Research Article
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Year 2021, Volume: 11 Issue: 2, 324 - 329, 30.06.2021
https://doi.org/10.33808/clinexphealthsci.798527

Abstract

References

  • Turell L, Radi R, Alvarez B. The thiol pool in human plasma: The central contribution of albumin to redox processes. Free Radic Biol Med 2013;65:244-253.
  • Moran LK, Gutteridge JM, Quinlan GJ. Thiols in cellular redox signaling and control. Curr Med Chem 2001;8: 763-772.
  • Cremers CM, Jakob U. Oxidant sensing by reversible disulfide bond formation. J Biol Chem 2013;288: 26489-26496.
  • Biswas S, Chida AS, Rahman I. Redox modifications of protein-thiols: emerging roles in cell signaling. Biochem Pharmacol 2006; 71: 551-564.
  • Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47: 326-332.
  • Kaman A, Aydin Teke T, Gayretli Aydin ZG, Karacan Kucukali G, Neselioglu S, Erel O, Tanır G. How does dynamic thiol/disulphide homeostasis work in the pathogenesis of Kawasaki disease? Pediatr int 2019;61: 913-918.
  • Agan V, Celik H, Eren MA, Agan FZ, Erel O, Neselioglu S, Koyuncu I, Gonel A. An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease. Medicina 2019; 55(6):275.
  • Degoute CS. Controlled hypotension: a guide to drug choice. Drugs 2007;67:1053-1076.
  • Karatas M, Ozis TN, Buyuksekerci M, Gunduzoz M, Ozakinci OG, Gok G, Neşelioğlu, S, Erel, Ö. Thiol-disulfide homeostasis and ischemia-modified albumin levels as indicators of oxidative stress in welders' lung disease. Hum Exp Toxicol 2019;38:1227-1234.
  • Maksimova MY, Ivanov AV, Virus ED, Alexandrin VV, Nikiforova KA, Bulgakova PO, Ochtova FR, Suanova ET, Piradov MA, Kubatiev AA. Disturbance of thiol/disulfide aminothiols homeostasis in patients with acute ischemic stroke stroke: Preliminary findings. Clin Neurol Neurosurg 2019;183:105393.
  • Gur M, Elbasan Z, Yildiray Sahin D, Yildiz Koyunsever N, Seker T, Ozaltun B, Caylı M, Kocyigit A. DNA damage and oxidative status in newly diagnosed, untreated, dipper and non-dipper hypertensive patients. Hypertens Res 2013;36(2):166-171.
  • Kundi H, Erel O, Balun A, Cicekcioglu H, Cetin M, Kiziltunc E, Neşelioğlu S, Topçuoğlu C, Örnek E. Association of thiol/disulfide ratio with syntax score in patients with NSTEMI. Scand Cardiovasc J 2015;49(2):95-100.
  • Go YM, Jones DP. Cysteine/cystine redox signaling in cardiovascular disease. Free Radic Biol Med. 2011;50: 495-509.
  • Topuz M, Kaplan M, Akkus O, Sen O, Yunsel HD, Allahverdiyev S, Erel O, Koc M, Gur M. The prognostic importance of thiol/disulfide homeostasis in patients with acute pulmonary thromboembolism. Am J Emerg Med 2016;34: 2315-2319.
  • Degoute CS, Ray MJ, Manchon M, Dubreuil C, Banssillon V. Remifentanil and controlled hypotension; comparison with nitroprusside or esmolol during tympanoplasty. Can J Anaesth 2001;48 :20-27.
