The Level of Serum C-Reactive Protein and Neutrophil Lymphocyte Ratio According to Thyroid Function Status

Year 2020, Volume: 10 Issue: 2, 142 - 147, 29.06.2020

Fatih Kar , Zeynep Küskü Kiraz Evin Kocatürk , Sema Uslu

https://doi.org/10.33808/clinexphealthsci.600151

Cited By: 4

Abstract

Objective: We aimed to investigate neutrophil lymphocyte ratio (NLR), leukocyte count (WBC), mean platelet volume (MPV) and C-reactive
protein levels (CRP) as inflammatory markers according to thyroid function status in hypo-hyperthyroidism patients.

Methods: Data of patients (n=454, age>18) who applied to the Eskisehir Osmangazi University Hospital between March 2018 and December
2018 were evaluated retrospectively. There were 79 patients in hyperthyroidism group (TSH<0.27 μIU/ml, group I), 297 patients in euthyroid
group (TSH=0.27-4.2 μIU/ml, group II) and 78 patients in hypothyroidism group (TSH>4.2 μIU/ml, group III).

Results: Serum TSH, fT4, fT3, anti-TG and anti-TPO levels were found statistically different between groups (p<0.001) but there were no
significant difference in WBC, NLR and MPV between groups. There was a positive correlation between the NLR and CRP (r=0,295, p<0.01). In
addition, NLR was positively correlated with WBC (r=0,412, p<0.001). Serum CRP levels were statistically higher in group I (3.5 mg/L [1.50-11])
than group II (2.1 mg/L [0.86-5.42]), (p<0.001). Although CRP levels were higher in group III (2.5 mg/L [1.18-5.73]) than group II, there was no
significant difference. CRP showed weak positive correlation with fT4 (r=0,118, p<0.05) and negative correlation with TSH (r=-0,108, p<0.05).

Conclusion: High CRP levels may play an important role in the evaluation of hyperthyroidism in terms of thyroid dysfunction observed in the
present study.

Keywords

Hyperthyroidism, Hypothyroidsm, Inflammation, TSH, CRP

References

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