147
AMA Güden DS, Tunçtan B. Endotelin-1’in diyabet patojenezindeki rolü. Clinical and Experimental Health Sciences. December 2014;4(3):158-167. doi:10.5455/musbed.20140723023147
Chicago Güden, Demet Sinem, and Bahar Tunçtan. “Endotelin-1’in Diyabet Patojenezindeki Rolü”. Clinical and Experimental Health Sciences 4, no. 3 (December 2014): 158-67. https://doi.org/10.5455/musbed.20140723023147.
EndNote Güden DS, Tunçtan B (December 1, 2014) Endotelin-1’in diyabet patojenezindeki rolü. Clinical and Experimental Health Sciences 4 3 158–167.
IEEE D. S. Güden and B. Tunçtan, “Endotelin-1’in diyabet patojenezindeki rolü”, Clinical and Experimental Health Sciences, vol. 4, no. 3, pp. 158–167, 2014, doi: 10.5455/musbed.20140723023147.
ISNAD Güden, Demet Sinem - Tunçtan, Bahar. “Endotelin-1’in Diyabet Patojenezindeki Rolü”. Clinical and Experimental Health Sciences 4/3 (December 2014), 158-167. https://doi.org/10.5455/musbed.20140723023147.
JAMA Güden DS, Tunçtan B. Endotelin-1’in diyabet patojenezindeki rolü. Clinical and Experimental Health Sciences. 2014;4:158–167.
MLA Güden, Demet Sinem and Bahar Tunçtan. “Endotelin-1’in Diyabet Patojenezindeki Rolü”. Clinical and Experimental Health Sciences, vol. 4, no. 3, 2014, pp. 158-67, doi:10.5455/musbed.20140723023147.
Vancouver Güden DS, Tunçtan B. Endotelin-1’in diyabet patojenezindeki rolü. Clinical and Experimental Health Sciences. 2014;4(3):158-67.

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