Research Article
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Year 2022, Volume: 12 Issue: 2, 294 - 301, 30.06.2022
https://doi.org/10.33808/clinexphealthsci.983877

Abstract

Project Number

2019.08.02.1415

References

  • [1] Di H, He Q, Liao Y, Kalionis B, Tai X. The role of inflammatory cytokines in the pathogenesis of cerebral palsy. Gynecol Obstet (Sunnyvale) 2016; 6(2): 1-7.
  • [2] Bennet L, Dhillon S, Lear CA, van den Heuij L, King V, Dean JM, Wassink G, Davidson JO, Gunn AJ. Chronic inflammation and impaired development of the preterm brain. J Reprod Immunol 2018; 125:45-55.
  • [3] Magalhães RC, Moreira JM, Lauar AO, da Silva AAS, Teixeira AL, E Silva ACS. Inflammatory biomarkers in children with cerebral palsy: A systematic review. Res Dev Disabil 2019; 95:1-13.
  • [4] Varner MW, Marshall NE, Rouse DJ, Jablonski KA, Leveno KJ, Reddy UM, Mercer BM, Iams JD, Wapner RJ, Sorokin Y, Thorp JM, Malone FD, Carpenter M, O’Sullivan MJ, Peaceman AM, Hankins GD, Dudley DJ, Caritis SN. The association of cord serum cytokines with neurodevelopmental outcomes. Am J Perinatol 2015; 30(2):115-122.
  • [5] Tsukimori K, Komatsu H, Yoshimura T, Hikino S, Hara T, Wake N, Nakano H. Increased inflammatory markers are associated with early periventricular leukomalacia. Dev Med Child Neurol 2007; 49(8):587-590.
  • [6] Lin CY, Chang YC, Wang ST, Lee TY, Lin CF, Huang CC. Altered inflammatory responses in preterm children with cerebral palsy. Ann Neurol 2010; 68(2):204-212.
  • [7] Hagberg H, Mallard C, Ferriero DM, Vannucci SJ, Levison SW, Vexler ZS, Gressens P. The role of inflammation in perinatal brain injury. Nat Rev Neurol 2015;11(4):192-208.
  • [8] Wu J, Li X. Plasma tumor necrosis factor-alpha (TNF-α) levels correlate with disease severity in spastic diplegia, triplegia, and quadriplegia in children with cerebral palsy. Med Sci Monit 2015; 21: 3868-3874.
  • [9] Dommergues MA, Patkai J, Renauld JC, Evrard P, Gressens P. Proinflammatory cytokines and interleukin-9 exacerbate excitotoxic lesions of the newborn murine neopallium. Ann Neurol. 2000; 47(1):54-63.
  • [10] Patkai J, Mesples B, Dommergues MA, Fromont G, Thornton EM, Renauld JC, Evrard P, Gressens P. Deleterious effects of IL-9–activated mast cells and neuroprotection by antihistamine drugs in the developing mouse brain. Pediatr Res 2001; 50(2): 222-230.
  • [11] Adlinolfi M. Infectious diseases in pregnancy, cytokines and neurological impairment: an hypothesis. Dev Med Child Neurol 1993; 35(6): 549-553.
  • [12] Khaksari M, Abbasloo E, Dehghan F, Soltani Z, Asadikaram G. The brain cytokine levels are modulated by estrogen following traumatic brain injury: Which estrogen receptor serves as modulator? Int Immunopharmacol 2015; 28(1): 279-287.
  • [13] Camire RB, Beaulac HJ, Willis CL. Transitory loss of glia and the subsequent modulation in inflammatory cytokines/ chemokines regulate paracellular claudin-5 expression in endothelial cells. J Neuroimmunol. 2015; 284: 57-66.
  • [14] Nelson KB, Blair E. Prenatal factors in singletons with cerebral palsy born at or near term. N Engl J Med 2015; 373(10): 946- 953.
  • [15] Armstrong-Wells J, Donnelly M, Post MD, Manco-Johnson MJ, Winn VD, Sébire G. Inflammatory predictors of neurologic disability after preterm premature rupture of membranes. Am J Obstet Gynecol 2015; 212(2): 1-17.
  • [16] Nelson KB, Dambrosia JM, Grether JK, Phillips TM. Neonatal cytokines and coagulation factors in children with cerebral palsy. Ann Neurol 1998; 44(4): 666-675.
  • [17] Foster-Barber A, Dickens B, Ferriero DM. Human perinatal asphyxia: correlation of neonatal cytokines with MRI and outcome. Dev Neurosci 2001; 23(3): 213-218.
  • [18] Leviton A. Preterm birth and cerebral palsy: is tumor necrosis factor the missing link? Dev Med Child Neurol. 1993; 35(6): 553-558.
  • [19] Zaitsu M, Narita S, Lambert KC, Grady JJ, Estes DM, Curran EM, Brooks EG, Watson CS, Goldblum RM, Midoro-Horiuti T. Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx. Mol Immunol. 2007; 44(8):1977-1985.
  • [20] Moon TC, Befus AD, Kulka M. Mast cell mediators: their differential release and the secretory pathways involved. Front Immunol 2014; 14(5): 1-18.
  • [21] Theoharides TC. Neuroendocrinology of mast cells: Challenges and controversies. Exp Dermatol 2017; 26(9): 751-759. [22] Koyuncu Irmak D, Kilinc E, Tore F. Shared fate of meningeal mast cells and sensory neurons in migraine. Front Cell Neurosci 2019; 13(136): 1-10.
  • [23] Kilinc E, Tore F, Dagistan Y, Bugdayci G. Thymoquinone inhibits neurogenic inflammation underlying migraine through modulation of calcitonin gene-related peptide release and stabilization of meningeal mast cells in glyceryltrinitrate- induced migraine model in rats. Inflammation 2020; 43(1):264-273.

