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An Evaluation of The Relationship Between Falls, Osteoporosis And The Parkinson’s Disease Rating Scale In Patients With Parkinson’s Disease

Year 2024, Volume: 14 Issue: 2, 525 - 530, 28.06.2024
https://doi.org/10.33808/clinexphealthsci.1114826

Abstract

Objective: The purpose of this study is to examine conditions such as balance disorder, risk of falling, fear of falling, vitamin D deficiency and osteoporosis in people with Parkinson's Disease (PD), and their association with the Movement Disorders Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) sub-components, which are used to follow-up these patients.
Methods: The study comprised 38 patients who were followed up for idiopathic PD. All the patients’ demographic data, falls efficacy scale, number of falls within the last year, history of fractures, Berg Balance Scale, the MDS-UPDRS sub-components, vitamin D levels, and bone mineral densitometry values were recorded.
Results: There was a positive correlation between the MDS-UPDRS Part I and the number of falls and the history of fractures, and a positive correlation with the Hoehn and Yahr scale, and the MDS-UPDRS Part II, III and total and the Berg Balance Scale, the Falls Efficacy Scale, and the number of falls. Our study found that the bone mineral densitometry values for the femoral neck were lower in women than in men, and there was a positive correlation between the bone mineral densitometry values for the femoral neck and the body mass index. A positive correlation was established between levodopa use and the falls efficacy scale.
Conclusion: Falls, imbalance, osteoporosis are life-threatening conditions in patients with PD. This study established that the MDS-UPDRS, used to follow-up patients, was associated with these conditions. It is believed that this assessment method may also give an idea about these conditions in PD patients who are followed up using this scale.

