Case Report
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Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings

Year 2020, Volume: 10 Issue: 4, 468 - 472, 30.12.2020
https://doi.org/10.33808/clinexphealthsci.669796

Abstract

Cemento-ossifying fibroma, which is considered a benign mesenchymal odontogenic tumour of the jaws, is a type of fibro-osseous lesion characterized by slow growth and proliferation of fibrous cellular stroma containing osteoid, bone or cementum-like tissue. The aim of this study was to report a case of cemento-ossifying fibroma in the mandible with clinical, radiological, and histopathological findings and surgical treatment. A 37-year-old woman was admitted to our clinic with the complaint of gradually growing painless swelling in the right mandibular premolar area. Intra-oral examination revealed a bony hard and non-tender mass with intact overlying mucosa on the buccal and lingual aspects of the mandibular right premolar teeth. Periapical, panoramic, and cone beam computed tomography images revealed the presence of a multilocular hypodense lesion with bicortical destruction and expansion in the relevant area. Excisional biopsy of the lesion was performed and histopathological examination exhibited the definite diagnosis of cemento-ossifying fibroma. Clinical, radiological, and histopathological examination should be considered in the diagnosis and treatment planning of cemento-ossifying fibroma.

References

  • 1. Liu Y, Wang H, You M, Yang Z, Miao J, Shimizutani K, Koseki T. Ossifying fibromas of the jaw bone: 20 cases. Dentomaxillofac Radiol 2010;39:57‑63.
  • 2. Pandey V, Sharma A, Sudarshan V. Cemento-ossifying fibroma - a rare case report with review of literature. IJCMR 2016;3:2681-2682.
  • 3. Speight PM, Takata T. New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumours. Virchows Arch 2018;472:331-339.
  • 4. Pindborg JJ, Kramer IRH. Histological typing of odontogenic tumors, jaw cysts and allied lesions. International histological classification of tumors. Geneva: WHO;1971. p.31-34.
  • 5. Kramer IR, Pindborg JJ, Shear M. The World Health Organization histological typing of odontogenic tumours; introducing the second edition. Eur J Cancer B Oral Oncol 1993;29:169-171.
  • 6. Reichart PA, Philipsen HP, Sciubba JJ. The new classification of Head and Neck Tumours (WHO) - any changes? Oral Oncol 2006;42:757-758.
  • 7. El-Mofty SK, Nelson B, Toyosawa S. Ossifying fibroma. El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO Classification of Head and Neck Tumours. 4th ed. Lyon: IARC Press; 2017. p. 251-252.
  • 8. Bala TK, Soni S, Dayal P, Ghosh I. Cemento-ossifying fibroma of the mandible a clinicopathological report. Saudi Med J 2017;38:541-545.
  • 9. Mithra R, Baskaran P, Sathyakumar M. Imaging in the diagnosis of cemento-ossifying fibroma A case series. J Clin Imaging Sci 2012;2:52.
  • 10. Sridevi U, Jain A, Turagam N, Prasad MD. Cemento-ossifying fibroma: A case report. Adv Cancer Prev 2016;1:111.
  • 11. Rani A, Kalra N, Poswal R, Sharma S. Cemento‑ossifying fibroma: Report of a case and emphasis on its diagnosis. Indian J Multidiscip Dent 2017;7:140-143.
  • 12. Dalghous A, Alkhabuli JO. Cemento-ossifying fibroma occurring in an elderly patient: A case report and a review of literature. Libyan J Med 2007;2:95-98.
  • 13. Wanzeler AMV, Rohden D, Arús NA, Silveira HLD, Hildebrand LC. Central cemento-ossifying fibroma: clinical-imaging and histopathological diagnosis. Int J Odontostomat 2018;12:233-236.
  • 14. Silvestre-Rangil J, Silvestre FJ, Requeni-Bernal J. Cemento-ossifying fibroma of the mandible: Presentation of a case and review of the literature. J Clin Exp Dent 2011;3:66-69.
  • 15. Peravali RK, Bhat HH, Reddy S. Maxillo-Mandibular Cemento-ossifying fibroma: A rare case report. J Maxillofac Oral Surg 2015;14:300-307.
  • 16. Kharsan V, Madan RS, Rathod P, Balani A, Tiwari S, Sharma S. Large ossifying fibroma of jaw bone: a rare case report. Pan Afr Med J 2018;30:306.
  • 17. Reddy R, Sarkar P, Manuel RA, Saxena D, Hoisala VR. Cemento-ossifying fibroma: A case report. IJSS Case Reports and Reviews 2016;3:13-15.
  • 18. Neville BW, Damm DD, Allen CMA, Chi AC. Oral and Maxillofacial Pathology. 4th ed. St. Louis, Missouri: Elsevier; 2016.
  • 19. Swami A, Kale L, Mishra S, Choudhary S. Central ossifying fibroma of mandible: A case report and review of literature. J Indian Acad Oral Med Radiol 2015;27:131-135.
  • 20. Atul SK, Bishen KA, Shitalkumar GS. Understanding massive maxillofacial central cement-ossifying fibroma. Indian J Stomatol 2014;5:148-150.
  • 21. Koury ME, Regezi JA, Perrott DH, Kaban LB. Atypical fibro-osseous lesions: diagnostic challenges and treatment concepts. Int J Oral Maxillofac Surg 1995;24:162-169.
  • 22. Regezi JA, Sciubba JJ, Jordan RCK. Oral Pathology: Clinical Pathologic Correlations. 7th ed. St. Louis, Missoouri: Elsevier; 2016.
Year 2020, Volume: 10 Issue: 4, 468 - 472, 30.12.2020
https://doi.org/10.33808/clinexphealthsci.669796