  • Hampton LJ, Little DM, Jr. Complications associated with the use of controlled hypotension in anesthesia. AMA Arch Surg 1953; 67:549-556.
  • Degoute CS, Ray MJ, Gueugniaud PY, Dubreuil C. Remifentanil induces consistent and sustained controlled hypotension in children during middle ear surgery. Can J Anaesth 2003; 50:270-276.
  • Fodale V, Schifilliti D, Pratico C, Santamaria LB. Remifentanil and the brain. Acta Anaesthesiol Scand 2008;52 :319-326.
  • Koksal GM, Sayilgan C, Aydin S, Uzun H, Oz H. The effects of sevoflurane and desflurane on lipid peroxidation during laparoscopic cholecystectomy. Eur J Anaesthesiol 2004;21:217-220.
  • Schilling T, Kozian A, Senturk M, Huth C, Reinhold A, Hedenstierna G, Hachenberg T. Effects of volatile and intravenous anesthesia on the alveolar and systemic inflammatory response in thoracic surgical patients. Anesthesiology 2011;115:65-74.
  • Erbas M, Demiraran Y, Yildirim HA, Sezen G, Iskender A, Karagoz I, Kandis H. Comparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesia. Rev Bras Anestesiol 2015;65 :68-72.
  • Ozcan ATD, Doger C, Ozturk L, Yungul A, Kurtsahin M, Neselioglu S, Ergin M, But A. Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy. Eurasian J Med 2019;51: 70-74.
  • Li Volti G, Basile F, Murabito P, Galvano F, Di Giacomo C, Gazzolo D, Vadalà S, Azzolina R, D'Orazio N, Mufeed H, Vanella L, Nicolosi A, Basile G, Biondi A. Antioxidant properties of anesthetics: the biochemist, the surgeon and the anesthetist. Clin Ter 2008; 159 :463-469.
  • Tsuchiya M, Sato EF, Inoue M, Asada A. Open abdominal surgery increases intraoperative oxidative stress: can it be prevented? Anesth Analg 2008;107:1946-1952.
  • Kevin LG, Novalija E, Riess ML, Camara AK, Rhodes SS, Stowe DF. Sevoflurane exposure generates superoxide but leads to decreased superoxide during ischemia and reperfusion in isolated hearts. Anesth Analg 2003; 96 :949-955.
  • Wong CH, Liu TZ, Chye SM, Lu FJ, Liu YC, Lin ZC, Chen CH. Sevoflurane-induced oxidative stress and cellular injury in human peripheral polymorphonuclear neutrophils. Food Chem Toxicol 2006;44:1399-1407.
  • Sato N, Fujii K, Yuge O. In vivo and in vitro sevoflurane- induced lipid peroxidation in guinea-pig liver microsomes. Pharmacol Toxicol 1994;75:366-370.
  • Habre W, Peták F. Perioperative use of oxygen: variabilities across age. Br J Anaesth 2014;113 Suppl 2:ii26-36.
  • Ozgunay SE, Ustundag Y, Karasu D, Uguz I, Erel O, Korfali G, Kaya M. The Effect of Different Intraabdominal Pressures On Thiol/Disulfide Homeostasis in Children Who Underwent Ambulatory Laparoscopic Surgery: a Prospective Randomized Study. J Laparoendosc Adv Surg Tech A 2018;28:1142-1147.
  • Polat C, Kahraman A, Yilmaz S, Koken T, Serteser M, Akbulut G, Arikan Y, Dilek ON, Gokce O. A comparison of the oxidative stress response and antioxidant capacity of open and laparoscopic hernia repairs. J Laparoendosc Adv Surg Tech A 2003;13(3):167-173.