References

  • Campenhausen SV, Bornschein B, Wick R, Bötzel K, Sampaio C, Poewe W, Oertel W, Siebert U, Berger K, Dodel R. Prevalence and incidence of Parkinson's disease in Europe. Eur Neuropsychopharmacol. 2005;15(4):473-490. DOI: 10.1016/j.euroneuro.2005.04.007
  • Grimbergen YA, Munneke M, Bloem BR. Falls in Parkinson's disease. Curr Opinion Neurol. 2004;17(4):405-415. DOI:10.1097/01.wco.0000137530.68867.93
  • Bloem BR, Steijns JA, Smits-Engelsman BC. An update on falls. Curr Opinion Neurol. 2003;16(1):15-26. DOI:10.1097/01.wco.0000053580.70044.70
  • Van DBF, Speelman AD, Samson M, Munneke M, Bloem BR, Verhaar HJ. Parkinson's disease and osteoporosis. Age and Ageing 2013;42(2):156-162. DOI:10.1093/ageing/afs161
  • Jenkinson C, Fitzpatrick RA, Greenhall R, Hyman N. The Parkinson's Disease Questionnaire (PDQ-39): Development and validation of a Parkinson's disease summary index score. Age and Ageing 1997;26(5):353-357. DOI:10.1093/ageing/26.5.353
  • Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez‐Martin P, Poewe W, Sampaio C, Stern M B, Dodel R, Dubois B, Holloway R, Jankovic R, Kulisevsky J, Lang AE, Lees A, Leurgans S, LeWitt PA, Nyenhuis D, Olanow CW, Rascol O, Scrhrag A, Teresi JA, Hilten JJV, LaPelle N. Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results. Mov Disord. 2008;23(15):2129-2170. DOI:10.1002/mds.22340
  • Berg KO, Maki BE, Williams JI, Holliday PJ. Clinical and laboratory measures of postural balance in an elderly population. Arch Phys Med Rehabil. 1992;73(11):1073-1080. PMID:1444775
  • Sahin F, Yilmaz F, Ozmaden A, Kotevoglu N, Sahin T, Kuran B. Reliability and validity of the Turkish version of the Berg Balance Scale. J Geriatr Phys Ther. 2008; 31(1):32-37. DOI:10.1519/00139143-200831010-00006
  • Tinetti ME, Richman D, Powell L. Falls efficacy as a measure of fear of falling. J Gerontol. 1990;45(6):239-243. DOI:10.1093/geronj/45.6.p239
  • Ulus Y, Durmus D, Akyol Y, Terzi, Y, Bilgici A, Kuru O. Reliability and validity of the Turkish version of the Falls Efficacy Scale International (FES-I) in community-dwelling older persons. Arch Gerontol Geriatr. 2012;54(3):429-433. DOI: 10.1016/j.archger.2011.06.010
  • Yardley L, Beyer N, Hauer K, Kempen G, Piot-Ziegler C, Todd C. Development and initial validation of the Falls Efficacy Scale-International (FES-I). Age and Ageing 2005; 34(6):614-619. DOI:10.1093/ageing/afi196
  • Akbostanci MC, Bayram E, Yilmaz V, Rzayev S, Özkan S, Tokcaer AB, Saka E, Çelik FND, Barut BÖ, Tüfekçioğlu Z, Acarer A, Balaban H, Erer S, Doğu O, Kibaroğlu S, Aydın N, Hanagasi H, Elibol B, Emre M, Stebbins GT, Goetz CG. Turkish standardization of movement disorders society unified Parkinson's disease rating scale and unified dyskinesia rating scale. Mov Disord Clin Pract. 2018;5(1):54-59. DOI: 10.1002/mdc3.12556