Abstract

Cemento-ossifying fibroma, which is considered a benign mesenchymal odontogenic tumour of the jaws, is a type of fibro-osseous lesion characterized by slow growth and proliferation of fibrous cellular stroma containing osteoid, bone or cementum-like tissue. The aim of this study was to report a case of cemento-ossifying fibroma in the mandible with clinical, radiological, and histopathological findings and surgical treatment.
A 37-year-old female patient was admitted to our clinic with the complaint of gradually growing painless swelling in the right mandibular premolar area. Intra-oral examination revealed a bony hard and non-tender mass with intact overlying mucosa on the buccal and lingual aspect of the mandibular right premolar teeth. Periapical, panoramic, and cone beam computed tomography images revealed the presence of a multilocular hypodense lesion with bicortical destruction and expansion in the relevant area. Excisional biopsy of the lesion was performed and histopathological examination exhibited the definite diagnosis of cemento-ossifying fibroma.
Clinical, radiological, and histopathological examination should be considered in the diagnosis and treatment planning of cemento-ossifying fibroma.

References

  • 1. Liu Y, Wang H, You M, Yang Z, Miao J, Shimizutani K, Koseki T. Ossifying fibromas of the jaw bone: 20 cases. Dentomaxillofac Radiol 2010;39:57‑63.
  • 2. Pandey V, Sharma A, Sudarshan V. Cemento-ossifying fibroma - a rare case report with review of literature. IJCMR 2016;3:2681-2682.
  • 3. Speight PM, Takata T. New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumours. Virchows Arch 2018;472:331-339.
  • 4. Pindborg JJ, Kramer IRH. Histological typing of odontogenic tumors, jaw cysts and allied lesions. International histological classification of tumors. Geneva: WHO;1971. p.31-34.
  • 5. Kramer IR, Pindborg JJ, Shear M. The World Health Organization histological typing of odontogenic tumours; introducing the second edition. Eur J Cancer B Oral Oncol 1993;29:169-171.
  • 6. Reichart PA, Philipsen HP, Sciubba JJ. The new classification of Head and Neck Tumours (WHO) - any changes? Oral Oncol 2006;42:757-758.
  • 7. El-Mofty SK, Nelson B, Toyosawa S. Ossifying fibroma. El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO Classification of Head and Neck Tumours. 4th ed. Lyon: IARC Press; 2017. p. 251-252.
  • 8. Bala TK, Soni S, Dayal P, Ghosh I. Cemento-ossifying fibroma of the mandible a clinicopathological report. Saudi Med J 2017;38:541-545.
  • 9. Mithra R, Baskaran P, Sathyakumar M. Imaging in the diagnosis of cemento-ossifying fibroma A case series. J Clin Imaging Sci 2012;2:52.
  • 10. Sridevi U, Jain A, Turagam N, Prasad MD. Cemento-ossifying fibroma: A case report. Adv Cancer Prev 2016;1:111.
  • 11. Rani A, Kalra N, Poswal R, Sharma S. Cemento‑ossifying fibroma: Report of a case and emphasis on its diagnosis. Indian J Multidiscip Dent 2017;7:140-143.
  • 12. Dalghous A, Alkhabuli JO. Cemento-ossifying fibroma occurring in an elderly patient: A case report and a review of literature. Libyan J Med 2007;2:95-98.
  • 13. Wanzeler AMV, Rohden D, Arús NA, Silveira HLD, Hildebrand LC. Central cemento-ossifying fibroma: clinical-imaging and histopathological diagnosis. Int J Odontostomat 2018;12:233-236.
  • 14. Silvestre-Rangil J, Silvestre FJ, Requeni-Bernal J. Cemento-ossifying fibroma of the mandible: Presentation of a case and review of the literature. J Clin Exp Dent 2011;3:66-69.
  • 15. Peravali RK, Bhat HH, Reddy S. Maxillo-Mandibular Cemento-ossifying fibroma: A rare case report. J Maxillofac Oral Surg 2015;14:300-307.
  • 16. Kharsan V, Madan RS, Rathod P, Balani A, Tiwari S, Sharma S. Large ossifying fibroma of jaw bone: a rare case report. Pan Afr Med J 2018;30:306.
  • 17. Reddy R, Sarkar P, Manuel RA, Saxena D, Hoisala VR. Cemento-ossifying fibroma: A case report. IJSS Case Reports and Reviews 2016;3:13-15.
  • 18. Neville BW, Damm DD, Allen CMA, Chi AC. Oral and Maxillofacial Pathology. 4th ed. St. Louis, Missouri: Elsevier; 2016.
  • 19. Swami A, Kale L, Mishra S, Choudhary S. Central ossifying fibroma of mandible: A case report and review of literature. J Indian Acad Oral Med Radiol 2015;27:131-135.
  • 20. Atul SK, Bishen KA, Shitalkumar GS. Understanding massive maxillofacial central cement-ossifying fibroma. Indian J Stomatol 2014;5:148-150.
  • 21. Koury ME, Regezi JA, Perrott DH, Kaban LB. Atypical fibro-osseous lesions: diagnostic challenges and treatment concepts. Int J Oral Maxillofac Surg 1995;24:162-169.
  • 22. Regezi JA, Sciubba JJ, Jordan RCK. Oral Pathology: Clinical Pathologic Correlations. 7th ed. St. Louis, Missoouri: Elsevier; 2016.
There are 22 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Report
Authors