Oxidative Stress in Controlled Hypotension: Assessment with A Novel Oxidative Stress Marker

Year 2021, Volume: 11 Issue: 2, 324 - 329, 30.06.2021
https://doi.org/10.33808/clinexphealthsci.798527

Abstract

Objectives: The aim of this study was to evaluate the effects of oxidative stress on thiol-disulfide homeostasis caused by hypotensive anesthesia in mastoidectomy-tympanoplasty cases undergoing controlled hypotension.

Methods: Fifty adult patients scheduled for mastoidectomy and tympanoplasty were included in the study. Anesthesia was induced with lidocaine, propofol, rocuronium, and remifentanil. The maintenance of anesthesia was continued with remifentanil infusion (target mean arterial pressure as 60-65 mmHg) along with 2% sevoflurane/40% O2/air mixture. Blood samples were taken 5 times at the t0 (before induction), t1 (intraoperatively after intubation), t2 (first hour) and t3 (second hour of the operation) and t4 (following recovery). Total thiol (TT) and Native Thiol (NT) levels were measured, and thus, Di-Sulphide (SS), Di-Sulphide/Native Thiol (SSNT), Di-Sulphide/Total Thiol (SSTT), and Native Thiol/Total Thiol (NTTT) values were estimated.

Results: During the operation, progressive decrease was observed in thiol levels of patients. There was a significant decrease in t3 thiol values when compared with t0 value. Thiol values were observed to have returned to baseline values after recovery from anesthesia (p>0.05). SS, SSNT and SSTT levels were found as increased in t1 blood samples, but increase in SSNT and SSTT levels was significant. Throughout the operation, values were observed to have dropped and reverted back to initial values.

Conclusion: Since the measurement of thiol-disulfide blood values is able to show the instantaneous state of oxidative stress, it can be used in anesthesia practice in which every event occurs very quickly.

