The Roles of the Golgi in Various Diseases

Year 2024, Volume: 14 Issue: 1, 264 - 272, 28.03.2024

Hilal Salcın , Burçin Tezcanlı Kaymaz

https://doi.org/10.33808/clinexphealthsci.1148777

Abstract

The primary function of the Golgi is to perform post-translational modifications on proteins, allow them to be transported within the cell. The Golgi has more functions in the cell, according to research into its unknown structure and functions. It has been discovered that, in addition to substance process and transport, it plays a role in autophagy, lipid formation, calcium homeostasis, and apoptosis regulation.
The fact that the Golgi has so many tasks has caused question marks about what kind of illnesses or diseases it can cause in case of a problem with Golgi. A mutation at Golgi can disrupt its function by cause of the Golgi fragmentation. It can be seized by living organisms or molecules, called infectious agents, outside the mutation. Disintegration and disorders in the Golgi structure and function are examples of neurodegenerative diseases and cancer. In addition, studies prove that the SARS-CoV-2 virus, which causes pandemic in the world, is also linked to the Golgi. The diseases that can be caused by the Golgi are highlighted in this review, as are treatment studies. Treatment strategies for the Golgi that causes many diseases are still developing and studies are ongoing.The primary function of the Golgi apparatus is to perform post-translational modifications on proteins, allowing them to be transported within the cell. The Golgi has more functions in the cell, according to research into its unknown structure and functions. It has been discovered that, in addition to substance processing and transport, it plays a role in autophagy, lipid formation, calcium homeostasis, and apoptosis regulation. The fact that Golgi has so many tasks has caused question marks about what kind of illnesses or diseases it can cause in case of a problem with Golgi. A mutation at Golgi can disrupt its function by causing Golgi fragmentation. It can be seized by living organisms or molecules, called infectious agents, outside the mutation. Disintegration and disorders in Golgi structure and function are examples of neurodegenerative diseases and cancer. In addition, studies prove that the SARS-CoV-2 virus, which causes pandemics in the world, is also linked to Golgi. The diseases that can be caused by Golgi are highlighted in this review, as are treatment studies. Treatment strategies for Golgi device that causes many diseases are still developing and studies are ongoing.

Keywords

Golgi, cancer, neurodegenerative diseases, SARS-CoV, treatment

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