  • Shepherd JA, Baim S, Bilezikian JP, Schousboe JT. Executive summary of the 2013 international society for clinical densitometry position development conference on body composition. J Clin Densitom. 2013;16(4):489-495. DOI:10.1016/j.jocd.2013.08.005
  • Bloem BR, Grimbergen YA, Cramer M, Willemsen M, Zwinderman AH. Prospective assessment of falls in Parkinson's disease. Journal of Neurology. 2001;248(11):950-958. DOI:10.1007/s004150170047
  • Contreras A, Grandas F. Risk of falls in Parkinson’s disease: a cross-sectional study of 160 patients. Parkinson’s Dis. 2012;10. DOI:10.1155/2012/362572
  • Kerr GK, Worringham CJ, Cole MH, Lacherez PF, Wood JM, Silburn PA. Predictors of future falls in Parkinson disease. Neurology 2010;75(2):116-124. DOI:10.1212/WNL.0b013e3181e7b688
  • Movement Disorder Society Task Force on Rating Scales for Parkinson's Disease. The unified Parkinson's disease rating scale (UPDRS): Status and recommendations. Mov Disord. 2003;18(7):738-750. DOI: 10.1002/mds.10473
  • Tassorelli C, Berlangieri M, Buscone S, Bolla M, De Icco R, Baricich A, Pacchetti C, Sandrini CCG. Falls, fractures and bone density in Parkinson's disease–a cross-sectional study. Int J Neurosci. 2017;127(4):299-304. DOI:10.1080/00207454.2016.1206897
  • Ozturk EA, Gundogdu I, Tonuk B, Umay E, Kocer BG, Cakci A. Bone mineral density and serum vitamin D status in Parkinson's disease: Are the stage and clinical features of the disease important? Neurol India. 2020;68(2):394. DOI: 10.4103/0028-3886.283755
  • Zhao Y, Shen L, Ji HF. Osteoporosis risk and bone mineral density levels in patients with Parkinson's disease: A meta-analysis. Bone 2013;52(1):498-505. DOI: 10.1016/j.bone.2012.09.013
  • Raglione LM, Sorbi S, Nacmias B. Osteoporosis and Parkinson’s disease. Clin Cases Miner Bone Metab. 2011;8(3):16. PMID: 22461823
  • Ozturk EA, Gundogdu I, Tonuk B, Kocer BG, Tombak Y, Comoglu S, Cakci A. Bone mass and vitamin D levels in Parkinson’s disease: Is there any difference between genders? J Phys Ther Sci. 2016;28(8):2204-2209. DOI: 10.1589/jpts.28.2204
  • Van der Marck MA, Dicke HC, Uc EY, Kentin ZH, Borm GF, Bloem BR, Overeem S, Munneke M. Body mass index in Parkinson’s disease: A meta-analysis. Parkinsonism Relat Disord. 2012;18(3):263-267. DOI: 10.1016/j.parkreldis.2011.10.016
  • De Laet C, Kanis JA, Odén A, Johanson H, Johnell O, Delmas P, Eisman JA, Kroger H, Fujiwara S, Garnero P, McCloskey EV, Mellstrom D, Melton LJ, Meunier PJ, Pols HAP, Reeve J, Silman A, Tenenhouse A. Body mass index as a predictor of fracture risk: Ameta-analysis. Osteoporos Int. 2005;16(11):1330-1338. DOI: 10.1007/s00198-005-1863-y
  • Van den Bos F, Speelman AD, Van Nimwegen M, Van Der Schouw YT, Backx FJG, Bloem BR, Munneke M, Verhaar HJJ. Bone mineral density and vitamin D status in Parkinson’s disease patients. J Neurol. 2013;260(3):754-760. DOI: 10. 1007/s00415-012-6697-x
Year 2024, Volume: 14 Issue: 2, 525 - 530, 28.06.2024
https://doi.org/10.33808/clinexphealthsci.1114826

