Polyamines and cancer; The role of diet polyamines in patients with cancer

Year 2015, Volume: 5 Issue: 2, 123 - 128, 01.10.2015

Nihal Büyükuslu Seda Erdoğdu Eröz

Abstract

Polyamines (putrescine, spermidine and spermine) are basic compounds that are found in all living systems. They are responsible for cell proliferation and differentiation, DNA, RNA and protein synthesis. In addition to the endogenous synthesis of polyamines inside the cell, exogenous intake is also possible. The activity of enzymes that are involved in polyamine synthesis increases in cancer tissues, and consequently the level of polyamines rise. Therefore, polyamine concentrations in serum and urine of cancer patients are found in high levels. Reducing polyamine dietary intake has been shown to be beneficial on the quality of life in cancer patients. The aim of this review is to explain the functions of polyamines in cancer and the importance of low dietary intake of polyamines on cancer development and the treatment of patients and to summarize the literature.

Keywords

Polyamine, cancer, nutrition, putrescine, spermidine, spermine

Poliaminler ve kanser; Kanserli hastaların beslenmesinde poliaminlerin rolleri

Abstract

Poliaminler (putresin, spermidin ve spermin) tüm canlılarda bulunan bazik moleküllerdir. Hücre büyümesi, farklılaşması, DNA, RNA ve protein sentezinden sorumludurlar. Hücrelerde endojen olarak üretildikleri gibi diyet yoluyla ekzojen olarak da alınırlar. Kanserli dokularda, poliamin sentezinden sorumlu enzimlerin aktiviteleri artar, buna bağlı olarak poliamin sentezinde de artış görülür. Dolayısıyla kanser hastalarının kan ve idrarında poliamin seviyesi yüksektir. Düşük poliamin içerikli diyetlerin kanser hastalarının yaşam kalite ve sürelerini olumlu etkilediği belirtilmektedir. Bu derlemenin amacı, poliaminlerin kanser oluşumundaki rolleri ve düşük poliamin içeren diyetle beslenmenin, hastalığın gelişimi ve kanserli hastaların yaşam kaliteleri üzerine etkilerini anlatmak, şimdiye kadar yapılan çalışmaları özetlemektir.