Increased Systemic Inflammatory Response with Mast Cell Activation In Elder Children With Cerebral Palsy

Year 2022, Volume: 12 Issue: 2, 294 - 301, 30.06.2022
https://doi.org/10.33808/clinexphealthsci.983877

Abstract

Objective: Increased systemic inflammatory response during intrauterine period or period before the age of 3 is associated with cerebral palsy (CP) pathogenesis; however, effects of inflammatory processes involving mast cell activation in elder children with CP remain unclear. We aimed to investigate the role of mast cells and proinflammatory cytokines in children with CP at 3-18 years of age.
Methods: In this cross-sectional study, venous blood samples were obtained from 30 volunteers with CP and 26 healthy volunteers at 3-18 years of age. Plasma levels of proinflammatory cytokines (IL-1β, IL-6 and IL-9) and mast cell biomarkers (histamine and tryptase beta-2) were determined using ELISA.
Results: IL-1β, IL-6 and histamine levels were higher in individuals with CP compared to healthy controls. Likewise, IL-1β, IL-6, IL-9 and histamine levels were higher in the female patients with CP compared to the male patients, and in the female patients in adolescence compared to the female patients in pre-adolescence.
Conclusion: Our findings indicate that the increased inflammatory response contributes to the pathogenesis of the disease in children with CP who are older than 2 years of age. Moreover the increased inflammatory response is more effective in female patients than in male patients, suggesting that there may be a gender difference in CP. Additionally mast cell activation contributes to the exacerbation of systemic inflammatory response in children with CP at 3-18 years of age.

Supporting Institution

Bolu Abant Izzet Baysal University Scientific Research Fund

Project Number

2019.08.02.1415

Thanks

This study was supported by Bolu Abant Izzet Baysal University Scientific Research Fund (Grant-number: 2019.08.02.1415).