Abstract

References

  • Campenhausen SV, Bornschein B, Wick R, Bötzel K, Sampaio C, Poewe W, Oertel W, Siebert U, Berger K, Dodel R. Prevalence and incidence of Parkinson's disease in Europe. Eur Neuropsychopharmacol. 2005;15(4):473-490. DOI: 10.1016/j.euroneuro.2005.04.007
  • Grimbergen YA, Munneke M, Bloem BR. Falls in Parkinson's disease. Curr Opinion Neurol. 2004;17(4):405-415. DOI:10.1097/01.wco.0000137530.68867.93
  • Bloem BR, Steijns JA, Smits-Engelsman BC. An update on falls. Curr Opinion Neurol. 2003;16(1):15-26. DOI:10.1097/01.wco.0000053580.70044.70
  • Van DBF, Speelman AD, Samson M, Munneke M, Bloem BR, Verhaar HJ. Parkinson's disease and osteoporosis. Age and Ageing 2013;42(2):156-162. DOI:10.1093/ageing/afs161
  • Jenkinson C, Fitzpatrick RA, Greenhall R, Hyman N. The Parkinson's Disease Questionnaire (PDQ-39): Development and validation of a Parkinson's disease summary index score. Age and Ageing 1997;26(5):353-357. DOI:10.1093/ageing/26.5.353
  • Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez‐Martin P, Poewe W, Sampaio C, Stern M B, Dodel R, Dubois B, Holloway R, Jankovic R, Kulisevsky J, Lang AE, Lees A, Leurgans S, LeWitt PA, Nyenhuis D, Olanow CW, Rascol O, Scrhrag A, Teresi JA, Hilten JJV, LaPelle N. Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results. Mov Disord. 2008;23(15):2129-2170. DOI:10.1002/mds.22340
  • Berg KO, Maki BE, Williams JI, Holliday PJ. Clinical and laboratory measures of postural balance in an elderly population. Arch Phys Med Rehabil. 1992;73(11):1073-1080. PMID:1444775
  • Sahin F, Yilmaz F, Ozmaden A, Kotevoglu N, Sahin T, Kuran B. Reliability and validity of the Turkish version of the Berg Balance Scale. J Geriatr Phys Ther. 2008; 31(1):32-37. DOI:10.1519/00139143-200831010-00006
  • Tinetti ME, Richman D, Powell L. Falls efficacy as a measure of fear of falling. J Gerontol. 1990;45(6):239-243. DOI:10.1093/geronj/45.6.p239
  • Ulus Y, Durmus D, Akyol Y, Terzi, Y, Bilgici A, Kuru O. Reliability and validity of the Turkish version of the Falls Efficacy Scale International (FES-I) in community-dwelling older persons. Arch Gerontol Geriatr. 2012;54(3):429-433. DOI: 10.1016/j.archger.2011.06.010
  • Yardley L, Beyer N, Hauer K, Kempen G, Piot-Ziegler C, Todd C. Development and initial validation of the Falls Efficacy Scale-International (FES-I). Age and Ageing 2005; 34(6):614-619. DOI:10.1093/ageing/afi196
  • Akbostanci MC, Bayram E, Yilmaz V, Rzayev S, Özkan S, Tokcaer AB, Saka E, Çelik FND, Barut BÖ, Tüfekçioğlu Z, Acarer A, Balaban H, Erer S, Doğu O, Kibaroğlu S, Aydın N, Hanagasi H, Elibol B, Emre M, Stebbins GT, Goetz CG. Turkish standardization of movement disorders society unified Parkinson's disease rating scale and unified dyskinesia rating scale. Mov Disord Clin Pract. 2018;5(1):54-59. DOI: 10.1002/mdc3.12556
  • Shepherd JA, Baim S, Bilezikian JP, Schousboe JT. Executive summary of the 2013 international society for clinical densitometry position development conference on body composition. J Clin Densitom. 2013;16(4):489-495. DOI:10.1016/j.jocd.2013.08.005
  • Bloem BR, Grimbergen YA, Cramer M, Willemsen M, Zwinderman AH. Prospective assessment of falls in Parkinson's disease. Journal of Neurology. 2001;248(11):950-958. DOI:10.1007/s004150170047
  • Contreras A, Grandas F. Risk of falls in Parkinson’s disease: a cross-sectional study of 160 patients. Parkinson’s Dis. 2012;10. DOI:10.1155/2012/362572
  • Kerr GK, Worringham CJ, Cole MH, Lacherez PF, Wood JM, Silburn PA. Predictors of future falls in Parkinson disease. Neurology 2010;75(2):116-124. DOI:10.1212/WNL.0b013e3181e7b688
  • Movement Disorder Society Task Force on Rating Scales for Parkinson's Disease. The unified Parkinson's disease rating scale (UPDRS): Status and recommendations. Mov Disord. 2003;18(7):738-750. DOI: 10.1002/mds.10473
  • Tassorelli C, Berlangieri M, Buscone S, Bolla M, De Icco R, Baricich A, Pacchetti C, Sandrini CCG. Falls, fractures and bone density in Parkinson's disease–a cross-sectional study. Int J Neurosci. 2017;127(4):299-304. DOI:10.1080/00207454.2016.1206897
  • Ozturk EA, Gundogdu I, Tonuk B, Umay E, Kocer BG, Cakci A. Bone mineral density and serum vitamin D status in Parkinson's disease: Are the stage and clinical features of the disease important? Neurol India. 2020;68(2):394. DOI: 10.4103/0028-3886.283755
  • Zhao Y, Shen L, Ji HF. Osteoporosis risk and bone mineral density levels in patients with Parkinson's disease: A meta-analysis. Bone 2013;52(1):498-505. DOI: 10.1016/j.bone.2012.09.013
  • Raglione LM, Sorbi S, Nacmias B. Osteoporosis and Parkinson’s disease. Clin Cases Miner Bone Metab. 2011;8(3):16. PMID: 22461823
  • Ozturk EA, Gundogdu I, Tonuk B, Kocer BG, Tombak Y, Comoglu S, Cakci A. Bone mass and vitamin D levels in Parkinson’s disease: Is there any difference between genders? J Phys Ther Sci. 2016;28(8):2204-2209. DOI: 10.1589/jpts.28.2204
  • Van der Marck MA, Dicke HC, Uc EY, Kentin ZH, Borm GF, Bloem BR, Overeem S, Munneke M. Body mass index in Parkinson’s disease: A meta-analysis. Parkinsonism Relat Disord. 2012;18(3):263-267. DOI: 10.1016/j.parkreldis.2011.10.016
  • De Laet C, Kanis JA, Odén A, Johanson H, Johnell O, Delmas P, Eisman JA, Kroger H, Fujiwara S, Garnero P, McCloskey EV, Mellstrom D, Melton LJ, Meunier PJ, Pols HAP, Reeve J, Silman A, Tenenhouse A. Body mass index as a predictor of fracture risk: Ameta-analysis. Osteoporos Int. 2005;16(11):1330-1338. DOI: 10.1007/s00198-005-1863-y
  • Van den Bos F, Speelman AD, Van Nimwegen M, Van Der Schouw YT, Backx FJG, Bloem BR, Munneke M, Verhaar HJJ. Bone mineral density and vitamin D status in Parkinson’s disease patients. J Neurol. 2013;260(3):754-760. DOI: 10. 1007/s00415-012-6697-x
There are 25 citations in total.