Keywords

Poliamin, kanser, beslenme, putresin, spermidin, spermin

References

• Bardocz S, Duguid TJ, Brown DS, Grant G, Pusztai A, White A, Ralph A. The importance of dietary polyamines in cell regeneration and growth. Br J Nutr. 1995; 73(6): 819-828.
• Yatin M. Polyamines in living organisms. J Cell Mol Biol. 2002; 1: 57-67.
• Igarashi K, Kashiwagi K. Modulation of cellular function by polyamines. Int J Biochem Cell Biol. 2010; 42(1): 39-51.
• Kakegawa T, Hirose S, Kashiwagi K, Igarashi K. Effect of polyamines on in vitro reconstitution of ribosomal subunits. Eur J Biochem. 1986; 158(2): 265-269.
• Igarashi K, Hashimoto S, Miyake A, Kashiwagi K, Hirose S. Increase of fidelity of polypeptide synthesis by spermine in eukaryotic cell-free systems. Eur J Biochem. 1982; 128(2-3): 597-604.
• Ficker E, Talgialatela M, Wible BA, Henley CM, Brown AM. Spermine and spermidine as gating molecules for inward rectifier K+ channels. Science. 1994; 266: 1068-1072.
• Kosaki T, Saka T. Polyamines and cancer cells. Proc Natl Acad of Japan. 1958; 34: 295-299.
• Russell D, Snyder SH. Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors. Proc Natl Acad Sci. 1968; 60: 1420-1427.
• Wayne EC. A review of polyamines and cancer. Turk J Med Sci. 2003; 33: 195-205.
• Tabor CW, Tabor H. Polyamines. Ann Rev Biochem. 1984; 53: 749-790.
• Allen JC. Biochemistry of the polyamines. Cell Biochem Funct. 1983; 1(3): 131-140.
• Nowotarski SL, Woster PM, Casero RA. Polyamines and cancer: implications for chemotherapy and chemoprevention. Expert Rev Mol Med. 2013;22:15:e3. doi: 10.1017/erm.2013.3.
• Thomas T, Thomas TJ. Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cell Mol Life Sci. 2001; 58(2): 244-258.
• Seiler N, Sarhan S, Grauffel C, Jones R, Knödgen B, Moulinoux JP. Endogenous and exogenous polyamines in support of tumor growth. Cancer Res. 1990; 50(16): 5077-5083.
• Manni A, Washington S, Griffith JW, Verderame MF, Mauger D, Demers LM, Samant LM, Welch DR. Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells. Clin Exp Metastasis. 2002; 19(2): 95-105.
• Smith MK, Goral MA, Wright JH, Matrisian LM, Morris RJ, Klein-Szanto AJ, Gilmour SK. Ornithine decarboxylase overexpression leads to increased epithelial tumor invasiveness. Cancer Res. 1997; 57(11): 2104-2108.
• Cipolla BG, Havouis R, Moulinoux JP. Polyamine reduced diet (PRD) nutrition therapy in hormone refractory prostate cancer patients. Biomed Pharmacother. 2010; 64: 363-368.
• Cipolla B, Bansard JY, Ecalard JP, Moulinoux JP. Treating metastatic castration-resistant prostate cancer with novel polyamine-free oral nutritional supplementation: Phase I study. BioMedicine. 2013; 3: 114-119.
• Frydman B , Valasinas A. Polyamine-based chemotherapy of cancer. Expert Opin Ther Pat. 1999; 9-8: 1055-1068.
• Kalac P, Krausova P. A review of dietary polyamines: formation, implications for growth and health and occurrence in foods. Food Chem. 2005; 90: 219-230.
• Nishimura K, Shiina R, Kashiwagi K, Igarashi K. Decrease in polyamines with aging and their ingestion from food and drink. J Biochem. 2006; 139(1): 81-90.
• Ali MA, Poortvliet E, Strömberg R, Yngve A. Polyamines: total daily intake in adolescents compared to the intake estimated from the Swedish Nutrition Recommendations ObjectiŞed (SNO). Food Nutr Res. 2011; 14: 55.
• Durlu-Ozkaya F, Ayhan K, Ozkan G. Biogenic amine determination in Tulum cheese by high performance liquid chromatography. Milchwissenschaft. 2000; 55(1): 27-28.
• Durlu-Özkaya F. Biogenic amine content of some traditional Turkish cheeses. Biogenic amines. J Food Prod Preservation. 2002; 26(4): 259- 265.
• Büyükuslu N. Besinlerin poliamin içerikleri. MÜSBED. 2014; 4(2): 105- 110.
• Thomas T, Thomas TJ. Polyamine metabolism and cancer. J Cell Mol Med. 2003; 7: 113-126.
• Wallace HM, Duthie J, Evans DM, Lamond S, Nicoll KM, Heys SD. Alterations in polyamine catabolic enzymes in human breast cancer tissue. Clin Cancer Res. 2000; 6: 3657-3661.
• Seidel ER, Scemama JL. Gastrointestinal polyamines and regulation of mucosal growth and function. J Nutr Biochem. 1997; 8: 104-111.
• Rao JN, Wang JY. Regulation of gastrointestinal mucosal growth. San Rafael (CA): Morgan & Claypool Life Sciences; 2010. Available from: http://www.ncbi.nlm.nih.gov/books/NBK54091/
• Kobayashi M, Xu YJ, Samejima K, Goda H, Niitsu M, Takahashi M, Hashimoto Y. Fate of orally administered 15N-labeled polyamines in rats bearing solid tumors. Biol Pharm Bull. 2003; 26: 285-288.
• Osborne DL, Seidel ER. Gastrointestinal luminal polyamines: cellular accumulation and enterohepatic circulation. Am J Physiol. 1990; 258(4): G576-584.
• Benamouzig R, Mahe S, Luengo C, Rautureau J, Tome D. Fasting and postprandial polyamine concentrations in the human digestive lumen. Am J Clin Nutr. 1997; 65(3): 766-770.
• Buts JP, De Keyser N, Kolanowski J, Sokal E, Van Hoof F. Maturation of villus and crypt cell functions in rat small intestine. Role of dietary polyamines. Dig Dis Sci. 1993; 38(6): 1091-1098.
• Ter Steege JC, Buurman WA, Forget PP. Spermine induces maturation of the immature intestinal immune system in neonatal mice. J Pediatr Gastroenterol Nutr. 1997; 25(3): 332-340.