References

  • Turell L, Radi R, Alvarez B. The thiol pool in human plasma: The central contribution of albumin to redox processes. Free Radic Biol Med 2013;65:244-253.
  • Moran LK, Gutteridge JM, Quinlan GJ. Thiols in cellular redox signaling and control. Curr Med Chem 2001;8: 763-772.
  • Cremers CM, Jakob U. Oxidant sensing by reversible disulfide bond formation. J Biol Chem 2013;288: 26489-26496.
  • Biswas S, Chida AS, Rahman I. Redox modifications of protein-thiols: emerging roles in cell signaling. Biochem Pharmacol 2006; 71: 551-564.
  • Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47: 326-332.
  • Kaman A, Aydin Teke T, Gayretli Aydin ZG, Karacan Kucukali G, Neselioglu S, Erel O, Tanır G. How does dynamic thiol/disulphide homeostasis work in the pathogenesis of Kawasaki disease? Pediatr int 2019;61: 913-918.
  • Agan V, Celik H, Eren MA, Agan FZ, Erel O, Neselioglu S, Koyuncu I, Gonel A. An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease. Medicina 2019; 55(6):275.
  • Degoute CS. Controlled hypotension: a guide to drug choice. Drugs 2007;67:1053-1076.
  • Karatas M, Ozis TN, Buyuksekerci M, Gunduzoz M, Ozakinci OG, Gok G, Neşelioğlu, S, Erel, Ö. Thiol-disulfide homeostasis and ischemia-modified albumin levels as indicators of oxidative stress in welders' lung disease. Hum Exp Toxicol 2019;38:1227-1234.
  • Maksimova MY, Ivanov AV, Virus ED, Alexandrin VV, Nikiforova KA, Bulgakova PO, Ochtova FR, Suanova ET, Piradov MA, Kubatiev AA. Disturbance of thiol/disulfide aminothiols homeostasis in patients with acute ischemic stroke stroke: Preliminary findings. Clin Neurol Neurosurg 2019;183:105393.
  • Gur M, Elbasan Z, Yildiray Sahin D, Yildiz Koyunsever N, Seker T, Ozaltun B, Caylı M, Kocyigit A. DNA damage and oxidative status in newly diagnosed, untreated, dipper and non-dipper hypertensive patients. Hypertens Res 2013;36(2):166-171.
  • Kundi H, Erel O, Balun A, Cicekcioglu H, Cetin M, Kiziltunc E, Neşelioğlu S, Topçuoğlu C, Örnek E. Association of thiol/disulfide ratio with syntax score in patients with NSTEMI. Scand Cardiovasc J 2015;49(2):95-100.
  • Go YM, Jones DP. Cysteine/cystine redox signaling in cardiovascular disease. Free Radic Biol Med. 2011;50: 495-509.
  • Topuz M, Kaplan M, Akkus O, Sen O, Yunsel HD, Allahverdiyev S, Erel O, Koc M, Gur M. The prognostic importance of thiol/disulfide homeostasis in patients with acute pulmonary thromboembolism. Am J Emerg Med 2016;34: 2315-2319.
  • Degoute CS, Ray MJ, Manchon M, Dubreuil C, Banssillon V. Remifentanil and controlled hypotension; comparison with nitroprusside or esmolol during tympanoplasty. Can J Anaesth 2001;48 :20-27.
  • Hampton LJ, Little DM, Jr. Complications associated with the use of controlled hypotension in anesthesia. AMA Arch Surg 1953; 67:549-556.
  • Degoute CS, Ray MJ, Gueugniaud PY, Dubreuil C. Remifentanil induces consistent and sustained controlled hypotension in children during middle ear surgery. Can J Anaesth 2003; 50:270-276.
  • Fodale V, Schifilliti D, Pratico C, Santamaria LB. Remifentanil and the brain. Acta Anaesthesiol Scand 2008;52 :319-326.
  • Koksal GM, Sayilgan C, Aydin S, Uzun H, Oz H. The effects of sevoflurane and desflurane on lipid peroxidation during laparoscopic cholecystectomy. Eur J Anaesthesiol 2004;21:217-220.
  • Schilling T, Kozian A, Senturk M, Huth C, Reinhold A, Hedenstierna G, Hachenberg T. Effects of volatile and intravenous anesthesia on the alveolar and systemic inflammatory response in thoracic surgical patients. Anesthesiology 2011;115:65-74.
  • Erbas M, Demiraran Y, Yildirim HA, Sezen G, Iskender A, Karagoz I, Kandis H. Comparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesia. Rev Bras Anestesiol 2015;65 :68-72.
  • Ozcan ATD, Doger C, Ozturk L, Yungul A, Kurtsahin M, Neselioglu S, Ergin M, But A. Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy. Eurasian J Med 2019;51: 70-74.
  • Li Volti G, Basile F, Murabito P, Galvano F, Di Giacomo C, Gazzolo D, Vadalà S, Azzolina R, D'Orazio N, Mufeed H, Vanella L, Nicolosi A, Basile G, Biondi A. Antioxidant properties of anesthetics: the biochemist, the surgeon and the anesthetist. Clin Ter 2008; 159 :463-469.
  • Tsuchiya M, Sato EF, Inoue M, Asada A. Open abdominal surgery increases intraoperative oxidative stress: can it be prevented? Anesth Analg 2008;107:1946-1952.
  • Kevin LG, Novalija E, Riess ML, Camara AK, Rhodes SS, Stowe DF. Sevoflurane exposure generates superoxide but leads to decreased superoxide during ischemia and reperfusion in isolated hearts. Anesth Analg 2003; 96 :949-955.
  • Wong CH, Liu TZ, Chye SM, Lu FJ, Liu YC, Lin ZC, Chen CH. Sevoflurane-induced oxidative stress and cellular injury in human peripheral polymorphonuclear neutrophils. Food Chem Toxicol 2006;44:1399-1407.
  • Sato N, Fujii K, Yuge O. In vivo and in vitro sevoflurane- induced lipid peroxidation in guinea-pig liver microsomes. Pharmacol Toxicol 1994;75:366-370.
  • Habre W, Peták F. Perioperative use of oxygen: variabilities across age. Br J Anaesth 2014;113 Suppl 2:ii26-36.
  • Ozgunay SE, Ustundag Y, Karasu D, Uguz I, Erel O, Korfali G, Kaya M. The Effect of Different Intraabdominal Pressures On Thiol/Disulfide Homeostasis in Children Who Underwent Ambulatory Laparoscopic Surgery: a Prospective Randomized Study. J Laparoendosc Adv Surg Tech A 2018;28:1142-1147.
  • Polat C, Kahraman A, Yilmaz S, Koken T, Serteser M, Akbulut G, Arikan Y, Dilek ON, Gokce O. A comparison of the oxidative stress response and antioxidant capacity of open and laparoscopic hernia repairs. J Laparoendosc Adv Surg Tech A 2003;13(3):167-173.
There are 30 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Cihan Döğer 0000-0003-3071-5181