Details

Primary Language English
Subjects Physical Activity and Health
Journal Section Articles
Authors

Asli Keles Onal 0000-0002-4016-0135

Şenay Özdolap Çoban 0000-0003-4986-5411

Selda Sarıkaya 0000-0002-8015-0513

Esra Aciman Demirel 0000-0002-1444-5022

Sibel Özdemir 0000-0001-5373-7506

Publication Date June 28, 2024
Submission Date May 12, 2022
Published in Issue Year 2024 Volume: 14 Issue: 2

Cite

APA Keles Onal, A., Özdolap Çoban, Ş., Sarıkaya, S., Aciman Demirel, E., et al. (2024). An Evaluation of The Relationship Between Falls, Osteoporosis And The Parkinson’s Disease Rating Scale In Patients With Parkinson’s Disease. Clinical and Experimental Health Sciences, 14(2), 525-530. https://doi.org/10.33808/clinexphealthsci.1114826
AMA Keles Onal A, Özdolap Çoban Ş, Sarıkaya S, Aciman Demirel E, Özdemir S. An Evaluation of The Relationship Between Falls, Osteoporosis And The Parkinson’s Disease Rating Scale In Patients With Parkinson’s Disease. Clinical and Experimental Health Sciences. June 2024;14(2):525-530. doi:10.33808/clinexphealthsci.1114826
Chicago Keles Onal, Asli, Şenay Özdolap Çoban, Selda Sarıkaya, Esra Aciman Demirel, and Sibel Özdemir. “An Evaluation of The Relationship Between Falls, Osteoporosis And The Parkinson’s Disease Rating Scale In Patients With Parkinson’s Disease”. Clinical and Experimental Health Sciences 14, no. 2 (June 2024): 525-30. https://doi.org/10.33808/clinexphealthsci.1114826.
EndNote Keles Onal A, Özdolap Çoban Ş, Sarıkaya S, Aciman Demirel E, Özdemir S (June 1, 2024) An Evaluation of The Relationship Between Falls, Osteoporosis And The Parkinson’s Disease Rating Scale In Patients With Parkinson’s Disease. Clinical and Experimental Health Sciences 14 2 525–530.
IEEE A. Keles Onal, Ş. Özdolap Çoban, S. Sarıkaya, E. Aciman Demirel, and S. Özdemir, “An Evaluation of The Relationship Between Falls, Osteoporosis And The Parkinson’s Disease Rating Scale In Patients With Parkinson’s Disease”, Clinical and Experimental Health Sciences, vol. 14, no. 2, pp. 525–530, 2024, doi: 10.33808/clinexphealthsci.1114826.
ISNAD Keles Onal, Asli et al. “An Evaluation of The Relationship Between Falls, Osteoporosis And The Parkinson’s Disease Rating Scale In Patients With Parkinson’s Disease”. Clinical and Experimental Health Sciences 14/2 (June 2024), 525-530. https://doi.org/10.33808/clinexphealthsci.1114826.
JAMA Keles Onal A, Özdolap Çoban Ş, Sarıkaya S, Aciman Demirel E, Özdemir S. An Evaluation of The Relationship Between Falls, Osteoporosis And The Parkinson’s Disease Rating Scale In Patients With Parkinson’s Disease. Clinical and Experimental Health Sciences. 2024;14:525–530.
MLA Keles Onal, Asli et al. “An Evaluation of The Relationship Between Falls, Osteoporosis And The Parkinson’s Disease Rating Scale In Patients With Parkinson’s Disease”. Clinical and Experimental Health Sciences, vol. 14, no. 2, 2024, pp. 525-30, doi:10.33808/clinexphealthsci.1114826.
Vancouver Keles Onal A, Özdolap Çoban Ş, Sarıkaya S, Aciman Demirel E, Özdemir S. An Evaluation of The Relationship Between Falls, Osteoporosis And The Parkinson’s Disease Rating Scale In Patients With Parkinson’s Disease. Clinical and Experimental Health Sciences. 2024;14(2):525-30.

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