• Grant AL, Holland RE, Thomas JW, King KJ, Liesman JS. Effects of dietary amines on the small intestine in calves fed soybean protein. J Nutr. 1989; 119(7): 1034-1041.
• Gerner EW, Meyskens FL. Polyamines and cancer: old molecules, new understanding. Nat Rev Cancer. 2004; 4: 781-792.
• Romano M, Bonelli P. Polyamine oxidase activity in serum of cancer patients and healthy subjects. Tumori. 1988; 74: 397-399.
• Clifford A, Morgan D, Yuspa SH, Soler AP, Gilmour S. Role of ornithine decarboxylase in epidermal tumorigenesis. Cancer Res. 1995; 55: 1680-1686.
• Casero R A, Marton LJ. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Discov. 2007; 6: 373-390.
• Linsalata M, Caruso MG, Leo S, Guerra V, Attoma B, Leo A. Prognostic value of tissue polyamine levels in human colorectal carcinoma. Anticancer Res. 2002; 22: 2465-2469.
• Becciolini A, Porciani S, Lanini A, Balzi M, Cionini L, Bandettini L. Polyamine levels in healthy and tumor tissues of patients with colon adenocarcinoma. Dis Colon Rectum. 1991; 34: 167-173.
• Canizares F, Salinas J, Heras M, Diaz J, Tovar I, Martinez P, Penafiel R. Prognostic value of ornithine decarboxylase and polyamines in human breast cancer: correlation with clinicopathologic parameters. Clin Cancer Res. 1999; 5: 2035-2041.
• Soda K. The mechanisms by which polyamines accelerate tumor spread. J Exp Clin Cancer Res. 2011; 11: 30-95.
• Bethel DR, Hibasami H, Pegg AE. Regulation of polyamine content in cultured fibroblasts. Am J Physiol. 1982; 243(5): C262-269.
• Moulinoux J-Ph, Quemener V, Cipolla B, Guille F, Havouis R, Martin C, Lobel B, Seiler N. The growth of MAT LyLu rat prostatic adenocarcinoma can be prevented in vivo by polyamine deprivation. J Urol. 1991; 146: 1408-1412.
• Muth A, Madan M, Archer JJ, Ocampo N, Prdriguez L, Phanstiel O. Polyamine inhibitors: design, synthesis, and combination therapies with difluoromethylornithine. J Med Chem. 2014; 57(2): 348-363.
• Muth A, Kamel J, Shicora AC, Ayene IS, Gilmour SK, Phansteiel O. Polyamine transport ligands with improved metabolic stability and selectivity against specific human cancers. J Med Chem. 2013; 56(14): 5819-5828.
• Gerner EW. Cancer chemoprevention locks onto a new polyamin metabolic target. Cancer Prev Res. 2010; 3(2): 125-127.
• Moulinoux JP, Quemener V, Khan NA, Delcros JG, Havouis R. Spermidine uptake by erythrocytes from normal and Lewis lung carcinoma (3LL) grafted mice: I. In vitro study. Anticancer Res. 1989; 9: 1057-1062.
• Park MH, Igarashi K. Polyamines and their metabolites as diagnostic markers of human diseases. Biomol Ther. 2013; 21(1): 1-9.
• Klein S, Miret JJ, Algranati ID, Lustig ES. Effect of alpha- difluoromethylornithine in lung metastases before and after surgery of primary adenocarcinoma tumors in mice. Biol Cell. 1985; 53: 33-36.
• Herr HW, Kleinert EL, Conti PS, Burchenal JH, Whitmore WF. Effects of alpha-difluoromethylornithine and methylglyoxal bis (guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice. Cancer Res. 1984; 44: 4382-4385.
• Olsen RR, Zetter BR. Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer. Mol Cancer Res. 2011; 9: 1285-1293.
• Aziz SM, Gillespie MN, Crooks PA, Tofiq SF, Tsuboi CP, Olson JW, Gosland MP. The potential of a novel polyamine transport inhibitor in cancer chemotherapy. J Pharmacol Exp Ther. 1996; 278: 185-192.
• Chen Y, Weeks RS, Burns MR, Boorman DW, Klein-Szanto A, O’Brien TG. Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma. Int J Cancer. 2006; 118: 2344-2349.
• Quemener V, Blanchard Y, Chamaillard L, Havouis R, Cipolla B, Moulinoux JP. Polyamine deprivation – a new tool in cancer- treatment. Anticancer Research. 1994; 14: 443-448.
• Vargas AJ, Wertheim BC, Gerner EW, Thomson CA, Rock CL, Thompson PA. Dietary polyamine intake and risk of colorectal adenomatous polyps. Am J Clin Nutr. 2012; 96(1): 133-141.
• Cipolla BG, Havouis R, Moulinoux JP. Polyamine contents in current foods: a basis for polyamine reduced diet and a study of its long term observance and tolerance in prostate carcinoma patients. Amino Acids. 2007; 33(2): 203-212.
• Löser C, Eisel A, Harms D, Fölsch UR. Dietary polyamines are essential luminal growth factors for small intestinal and colonic mucosal growth and development. Gut. 1999; 44: 12-16.
• Sarhan S, Knodgen B, Seiler N. The gastrointestinal tract as polyamine source for tumor growth. Anticancer Res. 1989; 9: 215-223.
• Minois N, Carmona-Gutierrez D, Madeo F. Polyamines in aging and disease. Aging. 2011; 3(8): 716-732.
• Bernacki RJ, Oberman EJ, Sewerymiak KE, Atwood A, Bergeron RJ, Porter CW. Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion. Clin Cancer Res. 1995; 1: 847-857.
• Amendola R, Cervelli M, Fratini E, Polticelli F, Sallustio DE, Mariottini P. Spermine metabolism and anticancer therapy. Curr Cancer Drug Targets. 2009; 9: 118-130.
• Raj KP, Zell JA, Rock CL, McLaren CE, Zoumas-Morse C, Gerner EW, Meyskens FL. Role of dietary polyamines in a phase III clinical trial of difluoromethylornithine (DFMO) and sulindac for prevention of sporadic colorectal adenomas. Br J Cancer. 2013; 108(3): 512-518.
• Gerner EW. Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models. Biochem Soc Trans. 2007; 35(Pt 2): 322-325.
• Bachrach U. Polyamines and cancer: minireview article. Amino Acids. 2004; 26: 307-309.