Comprehensive Review of Nobiletin, a Citrus Flavonoid: Metabolism and Anti-tumor Properties

Meryem Saban Güler; Hilal Yıldıran

doi:10.33808/clinexphealthsci.1356783

Review

Comprehensive Review of Nobiletin, a Citrus Flavonoid: Metabolism and Anti-tumor Properties

Year 2024, Volume: 14 Issue: 2, 561 - 571, 28.06.2024

Meryem Saban Güler Hilal Yıldıran

https://doi.org/10.33808/clinexphealthsci.1356783

Abstract

Nobiletin is a polymethoxylated flavone found in citrus peels. Thanks to its chemical structure and biological activities, nobiletin has been shown to have a positive effect on many diseases. In recent years, there has been a growing interest in research focusing on the impact of nobiletin and its metabolites on different cancer types. Nobiletin exhibits anticancer properties by impeding the proliferation of cancer cells, disrupting the cancer cell cycle, facilitating apoptosis, and regulating signaling pathways implicated in cancer development. In addition, studies have shown that its use with chemotherapeutic agents inhibits multi-drug resistance. This review aims to evaluate the metabolic properties of nobiletin and its possible effects on cancer.

Keywords

Nobiletin, bioavailability, cancer, signaling pathways, antiproliferation

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Year 2024, Volume: 14 Issue: 2, 561 - 571, 28.06.2024

Meryem Saban Güler Hilal Yıldıran

https://doi.org/10.33808/clinexphealthsci.1356783

Abstract

References

Nakajima A, Ohizumi Y. Potential benefits of nobiletin, a citrus flavonoid, against Alzheimer’s disease and Parkinson’s disease. Int J Mol Sci. 2019;20(14):3380:1-14. DOI: 10.3390/ijms20143380.
Yarım GF, Çenesiz M, Yarım M, Kazak F. Nöroprotektif etkili bir flavonoid: Nobiletin. Harran Üniv Vet Fak Derg. 2017;6(1):102-107. DOI:10.31196/huvfd.325789. (Turkish).
Braidy N, Behzad S, Habtemariam S, Ahmed T, Daglia M, Nabavi SM, Sobarzo-Sanchez E, Nabavi SF. Neuroprotective effects of citrus fruit-derived flavonoids, nobiletin, and tangeretin in Alzheimer’s and Parkinson’s disease. CNS Neurol Disord Drug Targets 2017;16(4):387-397. DOI: 10.2174/187.152.7316666.170.328113309.
Singh B, Singh JP, Kaur A, Singh N. Phenolic composition, antioxidant potential and health benefits of citrus peel. Food Res Int. 2020;132:109114:1-22. DOI: 10.1016/j.foodres.2020.
Huang H, Li L, Shi W, Liu H, Yang J, Yuan X, Wu L. The multifunctional effects of nobiletin and its metabolites in vivo and in vitro. Evid Based Complement Alternat Med. 2016;2016:2918796. DOI: 10.1155/2016/2918796.
Murakami A, Koshimizu K, Ohigashi H, Kuwahara S, Kuki W, Takahashi Y, Hosotani K, Kawahara S, Matsuoka Y. Characteristic rat tissue accumulation of nobiletin, a chemopreventivepolymethoxyflavonoid, in comparison with luteolin. Biofactors 2002;16(3-4):73-82. DOI: 10.1002/biof.552.016.0303.
Goh JXH, Tan LT, Goh JK, Chan KG, Pusparajah P, Lee LH, Goh BH. Nobiletin and derivatives: Functional compounds from citrus fruit peel for colon cancer chemoprevention. Cancers 2019;11(6):867:1-34. DOI: 10.3390/cancers11060867.
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Youn K, Yu Y, Lee J, Jeong WS, Ho CT, Jun M. Polymethoxyflavones: Novel β-secretase (BACE1) inhibitors from citrus peels. Nutrients 2017;9(9):973:1-12. DOI: 10.3390/nu9090973.
Ashrafizadeh M, Zarrabi A, Saberifar S, Hashemi F, Hushmandi K, Hashemi F, Moghadam ER, Mohammadinejad R, Najafi M, Garg M. Nobiletin in cancer therapy: How this plant-derivednatural compound targets various oncogene and oncosuppressor pathways. Biomedicines 2020;8(5):110:1-31. DOI:10.3390/biomedicines8050110.
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Hattori T, Tagawa H, Inai M, Kan T, Kimura S-i, Itai S, Mitragotri S, Iwao Y. Transdermal delivery of nobiletin using ionic liquids. Sci Rep. 2019;9(1):20191:1-11. DOI: 10.1038/s41598.019.56731-1.
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Primary Language	English
Subjects	Food Properties, Food Nutritional Balance
Journal Section	Review
Authors	Meryem Saban Güler 0000-0002-7202-0524 Hilal Yıldıran 0000-0001-7956-5087
Publication Date	June 28, 2024
Submission Date	September 12, 2023
Published in Issue	Year 2024 Volume: 14 Issue: 2

Cite

APA	Saban Güler, M., & Yıldıran, H. (2024). Comprehensive Review of Nobiletin, a Citrus Flavonoid: Metabolism and Anti-tumor Properties. Clinical and Experimental Health Sciences, 14(2), 561-571. https://doi.org/10.33808/clinexphealthsci.1356783
AMA	Saban Güler M, Yıldıran H. Comprehensive Review of Nobiletin, a Citrus Flavonoid: Metabolism and Anti-tumor Properties. Clinical and Experimental Health Sciences. June 2024;14(2):561-571. doi:10.33808/clinexphealthsci.1356783
Chicago	Saban Güler, Meryem, and Hilal Yıldıran. “Comprehensive Review of Nobiletin, a Citrus Flavonoid: Metabolism and Anti-Tumor Properties”. Clinical and Experimental Health Sciences 14, no. 2 (June 2024): 561-71. https://doi.org/10.33808/clinexphealthsci.1356783.
EndNote	Saban Güler M, Yıldıran H (June 1, 2024) Comprehensive Review of Nobiletin, a Citrus Flavonoid: Metabolism and Anti-tumor Properties. Clinical and Experimental Health Sciences 14 2 561–571.
IEEE	M. Saban Güler and H. Yıldıran, “Comprehensive Review of Nobiletin, a Citrus Flavonoid: Metabolism and Anti-tumor Properties”, Clinical and Experimental Health Sciences, vol. 14, no. 2, pp. 561–571, 2024, doi: 10.33808/clinexphealthsci.1356783.
ISNAD	Saban Güler, Meryem - Yıldıran, Hilal. “Comprehensive Review of Nobiletin, a Citrus Flavonoid: Metabolism and Anti-Tumor Properties”. Clinical and Experimental Health Sciences 14/2 (June 2024), 561-571. https://doi.org/10.33808/clinexphealthsci.1356783.
JAMA	Saban Güler M, Yıldıran H. Comprehensive Review of Nobiletin, a Citrus Flavonoid: Metabolism and Anti-tumor Properties. Clinical and Experimental Health Sciences. 2024;14:561–571.
MLA	Saban Güler, Meryem and Hilal Yıldıran. “Comprehensive Review of Nobiletin, a Citrus Flavonoid: Metabolism and Anti-Tumor Properties”. Clinical and Experimental Health Sciences, vol. 14, no. 2, 2024, pp. 561-7, doi:10.33808/clinexphealthsci.1356783.
Vancouver	Saban Güler M, Yıldıran H. Comprehensive Review of Nobiletin, a Citrus Flavonoid: Metabolism and Anti-tumor Properties. Clinical and Experimental Health Sciences. 2024;14(2):561-7.

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