Experimental Models Used in Hypertension Research

Year 2016, Volume: 6 Issue: 1, 35 - 43, 13.05.2016

Meryem Temiz Reşitoğlu Demet Sinem Güden Seyhan Şahan Fırat

Abstract

Hypertension is the most important risk factor for cardiovascular diseases such as stroke, coronary artery disease and sudden cardiac death. Depending on the etiology, there are many different hypertension types, these types of hypertension are investigated in different models.The use of experimental animal models has provided valuable information on many aspects of hypertension such as etiology, pathophysiology, complication and treatment. For this purpose, appropriate experimental method and animal to be used in these studies should be selected considering the design of the study and its limitations. Since significant differences exist between hypertension in experimental animals and human hypertension the extrapolation of results obtained from experimental studies to humans is extremely important. In this review, various experimental models which are used in hypertension research were evaluated.

Keywords

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Hipertansiyon Araştırmalarında Kullanılan Deneysel Modeller

Abstract

Hipertansiyon, inme, koroner arter hastalıkları ve ani kardiyak ölümleri gibi kardiyovasküler hastalıklar için en önemli risk faktörüdür. Etiyolojisine bağlı olarak birçok farklı hipertansiyon tipi bulunmakta olup, bu hipertansiyon tipleri farklı modellerde araştırılmaktadır. Deneysel hayvan modellerinin kullanımı hipertansiyonun etiyolojisi, patofizyolojisi, komplikasyonları ve tedavisi gibi pek çok konuda değerli bilgilerin elde edilmesini sağlamaktadır. Bu amaçla, çalışmalarda kullanılacak uygun deneysel yöntem ve deney hayvanı, araştırmanın tasarımı ve sınırlamaları düşünülerek seçilmelidir. Deney hayvanlarındaki hipertansiyon ile insanda görülen hipertansiyon arasında önemli farklılıklar olması nedeniyle deneysel çalışmalardan elde edilecek sonuçların insana ekstrapolasyonu da son derece önemlidir. Bu derlemede hipertansiyon araştırmalarında kullanılan çeşitli deneysel modeller incelenmiştir. 

Keywords

Hipertansiyon, deneysel modeller, deney hayvanları

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