Melda Pelin Akkitap 0000-0001-7744-6615

Birsay Gümrü 0000-0002-7734-4755

Ender İdman 0000-0001-7967-841X

Necip Fazıl Erdem 0000-0002-5374-3233

Zeynep Gümüşer 0000-0002-7834-4343

Fatma Aksakallı 0000-0002-2429-9196

Publication Date December 30, 2020
Submission Date January 3, 2020
Published in Issue Year 2020 Volume: 10 Issue: 4

Cite

APA Akkitap, M. P., Gümrü, B., İdman, E., Erdem, N. F., et al. (2020). Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings. Clinical and Experimental Health Sciences, 10(4), 468-472. https://doi.org/10.33808/clinexphealthsci.669796
AMA Akkitap MP, Gümrü B, İdman E, Erdem NF, Gümüşer Z, Aksakallı F. Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings. Clinical and Experimental Health Sciences. December 2020;10(4):468-472. doi:10.33808/clinexphealthsci.669796
Chicago Akkitap, Melda Pelin, Birsay Gümrü, Ender İdman, Necip Fazıl Erdem, Zeynep Gümüşer, and Fatma Aksakallı. “Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings”. Clinical and Experimental Health Sciences 10, no. 4 (December 2020): 468-72. https://doi.org/10.33808/clinexphealthsci.669796.
EndNote Akkitap MP, Gümrü B, İdman E, Erdem NF, Gümüşer Z, Aksakallı F (December 1, 2020) Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings. Clinical and Experimental Health Sciences 10 4 468–472.
IEEE M. P. Akkitap, B. Gümrü, E. İdman, N. F. Erdem, Z. Gümüşer, and F. Aksakallı, “Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings”, Clinical and Experimental Health Sciences, vol. 10, no. 4, pp. 468–472, 2020, doi: 10.33808/clinexphealthsci.669796.
ISNAD Akkitap, Melda Pelin et al. “Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings”. Clinical and Experimental Health Sciences 10/4 (December 2020), 468-472. https://doi.org/10.33808/clinexphealthsci.669796.
JAMA Akkitap MP, Gümrü B, İdman E, Erdem NF, Gümüşer Z, Aksakallı F. Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings. Clinical and Experimental Health Sciences. 2020;10:468–472.
MLA Akkitap, Melda Pelin et al. “Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings”. Clinical and Experimental Health Sciences, vol. 10, no. 4, 2020, pp. 468-72, doi:10.33808/clinexphealthsci.669796.
Vancouver Akkitap MP, Gümrü B, İdman E, Erdem NF, Gümüşer Z, Aksakallı F. Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings. Clinical and Experimental Health Sciences. 2020;10(4):468-72.

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