References

  • [1] Di H, He Q, Liao Y, Kalionis B, Tai X. The role of inflammatory cytokines in the pathogenesis of cerebral palsy. Gynecol Obstet (Sunnyvale) 2016; 6(2): 1-7.
  • [2] Bennet L, Dhillon S, Lear CA, van den Heuij L, King V, Dean JM, Wassink G, Davidson JO, Gunn AJ. Chronic inflammation and impaired development of the preterm brain. J Reprod Immunol 2018; 125:45-55.
  • [3] Magalhães RC, Moreira JM, Lauar AO, da Silva AAS, Teixeira AL, E Silva ACS. Inflammatory biomarkers in children with cerebral palsy: A systematic review. Res Dev Disabil 2019; 95:1-13.
  • [4] Varner MW, Marshall NE, Rouse DJ, Jablonski KA, Leveno KJ, Reddy UM, Mercer BM, Iams JD, Wapner RJ, Sorokin Y, Thorp JM, Malone FD, Carpenter M, O’Sullivan MJ, Peaceman AM, Hankins GD, Dudley DJ, Caritis SN. The association of cord serum cytokines with neurodevelopmental outcomes. Am J Perinatol 2015; 30(2):115-122.
  • [5] Tsukimori K, Komatsu H, Yoshimura T, Hikino S, Hara T, Wake N, Nakano H. Increased inflammatory markers are associated with early periventricular leukomalacia. Dev Med Child Neurol 2007; 49(8):587-590.
  • [6] Lin CY, Chang YC, Wang ST, Lee TY, Lin CF, Huang CC. Altered inflammatory responses in preterm children with cerebral palsy. Ann Neurol 2010; 68(2):204-212.
  • [7] Hagberg H, Mallard C, Ferriero DM, Vannucci SJ, Levison SW, Vexler ZS, Gressens P. The role of inflammation in perinatal brain injury. Nat Rev Neurol 2015;11(4):192-208.
  • [8] Wu J, Li X. Plasma tumor necrosis factor-alpha (TNF-α) levels correlate with disease severity in spastic diplegia, triplegia, and quadriplegia in children with cerebral palsy. Med Sci Monit 2015; 21: 3868-3874.
  • [9] Dommergues MA, Patkai J, Renauld JC, Evrard P, Gressens P. Proinflammatory cytokines and interleukin-9 exacerbate excitotoxic lesions of the newborn murine neopallium. Ann Neurol. 2000; 47(1):54-63.
  • [10] Patkai J, Mesples B, Dommergues MA, Fromont G, Thornton EM, Renauld JC, Evrard P, Gressens P. Deleterious effects of IL-9–activated mast cells and neuroprotection by antihistamine drugs in the developing mouse brain. Pediatr Res 2001; 50(2): 222-230.
  • [11] Adlinolfi M. Infectious diseases in pregnancy, cytokines and neurological impairment: an hypothesis. Dev Med Child Neurol 1993; 35(6): 549-553.
  • [12] Khaksari M, Abbasloo E, Dehghan F, Soltani Z, Asadikaram G. The brain cytokine levels are modulated by estrogen following traumatic brain injury: Which estrogen receptor serves as modulator? Int Immunopharmacol 2015; 28(1): 279-287.
  • [13] Camire RB, Beaulac HJ, Willis CL. Transitory loss of glia and the subsequent modulation in inflammatory cytokines/ chemokines regulate paracellular claudin-5 expression in endothelial cells. J Neuroimmunol. 2015; 284: 57-66.
  • [14] Nelson KB, Blair E. Prenatal factors in singletons with cerebral palsy born at or near term. N Engl J Med 2015; 373(10): 946- 953.
  • [15] Armstrong-Wells J, Donnelly M, Post MD, Manco-Johnson MJ, Winn VD, Sébire G. Inflammatory predictors of neurologic disability after preterm premature rupture of membranes. Am J Obstet Gynecol 2015; 212(2): 1-17.
  • [16] Nelson KB, Dambrosia JM, Grether JK, Phillips TM. Neonatal cytokines and coagulation factors in children with cerebral palsy. Ann Neurol 1998; 44(4): 666-675.
  • [17] Foster-Barber A, Dickens B, Ferriero DM. Human perinatal asphyxia: correlation of neonatal cytokines with MRI and outcome. Dev Neurosci 2001; 23(3): 213-218.
  • [18] Leviton A. Preterm birth and cerebral palsy: is tumor necrosis factor the missing link? Dev Med Child Neurol. 1993; 35(6): 553-558.
  • [19] Zaitsu M, Narita S, Lambert KC, Grady JJ, Estes DM, Curran EM, Brooks EG, Watson CS, Goldblum RM, Midoro-Horiuti T. Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx. Mol Immunol. 2007; 44(8):1977-1985.
  • [20] Moon TC, Befus AD, Kulka M. Mast cell mediators: their differential release and the secretory pathways involved. Front Immunol 2014; 14(5): 1-18.
  • [21] Theoharides TC. Neuroendocrinology of mast cells: Challenges and controversies. Exp Dermatol 2017; 26(9): 751-759. [22] Koyuncu Irmak D, Kilinc E, Tore F. Shared fate of meningeal mast cells and sensory neurons in migraine. Front Cell Neurosci 2019; 13(136): 1-10.
  • [23] Kilinc E, Tore F, Dagistan Y, Bugdayci G. Thymoquinone inhibits neurogenic inflammation underlying migraine through modulation of calcitonin gene-related peptide release and stabilization of meningeal mast cells in glyceryltrinitrate- induced migraine model in rats. Inflammation 2020; 43(1):264-273.
There are 22 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Cemalettin Demir 0000-0001-8140-9892