Ayça Tuba Dumanlı Özcan 0000-0002-9881-8534

Ezgi Erkılıç 0000-0002-1211-9354

Süleyman Ellik 0000-0003-4347-6335

Şemsi Mustafa Aksoy 0000-0003-3197-5655

Murat Alışık 0000-0003-0434-3206

Özcan Erel 0000-0002-2996-3236

Publication Date June 30, 2021
Submission Date September 22, 2020
Published in Issue Year 2021 Volume: 11 Issue: 2

Cite

APA Döğer, C., Dumanlı Özcan, A. T., Erkılıç, E., Ellik, S., et al. (2021). Oxidative Stress in Controlled Hypotension: Assessment with A Novel Oxidative Stress Marker. Clinical and Experimental Health Sciences, 11(2), 324-329. https://doi.org/10.33808/clinexphealthsci.798527
AMA Döğer C, Dumanlı Özcan AT, Erkılıç E, Ellik S, Aksoy ŞM, Alışık M, Erel Ö. Oxidative Stress in Controlled Hypotension: Assessment with A Novel Oxidative Stress Marker. Clinical and Experimental Health Sciences. June 2021;11(2):324-329. doi:10.33808/clinexphealthsci.798527
Chicago Döğer, Cihan, Ayça Tuba Dumanlı Özcan, Ezgi Erkılıç, Süleyman Ellik, Şemsi Mustafa Aksoy, Murat Alışık, and Özcan Erel. “Oxidative Stress in Controlled Hypotension: Assessment With A Novel Oxidative Stress Marker”. Clinical and Experimental Health Sciences 11, no. 2 (June 2021): 324-29. https://doi.org/10.33808/clinexphealthsci.798527.
EndNote Döğer C, Dumanlı Özcan AT, Erkılıç E, Ellik S, Aksoy ŞM, Alışık M, Erel Ö (June 1, 2021) Oxidative Stress in Controlled Hypotension: Assessment with A Novel Oxidative Stress Marker. Clinical and Experimental Health Sciences 11 2 324–329.
IEEE C. Döğer, “Oxidative Stress in Controlled Hypotension: Assessment with A Novel Oxidative Stress Marker”, Clinical and Experimental Health Sciences, vol. 11, no. 2, pp. 324–329, 2021, doi: 10.33808/clinexphealthsci.798527.
ISNAD Döğer, Cihan et al. “Oxidative Stress in Controlled Hypotension: Assessment With A Novel Oxidative Stress Marker”. Clinical and Experimental Health Sciences 11/2 (June 2021), 324-329. https://doi.org/10.33808/clinexphealthsci.798527.
JAMA Döğer C, Dumanlı Özcan AT, Erkılıç E, Ellik S, Aksoy ŞM, Alışık M, Erel Ö. Oxidative Stress in Controlled Hypotension: Assessment with A Novel Oxidative Stress Marker. Clinical and Experimental Health Sciences. 2021;11:324–329.
MLA Döğer, Cihan et al. “Oxidative Stress in Controlled Hypotension: Assessment With A Novel Oxidative Stress Marker”. Clinical and Experimental Health Sciences, vol. 11, no. 2, 2021, pp. 324-9, doi:10.33808/clinexphealthsci.798527.
Vancouver Döğer C, Dumanlı Özcan AT, Erkılıç E, Ellik S, Aksoy ŞM, Alışık M, Erel Ö. Oxidative Stress in Controlled Hypotension: Assessment with A Novel Oxidative Stress Marker. Clinical and Experimental Health Sciences. 2021;11(2):324-9.

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