Yasemin Baranoğlu Kılınç 0000-0002-1795-5677

Erkan Kılınç 0000-0001-9261-2634

Project Number 2019.08.02.1415
Publication Date June 30, 2022
Submission Date August 17, 2021
Published in Issue Year 2022 Volume: 12 Issue: 2

Cite

APA Demir, C., Baranoğlu Kılınç, Y., & Kılınç, E. (2022). Increased Systemic Inflammatory Response with Mast Cell Activation In Elder Children With Cerebral Palsy. Clinical and Experimental Health Sciences, 12(2), 294-301. https://doi.org/10.33808/clinexphealthsci.983877
AMA Demir C, Baranoğlu Kılınç Y, Kılınç E. Increased Systemic Inflammatory Response with Mast Cell Activation In Elder Children With Cerebral Palsy. Clinical and Experimental Health Sciences. June 2022;12(2):294-301. doi:10.33808/clinexphealthsci.983877
Chicago Demir, Cemalettin, Yasemin Baranoğlu Kılınç, and Erkan Kılınç. “Increased Systemic Inflammatory Response With Mast Cell Activation In Elder Children With Cerebral Palsy”. Clinical and Experimental Health Sciences 12, no. 2 (June 2022): 294-301. https://doi.org/10.33808/clinexphealthsci.983877.
EndNote Demir C, Baranoğlu Kılınç Y, Kılınç E (June 1, 2022) Increased Systemic Inflammatory Response with Mast Cell Activation In Elder Children With Cerebral Palsy. Clinical and Experimental Health Sciences 12 2 294–301.
IEEE C. Demir, Y. Baranoğlu Kılınç, and E. Kılınç, “Increased Systemic Inflammatory Response with Mast Cell Activation In Elder Children With Cerebral Palsy”, Clinical and Experimental Health Sciences, vol. 12, no. 2, pp. 294–301, 2022, doi: 10.33808/clinexphealthsci.983877.
ISNAD Demir, Cemalettin et al. “Increased Systemic Inflammatory Response With Mast Cell Activation In Elder Children With Cerebral Palsy”. Clinical and Experimental Health Sciences 12/2 (June 2022), 294-301. https://doi.org/10.33808/clinexphealthsci.983877.
JAMA Demir C, Baranoğlu Kılınç Y, Kılınç E. Increased Systemic Inflammatory Response with Mast Cell Activation In Elder Children With Cerebral Palsy. Clinical and Experimental Health Sciences. 2022;12:294–301.
MLA Demir, Cemalettin et al. “Increased Systemic Inflammatory Response With Mast Cell Activation In Elder Children With Cerebral Palsy”. Clinical and Experimental Health Sciences, vol. 12, no. 2, 2022, pp. 294-01, doi:10.33808/clinexphealthsci.983877.
Vancouver Demir C, Baranoğlu Kılınç Y, Kılınç E. Increased Systemic Inflammatory Response with Mast Cell Activation In Elder Children With Cerebral Palsy. Clinical and Experimental Health Sciences. 2022;12(2):294-301.

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